Ion_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ion transport protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9A2_LEIBR

TriTrypDb:

LbrM.17.1590 , LBRM2903_170023500

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H9A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9A2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005216	monoatomic ion channel activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015267	channel activity	4	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0022803	passive transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.563
CLV_C14_Caspase3-7	654	658	PF00656	0.784
CLV_MEL_PAP_1	500	506	PF00089	0.521
CLV_NRD_NRD_1	478	480	PF00675	0.510
CLV_NRD_NRD_1	50	52	PF00675	0.750
CLV_NRD_NRD_1	550	552	PF00675	0.459
CLV_NRD_NRD_1	627	629	PF00675	0.582
CLV_NRD_NRD_1	93	95	PF00675	0.820
CLV_PCSK_KEX2_1	386	388	PF00082	0.650
CLV_PCSK_KEX2_1	478	480	PF00082	0.510
CLV_PCSK_KEX2_1	50	52	PF00082	0.750
CLV_PCSK_KEX2_1	626	628	PF00082	0.593
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.650
CLV_PCSK_SKI1_1	294	298	PF00082	0.650
CLV_PCSK_SKI1_1	349	353	PF00082	0.449
CLV_PCSK_SKI1_1	636	640	PF00082	0.573
DEG_APCC_DBOX_1	566	574	PF00400	0.730
DOC_CYCLIN_RxL_1	346	354	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.650
DOC_MAPK_gen_1	386	393	PF00069	0.387
DOC_MAPK_gen_1	478	485	PF00069	0.709
DOC_MAPK_gen_1	551	557	PF00069	0.685
DOC_MAPK_gen_1	567	575	PF00069	0.567
DOC_MAPK_gen_1	626	635	PF00069	0.780
DOC_MAPK_MEF2A_6	321	329	PF00069	0.549
DOC_MAPK_MEF2A_6	598	606	PF00069	0.730
DOC_MAPK_RevD_3	35	51	PF00069	0.543
DOC_MAPK_RevD_3	371	387	PF00069	0.549
DOC_MAPK_RevD_3	464	479	PF00069	0.726
DOC_PP2B_LxvP_1	141	144	PF13499	0.629
DOC_PP2B_LxvP_1	529	532	PF13499	0.648
DOC_PP2B_LxvP_1	639	642	PF13499	0.764
DOC_PP4_FxxP_1	462	465	PF00568	0.660
DOC_USP7_MATH_1	193	197	PF00917	0.641
DOC_USP7_MATH_1	259	263	PF00917	0.650
DOC_USP7_MATH_1	558	562	PF00917	0.749
DOC_USP7_MATH_1	615	619	PF00917	0.802
DOC_USP7_MATH_1	640	644	PF00917	0.761
DOC_USP7_MATH_1	652	656	PF00917	0.668
DOC_WW_Pin1_4	314	319	PF00397	0.549
DOC_WW_Pin1_4	610	615	PF00397	0.792
LIG_14-3-3_CanoR_1	180	187	PF00244	0.651
LIG_14-3-3_CanoR_1	216	226	PF00244	0.651
LIG_14-3-3_CanoR_1	349	359	PF00244	0.650
LIG_14-3-3_CanoR_1	423	428	PF00244	0.449
LIG_14-3-3_CanoR_1	569	575	PF00244	0.710
LIG_Actin_WH2_2	305	323	PF00022	0.549
LIG_APCC_ABBA_1	464	469	PF00400	0.749
LIG_BIR_II_1	1	5	PF00653	0.774
LIG_BRCT_BRCA1_1	643	647	PF00533	0.775
LIG_Clathr_ClatBox_1	397	401	PF01394	0.449
LIG_deltaCOP1_diTrp_1	142	151	PF00928	0.630
LIG_EH1_1	240	248	PF00400	0.549
LIG_EH1_1	345	353	PF00400	0.650
LIG_FHA_1	228	234	PF00498	0.615
LIG_FHA_1	243	249	PF00498	0.287
LIG_FHA_1	295	301	PF00498	0.387
LIG_FHA_1	321	327	PF00498	0.549
LIG_FHA_1	356	362	PF00498	0.523
LIG_FHA_1	368	374	PF00498	0.366
LIG_FHA_1	376	382	PF00498	0.218
LIG_FHA_1	435	441	PF00498	0.549
LIG_FHA_1	459	465	PF00498	0.549
LIG_FHA_1	507	513	PF00498	0.754
