DZANK-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type/Double zinc ribbon, putative

Species:

Leishmania braziliensis

UniProt:

A4H9B2_LEIBR

TriTrypDb:

LbrM.18.0090 , LBRM2903_180005800

Length:

721

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9B2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.335
CLV_NRD_NRD_1	145	147	PF00675	0.625
CLV_NRD_NRD_1	241	243	PF00675	0.275
CLV_NRD_NRD_1	300	302	PF00675	0.561
CLV_NRD_NRD_1	401	403	PF00675	0.311
CLV_NRD_NRD_1	415	417	PF00675	0.417
CLV_NRD_NRD_1	591	593	PF00675	0.287
CLV_NRD_NRD_1	611	613	PF00675	0.444
CLV_NRD_NRD_1	652	654	PF00675	0.444
CLV_NRD_NRD_1	693	695	PF00675	0.292
CLV_PCSK_FUR_1	137	141	PF00082	0.531
CLV_PCSK_KEX2_1	139	141	PF00082	0.736
CLV_PCSK_KEX2_1	145	147	PF00082	0.704
CLV_PCSK_KEX2_1	185	187	PF00082	0.308
CLV_PCSK_KEX2_1	240	242	PF00082	0.328
CLV_PCSK_KEX2_1	300	302	PF00082	0.526
CLV_PCSK_KEX2_1	401	403	PF00082	0.209
CLV_PCSK_KEX2_1	415	417	PF00082	0.217
CLV_PCSK_KEX2_1	591	593	PF00082	0.368
CLV_PCSK_KEX2_1	610	612	PF00082	0.478
CLV_PCSK_KEX2_1	652	654	PF00082	0.412
CLV_PCSK_KEX2_1	693	695	PF00082	0.404
CLV_PCSK_KEX2_1	719	721	PF00082	0.548
CLV_PCSK_KEX2_1	9	11	PF00082	0.528
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.527
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.308
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.573
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.433
CLV_PCSK_PC7_1	587	593	PF00082	0.193
CLV_PCSK_SKI1_1	241	245	PF00082	0.307
CLV_PCSK_SKI1_1	482	486	PF00082	0.377
CLV_PCSK_SKI1_1	611	615	PF00082	0.508
CLV_PCSK_SKI1_1	98	102	PF00082	0.283
DOC_MAPK_gen_1	642	651	PF00069	0.373
DOC_MAPK_gen_1	66	75	PF00069	0.383
DOC_PP2B_LxvP_1	497	500	PF13499	0.536
DOC_PP2B_LxvP_1	674	677	PF13499	0.487
DOC_USP7_MATH_1	264	268	PF00917	0.534
DOC_USP7_MATH_1	269	273	PF00917	0.545
DOC_USP7_MATH_1	283	287	PF00917	0.696
DOC_USP7_MATH_1	330	334	PF00917	0.555
DOC_USP7_MATH_1	336	340	PF00917	0.545
DOC_USP7_MATH_1	381	385	PF00917	0.271
DOC_USP7_MATH_1	454	458	PF00917	0.625
DOC_USP7_MATH_1	531	535	PF00917	0.600
DOC_USP7_MATH_1	540	544	PF00917	0.526
DOC_USP7_MATH_1	553	557	PF00917	0.725
DOC_USP7_MATH_2	531	537	PF00917	0.498
DOC_USP7_UBL2_3	113	117	PF12436	0.541
DOC_WW_Pin1_4	118	123	PF00397	0.594
DOC_WW_Pin1_4	144	149	PF00397	0.651
DOC_WW_Pin1_4	151	156	PF00397	0.619
DOC_WW_Pin1_4	262	267	PF00397	0.641
DOC_WW_Pin1_4	276	281	PF00397	0.582
DOC_WW_Pin1_4	400	405	PF00397	0.404
DOC_WW_Pin1_4	452	457	PF00397	0.631
DOC_WW_Pin1_4	504	509	PF00397	0.630
DOC_WW_Pin1_4	549	554	PF00397	0.564
DOC_WW_Pin1_4	629	634	PF00397	0.600
LIG_14-3-3_CanoR_1	140	144	PF00244	0.679
LIG_14-3-3_CanoR_1	149	154	PF00244	0.643
LIG_14-3-3_CanoR_1	312	317	PF00244	0.626
LIG_14-3-3_CanoR_1	462	470	PF00244	0.398
