Ubiquitinyl hydrolase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

otubain cysteine peptidase, Clan CA, family C65, putative

Species:

Leishmania braziliensis

UniProt:

A4H997_LEIBR

TriTrypDb:

LbrM.17.1540 , LBRM2903_170022500

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H997

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H997

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0016579	protein deubiquitination	6	6
GO:0036211	protein modification process	4	6
GO:0043412	macromolecule modification	4	6
GO:0070646	protein modification by small protein removal	5	6
GO:0070647	protein modification by small protein conjugation or removal	5	6
GO:0071108	protein K48-linked deubiquitination	7	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004843	cysteine-type deubiquitinase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0032182	ubiquitin-like protein binding	3	4
GO:0043130	ubiquitin binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.376
CLV_C14_Caspase3-7	153	157	PF00656	0.276
CLV_C14_Caspase3-7	75	79	PF00656	0.353
CLV_NRD_NRD_1	17	19	PF00675	0.449
CLV_NRD_NRD_1	76	78	PF00675	0.262
CLV_PCSK_KEX2_1	76	78	PF00082	0.262
CLV_PCSK_SKI1_1	140	144	PF00082	0.384
CLV_PCSK_SKI1_1	38	42	PF00082	0.201
DOC_MAPK_gen_1	97	107	PF00069	0.178
DOC_MAPK_MEF2A_6	216	224	PF00069	0.302
DOC_PP2B_LxvP_1	256	259	PF13499	0.392
DOC_PP2B_LxvP_1	29	32	PF13499	0.398
DOC_USP7_UBL2_3	109	113	PF12436	0.178
DOC_WW_Pin1_4	21	26	PF00397	0.229
LIG_14-3-3_CanoR_1	165	172	PF00244	0.416
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BRCT_BRCA1_1	115	119	PF00533	0.353
LIG_BRCT_BRCA1_1	120	124	PF00533	0.296
LIG_DLG_GKlike_1	111	118	PF00625	0.353
LIG_FHA_1	125	131	PF00498	0.345
LIG_FHA_1	2	8	PF00498	0.519
LIG_FHA_1	51	57	PF00498	0.376
LIG_FHA_2	139	145	PF00498	0.230
LIG_FHA_2	151	157	PF00498	0.141
LIG_FHA_2	188	194	PF00498	0.311
LIG_FHA_2	237	243	PF00498	0.452
LIG_LIR_Gen_1	103	108	PF02991	0.405
LIG_LIR_Gen_1	68	74	PF02991	0.285
LIG_LIR_LC3C_4	249	253	PF02991	0.391
LIG_LIR_Nem_3	103	107	PF02991	0.347
LIG_LIR_Nem_3	116	122	PF02991	0.205
LIG_LIR_Nem_3	132	137	PF02991	0.178
LIG_LIR_Nem_3	176	182	PF02991	0.265
LIG_LIR_Nem_3	68	72	PF02991	0.290
LIG_NRP_CendR_1	266	267	PF00754	0.352
LIG_Pex14_2	122	126	PF04695	0.262
LIG_Pex14_2	214	218	PF04695	0.281
LIG_RPA_C_Fungi	106	118	PF08784	0.353
LIG_SH2_CRK	188	192	PF00017	0.392
LIG_SH2_CRK	262	266	PF00017	0.262
LIG_SH2_PTP2	104	107	PF00017	0.353
LIG_SH2_STAT3	49	52	PF00017	0.392
LIG_SH2_STAT5	104	107	PF00017	0.344
LIG_SH2_STAT5	159	162	PF00017	0.283
LIG_SH2_STAT5	166	169	PF00017	0.284
LIG_SH2_STAT5	171	174	PF00017	0.306
LIG_SH2_STAT5	194	197	PF00017	0.449
LIG_SH2_STAT5	49	52	PF00017	0.392
LIG_SH3_3	92	98	PF00018	0.392
LIG_SUMO_SIM_anti_2	103	110	PF11976	0.381
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.353
LIG_SUMO_SIM_par_1	2	8	PF11976	0.371
LIG_SUMO_SIM_par_1	24	30	PF11976	0.356
LIG_TYR_ITIM	186	191	PF00017	0.281
LIG_WRC_WIRS_1	119	124	PF05994	0.178
MOD_CK1_1	60	66	PF00069	0.380
MOD_CK2_1	5	11	PF00069	0.494
MOD_GlcNHglycan	168	171	PF01048	0.394
MOD_GlcNHglycan	59	62	PF01048	0.360
MOD_GlcNHglycan	7	10	PF01048	0.507
MOD_GSK3_1	1	8	PF00069	0.452
MOD_GSK3_1	103	110	PF00069	0.381
MOD_GSK3_1	21	28	PF00069	0.287
MOD_GSK3_1	57	64	PF00069	0.374
MOD_GSK3_1	68	75	PF00069	0.181
MOD_N-GLC_1	233	238	PF02516	0.369
MOD_N-GLC_2	219	221	PF02516	0.392
MOD_NEK2_1	1	6	PF00069	0.471
MOD_NEK2_1	118	123	PF00069	0.178
MOD_NEK2_1	27	32	PF00069	0.337
MOD_NEK2_1	50	55	PF00069	0.423
MOD_NEK2_1	57	62	PF00069	0.431
MOD_NEK2_2	138	143	PF00069	0.215
MOD_NEK2_2	187	192	PF00069	0.368
MOD_PKA_2	72	78	PF00069	0.389
MOD_Plk_1	111	117	PF00069	0.353
MOD_Plk_1	138	144	PF00069	0.398
MOD_Plk_1	236	242	PF00069	0.400
MOD_Plk_2-3	243	249	PF00069	0.364
MOD_Plk_4	1	7	PF00069	0.401
MOD_Plk_4	103	109	PF00069	0.315
MOD_Plk_4	118	124	PF00069	0.149
MOD_Plk_4	52	58	PF00069	0.214
MOD_ProDKin_1	21	27	PF00069	0.229
MOD_SUMO_rev_2	237	246	PF00179	0.178
TRG_DiLeu_BaEn_1	103	108	PF01217	0.353
TRG_DiLeu_BaEn_2	177	183	PF01217	0.178
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.374
TRG_ENDOCYTIC_2	104	107	PF00928	0.392
TRG_ENDOCYTIC_2	149	152	PF00928	0.392
TRG_ENDOCYTIC_2	179	182	PF00928	0.317
TRG_ENDOCYTIC_2	188	191	PF00928	0.242
TRG_ENDOCYTIC_2	262	265	PF00928	0.262
TRG_ER_diArg_1	265	267	PF00400	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P6	Leptomonas seymouri	61%	98%
A0A0S4J6F9	Bodo saltans	30%	100%
A0A1X0NSN1	Trypanosomatidae	35%	100%
A0A3S7WUP0	Leishmania donovani	84%	99%
A0A422NBK6	Trypanosoma rangeli	37%	100%
A4HXL8	Leishmania infantum	83%	99%
A8XDJ2	Caenorhabditis briggsae	30%	93%
B2RYG6	Rattus norvegicus	33%	99%
C9ZPB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ARB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QE49	Leishmania major	84%	100%
Q7TQI3	Mus musculus	33%	99%
Q8LG98	Arabidopsis thaliana	28%	87%
Q96DC9	Homo sapiens	26%	100%
Q96FW1	Homo sapiens	33%	99%
Q9CQX0	Mus musculus	28%	100%
Q9VL00	Drosophila melanogaster	30%	100%
Q9XVR6	Caenorhabditis elegans	28%	94%
V5BNY1	Trypanosoma cruzi	38%	100%