LIG_FHA_1	88	94	PF00498	0.625
LIG_FHA_2	187	193	PF00498	0.640
LIG_FHA_2	27	33	PF00498	0.572
LIG_FHA_2	572	578	PF00498	0.668
LIG_GBD_Chelix_1	445	453	PF00786	0.549
LIG_LIR_Apic_2	156	161	PF02991	0.641
LIG_LIR_Apic_2	461	465	PF02991	0.549
LIG_LIR_Gen_1	103	113	PF02991	0.621
LIG_LIR_Gen_1	134	144	PF02991	0.639
LIG_LIR_Gen_1	31	42	PF02991	0.547
LIG_LIR_Gen_1	364	373	PF02991	0.549
LIG_LIR_Gen_1	388	397	PF02991	0.449
LIG_LIR_Gen_1	406	416	PF02991	0.224
LIG_LIR_Gen_1	432	440	PF02991	0.449
LIG_LIR_Gen_1	441	450	PF02991	0.392
LIG_LIR_Gen_1	8	18	PF02991	0.549
LIG_LIR_Nem_3	103	108	PF02991	0.619
LIG_LIR_Nem_3	134	140	PF02991	0.644
LIG_LIR_Nem_3	182	187	PF02991	0.649
LIG_LIR_Nem_3	31	37	PF02991	0.552
LIG_LIR_Nem_3	364	368	PF02991	0.549
LIG_LIR_Nem_3	388	392	PF02991	0.449
LIG_LIR_Nem_3	406	411	PF02991	0.224
LIG_LIR_Nem_3	432	436	PF02991	0.449
LIG_LIR_Nem_3	437	442	PF02991	0.462
LIG_LIR_Nem_3	577	582	PF02991	0.666
LIG_LIR_Nem_3	8	13	PF02991	0.549
LIG_Pex14_2	438	442	PF04695	0.549
LIG_Pex14_2	647	651	PF04695	0.788
LIG_SH2_CRK	137	141	PF00017	0.644
LIG_SH2_CRK	184	188	PF00017	0.648
LIG_SH2_CRK	34	38	PF00017	0.547
LIG_SH2_CRK	433	437	PF00017	0.449
LIG_SH2_CRK	579	583	PF00017	0.664
LIG_SH2_CRK	649	653	PF00017	0.782
LIG_SH2_GRB2like	137	140	PF00017	0.643
LIG_SH2_NCK_1	365	369	PF00017	0.549
LIG_SH2_NCK_1	433	437	PF00017	0.449
LIG_SH2_SRC	137	140	PF00017	0.643
LIG_SH2_SRC	541	544	PF00017	0.638
LIG_SH2_STAP1	105	109	PF00017	0.617
LIG_SH2_STAP1	137	141	PF00017	0.644
LIG_SH2_STAP1	34	38	PF00017	0.547
LIG_SH2_STAP1	541	545	PF00017	0.640
LIG_SH2_STAT3	38	41	PF00017	0.542
LIG_SH2_STAT5	253	256	PF00017	0.549
LIG_SH2_STAT5	295	298	PF00017	0.449
LIG_SH2_STAT5	382	385	PF00017	0.449
LIG_SH2_STAT5	596	599	PF00017	0.714
LIG_SH2_STAT5	649	652	PF00017	0.784
LIG_SH2_STAT5	86	89	PF00017	0.635
LIG_SH3_1	158	164	PF00018	0.646
LIG_SH3_3	137	143	PF00018	0.639
LIG_SH3_3	158	164	PF00018	0.646
LIG_SH3_3	220	226	PF00018	0.652
LIG_SH3_3	312	318	PF00018	0.549
LIG_SH3_3	389	395	PF00018	0.449
LIG_SH3_5	75	79	PF00018	0.612
LIG_SUMO_SIM_anti_2	336	343	PF11976	0.650
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.462
LIG_SUMO_SIM_anti_2	629	636	PF11976	0.776
LIG_SUMO_SIM_par_1	245	250	PF11976	0.549
LIG_SUMO_SIM_par_1	267	273	PF11976	0.650
LIG_SUMO_SIM_par_1	311	317	PF11976	0.462
LIG_SUMO_SIM_par_1	358	364	PF11976	0.549
LIG_SUMO_SIM_par_1	369	375	PF11976	0.357
LIG_SUMO_SIM_par_1	394	401	PF11976	0.449
LIG_TYR_ITIM	539	544	PF00017	0.535
LIG_TYR_ITIM	594	599	PF00017	0.629
LIG_UBA3_1	632	636	PF00899	0.730
LIG_WRC_WIRS_1	439	444	PF05994	0.549
LIG_WRC_WIRS_1	459	464	PF05994	0.199
MOD_CDK_SPxxK_3	314	321	PF00069	0.549
MOD_CK1_1	212	218	PF00069	0.817
MOD_CK1_1	314	320	PF00069	0.462
MOD_CK1_1	434	440	PF00069	0.549
MOD_CK1_1	610	616	PF00069	0.750
MOD_CK2_1	277	283	PF00069	0.549
MOD_CK2_1	571	577	PF00069	0.596
MOD_CK2_1	615	621	PF00069	0.765
MOD_GlcNHglycan	279	282	PF01048	0.549
MOD_GlcNHglycan	353	356	PF01048	0.549
