Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9A3_LEIBR

TriTrypDb:

LbrM.17.1600 , LBRM2903_170023600

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9A3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.714
CLV_MEL_PAP_1	212	218	PF00089	0.197
CLV_NRD_NRD_1	248	250	PF00675	0.373
CLV_NRD_NRD_1	78	80	PF00675	0.457
CLV_NRD_NRD_1	88	90	PF00675	0.598
CLV_PCSK_KEX2_1	13	15	PF00082	0.611
CLV_PCSK_KEX2_1	248	250	PF00082	0.373
CLV_PCSK_KEX2_1	67	69	PF00082	0.512
CLV_PCSK_KEX2_1	78	80	PF00082	0.457
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.371
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.480
CLV_PCSK_PC7_1	63	69	PF00082	0.287
CLV_PCSK_SKI1_1	14	18	PF00082	0.521
CLV_PCSK_SKI1_1	315	319	PF00082	0.333
CLV_PCSK_SKI1_1	409	413	PF00082	0.419
CLV_PCSK_SKI1_1	477	481	PF00082	0.372
CLV_PCSK_SKI1_1	93	97	PF00082	0.689
DEG_MDM2_SWIB_1	259	266	PF02201	0.197
DEG_MDM2_SWIB_1	38	46	PF02201	0.382
DEG_Nend_UBRbox_3	1	3	PF02207	0.547
DEG_SCF_FBW7_1	84	91	PF00400	0.431
DOC_CYCLIN_yClb1_LxF_4	1	7	PF00134	0.536
DOC_MAPK_gen_1	267	277	PF00069	0.197
DOC_MAPK_gen_1	365	373	PF00069	0.263
DOC_MAPK_gen_1	472	481	PF00069	0.396
DOC_MAPK_gen_1	89	97	PF00069	0.702
DOC_PP1_RVXF_1	157	163	PF00149	0.297
DOC_PP1_RVXF_1	313	319	PF00149	0.297
DOC_PP1_RVXF_1	91	98	PF00149	0.654
DOC_PP2B_LxvP_1	49	52	PF13499	0.461
DOC_PP4_FxxP_1	27	30	PF00568	0.473
DOC_USP7_MATH_1	109	113	PF00917	0.729
DOC_USP7_MATH_1	222	226	PF00917	0.403
DOC_USP7_MATH_1	398	402	PF00917	0.497
DOC_WW_Pin1_4	107	112	PF00397	0.675
DOC_WW_Pin1_4	402	407	PF00397	0.537
DOC_WW_Pin1_4	84	89	PF00397	0.635
LIG_14-3-3_CanoR_1	14	21	PF00244	0.458
LIG_14-3-3_CanoR_1	248	258	PF00244	0.360
LIG_Actin_WH2_2	458	476	PF00022	0.550
LIG_AP2alpha_1	228	232	PF02296	0.197
LIG_APCC_ABBA_1	164	169	PF00400	0.294
LIG_BIR_III_4	374	378	PF00653	0.410
LIG_BRCT_BRCA1_1	224	228	PF00533	0.410
LIG_FHA_1	15	21	PF00498	0.511
LIG_FHA_1	386	392	PF00498	0.522
LIG_FHA_1	46	52	PF00498	0.477
LIG_FHA_1	465	471	PF00498	0.464
LIG_FHA_2	100	106	PF00498	0.502
LIG_FHA_2	116	122	PF00498	0.577
LIG_FHA_2	286	292	PF00498	0.351
LIG_LIR_Apic_2	24	30	PF02991	0.454
LIG_LIR_Gen_1	230	240	PF02991	0.317
LIG_LIR_Gen_1	337	347	PF02991	0.398
LIG_LIR_Gen_1	39	50	PF02991	0.502
LIG_LIR_Nem_3	225	231	PF02991	0.319
LIG_LIR_Nem_3	233	239	PF02991	0.257
LIG_LIR_Nem_3	3	9	PF02991	0.545
LIG_LIR_Nem_3	337	342	PF02991	0.348
LIG_LIR_Nem_3	39	45	PF02991	0.320
LIG_NRBOX	293	299	PF00104	0.421
LIG_PCNA_yPIPBox_3	289	302	PF02747	0.355
LIG_Pex14_1	331	335	PF04695	0.410
LIG_Pex14_1	40	44	PF04695	0.439
LIG_Pex14_2	228	232	PF04695	0.411
LIG_Pex14_2	259	263	PF04695	0.197
LIG_Pex14_2	318	322	PF04695	0.322
LIG_Pex14_2	38	42	PF04695	0.382
LIG_PTB_Apo_2	185	192	PF02174	0.355
LIG_PTB_Phospho_1	185	191	PF10480	0.355
LIG_SH2_PTP2	339	342	PF00017	0.355
LIG_SH2_SRC	339	342	PF00017	0.246
LIG_SH2_STAP1	140	144	PF00017	0.297
LIG_SH2_STAP1	396	400	PF00017	0.425
