Coiled-coil domain-containing protein 146

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9A0_LEIBR

TriTrypDb:

LbrM.17.1570 , LBRM2903_170023200

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9A0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.479
CLV_NRD_NRD_1	176	178	PF00675	0.473
CLV_NRD_NRD_1	186	188	PF00675	0.480
CLV_NRD_NRD_1	38	40	PF00675	0.580
CLV_NRD_NRD_1	56	58	PF00675	0.460
CLV_NRD_NRD_1	74	76	PF00675	0.476
CLV_NRD_NRD_1	84	86	PF00675	0.613
CLV_PCSK_KEX2_1	107	109	PF00082	0.562
CLV_PCSK_KEX2_1	171	173	PF00082	0.494
CLV_PCSK_KEX2_1	178	180	PF00082	0.467
CLV_PCSK_KEX2_1	40	42	PF00082	0.586
CLV_PCSK_KEX2_1	56	58	PF00082	0.460
CLV_PCSK_KEX2_1	74	76	PF00082	0.490
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.600
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.397
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.586
CLV_PCSK_SKI1_1	173	177	PF00082	0.575
CLV_PCSK_SKI1_1	194	198	PF00082	0.583
DEG_APCC_DBOX_1	203	211	PF00400	0.524
DEG_SCF_FBW7_1	227	232	PF00400	0.491
DOC_CYCLIN_RxL_1	170	180	PF00134	0.424
DOC_CYCLIN_RxL_1	188	201	PF00134	0.511
DOC_USP7_MATH_1	229	233	PF00917	0.626
DOC_USP7_MATH_1	94	98	PF00917	0.359
DOC_USP7_UBL2_3	208	212	PF12436	0.396
DOC_WW_Pin1_4	225	230	PF00397	0.498
LIG_14-3-3_CanoR_1	171	176	PF00244	0.508
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_FHA_1	226	232	PF00498	0.635
LIG_FHA_2	139	145	PF00498	0.478
LIG_FHA_2	179	185	PF00498	0.539
LIG_FHA_2	233	239	PF00498	0.690
LIG_LIR_Gen_1	11	21	PF02991	0.529
LIG_LIR_Nem_3	11	16	PF02991	0.509
LIG_PCNA_PIPBox_1	24	33	PF02747	0.550
LIG_PCNA_yPIPBox_3	24	33	PF02747	0.554
LIG_SH2_CRK	13	17	PF00017	0.519
LIG_SH2_STAT3	31	34	PF00017	0.544
LIG_SH2_STAT5	31	34	PF00017	0.459
LIG_SH2_STAT5	37	40	PF00017	0.437
LIG_TRAF2_1	128	131	PF00917	0.559
LIG_TRAF2_1	249	252	PF00917	0.701
LIG_TRAF2_1	99	102	PF00917	0.607
MOD_CK1_1	232	238	PF00069	0.656
MOD_CK2_1	138	144	PF00069	0.462
MOD_CK2_1	178	184	PF00069	0.547
MOD_CK2_1	245	251	PF00069	0.714
MOD_GlcNHglycan	247	250	PF01048	0.733
MOD_GlcNHglycan	70	73	PF01048	0.393
MOD_GSK3_1	156	163	PF00069	0.497
MOD_GSK3_1	225	232	PF00069	0.645
MOD_NEK2_1	203	208	PF00069	0.597
MOD_PIKK_1	229	235	PF00454	0.603
MOD_PIKK_1	85	91	PF00454	0.502
MOD_PKA_1	171	177	PF00069	0.506
MOD_PKA_1	178	184	PF00069	0.489
MOD_PKA_1	85	91	PF00069	0.610
MOD_PKA_2	171	177	PF00069	0.556
MOD_PKA_2	178	184	PF00069	0.539
MOD_PKA_2	203	209	PF00069	0.382
MOD_Plk_1	240	246	PF00069	0.592
MOD_Plk_4	122	128	PF00069	0.462
MOD_Plk_4	171	177	PF00069	0.553
MOD_ProDKin_1	225	231	PF00069	0.496
MOD_SUMO_rev_2	180	189	PF00179	0.534
MOD_SUMO_rev_2	82	88	PF00179	0.485
TRG_DiLeu_BaEn_1	119	124	PF01217	0.577
TRG_DiLeu_BaEn_2	143	149	PF01217	0.610
TRG_ENDOCYTIC_2	13	16	PF00928	0.499
TRG_ER_diArg_1	176	179	PF00400	0.522
TRG_ER_diArg_1	38	41	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEK9	Leptomonas seymouri	75%	94%
A0A0S4J6Y0	Bodo saltans	35%	94%
A0A1X0NU37	Trypanosomatidae	46%	96%
A0A3S7WUP8	Leishmania donovani	90%	100%
A0A422NB62	Trypanosoma rangeli	45%	96%
A4HXM0	Leishmania infantum	90%	100%
C9ZPB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	75%
E9ARB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QE47	Leishmania major	88%	100%
V5BNY4	Trypanosoma cruzi	44%	96%