MOD_GlcNHglycan	425	428	PF01048	0.549
MOD_GlcNHglycan	433	436	PF01048	0.410
MOD_GlcNHglycan	559	563	PF01048	0.700
MOD_GlcNHglycan	609	612	PF01048	0.754
MOD_GlcNHglycan	75	78	PF01048	0.777
MOD_GlcNHglycan	90	93	PF01048	0.529
MOD_GSK3_1	179	186	PF00069	0.832
MOD_GSK3_1	205	212	PF00069	0.807
MOD_GSK3_1	351	358	PF00069	0.462
MOD_GSK3_1	434	441	PF00069	0.549
MOD_GSK3_1	454	461	PF00069	0.199
MOD_GSK3_1	502	509	PF00069	0.666
MOD_GSK3_1	511	518	PF00069	0.566
MOD_GSK3_1	84	91	PF00069	0.805
MOD_N-GLC_1	423	428	PF02516	0.549
MOD_N-GLC_1	79	84	PF02516	0.790
MOD_NEK2_1	242	247	PF00069	0.549
MOD_NEK2_1	254	259	PF00069	0.339
MOD_NEK2_1	311	316	PF00069	0.510
MOD_NEK2_1	320	325	PF00069	0.431
MOD_NEK2_1	350	355	PF00069	0.549
MOD_NEK2_1	438	443	PF00069	0.549
MOD_NEK2_1	525	530	PF00069	0.544
MOD_NEK2_1	557	562	PF00069	0.679
MOD_NEK2_1	602	607	PF00069	0.689
MOD_NEK2_1	647	652	PF00069	0.741
MOD_NEK2_1	84	89	PF00069	0.807
MOD_NEK2_2	33	38	PF00069	0.685
MOD_OFUCOSY	565	572	PF10250	0.688
MOD_PK_1	387	393	PF00069	0.462
MOD_PKA_1	94	100	PF00069	0.781
MOD_PKA_2	153	159	PF00069	0.817
MOD_PKA_2	166	172	PF00069	0.615
MOD_PKA_2	179	185	PF00069	0.604
MOD_PKA_2	320	326	PF00069	0.549
MOD_PKA_2	502	508	PF00069	0.669
MOD_PKA_2	568	574	PF00069	0.656
MOD_Plk_1	387	393	PF00069	0.549
MOD_Plk_1	589	595	PF00069	0.589
MOD_Plk_1	79	85	PF00069	0.729
MOD_Plk_2-3	401	407	PF00069	0.492
MOD_Plk_4	109	115	PF00069	0.528
MOD_Plk_4	205	211	PF00069	0.808
MOD_Plk_4	242	248	PF00069	0.549
MOD_Plk_4	259	265	PF00069	0.252
MOD_Plk_4	327	333	PF00069	0.549
MOD_Plk_4	33	39	PF00069	0.684
MOD_Plk_4	367	373	PF00069	0.549
MOD_Plk_4	434	440	PF00069	0.549
MOD_Plk_4	444	450	PF00069	0.375
MOD_Plk_4	454	460	PF00069	0.199
MOD_Plk_4	496	502	PF00069	0.616
MOD_Plk_4	79	85	PF00069	0.791
MOD_Plk_4	94	100	PF00069	0.519
MOD_ProDKin_1	314	320	PF00069	0.549
MOD_ProDKin_1	610	616	PF00069	0.750
TRG_DiLeu_BaEn_1	142	147	PF01217	0.799
TRG_DiLeu_BaEn_1	629	634	PF01217	0.725
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.718
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.549
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.549
TRG_ENDOCYTIC_2	105	108	PF00928	0.785
TRG_ENDOCYTIC_2	137	140	PF00928	0.820
TRG_ENDOCYTIC_2	184	187	PF00928	0.828
TRG_ENDOCYTIC_2	34	37	PF00928	0.687
TRG_ENDOCYTIC_2	365	368	PF00928	0.549
TRG_ENDOCYTIC_2	433	436	PF00928	0.549
TRG_ENDOCYTIC_2	541	544	PF00928	0.533
TRG_ENDOCYTIC_2	579	582	PF00928	0.573
TRG_ENDOCYTIC_2	596	599	PF00928	0.416
TRG_ER_diArg_1	478	480	PF00400	0.633
TRG_ER_diArg_1	49	51	PF00400	0.691
TRG_ER_diArg_1	62	65	PF00400	0.546
TRG_ER_diArg_1	625	628	PF00400	0.750
TRG_NES_CRM1_1	521	535	PF08389	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
C9D7C2	APIME	21%	35%
O35505	CAVPO	21%	31%
O57483	LITCT	26%	39%
P07293	RABIT	25%	36%
P15381	RABIT	22%	31%
P22002	RAT	21%	31%
P27732	RAT	21%	30%
P54282	RAT	20%	30%
P91645	DROME	21%	36%
Q01815	MOUSE	22%	31%
Q02485	RAT	25%	36%
Q02789	MOUSE	27%	36%
Q13698	HUMAN	26%	36%
Q99246	MOUSE	22%	31%