Putative alpha glucosidase II subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alpha glucosidase II subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H9B4_LEIBR

TriTrypDb:

LbrM.18.0110 , LBRM2903_180006000

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9B4

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	6
GO:0009100	glycoprotein metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	6
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0005975	carbohydrate metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	12
GO:0004558	alpha-1,4-glucosidase activity	7	7
GO:0005488	binding	1	12
GO:0015926	glucosidase activity	5	8
GO:0016787	hydrolase activity	2	12
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	12
GO:0030246	carbohydrate binding	2	12
GO:0032450	maltose alpha-glucosidase activity	8	7
GO:0090599	alpha-glucosidase activity	6	8
GO:0033919	glucan 1,3-alpha-glucosidase activity	8	1
GO:0090600	alpha-1,3-glucosidase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.341
CLV_NRD_NRD_1	547	549	PF00675	0.292
CLV_NRD_NRD_1	678	680	PF00675	0.348
CLV_NRD_NRD_1	794	796	PF00675	0.424
CLV_PCSK_FUR_1	676	680	PF00082	0.355
CLV_PCSK_KEX2_1	329	331	PF00082	0.339
CLV_PCSK_KEX2_1	547	549	PF00082	0.293
CLV_PCSK_KEX2_1	678	680	PF00082	0.348
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.326
CLV_PCSK_SKI1_1	294	298	PF00082	0.292
CLV_PCSK_SKI1_1	3	7	PF00082	0.558
CLV_PCSK_SKI1_1	307	311	PF00082	0.292
CLV_PCSK_SKI1_1	319	323	PF00082	0.236
CLV_PCSK_SKI1_1	466	470	PF00082	0.216
CLV_PCSK_SKI1_1	562	566	PF00082	0.307
CLV_PCSK_SKI1_1	568	572	PF00082	0.307
CLV_PCSK_SKI1_1	591	595	PF00082	0.292
CLV_PCSK_SKI1_1	767	771	PF00082	0.429
DEG_APCC_DBOX_1	2	10	PF00400	0.447
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DOC_CDC14_PxL_1	569	577	PF14671	0.307
DOC_CKS1_1	779	784	PF01111	0.465
DOC_CKS1_1	94	99	PF01111	0.318
DOC_CYCLIN_RxL_1	588	596	PF00134	0.294
DOC_MAPK_DCC_7	666	675	PF00069	0.266
DOC_MAPK_FxFP_2	127	130	PF00069	0.402
DOC_MAPK_FxFP_2	161	164	PF00069	0.215
DOC_MAPK_gen_1	316	323	PF00069	0.292
DOC_MAPK_gen_1	795	802	PF00069	0.416
DOC_MAPK_JIP1_4	796	802	PF00069	0.274
DOC_MAPK_MEF2A_6	3	10	PF00069	0.653
DOC_MAPK_MEF2A_6	666	675	PF00069	0.266
DOC_PP2B_LxvP_1	22	25	PF13499	0.623
DOC_PP2B_PxIxI_1	613	619	PF00149	0.437
DOC_PP4_FxxP_1	127	130	PF00568	0.396
DOC_PP4_FxxP_1	161	164	PF00568	0.215
DOC_PP4_FxxP_1	191	194	PF00568	0.437
DOC_PP4_FxxP_1	222	225	PF00568	0.307
DOC_PP4_FxxP_1	303	306	PF00568	0.292
DOC_USP7_MATH_1	164	168	PF00917	0.447
DOC_USP7_MATH_1	206	210	PF00917	0.458
DOC_USP7_MATH_1	312	316	PF00917	0.326