LIG_SH2_STAP1	466	470	PF00017	0.408
LIG_SH2_STAT3	140	143	PF00017	0.357
LIG_SH2_STAT3	302	305	PF00017	0.292
LIG_SH2_STAT5	244	247	PF00017	0.197
LIG_SH2_STAT5	265	268	PF00017	0.197
LIG_SH2_STAT5	309	312	PF00017	0.287
LIG_SH2_STAT5	339	342	PF00017	0.418
LIG_SH2_STAT5	358	361	PF00017	0.368
LIG_SH2_STAT5	466	469	PF00017	0.398
LIG_SH3_1	420	426	PF00018	0.519
LIG_SH3_3	128	134	PF00018	0.550
LIG_SH3_3	420	426	PF00018	0.504
LIG_TYR_ITIM	234	239	PF00017	0.355
MOD_CDK_SPK_2	84	89	PF00069	0.579
MOD_CDK_SPxK_1	84	90	PF00069	0.582
MOD_CDK_SPxxK_3	402	409	PF00069	0.590
MOD_CK1_1	101	107	PF00069	0.625
MOD_CK1_1	136	142	PF00069	0.623
MOD_CK1_1	405	411	PF00069	0.587
MOD_CK2_1	120	126	PF00069	0.601
MOD_CK2_1	181	187	PF00069	0.440
MOD_CK2_1	80	86	PF00069	0.606
MOD_CK2_1	99	105	PF00069	0.696
MOD_GlcNHglycan	105	110	PF01048	0.718
MOD_GlcNHglycan	111	114	PF01048	0.747
MOD_GlcNHglycan	224	227	PF01048	0.453
MOD_GlcNHglycan	272	275	PF01048	0.422
MOD_GSK3_1	105	112	PF00069	0.657
MOD_GSK3_1	115	122	PF00069	0.519
MOD_GSK3_1	132	139	PF00069	0.442
MOD_GSK3_1	398	405	PF00069	0.438
MOD_GSK3_1	460	467	PF00069	0.386
MOD_GSK3_1	80	87	PF00069	0.605
MOD_GSK3_1	97	104	PF00069	0.669
MOD_N-GLC_1	452	457	PF02516	0.540
MOD_NEK2_1	120	125	PF00069	0.705
MOD_NEK2_1	181	186	PF00069	0.447
MOD_NEK2_1	324	329	PF00069	0.411
MOD_NEK2_1	351	356	PF00069	0.309
MOD_NEK2_1	45	50	PF00069	0.488
MOD_NEK2_1	59	64	PF00069	0.551
MOD_NEK2_1	80	85	PF00069	0.555
MOD_NEK2_1	97	102	PF00069	0.708
MOD_NEK2_2	427	432	PF00069	0.484
MOD_PIKK_1	268	274	PF00454	0.197
MOD_PKA_2	21	27	PF00069	0.471
MOD_PKA_2	88	94	PF00069	0.631
MOD_Plk_1	125	131	PF00069	0.694
MOD_Plk_1	136	142	PF00069	0.531
MOD_Plk_1	155	161	PF00069	0.207
MOD_Plk_1	2	8	PF00069	0.484
MOD_Plk_1	324	330	PF00069	0.272
MOD_Plk_1	351	357	PF00069	0.301
MOD_Plk_1	427	433	PF00069	0.474
MOD_Plk_1	80	86	PF00069	0.547
MOD_Plk_2-3	99	105	PF00069	0.749
MOD_Plk_4	181	187	PF00069	0.444
MOD_Plk_4	2	8	PF00069	0.561
MOD_Plk_4	303	309	PF00069	0.261
MOD_ProDKin_1	107	113	PF00069	0.674
MOD_ProDKin_1	402	408	PF00069	0.537
MOD_ProDKin_1	84	90	PF00069	0.638
MOD_SUMO_rev_2	343	348	PF00179	0.222
TRG_DiLeu_BaEn_2	196	202	PF01217	0.297
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.300
TRG_ENDOCYTIC_2	183	186	PF00928	0.361
TRG_ENDOCYTIC_2	236	239	PF00928	0.410
TRG_ENDOCYTIC_2	244	247	PF00928	0.410
TRG_ENDOCYTIC_2	339	342	PF00928	0.379
TRG_ER_diArg_1	247	249	PF00400	0.410
TRG_ER_diArg_1	78	80	PF00400	0.470
TRG_NES_CRM1_1	362	374	PF08389	0.355
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P848	Leptomonas seymouri	56%	100%
A0A0S4IV10	Bodo saltans	26%	84%
A0A1X0NSL3	Trypanosomatidae	29%	92%
A0A3S7WUR8	Leishmania donovani	78%	100%
A0A422NB36	Trypanosoma rangeli	30%	99%
A4HXM3	Leishmania infantum	78%	100%
E9ARB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QE44	Leishmania major	77%	100%
V5BEU9	Trypanosoma cruzi	32%	97%