LIG_14-3-3_CanoR_1	522	531	PF00244	0.628
LIG_14-3-3_CanoR_1	706	712	PF00244	0.508
LIG_APCC_ABBAyCdc20_2	482	488	PF00400	0.338
LIG_BIR_III_4	427	431	PF00653	0.289
LIG_BRCT_BRCA1_1	647	651	PF00533	0.446
LIG_CSL_BTD_1	561	564	PF09270	0.511
LIG_deltaCOP1_diTrp_1	643	651	PF00928	0.488
LIG_FHA_1	160	166	PF00498	0.376
LIG_FHA_1	170	176	PF00498	0.307
LIG_FHA_1	280	286	PF00498	0.558
LIG_FHA_1	512	518	PF00498	0.626
LIG_FHA_1	523	529	PF00498	0.524
LIG_FHA_1	676	682	PF00498	0.401
LIG_FHA_2	575	581	PF00498	0.665
LIG_FHA_2	668	674	PF00498	0.518
LIG_LIR_Gen_1	223	233	PF02991	0.423
LIG_LIR_Gen_1	351	359	PF02991	0.316
LIG_LIR_Gen_1	81	91	PF02991	0.402
LIG_LIR_LC3C_4	246	250	PF02991	0.289
LIG_LIR_Nem_3	223	229	PF02991	0.434
LIG_LIR_Nem_3	349	353	PF02991	0.316
LIG_LIR_Nem_3	81	86	PF02991	0.384
LIG_MYND_1	157	161	PF01753	0.563
LIG_NBox_RRM_1	651	661	PF00076	0.557
LIG_NRP_CendR_1	719	721	PF00754	0.573
LIG_PTB_Apo_2	679	686	PF02174	0.587
LIG_PTB_Phospho_1	679	685	PF10480	0.594
LIG_SH2_STAP1	183	187	PF00017	0.425
LIG_SH2_STAT5	164	167	PF00017	0.274
LIG_SH2_STAT5	21	24	PF00017	0.271
LIG_SH2_STAT5	353	356	PF00017	0.344
LIG_SH2_STAT5	459	462	PF00017	0.643
LIG_SH2_STAT5	471	474	PF00017	0.448
LIG_SH2_STAT5	685	688	PF00017	0.289
LIG_SH3_2	637	642	PF14604	0.666
LIG_SH3_2	714	719	PF14604	0.541
LIG_SH3_3	116	122	PF00018	0.580
LIG_SH3_3	152	158	PF00018	0.594
LIG_SH3_3	199	205	PF00018	0.482
LIG_SH3_3	254	260	PF00018	0.583
LIG_SH3_3	525	531	PF00018	0.624
LIG_SH3_3	547	553	PF00018	0.611
LIG_SH3_3	56	62	PF00018	0.424
LIG_SH3_3	634	640	PF00018	0.630
LIG_SH3_3	683	689	PF00018	0.335
LIG_SH3_3	708	714	PF00018	0.533
LIG_SH3_3	88	94	PF00018	0.404
LIG_SH3_CIN85_PxpxPR_1	714	719	PF14604	0.541
LIG_TRAF2_1	564	567	PF00917	0.629
LIG_UBA3_1	1	9	PF00899	0.475
LIG_WW_1	676	679	PF00397	0.504
LIG_WW_3	716	720	PF00397	0.531
MOD_CDC14_SPxK_1	121	124	PF00782	0.497
MOD_CDC14_SPxK_1	265	268	PF00782	0.653
MOD_CDK_SPK_2	144	149	PF00069	0.624
MOD_CDK_SPxK_1	118	124	PF00069	0.600
MOD_CDK_SPxK_1	262	268	PF00069	0.645
MOD_CDK_SPxxK_3	144	151	PF00069	0.683
MOD_CK1_1	214	220	PF00069	0.593
MOD_CK1_1	276	282	PF00069	0.566
MOD_CK1_1	286	292	PF00069	0.568
MOD_CK1_1	315	321	PF00069	0.627
MOD_CK1_1	455	461	PF00069	0.673
MOD_CK1_1	507	513	PF00069	0.694
MOD_CK1_1	552	558	PF00069	0.566
MOD_CK2_1	214	220	PF00069	0.558
MOD_CK2_1	42	48	PF00069	0.469
MOD_CK2_1	576	582	PF00069	0.571
MOD_Cter_Amidation	137	140	PF01082	0.535
MOD_Cter_Amidation	589	592	PF01082	0.284
MOD_DYRK1A_RPxSP_1	151	155	PF00069	0.623
MOD_GlcNHglycan	213	216	PF01048	0.450
MOD_GlcNHglycan	271	274	PF01048	0.561
MOD_GlcNHglycan	28	31	PF01048	0.289
MOD_GlcNHglycan	285	288	PF01048	0.506
MOD_GlcNHglycan	294	297	PF01048	0.641
MOD_GlcNHglycan	332	335	PF01048	0.598
MOD_GlcNHglycan	555	558	PF01048	0.692
MOD_GSK3_1	118	125	PF00069	0.516
