Putative zinc-finger protein ZPR1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein ZPR1, putative

Species:

Leishmania braziliensis

UniProt:

A4H998_LEIBR

TriTrypDb:

LbrM.17.1550 , LBRM2903_170022800

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H998

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H998

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.647
CLV_NRD_NRD_1	163	165	PF00675	0.264
CLV_NRD_NRD_1	271	273	PF00675	0.322
CLV_PCSK_KEX2_1	331	333	PF00082	0.245
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.245
CLV_PCSK_SKI1_1	232	236	PF00082	0.454
CLV_PCSK_SKI1_1	332	336	PF00082	0.267
CLV_PCSK_SKI1_1	393	397	PF00082	0.285
CLV_PCSK_SKI1_1	9	13	PF00082	0.701
DEG_APCC_DBOX_1	370	378	PF00400	0.437
DEG_COP1_1	120	130	PF00400	0.361
DEG_Kelch_Keap1_1	25	30	PF01344	0.512
DOC_ANK_TNKS_1	250	257	PF00023	0.421
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.392
DOC_MAPK_gen_1	316	324	PF00069	0.462
DOC_MAPK_gen_1	99	107	PF00069	0.448
DOC_MAPK_MEF2A_6	232	239	PF00069	0.471
DOC_MAPK_MEF2A_6	316	324	PF00069	0.462
DOC_PP2B_LxvP_1	132	135	PF13499	0.448
DOC_PP2B_LxvP_1	235	238	PF13499	0.365
DOC_PP2B_LxvP_1	342	345	PF13499	0.437
DOC_PP2B_LxvP_1	432	435	PF13499	0.518
DOC_PP4_FxxP_1	78	81	PF00568	0.365
DOC_USP7_MATH_1	200	204	PF00917	0.448
DOC_WW_Pin1_4	349	354	PF00397	0.415
LIG_14-3-3_CanoR_1	319	323	PF00244	0.538
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_2	437	441	PF00653	0.357
LIG_CaM_IQ_9	243	259	PF13499	0.557
LIG_FHA_1	122	128	PF00498	0.431
LIG_FHA_1	191	197	PF00498	0.454
LIG_FHA_1	319	325	PF00498	0.454
LIG_FHA_1	337	343	PF00498	0.398
LIG_FHA_1	411	417	PF00498	0.446
LIG_FHA_1	57	63	PF00498	0.447
LIG_FHA_2	124	130	PF00498	0.466
LIG_FHA_2	142	148	PF00498	0.481
LIG_FHA_2	193	199	PF00498	0.476
LIG_FHA_2	219	225	PF00498	0.438
LIG_FHA_2	226	232	PF00498	0.443
LIG_FHA_2	244	250	PF00498	0.549
LIG_FHA_2	307	313	PF00498	0.458
LIG_LIR_Apic_2	203	207	PF02991	0.467
LIG_LIR_Apic_2	210	214	PF02991	0.491
LIG_LIR_Apic_2	76	81	PF02991	0.365
LIG_LIR_Gen_1	120	130	PF02991	0.448
LIG_LIR_Gen_1	255	265	PF02991	0.481
LIG_LIR_Gen_1	411	420	PF02991	0.522
LIG_LIR_Nem_3	120	125	PF02991	0.437
LIG_LIR_Nem_3	151	157	PF02991	0.548
LIG_LIR_Nem_3	255	261	PF02991	0.530
LIG_LIR_Nem_3	298	302	PF02991	0.437
LIG_LIR_Nem_3	411	415	PF02991	0.522
LIG_MYND_3	127	131	PF01753	0.361
LIG_NRBOX	401	407	PF00104	0.448
LIG_Pex14_2	92	96	PF04695	0.448
LIG_SH2_PTP2	204	207	PF00017	0.523
LIG_SH2_SRC	204	207	PF00017	0.437
LIG_SH2_STAP1	103	107	PF00017	0.437
LIG_SH2_STAT3	103	106	PF00017	0.496
LIG_SH2_STAT3	155	158	PF00017	0.361
LIG_SH2_STAT3	286	289	PF00017	0.523
LIG_SH2_STAT5	204	207	PF00017	0.431
LIG_SH2_STAT5	276	279	PF00017	0.466
LIG_SH2_STAT5	286	289	PF00017	0.423
LIG_SH2_STAT5	299	302	PF00017	0.424
LIG_SH2_STAT5	36	39	PF00017	0.559
LIG_SH2_STAT5	424	427	PF00017	0.437
LIG_SH2_STAT5	447	450	PF00017	0.463
LIG_SH3_3	122	128	PF00018	0.415
LIG_SH3_3	471	477	PF00018	0.484
LIG_SH3_5	207	211	PF00018	0.584
LIG_SUMO_SIM_par_1	123	129	PF11976	0.523
LIG_SUMO_SIM_par_1	192	198	PF11976	0.497
LIG_SUMO_SIM_par_1	337	346	PF11976	0.494
LIG_SxIP_EBH_1	60	71	PF03271	0.431