DOC_USP7_MATH_1	361	365	PF00917	0.292
DOC_USP7_MATH_1	388	392	PF00917	0.357
DOC_USP7_MATH_1	451	455	PF00917	0.215
DOC_USP7_MATH_1	51	55	PF00917	0.342
DOC_WW_Pin1_4	225	230	PF00397	0.307
DOC_WW_Pin1_4	737	742	PF00397	0.476
DOC_WW_Pin1_4	778	783	PF00397	0.467
DOC_WW_Pin1_4	93	98	PF00397	0.322
LIG_14-3-3_CanoR_1	3	9	PF00244	0.579
LIG_14-3-3_CanoR_1	318	324	PF00244	0.386
LIG_14-3-3_CanoR_1	363	367	PF00244	0.266
LIG_14-3-3_CanoR_1	676	686	PF00244	0.370
LIG_14-3-3_CanoR_1	723	728	PF00244	0.293
LIG_AP2alpha_2	687	689	PF02296	0.323
LIG_BIR_III_4	349	353	PF00653	0.357
LIG_BRCT_BRCA1_1	378	382	PF00533	0.357
LIG_deltaCOP1_diTrp_1	358	366	PF00928	0.300
LIG_deltaCOP1_diTrp_1	376	382	PF00928	0.245
LIG_deltaCOP1_diTrp_1	549	553	PF00928	0.307
LIG_deltaCOP1_diTrp_1	636	643	PF00928	0.437
LIG_deltaCOP1_diTrp_1	804	809	PF00928	0.423
LIG_FHA_1	126	132	PF00498	0.310
LIG_FHA_1	166	172	PF00498	0.437
LIG_FHA_1	184	190	PF00498	0.171
LIG_FHA_1	280	286	PF00498	0.492
LIG_FHA_1	308	314	PF00498	0.424
LIG_FHA_1	39	45	PF00498	0.571
LIG_FHA_1	550	556	PF00498	0.233
LIG_FHA_1	628	634	PF00498	0.343
LIG_FHA_1	651	657	PF00498	0.335
LIG_FHA_1	688	694	PF00498	0.292
LIG_FHA_1	748	754	PF00498	0.498
LIG_FHA_1	775	781	PF00498	0.540
LIG_FHA_1	789	795	PF00498	0.362
LIG_FHA_1	89	95	PF00498	0.268
LIG_FHA_2	195	201	PF00498	0.335
LIG_FHA_2	300	306	PF00498	0.407
LIG_FHA_2	320	326	PF00498	0.304
LIG_FHA_2	394	400	PF00498	0.326
LIG_FHA_2	517	523	PF00498	0.321
LIG_FHA_2	770	776	PF00498	0.494
LIG_FHA_2	779	785	PF00498	0.416
LIG_IBAR_NPY_1	299	301	PF08397	0.236
LIG_IRF3_LxIS_1	497	503	PF10401	0.355
LIG_KLC1_Yacidic_2	704	708	PF13176	0.437
LIG_LIR_Apic_2	124	130	PF02991	0.396
LIG_LIR_Apic_2	158	164	PF02991	0.215
LIG_LIR_Apic_2	220	225	PF02991	0.307
LIG_LIR_Apic_2	302	306	PF02991	0.380
LIG_LIR_Gen_1	256	265	PF02991	0.321
LIG_LIR_Gen_1	281	291	PF02991	0.324
LIG_LIR_Gen_1	376	383	PF02991	0.329
LIG_LIR_Gen_1	396	405	PF02991	0.356
LIG_LIR_Gen_1	437	444	PF02991	0.226
LIG_LIR_Gen_1	472	482	PF02991	0.326
LIG_LIR_Gen_1	637	648	PF02991	0.390
LIG_LIR_Gen_1	687	697	PF02991	0.303
LIG_LIR_Gen_1	784	793	PF02991	0.460
LIG_LIR_Gen_1	804	812	PF02991	0.225
LIG_LIR_Nem_3	281	287	PF02991	0.324
LIG_LIR_Nem_3	297	301	PF02991	0.394
LIG_LIR_Nem_3	364	369	PF02991	0.290
LIG_LIR_Nem_3	376	381	PF02991	0.287
LIG_LIR_Nem_3	437	442	PF02991	0.335
LIG_LIR_Nem_3	636	642	PF02991	0.302
LIG_LIR_Nem_3	687	692	PF02991	0.310
LIG_LIR_Nem_3	701	705	PF02991	0.288
LIG_LIR_Nem_3	784	788	PF02991	0.476
LIG_LIR_Nem_3	804	809	PF02991	0.208
LIG_Pex14_1	639	643	PF04695	0.386
LIG_Pex14_1	805	809	PF04695	0.465
LIG_PTB_Apo_2	501	508	PF02174	0.292
LIG_PTB_Apo_2	714	721	PF02174	0.236
