LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania braziliensis
UniProt:
A4H9A1_LEIBR
TriTrypDb:
LbrM.17.1580 , LBRM2903_170023400 *
Length:
482

Annotations

LeishMANIAdb annotations

An MFS-superfamily protein homologous to human FLVCR2 hem transporter. Only duplicated extensively in Strigomonas

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4H9A1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9A1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 8
GO:0022857 transmembrane transporter activity 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 373 377 PF00656 0.193
CLV_C14_Caspase3-7 51 55 PF00656 0.683
CLV_NRD_NRD_1 225 227 PF00675 0.584
CLV_NRD_NRD_1 474 476 PF00675 0.456
CLV_PCSK_SKI1_1 157 161 PF00082 0.393
CLV_PCSK_SKI1_1 273 277 PF00082 0.301
DEG_Nend_Nbox_1 1 3 PF02207 0.761
DOC_CDC14_PxL_1 175 183 PF14671 0.354
DOC_CDC14_PxL_1 383 391 PF14671 0.478
DOC_CYCLIN_RxL_1 268 281 PF00134 0.393
DOC_CYCLIN_yCln2_LP_2 109 115 PF00134 0.407
DOC_CYCLIN_yCln2_LP_2 39 45 PF00134 0.564
DOC_CYCLIN_yCln2_LP_2 392 398 PF00134 0.437
DOC_PP1_RVXF_1 271 278 PF00149 0.393
DOC_PP2B_LxvP_1 109 112 PF13499 0.407
DOC_PP2B_LxvP_1 176 179 PF13499 0.354
DOC_PP2B_LxvP_1 392 395 PF13499 0.437
DOC_PP2B_PxIxI_1 111 117 PF00149 0.270
DOC_PP4_FxxP_1 212 215 PF00568 0.356
DOC_SPAK_OSR1_1 65 69 PF12202 0.584
DOC_USP7_MATH_1 143 147 PF00917 0.478
DOC_USP7_MATH_1 17 21 PF00917 0.766
DOC_USP7_MATH_1 197 201 PF00917 0.398
DOC_USP7_MATH_1 372 376 PF00917 0.193
DOC_USP7_MATH_1 46 50 PF00917 0.575
DOC_USP7_MATH_1 85 89 PF00917 0.437
DOC_WW_Pin1_4 211 216 PF00397 0.407
DOC_WW_Pin1_4 439 444 PF00397 0.355
DOC_WW_Pin1_4 59 64 PF00397 0.656
LIG_14-3-3_CanoR_1 192 202 PF00244 0.495
LIG_14-3-3_CanoR_1 258 267 PF00244 0.594
LIG_14-3-3_CanoR_1 348 353 PF00244 0.393
LIG_Actin_WH2_2 134 151 PF00022 0.389
LIG_BRCT_BRCA1_1 231 235 PF00533 0.210
LIG_BRCT_BRCA1_1 422 426 PF00533 0.407
LIG_CSL_BTD_1 153 156 PF09270 0.193
LIG_CSL_BTD_1 185 188 PF09270 0.533
LIG_CtBP_PxDLS_1 42 46 PF00389 0.563
LIG_eIF4E_1 349 355 PF01652 0.278
LIG_eIF4E_1 383 389 PF01652 0.313
LIG_FHA_1 288 294 PF00498 0.403
LIG_FHA_1 297 303 PF00498 0.257
LIG_FHA_1 349 355 PF00498 0.363
LIG_FHA_1 377 383 PF00498 0.321
LIG_FHA_1 416 422 PF00498 0.498
LIG_FHA_1 440 446 PF00498 0.370
LIG_FHA_1 453 459 PF00498 0.395
LIG_FHA_2 260 266 PF00498 0.505
LIG_FHA_2 436 442 PF00498 0.277
LIG_GBD_Chelix_1 194 202 PF00786 0.210
LIG_GBD_Chelix_1 242 250 PF00786 0.478
LIG_GBD_Chelix_1 301 309 PF00786 0.407
LIG_GBD_Chelix_1 399 407 PF00786 0.407
LIG_GBD_Chelix_1 457 465 PF00786 0.210
LIG_LIR_Apic_2 264 270 PF02991 0.533
LIG_LIR_Apic_2 406 412 PF02991 0.495
LIG_LIR_Gen_1 281 291 PF02991 0.522
LIG_LIR_Gen_1 379 389 PF02991 0.281
LIG_LIR_Gen_1 446 457 PF02991 0.390
LIG_LIR_Nem_3 281 287 PF02991 0.522
LIG_LIR_Nem_3 288 294 PF02991 0.347
LIG_LIR_Nem_3 3 7 PF02991 0.586
LIG_LIR_Nem_3 31 37 PF02991 0.655
LIG_LIR_Nem_3 344 349 PF02991 0.573
LIG_LIR_Nem_3 379 384 PF02991 0.346
LIG_LIR_Nem_3 423 429 PF02991 0.407
LIG_LIR_Nem_3 446 452 PF02991 0.335
LIG_LIR_Nem_3 62 67 PF02991 0.528
LIG_LIR_Nem_3 93 99 PF02991 0.317
LIG_NRBOX 105 111 PF00104 0.478
LIG_NRBOX 240 246 PF00104 0.465
LIG_PDZ_Class_3 477 482 PF00595 0.521
LIG_Pex14_1 154 158 PF04695 0.295
LIG_Pex14_2 150 154 PF04695 0.252
LIG_Pex14_2 235 239 PF04695 0.299
LIG_PTAP_UEV_1 22 27 PF05743 0.600
LIG_REV1ctd_RIR_1 465 474 PF16727 0.549
