RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 27, putative

Species:

Leishmania braziliensis

UniProt:

A4H9A9_LEIBR

TriTrypDb:

LbrM.18.0040 , LBRM2903_180005500

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9A9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	146	150	PF00082	0.461
CLV_PCSK_SKI1_1	217	221	PF00082	0.713
CLV_PCSK_SKI1_1	271	275	PF00082	0.551
CLV_PCSK_SKI1_1	315	319	PF00082	0.571
CLV_PCSK_SKI1_1	340	344	PF00082	0.566
CLV_PCSK_SKI1_1	55	59	PF00082	0.205
DEG_APCC_KENBOX_2	294	298	PF00400	0.520
DEG_SPOP_SBC_1	100	104	PF00917	0.662
DEG_SPOP_SBC_1	317	321	PF00917	0.446
DOC_CYCLIN_RxL_1	268	278	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	126	129	PF00134	0.644
DOC_MAPK_gen_1	163	171	PF00069	0.342
DOC_MAPK_gen_1	71	79	PF00069	0.482
DOC_PP1_RVXF_1	36	42	PF00149	0.586
DOC_PP2B_LxvP_1	126	129	PF13499	0.644
DOC_USP7_MATH_1	316	320	PF00917	0.568
DOC_WW_Pin1_4	207	212	PF00397	0.690
DOC_WW_Pin1_4	236	241	PF00397	0.581
DOC_WW_Pin1_4	78	83	PF00397	0.501
LIG_14-3-3_CanoR_1	109	114	PF00244	0.518
LIG_14-3-3_CanoR_1	188	195	PF00244	0.407
LIG_14-3-3_CanoR_1	217	222	PF00244	0.689
LIG_14-3-3_CanoR_1	315	323	PF00244	0.591
LIG_14-3-3_CanoR_1	55	64	PF00244	0.463
LIG_APCC_ABBA_1	169	174	PF00400	0.605
LIG_APCC_ABBA_1	8	13	PF00400	0.355
LIG_Clathr_ClatBox_1	326	330	PF01394	0.720
LIG_FHA_1	116	122	PF00498	0.646
LIG_FHA_1	177	183	PF00498	0.518
LIG_FHA_1	216	222	PF00498	0.663
LIG_FHA_2	84	90	PF00498	0.488
LIG_LIR_Gen_1	120	131	PF02991	0.603
LIG_LIR_Gen_1	156	164	PF02991	0.543
LIG_LIR_Gen_1	170	177	PF02991	0.543
LIG_LIR_Gen_1	26	35	PF02991	0.473
LIG_LIR_Nem_3	120	126	PF02991	0.602
LIG_LIR_Nem_3	156	161	PF02991	0.494
LIG_LIR_Nem_3	170	175	PF02991	0.534
LIG_LIR_Nem_3	248	254	PF02991	0.539
LIG_LIR_Nem_3	26	30	PF02991	0.482
LIG_LIR_Nem_3	304	308	PF02991	0.627
LIG_MYND_3	141	145	PF01753	0.546
LIG_NRBOX	188	194	PF00104	0.551
LIG_PCNA_yPIPBox_3	163	172	PF02747	0.457
LIG_PCNA_yPIPBox_3	334	343	PF02747	0.615
LIG_PDZ_Class_2	339	344	PF00595	0.645
LIG_SH2_NCK_1	84	88	PF00017	0.522
LIG_SH2_PTP2	9	12	PF00017	0.447
LIG_SH2_STAT5	51	54	PF00017	0.570
LIG_SH2_STAT5	66	69	PF00017	0.430
LIG_SH2_STAT5	9	12	PF00017	0.447
LIG_SH3_3	91	97	PF00018	0.746
LIG_SUMO_SIM_par_1	241	248	PF11976	0.568
LIG_SUMO_SIM_par_1	252	259	PF11976	0.366
LIG_SUMO_SIM_par_1	327	332	PF11976	0.452
LIG_SUMO_SIM_par_1	75	81	PF11976	0.623
LIG_TRAF2_1	276	279	PF00917	0.448
LIG_TYR_ITIM	7	12	PF00017	0.493
MOD_CDK_SPxK_1	236	242	PF00069	0.612
MOD_CK1_1	102	108	PF00069	0.703
MOD_CK1_1	255	261	PF00069	0.542
MOD_CK2_1	113	119	PF00069	0.578
MOD_CK2_1	83	89	PF00069	0.523
MOD_GlcNHglycan	104	107	PF01048	0.696
MOD_GlcNHglycan	199	202	PF01048	0.553
MOD_GlcNHglycan	55	58	PF01048	0.240
MOD_GlcNHglycan	67	70	PF01048	0.234
MOD_GSK3_1	109	116	PF00069	0.712
MOD_GSK3_1	144	151	PF00069	0.644
MOD_GSK3_1	255	262	PF00069	0.475
MOD_GSK3_1	283	290	PF00069	0.607
MOD_GSK3_1	78	85	PF00069	0.512
MOD_NEK2_1	101	106	PF00069	0.654
MOD_NEK2_1	144	149	PF00069	0.557
MOD_NEK2_1	202	207	PF00069	0.635
MOD_NEK2_1	83	88	PF00069	0.571
MOD_PIKK_1	259	265	PF00454	0.560
MOD_PKA_2	187	193	PF00069	0.468
MOD_Plk_1	144	150	PF00069	0.456
MOD_Plk_2-3	113	119	PF00069	0.455
MOD_Plk_4	202	208	PF00069	0.674
MOD_Plk_4	304	310	PF00069	0.544
MOD_ProDKin_1	207	213	PF00069	0.690
MOD_ProDKin_1	236	242	PF00069	0.579
MOD_ProDKin_1	78	84	PF00069	0.502
MOD_SUMO_rev_2	33	39	PF00179	0.484
TRG_ENDOCYTIC_2	172	175	PF00928	0.515
TRG_ENDOCYTIC_2	51	54	PF00928	0.570
TRG_ENDOCYTIC_2	9	12	PF00928	0.447
TRG_NES_CRM1_1	167	180	PF08389	0.606
TRG_NES_CRM1_1	26	40	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR6	Leptomonas seymouri	43%	99%
A0A3S7WUR3	Leishmania donovani	66%	100%
A0A422NWM0	Trypanosoma rangeli	30%	96%
A4HXM9	Leishmania infantum	66%	100%
C9ZZY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A069	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ARE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QE39	Leishmania major	65%	100%
V5B9X5	Trypanosoma cruzi	30%	99%