LIG_SH2_CRK	172	176	PF00017	0.292
LIG_SH2_CRK	378	382	PF00017	0.266
LIG_SH2_CRK	439	443	PF00017	0.335
LIG_SH2_CRK	569	573	PF00017	0.292
LIG_SH2_CRK	759	763	PF00017	0.346
LIG_SH2_GRB2like	40	43	PF00017	0.401
LIG_SH2_GRB2like	715	718	PF00017	0.271
LIG_SH2_GRB2like	727	730	PF00017	0.467
LIG_SH2_NCK_1	569	573	PF00017	0.321
LIG_SH2_SRC	383	386	PF00017	0.215
LIG_SH2_SRC	715	718	PF00017	0.215
LIG_SH2_STAP1	280	284	PF00017	0.292
LIG_SH2_STAP1	378	382	PF00017	0.292
LIG_SH2_STAP1	383	387	PF00017	0.292
LIG_SH2_STAP1	439	443	PF00017	0.437
LIG_SH2_STAP1	475	479	PF00017	0.292
LIG_SH2_STAP1	576	580	PF00017	0.292
LIG_SH2_STAP1	727	731	PF00017	0.473
LIG_SH2_STAT3	181	184	PF00017	0.291
LIG_SH2_STAT3	727	730	PF00017	0.473
LIG_SH2_STAT5	248	251	PF00017	0.306
LIG_SH2_STAT5	295	298	PF00017	0.295
LIG_SH2_STAT5	301	304	PF00017	0.350
LIG_SH2_STAT5	346	349	PF00017	0.288
LIG_SH2_STAT5	40	43	PF00017	0.295
LIG_SH2_STAT5	574	577	PF00017	0.292
LIG_SH2_STAT5	610	613	PF00017	0.333
LIG_SH2_STAT5	642	645	PF00017	0.437
LIG_SH2_STAT5	706	709	PF00017	0.367
LIG_SH2_STAT5	761	764	PF00017	0.517
LIG_SH3_1	595	601	PF00018	0.215
LIG_SH3_3	241	247	PF00018	0.439
LIG_SH3_3	320	326	PF00018	0.386
LIG_SH3_3	455	461	PF00018	0.292
LIG_SH3_3	529	535	PF00018	0.340
LIG_SH3_3	595	601	PF00018	0.313
LIG_SH3_3	618	624	PF00018	0.348
LIG_SH3_3	626	632	PF00018	0.277
LIG_SH3_3	776	782	PF00018	0.587
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.549
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.552
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.281
LIG_SUMO_SIM_par_1	12	18	PF11976	0.585
LIG_SUMO_SIM_par_1	319	325	PF11976	0.292
LIG_SUMO_SIM_par_1	496	501	PF11976	0.292
LIG_SUMO_SIM_par_1	798	804	PF11976	0.321
LIG_SUMO_SIM_par_1	87	93	PF11976	0.402
LIG_TRAF2_1	519	522	PF00917	0.307
LIG_TRFH_1	569	573	PF08558	0.259
LIG_TYR_ITIM	567	572	PF00017	0.292
LIG_TYR_ITIM	757	762	PF00017	0.386
LIG_UBA3_1	70	74	PF00899	0.327
LIG_WRC_WIRS_1	576	581	PF05994	0.386
LIG_WRC_WIRS_1	806	811	PF05994	0.400
MOD_CDK_SPxxK_3	93	100	PF00069	0.296
MOD_CK1_1	117	123	PF00069	0.403
MOD_CK1_1	202	208	PF00069	0.455
MOD_CK1_1	332	338	PF00069	0.215
MOD_CK1_1	4	10	PF00069	0.733
MOD_CK1_1	437	443	PF00069	0.326
MOD_CK1_1	93	99	PF00069	0.460
MOD_CK2_1	106	112	PF00069	0.512
MOD_CK2_1	194	200	PF00069	0.335
MOD_CK2_1	265	271	PF00069	0.437
MOD_CK2_1	490	496	PF00069	0.307
MOD_CK2_1	516	522	PF00069	0.321
MOD_CK2_1	538	544	PF00069	0.253
MOD_CK2_1	778	784	PF00069	0.557
MOD_Cter_Amidation	316	319	PF01082	0.292
MOD_GlcNHglycan	200	204	PF01048	0.366
MOD_GlcNHglycan	3	6	PF01048	0.676
MOD_GlcNHglycan	331	334	PF01048	0.283