MOD_GSK3_1	269	276	PF00069	0.593
MOD_GSK3_1	279	286	PF00069	0.640
MOD_GSK3_1	288	295	PF00069	0.591
MOD_GSK3_1	311	318	PF00069	0.599
MOD_GSK3_1	363	370	PF00069	0.489
MOD_GSK3_1	396	403	PF00069	0.307
MOD_GSK3_1	457	464	PF00069	0.589
MOD_GSK3_1	507	514	PF00069	0.747
MOD_GSK3_1	541	548	PF00069	0.615
MOD_GSK3_1	549	556	PF00069	0.536
MOD_N-GLC_1	511	516	PF02516	0.570
MOD_N-GLC_1	541	546	PF02516	0.504
MOD_N-GLC_1	614	619	PF02516	0.544
MOD_N-GLC_2	431	433	PF02516	0.289
MOD_NEK2_1	386	391	PF00069	0.249
MOD_NEK2_1	545	550	PF00069	0.500
MOD_NEK2_1	614	619	PF00069	0.582
MOD_NEK2_2	381	386	PF00069	0.193
MOD_NEK2_2	466	471	PF00069	0.350
MOD_NEK2_2	667	672	PF00069	0.396
MOD_OFUCOSY	385	390	PF10250	0.193
MOD_PIKK_1	42	48	PF00454	0.469
MOD_PK_1	645	651	PF00069	0.359
MOD_PKA_1	139	145	PF00069	0.617
MOD_PKA_1	300	306	PF00069	0.526
MOD_PKA_1	42	48	PF00069	0.469
MOD_PKA_2	139	145	PF00069	0.643
MOD_PKA_2	300	306	PF00069	0.685
MOD_PKA_2	311	317	PF00069	0.545
MOD_PKA_2	381	387	PF00069	0.193
MOD_PKA_2	461	467	PF00069	0.430
MOD_PKA_2	521	527	PF00069	0.609
MOD_PKB_1	310	318	PF00069	0.514
MOD_Plk_1	511	517	PF00069	0.517
MOD_Plk_1	541	547	PF00069	0.503
MOD_Plk_2-3	423	429	PF00069	0.335
MOD_Plk_4	466	472	PF00069	0.338
MOD_ProDKin_1	118	124	PF00069	0.600
MOD_ProDKin_1	144	150	PF00069	0.651
MOD_ProDKin_1	151	157	PF00069	0.611
MOD_ProDKin_1	262	268	PF00069	0.645
MOD_ProDKin_1	276	282	PF00069	0.582
MOD_ProDKin_1	400	406	PF00069	0.404
MOD_ProDKin_1	452	458	PF00069	0.629
MOD_ProDKin_1	504	510	PF00069	0.631
MOD_ProDKin_1	549	555	PF00069	0.565
MOD_ProDKin_1	629	635	PF00069	0.601
MOD_SUMO_rev_2	463	469	PF00179	0.543
MOD_SUMO_rev_2	477	485	PF00179	0.523
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.534
TRG_ENDOCYTIC_2	353	356	PF00928	0.319
TRG_ENDOCYTIC_2	83	86	PF00928	0.514
TRG_ER_diArg_1	144	146	PF00400	0.767
TRG_ER_diArg_1	148	151	PF00400	0.748
TRG_ER_diArg_1	195	198	PF00400	0.690
TRG_ER_diArg_1	210	213	PF00400	0.552
TRG_ER_diArg_1	240	242	PF00400	0.328
TRG_ER_diArg_1	310	313	PF00400	0.568
TRG_ER_diArg_1	415	417	PF00400	0.245
TRG_ER_diArg_1	591	593	PF00400	0.374
TRG_ER_diArg_1	611	613	PF00400	0.528
TRG_ER_diArg_1	651	653	PF00400	0.449
TRG_ER_diArg_1	693	695	PF00400	0.404
TRG_ER_diArg_1	718	721	PF00400	0.550
TRG_NLS_Bipartite_1	591	613	PF00514	0.378
TRG_NLS_MonoCore_2	608	613	PF00514	0.559
TRG_NLS_MonoExtN_4	609	614	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P519	Leptomonas seymouri	55%	97%
A0A1X0P6N6	Trypanosomatidae	46%	96%
A0A3Q8I9V6	Leishmania donovani	72%	100%
A0A3S5IS42	Trypanosoma rangeli	43%	96%
A4HXN3	Leishmania infantum	72%	100%
D0A010	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
E9ARE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QE35	Leishmania major	71%	100%
V5BEH8	Trypanosoma cruzi	51%	100%