LIG_TRAF2_1	18	21	PF00917	0.641
LIG_TRAF2_1	246	249	PF00917	0.614
LIG_TRAF2_1	477	480	PF00917	0.594
LIG_UBA3_1	405	409	PF00899	0.365
LIG_UBA3_1	63	71	PF00899	0.412
LIG_WRC_WIRS_1	75	80	PF05994	0.437
MOD_CK1_1	142	148	PF00069	0.452
MOD_CK1_1	184	190	PF00069	0.523
MOD_CK1_1	259	265	PF00069	0.558
MOD_CK1_1	352	358	PF00069	0.495
MOD_CK2_1	123	129	PF00069	0.481
MOD_CK2_1	141	147	PF00069	0.481
MOD_CK2_1	200	206	PF00069	0.437
MOD_CK2_1	218	224	PF00069	0.437
MOD_CK2_1	24	30	PF00069	0.633
MOD_CK2_1	243	249	PF00069	0.568
MOD_CK2_1	306	312	PF00069	0.415
MOD_CK2_1	358	364	PF00069	0.437
MOD_CK2_1	83	89	PF00069	0.461
MOD_GlcNHglycan	186	189	PF01048	0.311
MOD_GlcNHglycan	386	389	PF01048	0.250
MOD_GlcNHglycan	459	462	PF01048	0.590
MOD_GSK3_1	117	124	PF00069	0.437
MOD_GSK3_1	135	142	PF00069	0.437
MOD_GSK3_1	20	27	PF00069	0.669
MOD_GSK3_1	218	225	PF00069	0.482
MOD_GSK3_1	334	341	PF00069	0.437
MOD_GSK3_1	359	366	PF00069	0.437
MOD_GSK3_1	88	95	PF00069	0.415
MOD_N-GLC_1	24	29	PF02516	0.576
MOD_NEK2_1	150	155	PF00069	0.501
MOD_NEK2_1	287	292	PF00069	0.431
MOD_NEK2_1	318	323	PF00069	0.481
MOD_NEK2_1	410	415	PF00069	0.361
MOD_NEK2_1	457	462	PF00069	0.508
MOD_NEK2_1	62	67	PF00069	0.386
MOD_NEK2_1	92	97	PF00069	0.497
MOD_PIKK_1	135	141	PF00454	0.437
MOD_PIKK_1	243	249	PF00454	0.575
MOD_PIKK_1	259	265	PF00454	0.572
MOD_PIKK_1	365	371	PF00454	0.497
MOD_PKA_2	318	324	PF00069	0.545
MOD_Plk_1	150	156	PF00069	0.542
MOD_Plk_1	259	265	PF00069	0.582
MOD_Plk_1	410	416	PF00069	0.523
MOD_Plk_1	7	13	PF00069	0.521
MOD_Plk_1	88	94	PF00069	0.365
MOD_Plk_4	150	156	PF00069	0.361
MOD_Plk_4	200	206	PF00069	0.437
MOD_Plk_4	287	293	PF00069	0.437
MOD_Plk_4	338	344	PF00069	0.484
MOD_Plk_4	391	397	PF00069	0.471
MOD_ProDKin_1	349	355	PF00069	0.415
MOD_SUMO_for_1	118	121	PF00179	0.461
MOD_SUMO_for_1	180	183	PF00179	0.525
MOD_SUMO_for_1	324	327	PF00179	0.461
MOD_SUMO_for_1	335	338	PF00179	0.442
MOD_SUMO_for_1	408	411	PF00179	0.458
MOD_SUMO_for_1	440	443	PF00179	0.546
MOD_SUMO_rev_2	2	11	PF00179	0.752
MOD_SUMO_rev_2	304	309	PF00179	0.437
MOD_SUMO_rev_2	436	442	PF00179	0.524
TRG_DiLeu_BaEn_1	338	343	PF01217	0.458
TRG_DiLeu_BaEn_1	401	406	PF01217	0.454
TRG_ENDOCYTIC_2	154	157	PF00928	0.536
TRG_ENDOCYTIC_2	276	279	PF00928	0.506
TRG_NES_CRM1_1	401	411	PF08389	0.361
TRG_NLS_MonoExtC_3	98	104	PF00514	0.523
TRG_NLS_MonoExtN_4	98	103	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6X5	Leptomonas seymouri	85%	90%
A0A0S4J2U4	Bodo saltans	59%	100%
A0A1X0NSX4	Trypanosomatidae	71%	100%
A0A3Q8IB01	Leishmania donovani	83%	97%
A0A3S5IQV9	Trypanosoma rangeli	65%	100%
A4HXL9	Leishmania infantum	83%	97%
A9CB27	Papio anubis	41%	100%
C9ZPB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9ARB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%
O13724	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O16999	Caenorhabditis elegans	40%	100%
O75312	Homo sapiens	41%	100%
P53303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	99%
Q2TBX0	Bos taurus	41%	100%
Q4QE48	Leishmania major	83%	100%
Q55E13	Dictyostelium discoideum	42%	100%
Q62384	Mus musculus	41%	100%
Q9W379	Drosophila melanogaster	41%	100%
V5BJH3	Trypanosoma cruzi	68%	100%