MOD_GlcNHglycan	349	353	PF01048	0.361
MOD_GlcNHglycan	607	610	PF01048	0.215
MOD_GlcNHglycan	643	646	PF01048	0.350
MOD_GlcNHglycan	734	737	PF01048	0.545
MOD_GSK3_1	202	209	PF00069	0.500
MOD_GSK3_1	409	416	PF00069	0.447
MOD_GSK3_1	496	503	PF00069	0.307
MOD_GSK3_1	538	545	PF00069	0.319
MOD_GSK3_1	581	588	PF00069	0.399
MOD_GSK3_1	737	744	PF00069	0.461
MOD_GSK3_1	774	781	PF00069	0.538
MOD_LATS_1	327	333	PF00433	0.297
MOD_N-GLC_1	117	122	PF02516	0.538
MOD_N-GLC_1	125	130	PF02516	0.428
MOD_N-GLC_1	165	170	PF02516	0.442
MOD_N-GLC_1	624	629	PF02516	0.255
MOD_NEK2_1	1	6	PF00069	0.658
MOD_NEK2_1	101	106	PF00069	0.444
MOD_NEK2_1	15	20	PF00069	0.433
MOD_NEK2_1	253	258	PF00069	0.215
MOD_NEK2_1	369	374	PF00069	0.429
MOD_NEK2_1	38	43	PF00069	0.325
MOD_NEK2_1	413	418	PF00069	0.215
MOD_NEK2_1	462	467	PF00069	0.312
MOD_NEK2_1	490	495	PF00069	0.292
MOD_NEK2_1	498	503	PF00069	0.292
MOD_NEK2_1	536	541	PF00069	0.276
MOD_NEK2_1	575	580	PF00069	0.283
MOD_NEK2_1	677	682	PF00069	0.405
MOD_NEK2_1	725	730	PF00069	0.328
MOD_NEK2_1	732	737	PF00069	0.357
MOD_NEK2_1	747	752	PF00069	0.335
MOD_NEK2_1	90	95	PF00069	0.485
MOD_PIKK_1	376	382	PF00454	0.357
MOD_PIKK_1	469	475	PF00454	0.326
MOD_PIKK_1	542	548	PF00454	0.215
MOD_PKA_1	329	335	PF00069	0.297
MOD_PKA_1	678	684	PF00069	0.340
MOD_PKA_2	329	335	PF00069	0.306
MOD_PKA_2	362	368	PF00069	0.284
MOD_PKA_2	45	51	PF00069	0.398
MOD_PKA_2	451	457	PF00069	0.215
MOD_PKA_2	677	683	PF00069	0.347
MOD_PKA_2	763	769	PF00069	0.479
MOD_PKB_1	676	684	PF00069	0.345
MOD_Plk_1	111	117	PF00069	0.472
MOD_Plk_1	125	131	PF00069	0.481
MOD_Plk_1	165	171	PF00069	0.271
MOD_Plk_1	490	496	PF00069	0.386
MOD_Plk_1	51	57	PF00069	0.344
MOD_Plk_1	627	633	PF00069	0.357
MOD_Plk_2-3	265	271	PF00069	0.386
MOD_Plk_2-3	393	399	PF00069	0.307
MOD_Plk_2-3	709	715	PF00069	0.359
MOD_Plk_4	106	112	PF00069	0.430
MOD_Plk_4	131	137	PF00069	0.452
MOD_Plk_4	240	246	PF00069	0.323
MOD_Plk_4	279	285	PF00069	0.300
MOD_Plk_4	393	399	PF00069	0.386
MOD_Plk_4	4	10	PF00069	0.452
MOD_Plk_4	401	407	PF00069	0.284
MOD_Plk_4	434	440	PF00069	0.315
MOD_Plk_4	556	562	PF00069	0.344
MOD_Plk_4	575	581	PF00069	0.188
MOD_Plk_4	585	591	PF00069	0.386
MOD_Plk_4	612	618	PF00069	0.307
MOD_Plk_4	634	640	PF00069	0.226
MOD_Plk_4	741	747	PF00069	0.472
MOD_Plk_4	788	794	PF00069	0.427
MOD_Plk_4	90	96	PF00069	0.464
MOD_ProDKin_1	225	231	PF00069	0.307
MOD_ProDKin_1	737	743	PF00069	0.489
MOD_ProDKin_1	778	784	PF00069	0.470
MOD_ProDKin_1	93	99	PF00069	0.314
MOD_SUMO_for_1	49	52	PF00179	0.539
TRG_DiLeu_BaEn_1	556	561	PF01217	0.437
TRG_DiLeu_BaEn_2	519	525	PF01217	0.437
TRG_DiLeu_BaEn_2	715	721	PF01217	0.333
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.330
TRG_ENDOCYTIC_2	172	175	PF00928	0.292
TRG_ENDOCYTIC_2	248	251	PF00928	0.356
TRG_ENDOCYTIC_2	280	283	PF00928	0.292
TRG_ENDOCYTIC_2	378	381	PF00928	0.292
TRG_ENDOCYTIC_2	439	442	PF00928	0.213
TRG_ENDOCYTIC_2	475	478	PF00928	0.292
TRG_ENDOCYTIC_2	569	572	PF00928	0.292
TRG_ENDOCYTIC_2	576	579	PF00928	0.292
TRG_ENDOCYTIC_2	640	643	PF00928	0.386
TRG_ENDOCYTIC_2	702	705	PF00928	0.367
TRG_ENDOCYTIC_2	759	762	PF00928	0.337
TRG_ER_diArg_1	675	678	PF00400	0.363
TRG_Pf-PMV_PEXEL_1	591	596	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F9	Leptomonas seymouri	68%	99%
A0A0S4ITP0	Bodo saltans	38%	94%
A0A0S4JEB6	Bodo saltans	45%	97%
A0A0S4JFD6	Bodo saltans	28%	85%
A0A0S4JJL0	Bodo saltans	27%	100%
A0A1X0P3Y3	Trypanosomatidae	30%	67%
A0A1X0P7R2	Trypanosomatidae	53%	99%
A0A3R7MQZ9	Trypanosoma rangeli	51%	99%
A0A3S5H722	Leishmania donovani	82%	100%
A0A422NT82	Trypanosoma rangeli	32%	77%
A4HXN5	Leishmania infantum	82%	100%
A7LXT0	Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153)	26%	85%
B3PEE6	Cellvibrio japonicus (strain Ueda107)	26%	100%
B9F676	Oryza sativa subsp. japonica	42%	88%
D0A012	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A8P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	77%
D0KQM8	Saccharolobus solfataricus (strain 98/2)	31%	100%
E9ARE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O00906	Tetrahymena pyriformis	24%	88%
O04893	Spinacia oleracea	32%	90%
O04931	Beta vulgaris	31%	89%
P0CD66	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	100%
P10253	Homo sapiens	31%	85%
P31434	Escherichia coli (strain K12)	26%	100%
P38138	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	85%
P70699	Mus musculus	33%	85%
P79403	Sus scrofa	43%	86%
P96793	Lactiplantibacillus pentosus	25%	100%
Q14697	Homo sapiens	43%	86%
Q43763	Hordeum vulgare	30%	93%
Q4QE33	Leishmania major	82%	100%
Q4R4N7	Macaca fascicularis	43%	86%
Q5AW25	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q5R7A9	Pongo abelii	30%	85%
Q653V7	Oryza sativa subsp. japonica	32%	92%
Q6P7A9	Rattus norvegicus	32%	85%
Q8BHN3	Mus musculus	44%	86%
Q8BVW0	Mus musculus	40%	90%
Q8TET4	Homo sapiens	40%	89%
Q92442	Mucor javanicus	26%	94%
Q94502	Dictyostelium discoideum	39%	86%
Q9BE70	Macaca fascicularis	41%	100%
Q9F234	Bacillus thermoamyloliquefaciens	36%	100%
Q9FN05	Arabidopsis thaliana	39%	88%
Q9MYM4	Bos taurus	31%	87%
Q9P999	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	29%	100%
Q9S7Y7	Arabidopsis thaliana	31%	89%
Q9US55	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	88%
V5BS12	Trypanosoma cruzi	31%	77%
V5D5S5	Trypanosoma cruzi	52%	99%