LIG_SH2_CRK 126 130 PF00017 0.538
LIG_SH2_CRK 133 137 PF00017 0.375
LIG_SH2_CRK 158 162 PF00017 0.193
LIG_SH2_CRK 267 271 PF00017 0.514
LIG_SH2_CRK 34 38 PF00017 0.581
LIG_SH2_CRK 349 353 PF00017 0.355
LIG_SH2_NCK_1 126 130 PF00017 0.522
LIG_SH2_PTP2 383 386 PF00017 0.407
LIG_SH2_SRC 383 386 PF00017 0.210
LIG_SH2_STAP1 158 162 PF00017 0.193
LIG_SH2_STAP1 349 353 PF00017 0.299
LIG_SH2_STAT5 115 118 PF00017 0.354
LIG_SH2_STAT5 124 127 PF00017 0.370
LIG_SH2_STAT5 349 352 PF00017 0.354
LIG_SH2_STAT5 383 386 PF00017 0.407
LIG_SH2_STAT5 83 86 PF00017 0.388
LIG_SH2_STAT5 96 99 PF00017 0.254
LIG_SH3_3 11 17 PF00018 0.725
LIG_SH3_3 150 156 PF00018 0.356
LIG_SH3_3 20 26 PF00018 0.752
LIG_SH3_3 392 398 PF00018 0.392
LIG_SUMO_SIM_anti_2 240 246 PF11976 0.407
LIG_SUMO_SIM_anti_2 350 356 PF11976 0.378
LIG_SUMO_SIM_anti_2 358 363 PF11976 0.433
LIG_SUMO_SIM_par_1 285 290 PF11976 0.270
LIG_SUMO_SIM_par_1 353 358 PF11976 0.323
LIG_SUMO_SIM_par_1 360 366 PF11976 0.383
LIG_SUMO_SIM_par_1 416 423 PF11976 0.536
LIG_TYR_ITIM 131 136 PF00017 0.523
LIG_UBA3_1 181 190 PF00899 0.210
LIG_UBA3_1 246 254 PF00899 0.478
LIG_UBA3_1 271 276 PF00899 0.584
LIG_WRC_WIRS_1 426 431 PF05994 0.407
MOD_CDK_SPxK_1 59 65 PF00069 0.597
MOD_CK1_1 21 27 PF00069 0.764
MOD_CK1_1 260 266 PF00069 0.501
MOD_CK1_1 417 423 PF00069 0.338
MOD_CK1_1 456 462 PF00069 0.409
MOD_CK1_1 49 55 PF00069 0.616
MOD_CK2_1 259 265 PF00069 0.533
MOD_GlcNHglycan 23 26 PF01048 0.397
MOD_GlcNHglycan 318 321 PF01048 0.498
MOD_GlcNHglycan 324 327 PF01048 0.360
MOD_GlcNHglycan 328 331 PF01048 0.362
MOD_GlcNHglycan 461 464 PF01048 0.409
MOD_GSK3_1 17 24 PF00069 0.732
MOD_GSK3_1 193 200 PF00069 0.370
MOD_GSK3_1 257 264 PF00069 0.495
MOD_GSK3_1 292 299 PF00069 0.425
MOD_GSK3_1 312 319 PF00069 0.149
MOD_GSK3_1 322 329 PF00069 0.325
MOD_GSK3_1 366 373 PF00069 0.210
MOD_GSK3_1 411 418 PF00069 0.512
MOD_GSK3_1 435 442 PF00069 0.446
MOD_GSK3_1 452 459 PF00069 0.398
MOD_GSK3_1 46 53 PF00069 0.584
MOD_NEK2_1 174 179 PF00069 0.385
MOD_NEK2_1 18 23 PF00069 0.717
MOD_NEK2_1 237 242 PF00069 0.425
MOD_NEK2_1 287 292 PF00069 0.357
MOD_NEK2_1 322 327 PF00069 0.350
MOD_NEK2_1 328 333 PF00069 0.346
MOD_NEK2_1 363 368 PF00069 0.299
MOD_NEK2_1 435 440 PF00069 0.379
MOD_NEK2_1 452 457 PF00069 0.390
MOD_PIKK_1 28 34 PF00454 0.590
MOD_PK_1 33 39 PF00069 0.762
MOD_PKA_2 257 263 PF00069 0.584
MOD_PKA_2 347 353 PF00069 0.393
MOD_PKA_2 90 96 PF00069 0.384
MOD_Plk_1 18 24 PF00069 0.722
MOD_Plk_1 190 196 PF00069 0.533
MOD_Plk_1 341 347 PF00069 0.584
MOD_Plk_1 445 451 PF00069 0.333
MOD_Plk_2-3 441 447 PF00069 0.440
MOD_Plk_4 105 111 PF00069 0.247
MOD_Plk_4 143 149 PF00069 0.478
MOD_Plk_4 197 203 PF00069 0.475
MOD_Plk_4 363 369 PF00069 0.407
MOD_Plk_4 376 382 PF00069 0.228
MOD_Plk_4 453 459 PF00069 0.415
MOD_Plk_4 54 60 PF00069 0.567
MOD_Plk_4 85 91 PF00069 0.341
MOD_ProDKin_1 211 217 PF00069 0.407
MOD_ProDKin_1 439 445 PF00069 0.355
MOD_ProDKin_1 59 65 PF00069 0.650
MOD_SUMO_rev_2 310 319 PF00179 0.384
TRG_DiLeu_BaLyEn_6 177 182 PF01217 0.407
TRG_DiLeu_BaLyEn_6 267 272 PF01217 0.584
TRG_DiLeu_BaLyEn_6 384 389 PF01217 0.252
TRG_ENDOCYTIC_2 126 129 PF00928 0.522
TRG_ENDOCYTIC_2 133 136 PF00928 0.397
TRG_ENDOCYTIC_2 158 161 PF00928 0.336
TRG_ENDOCYTIC_2 34 37 PF00928 0.581
TRG_ENDOCYTIC_2 349 352 PF00928 0.355
TRG_ENDOCYTIC_2 383 386 PF00928 0.407
TRG_ENDOCYTIC_2 83 86 PF00928 0.388
TRG_ENDOCYTIC_2 96 99 PF00928 0.283

