Diphosphomevalonate decarboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mevalonate-diphosphate decarboxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9A8_LEIBR

TriTrypDb:

LbrM.18.0030 , LBRM2903_180005400

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H9A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9A8

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	12
GO:0006084	acetyl-CoA metabolic process	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006629	lipid metabolic process	3	13
GO:0006637	acyl-CoA metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006694	steroid biosynthetic process	5	12
GO:0006695	cholesterol biosynthetic process	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006790	sulfur compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	13
GO:0008202	steroid metabolic process	4	12
GO:0008203	cholesterol metabolic process	5	12
GO:0008610	lipid biosynthetic process	4	13
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	13
GO:0009117	nucleotide metabolic process	5	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009240	isopentenyl diphosphate biosynthetic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009987	cellular process	1	13
GO:0016125	sterol metabolic process	4	12
GO:0016126	sterol biosynthetic process	5	12
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0033865	nucleoside bisphosphate metabolic process	5	12
GO:0033875	ribonucleoside bisphosphate metabolic process	6	12
GO:0034032	purine nucleoside bisphosphate metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0035383	thioester metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044255	cellular lipid metabolic process	3	13
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046165	alcohol biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046490	isopentenyl diphosphate metabolic process	5	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	13
GO:0072521	purine-containing compound metabolic process	4	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	13
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901617	organic hydroxy compound biosynthetic process	4	12
GO:1902652	secondary alcohol metabolic process	4	12
GO:1902653	secondary alcohol biosynthetic process	5	12
GO:0006720	isoprenoid metabolic process	4	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0044249	cellular biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004163	diphosphomevalonate decarboxylase activity	5	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016829	lyase activity	2	13
GO:0016830	carbon-carbon lyase activity	3	13
GO:0016831	carboxy-lyase activity	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.368
CLV_NRD_NRD_1	66	68	PF00675	0.365
CLV_PCSK_KEX2_1	33	35	PF00082	0.324
CLV_PCSK_KEX2_1	364	366	PF00082	0.148
CLV_PCSK_KEX2_1	66	68	PF00082	0.296
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.324
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.148
CLV_PCSK_SKI1_1	105	109	PF00082	0.462
CLV_PCSK_SKI1_1	237	241	PF00082	0.188
CLV_PCSK_SKI1_1	39	43	PF00082	0.445
CLV_PCSK_SKI1_1	67	71	PF00082	0.299
DEG_Nend_UBRbox_2	1	3	PF02207	0.448
DEG_SPOP_SBC_1	208	212	PF00917	0.391
DOC_CKS1_1	84	89	PF01111	0.500
DOC_MAPK_gen_1	364	371	PF00069	0.406
DOC_MAPK_gen_1	55	65	PF00069	0.336
DOC_PP2B_LxvP_1	40	43	PF13499	0.310
DOC_USP7_MATH_1	132	136	PF00917	0.204
DOC_USP7_MATH_1	158	162	PF00917	0.373
DOC_USP7_MATH_1	222	226	PF00917	0.383
DOC_USP7_MATH_1	56	60	PF00917	0.326
DOC_USP7_UBL2_3	202	206	PF12436	0.440
DOC_USP7_UBL2_3	29	33	PF12436	0.283
DOC_WW_Pin1_4	218	223	PF00397	0.387
DOC_WW_Pin1_4	370	375	PF00397	0.406
DOC_WW_Pin1_4	387	392	PF00397	0.348
DOC_WW_Pin1_4	6	11	PF00397	0.421
DOC_WW_Pin1_4	83	88	PF00397	0.399
LIG_14-3-3_CanoR_1	16	20	PF00244	0.435
LIG_14-3-3_CanoR_1	227	232	PF00244	0.367
LIG_14-3-3_CanoR_1	58	64	PF00244	0.315
LIG_14-3-3_CanoR_1	88	93	PF00244	0.335
LIG_EH1_1	280	288	PF00400	0.406
LIG_eIF4E_1	281	287	PF01652	0.406
LIG_FHA_1	142	148	PF00498	0.303
LIG_FHA_1	176	182	PF00498	0.411
LIG_FHA_1	84	90	PF00498	0.451
LIG_FHA_2	329	335	PF00498	0.424
LIG_FHA_2	352	358	PF00498	0.446
LIG_FHA_2	59	65	PF00498	0.407
LIG_FHA_2	68	74	PF00498	0.471
LIG_LIR_Gen_1	128	138	PF02991	0.267
LIG_LIR_Gen_1	247	256	PF02991	0.416
LIG_LIR_Gen_1	278	289	PF02991	0.406
LIG_LIR_Gen_1	331	341	PF02991	0.426
LIG_LIR_Nem_3	128	133	PF02991	0.300
LIG_LIR_Nem_3	161	166	PF02991	0.319
LIG_LIR_Nem_3	247	251	PF02991	0.407
LIG_LIR_Nem_3	278	284	PF02991	0.406
LIG_LIR_Nem_3	354	359	PF02991	0.423
LIG_LIR_Nem_3	6	11	PF02991	0.421
LIG_Pex14_1	333	337	PF04695	0.461
LIG_Pex14_2	27	31	PF04695	0.283
LIG_Pex14_2	329	333	PF04695	0.458
LIG_SH2_CRK	130	134	PF00017	0.291
LIG_SH2_CRK	281	285	PF00017	0.406
LIG_SH2_CRK	350	354	PF00017	0.523
LIG_SH2_STAP1	141	145	PF00017	0.220
LIG_SH2_STAP1	301	305	PF00017	0.406
LIG_SH2_STAT5	110	113	PF00017	0.382
LIG_SH2_STAT5	130	133	PF00017	0.135
LIG_SH2_STAT5	301	304	PF00017	0.406
LIG_SH3_3	16	22	PF00018	0.281
LIG_SH3_3	360	366	PF00018	0.365
LIG_SH3_3	8	14	PF00018	0.497
LIG_SUMO_SIM_par_1	142	148	PF11976	0.456
LIG_TRAF2_1	3	6	PF00917	0.434
LIG_UBA3_1	311	316	PF00899	0.415
MOD_CDK_SPK_2	83	88	PF00069	0.399
MOD_CK1_1	125	131	PF00069	0.294
MOD_CK1_1	148	154	PF00069	0.432
MOD_CK1_1	209	215	PF00069	0.424
MOD_CK1_1	217	223	PF00069	0.393
MOD_CK1_1	387	393	PF00069	0.291
MOD_CK1_1	59	65	PF00069	0.315
MOD_CK1_1	91	97	PF00069	0.376
MOD_CK2_1	328	334	PF00069	0.361
MOD_CK2_1	351	357	PF00069	0.446
MOD_CK2_1	58	64	PF00069	0.407
MOD_CK2_1	67	73	PF00069	0.484
MOD_Cter_Amidation	31	34	PF01082	0.285
MOD_Cter_Amidation	77	80	PF01082	0.533
MOD_GlcNHglycan	125	128	PF01048	0.309
MOD_GlcNHglycan	134	137	PF01048	0.255
MOD_GlcNHglycan	141	144	PF01048	0.306
MOD_GlcNHglycan	154	157	PF01048	0.272
MOD_GlcNHglycan	160	163	PF01048	0.257
MOD_GSK3_1	141	148	PF00069	0.297
MOD_GSK3_1	154	161	PF00069	0.270
MOD_GSK3_1	214	221	PF00069	0.410
MOD_GSK3_1	44	51	PF00069	0.298
MOD_GSK3_1	99	106	PF00069	0.395
MOD_N-GLC_1	44	49	PF02516	0.300
MOD_N-GLC_1	6	11	PF02516	0.421
MOD_NEK2_1	123	128	PF00069	0.325
MOD_NEK2_1	214	219	PF00069	0.410
MOD_NEK2_1	310	315	PF00069	0.482
MOD_NEK2_1	48	53	PF00069	0.305
MOD_PIKK_1	180	186	PF00454	0.320
MOD_PK_1	227	233	PF00069	0.460
MOD_PK_1	88	94	PF00069	0.390
MOD_PKA_2	15	21	PF00069	0.444
MOD_Plk_1	145	151	PF00069	0.286
MOD_Plk_1	277	283	PF00069	0.406
MOD_Plk_1	44	50	PF00069	0.299
MOD_Plk_4	145	151	PF00069	0.299
MOD_Plk_4	227	233	PF00069	0.475
MOD_Plk_4	384	390	PF00069	0.374
MOD_Plk_4	88	94	PF00069	0.359
MOD_ProDKin_1	218	224	PF00069	0.387
MOD_ProDKin_1	370	376	PF00069	0.406
MOD_ProDKin_1	387	393	PF00069	0.373
MOD_ProDKin_1	6	12	PF00069	0.413
MOD_ProDKin_1	83	89	PF00069	0.390
MOD_SUMO_for_1	201	204	PF00179	0.475
MOD_SUMO_rev_2	340	349	PF00179	0.445
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.482
TRG_ENDOCYTIC_2	130	133	PF00928	0.264
TRG_ENDOCYTIC_2	163	166	PF00928	0.401
TRG_ENDOCYTIC_2	281	284	PF00928	0.406
TRG_ENDOCYTIC_2	296	299	PF00928	0.406
TRG_ER_diArg_1	65	67	PF00400	0.265
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.174

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ7	Leptomonas seymouri	83%	100%
A0A0S4JH23	Bodo saltans	67%	100%
A0A1D8PC43	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	100%
A0A1X0P6N9	Trypanosomatidae	71%	100%
A0A3S7WUN8	Leishmania donovani	88%	100%
A0A422NWH3	Trypanosoma rangeli	70%	100%
A4HXM8	Leishmania infantum	88%	100%
C9ZZY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A068	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0EAP4	Panax ginseng	37%	94%
D4GXZ3	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	28%	100%
E9ARD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
F4JCU3	Arabidopsis thaliana	38%	94%
F8QQQ7	Panax ginseng	36%	94%
G9BIY1	Ganoderma lucidum	40%	98%
I1S130	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	39%	100%
O13963	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
O23722	Arabidopsis thaliana	37%	95%
P32377	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	99%
P53602	Homo sapiens	46%	98%
Q0P570	Bos taurus	44%	98%
Q4QE40	Leishmania major	87%	100%
Q4WNV9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	97%
Q54YQ9	Dictyostelium discoideum	44%	100%
Q5U403	Danio rerio	45%	98%
Q62967	Rattus norvegicus	45%	98%
Q6BY07	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	40%	100%
Q751D8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	39%	99%
Q97UL5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	34%	100%
Q99JF5	Mus musculus	45%	98%
V5BEI4	Trypanosoma cruzi	67%	100%