Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9B5_LEIBR

TriTrypDb:

LbrM.18.0120 , LBRM2903_180006100

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9B5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.310
CLV_NRD_NRD_1	177	179	PF00675	0.571
CLV_NRD_NRD_1	237	239	PF00675	0.404
CLV_NRD_NRD_1	276	278	PF00675	0.424
CLV_NRD_NRD_1	377	379	PF00675	0.420
CLV_NRD_NRD_1	449	451	PF00675	0.544
CLV_PCSK_FUR_1	447	451	PF00082	0.379
CLV_PCSK_KEX2_1	138	140	PF00082	0.629
CLV_PCSK_KEX2_1	176	178	PF00082	0.547
CLV_PCSK_KEX2_1	237	239	PF00082	0.417
CLV_PCSK_KEX2_1	276	278	PF00082	0.405
CLV_PCSK_KEX2_1	449	451	PF00082	0.544
CLV_PCSK_KEX2_1	66	68	PF00082	0.427
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.629
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.490
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.444
CLV_PCSK_SKI1_1	14	18	PF00082	0.464
CLV_PCSK_SKI1_1	237	241	PF00082	0.447
CLV_PCSK_SKI1_1	326	330	PF00082	0.292
DOC_CDC14_PxL_1	330	338	PF14671	0.343
DOC_CKS1_1	48	53	PF01111	0.594
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.451
DOC_MAPK_gen_1	378	386	PF00069	0.397
DOC_MAPK_gen_1	66	73	PF00069	0.503
DOC_MAPK_MEF2A_6	208	216	PF00069	0.544
DOC_MAPK_MEF2A_6	356	364	PF00069	0.550
DOC_MAPK_MEF2A_6	378	386	PF00069	0.567
DOC_MAPK_MEF2A_6	66	73	PF00069	0.500
DOC_MAPK_NFAT4_5	379	387	PF00069	0.554
DOC_MAPK_RevD_3	436	450	PF00069	0.295
DOC_PP1_RVXF_1	261	268	PF00149	0.462
DOC_PP1_RVXF_1	324	330	PF00149	0.436
DOC_PP2B_LxvP_1	26	29	PF13499	0.435
DOC_PP2B_LxvP_1	386	389	PF13499	0.412
DOC_PP4_FxxP_1	216	219	PF00568	0.621
DOC_USP7_MATH_1	126	130	PF00917	0.497
DOC_USP7_MATH_1	33	37	PF00917	0.481
DOC_USP7_UBL2_3	14	18	PF12436	0.325
DOC_USP7_UBL2_3	423	427	PF12436	0.325
DOC_WW_Pin1_4	188	193	PF00397	0.613
DOC_WW_Pin1_4	19	24	PF00397	0.393
DOC_WW_Pin1_4	297	302	PF00397	0.672
DOC_WW_Pin1_4	403	408	PF00397	0.326
DOC_WW_Pin1_4	47	52	PF00397	0.512
LIG_14-3-3_CanoR_1	112	120	PF00244	0.521
LIG_14-3-3_CanoR_1	164	168	PF00244	0.550
LIG_14-3-3_CanoR_1	208	212	PF00244	0.613
LIG_14-3-3_CanoR_1	245	255	PF00244	0.390
LIG_14-3-3_CanoR_1	341	345	PF00244	0.514
LIG_14-3-3_CanoR_1	37	46	PF00244	0.338
LIG_14-3-3_CanoR_1	434	439	PF00244	0.439
LIG_BIR_II_1	1	5	PF00653	0.416
LIG_BIR_III_4	226	230	PF00653	0.315
LIG_BRCT_BRCA1_1	240	244	PF00533	0.472
LIG_CSL_BTD_1	26	29	PF09270	0.318
LIG_EVH1_2	212	216	PF00568	0.579
LIG_FHA_1	113	119	PF00498	0.591
LIG_FHA_1	193	199	PF00498	0.621
LIG_FHA_1	361	367	PF00498	0.315
LIG_FHA_1	39	45	PF00498	0.463
LIG_FHA_1	409	415	PF00498	0.490
LIG_FHA_1	57	63	PF00498	0.447
LIG_FHA_1	83	89	PF00498	0.494
LIG_FHA_2	221	227	PF00498	0.467
LIG_FHA_2	245	251	PF00498	0.574
LIG_FHA_2	280	286	PF00498	0.440
LIG_FHA_2	55	61	PF00498	0.461
LIG_LIR_Nem_3	25	30	PF02991	0.346
LIG_LIR_Nem_3	322	328	PF02991	0.321
LIG_LIR_Nem_3	331	336	PF02991	0.392
LIG_LYPXL_yS_3	333	336	PF13949	0.355
LIG_MAD2	326	334	PF02301	0.307
LIG_PCNA_PIPBox_1	390	399	PF02747	0.475
LIG_Pex14_2	240	244	PF04695	0.389
LIG_Pex14_2	325	329	PF04695	0.303
LIG_Rb_LxCxE_1	1	22	PF01857	0.429
LIG_SH2_STAT5	268	271	PF00017	0.400
LIG_SH2_STAT5	342	345	PF00017	0.433
LIG_SH2_STAT5	440	443	PF00017	0.420
LIG_SH3_3	214	220	PF00018	0.553
LIG_SH3_3	29	35	PF00018	0.355
LIG_SH3_3	45	51	PF00018	0.489
LIG_SH3_3	84	90	PF00018	0.449
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.566
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.298
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.442
LIG_SUMO_SIM_par_1	30	36	PF11976	0.449
LIG_SUMO_SIM_par_1	363	369	PF11976	0.298
LIG_SUMO_SIM_par_1	59	65	PF11976	0.461
LIG_TRAF2_1	248	251	PF00917	0.582
LIG_TRFH_1	216	220	PF08558	0.406
MOD_CDK_SPK_2	188	193	PF00069	0.596
MOD_CDK_SPxxK_3	403	410	PF00069	0.338
MOD_CK1_1	104	110	PF00069	0.474
MOD_CK1_1	127	133	PF00069	0.583
MOD_CK1_1	145	151	PF00069	0.533
MOD_CK1_1	163	169	PF00069	0.724
MOD_CK1_1	246	252	PF00069	0.543
MOD_CK1_1	253	259	PF00069	0.405
MOD_CK1_1	340	346	PF00069	0.515
MOD_CK1_1	369	375	PF00069	0.387
MOD_CK2_1	244	250	PF00069	0.535
MOD_CK2_1	279	285	PF00069	0.504
MOD_CK2_1	291	297	PF00069	0.782
MOD_Cter_Amidation	107	110	PF01082	0.483
MOD_GlcNHglycan	106	109	PF01048	0.453
MOD_GlcNHglycan	126	129	PF01048	0.570
MOD_GlcNHglycan	368	371	PF01048	0.318
MOD_GSK3_1	126	133	PF00069	0.608
MOD_GSK3_1	145	152	PF00069	0.629
MOD_GSK3_1	188	195	PF00069	0.572
MOD_GSK3_1	197	204	PF00069	0.549
MOD_GSK3_1	228	235	PF00069	0.549
MOD_GSK3_1	246	253	PF00069	0.425
MOD_GSK3_1	275	282	PF00069	0.509
MOD_GSK3_1	293	300	PF00069	0.664
MOD_GSK3_1	340	347	PF00069	0.533
MOD_GSK3_1	362	369	PF00069	0.317
MOD_GSK3_1	4	11	PF00069	0.500
MOD_GSK3_1	415	422	PF00069	0.384
MOD_GSK3_1	54	61	PF00069	0.496
MOD_N-GLC_1	142	147	PF02516	0.603
MOD_N-GLC_1	401	406	PF02516	0.503
MOD_N-GLC_1	434	439	PF02516	0.498
MOD_NEK2_1	154	159	PF00069	0.598
MOD_NEK2_1	198	203	PF00069	0.520
MOD_NEK2_1	244	249	PF00069	0.454
MOD_NEK2_1	275	280	PF00069	0.308
MOD_NEK2_1	362	367	PF00069	0.377
MOD_NEK2_1	382	387	PF00069	0.480
MOD_NEK2_1	401	406	PF00069	0.249
MOD_NEK2_1	54	59	PF00069	0.469
MOD_PIKK_1	112	118	PF00454	0.401
MOD_PIKK_1	192	198	PF00454	0.514
MOD_PIKK_1	207	213	PF00454	0.557
MOD_PIKK_1	299	305	PF00454	0.393
MOD_PKA_2	101	107	PF00069	0.476
MOD_PKA_2	160	166	PF00069	0.637
MOD_PKA_2	192	198	PF00069	0.542
MOD_PKA_2	207	213	PF00069	0.564
MOD_PKA_2	244	250	PF00069	0.463
MOD_PKA_2	275	281	PF00069	0.542
MOD_PKA_2	291	297	PF00069	0.674
MOD_PKA_2	340	346	PF00069	0.543
MOD_PKA_2	419	425	PF00069	0.586
MOD_PKB_1	277	285	PF00069	0.455
MOD_Plk_1	145	151	PF00069	0.626
MOD_Plk_1	220	226	PF00069	0.463
MOD_Plk_1	344	350	PF00069	0.469
MOD_Plk_1	382	388	PF00069	0.556
MOD_Plk_1	401	407	PF00069	0.245
MOD_Plk_1	434	440	PF00069	0.495
MOD_Plk_1	8	14	PF00069	0.446
MOD_Plk_1	82	88	PF00069	0.498
MOD_Plk_4	220	226	PF00069	0.555
MOD_Plk_4	228	234	PF00069	0.360
MOD_Plk_4	362	368	PF00069	0.331
MOD_Plk_4	382	388	PF00069	0.525
MOD_Plk_4	58	64	PF00069	0.550
MOD_Plk_4	82	88	PF00069	0.516
MOD_ProDKin_1	188	194	PF00069	0.612
MOD_ProDKin_1	19	25	PF00069	0.389
MOD_ProDKin_1	297	303	PF00069	0.667
MOD_ProDKin_1	403	409	PF00069	0.331
MOD_ProDKin_1	47	53	PF00069	0.505
MOD_SUMO_for_1	309	312	PF00179	0.441
MOD_SUMO_rev_2	291	296	PF00179	0.759
MOD_SUMO_rev_2	437	446	PF00179	0.393
TRG_ENDOCYTIC_2	333	336	PF00928	0.436
TRG_ENDOCYTIC_2	81	84	PF00928	0.348
TRG_ER_diArg_1	139	142	PF00400	0.697
TRG_ER_diArg_1	177	179	PF00400	0.593
TRG_ER_diArg_1	237	239	PF00400	0.399
TRG_ER_diArg_1	275	277	PF00400	0.369
TRG_ER_diArg_1	446	449	PF00400	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P518	Leptomonas seymouri	57%	99%
A0A1X0P854	Trypanosomatidae	29%	100%
A0A3Q8IJL1	Leishmania donovani	77%	99%
A0A3R7KLI0	Trypanosoma rangeli	31%	100%
A4HXN6	Leishmania infantum	77%	100%
D0A013	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
E9ARE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QE32	Leishmania major	78%	100%
V5APZ6	Trypanosoma cruzi	27%	100%