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILZ7 Leptomonas seymouri 62% 90%
A0A0S4J692 Bodo saltans 32% 80%
A0A0S4JN91 Bodo saltans 27% 100%
A0A1X0NWR8 Trypanosomatidae 28% 100%
A0A1X0PA49 Trypanosomatidae 27% 84%
A0A3R7LY82 Trypanosoma rangeli 28% 88%
A0A3S7WUW1 Leishmania donovani 74% 94%
A0A3S7WW86 Leishmania donovani 23% 100%
A0A422NQJ7 Trypanosoma rangeli 26% 84%
A4HBK5 Leishmania braziliensis 24% 100%
A4HXM1 Leishmania infantum 74% 94%
B2RXV4 Mus musculus 26% 86%
D0A244 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 88%
E9AGU5 Leishmania infantum 23% 100%
E9ARB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%
O01735 Caenorhabditis elegans 23% 82%
P60815 Rattus norvegicus 28% 88%
Q11073 Caenorhabditis elegans 23% 95%
Q28FF3 Xenopus tropicalis 26% 100%
Q4H425 Epichloe festucae (strain Fl1) 22% 100%
Q4QCK8 Leishmania major 23% 100%
Q4QE46 Leishmania major 74% 100%
Q501I9 Xenopus tropicalis 25% 100%
Q503P5 Danio rerio 23% 100%
Q66H95 Rattus norvegicus 22% 100%
Q6GNV7 Xenopus laevis 24% 100%
Q6UXD7 Homo sapiens 26% 86%
Q8BFQ6 Mus musculus 22% 100%
Q8CE47 Mus musculus 26% 93%
Q91X85 Mus musculus 27% 87%
Q96SL1 Homo sapiens 23% 100%
Q9ES43 Mus terricolor 26% 86%
Q9N1F2 Felis catus 27% 86%
Q9UPI3 Homo sapiens 28% 92%
Q9Y5Y0 Homo sapiens 29% 87%
V5BQV3 Trypanosoma cruzi 26% 88%
V5DGX2 Trypanosoma cruzi 23% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS