CUE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9A5_LEIBR

TriTrypDb:

LbrM.17.1620 , LBRM2903_170023900

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H9A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.678
CLV_PCSK_KEX2_1	197	199	PF00082	0.550
CLV_PCSK_KEX2_1	211	213	PF00082	0.322
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.550
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.322
CLV_PCSK_SKI1_1	188	192	PF00082	0.552
CLV_PCSK_SKI1_1	24	28	PF00082	0.425
DEG_ODPH_VHL_1	17	29	PF01847	0.486
DEG_SPOP_SBC_1	141	145	PF00917	0.630
DOC_MAPK_gen_1	60	68	PF00069	0.599
DOC_MAPK_MEF2A_6	24	33	PF00069	0.225
DOC_MAPK_NFAT4_5	24	32	PF00069	0.225
DOC_USP7_MATH_1	141	145	PF00917	0.630
DOC_USP7_MATH_1	166	170	PF00917	0.633
DOC_USP7_MATH_1	91	95	PF00917	0.714
DOC_USP7_UBL2_3	197	201	PF12436	0.726
DOC_WW_Pin1_4	142	147	PF00397	0.792
DOC_WW_Pin1_4	161	166	PF00397	0.699
DOC_WW_Pin1_4	87	92	PF00397	0.793
LIG_14-3-3_CanoR_1	181	189	PF00244	0.618
LIG_14-3-3_CanoR_1	52	62	PF00244	0.708
LIG_Actin_WH2_2	36	54	PF00022	0.244
LIG_BIR_II_1	1	5	PF00653	0.362
LIG_FHA_1	131	137	PF00498	0.621
LIG_FHA_1	178	184	PF00498	0.698
LIG_FHA_1	34	40	PF00498	0.244
LIG_FHA_2	115	121	PF00498	0.665
LIG_FHA_2	143	149	PF00498	0.751
LIG_LIR_Gen_1	21	30	PF02991	0.361
LIG_LIR_Gen_1	7	17	PF02991	0.493
LIG_LIR_Nem_3	21	25	PF02991	0.369
LIG_LIR_Nem_3	7	12	PF02991	0.482
LIG_PTAP_UEV_1	105	110	PF05743	0.631
LIG_SH2_CRK	22	26	PF00017	0.459
LIG_SH2_NCK_1	22	26	PF00017	0.392
LIG_SH2_STAP1	22	26	PF00017	0.427
LIG_SH2_STAP1	53	57	PF00017	0.693
LIG_SH3_1	103	109	PF00018	0.636
LIG_SH3_2	98	103	PF14604	0.646
LIG_SH3_3	103	109	PF00018	0.636
LIG_SH3_3	157	163	PF00018	0.809
LIG_SH3_3	8	14	PF00018	0.543
LIG_SH3_3	95	101	PF00018	0.647
LIG_TRAF2_1	146	149	PF00917	0.774
LIG_TYR_ITIM	20	25	PF00017	0.404
LIG_WRC_WIRS_1	122	127	PF05994	0.586
MOD_CDC14_SPxK_1	164	167	PF00782	0.695
MOD_CDK_SPxK_1	161	167	PF00069	0.769
MOD_CK1_1	130	136	PF00069	0.562
MOD_CK1_1	144	150	PF00069	0.613
MOD_CK1_1	169	175	PF00069	0.762
MOD_CK1_1	92	98	PF00069	0.674
MOD_CK2_1	121	127	PF00069	0.594
MOD_CK2_1	142	148	PF00069	0.641
MOD_CK2_1	231	237	PF00069	0.631
MOD_GlcNHglycan	106	109	PF01048	0.565
MOD_GlcNHglycan	233	236	PF01048	0.488
MOD_GlcNHglycan	87	90	PF01048	0.579
MOD_GSK3_1	137	144	PF00069	0.671
MOD_GSK3_1	161	168	PF00069	0.810
MOD_GSK3_1	81	88	PF00069	0.748
MOD_GSK3_1	89	96	PF00069	0.704
MOD_N-GLC_1	153	158	PF02516	0.628
MOD_NEK2_1	51	56	PF00069	0.571
MOD_NEK2_1	83	88	PF00069	0.723
MOD_PIKK_1	158	164	PF00454	0.772
MOD_PIKK_1	182	188	PF00454	0.797
MOD_PIKK_1	51	57	PF00454	0.573
MOD_PKA_1	197	203	PF00069	0.641
MOD_PKA_1	81	87	PF00069	0.686
MOD_PKA_2	197	203	PF00069	0.641
MOD_PKA_2	51	57	PF00069	0.678
MOD_Plk_1	114	120	PF00069	0.669
MOD_Plk_4	121	127	PF00069	0.607
MOD_Plk_4	33	39	PF00069	0.244
MOD_ProDKin_1	142	148	PF00069	0.793
MOD_ProDKin_1	161	167	PF00069	0.698
MOD_ProDKin_1	87	93	PF00069	0.793
MOD_SUMO_for_1	4	7	PF00179	0.359
TRG_DiLeu_BaEn_1	127	132	PF01217	0.629
TRG_DiLeu_BaEn_1	222	227	PF01217	0.724
TRG_DiLeu_BaEn_4	222	228	PF01217	0.724
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.540
TRG_ENDOCYTIC_2	22	25	PF00928	0.472
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR49	Leptomonas seymouri	44%	100%
A0A3Q8IE41	Leishmania donovani	60%	100%
A4HTR3	Leishmania infantum	62%	100%
A4HXM5	Leishmania infantum	60%	100%
C9ZUK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ARC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	83%
Q4QBZ4	Leishmania major	60%	100%
Q4QE42	Leishmania major	60%	100%