IQ calmodulin-binding motif family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H995_LEIBR

TriTrypDb:

LbrM.17.1520 , LBRM2903_170022200

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H995

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H995

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.670
CLV_NRD_NRD_1	116	118	PF00675	0.759
CLV_NRD_NRD_1	186	188	PF00675	0.455
CLV_NRD_NRD_1	368	370	PF00675	0.514
CLV_NRD_NRD_1	383	385	PF00675	0.571
CLV_NRD_NRD_1	424	426	PF00675	0.477
CLV_NRD_NRD_1	488	490	PF00675	0.275
CLV_NRD_NRD_1	500	502	PF00675	0.398
CLV_NRD_NRD_1	516	518	PF00675	0.500
CLV_NRD_NRD_1	522	524	PF00675	0.474
CLV_NRD_NRD_1	577	579	PF00675	0.499
CLV_NRD_NRD_1	601	603	PF00675	0.563
CLV_NRD_NRD_1	641	643	PF00675	0.343
CLV_PCSK_FUR_1	498	502	PF00082	0.406
CLV_PCSK_KEX2_1	186	188	PF00082	0.455
CLV_PCSK_KEX2_1	368	370	PF00082	0.515
CLV_PCSK_KEX2_1	383	385	PF00082	0.587
CLV_PCSK_KEX2_1	423	425	PF00082	0.398
CLV_PCSK_KEX2_1	488	490	PF00082	0.350
CLV_PCSK_KEX2_1	500	502	PF00082	0.445
CLV_PCSK_KEX2_1	516	518	PF00082	0.525
CLV_PCSK_KEX2_1	522	524	PF00082	0.497
CLV_PCSK_KEX2_1	577	579	PF00082	0.517
CLV_PCSK_KEX2_1	600	602	PF00082	0.575
CLV_PCSK_KEX2_1	623	625	PF00082	0.476
CLV_PCSK_KEX2_1	641	643	PF00082	0.216
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.448
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.598
CLV_PCSK_SKI1_1	117	121	PF00082	0.753
CLV_PCSK_SKI1_1	221	225	PF00082	0.529
CLV_PCSK_SKI1_1	369	373	PF00082	0.532
CLV_PCSK_SKI1_1	478	482	PF00082	0.320
CLV_PCSK_SKI1_1	532	536	PF00082	0.457
DEG_Nend_Nbox_1	1	3	PF02207	0.459
DOC_CKS1_1	144	149	PF01111	0.561
DOC_CKS1_1	159	164	PF01111	0.371
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.714
DOC_MAPK_gen_1	368	376	PF00069	0.454
DOC_MAPK_gen_1	380	390	PF00069	0.589
DOC_MAPK_gen_1	541	550	PF00069	0.507
DOC_MAPK_gen_1	585	595	PF00069	0.440
DOC_MAPK_gen_1	600	606	PF00069	0.509
DOC_MAPK_gen_1	638	648	PF00069	0.553
DOC_MAPK_MEF2A_6	293	300	PF00069	0.467
DOC_MAPK_MEF2A_6	383	392	PF00069	0.600
DOC_MAPK_MEF2A_6	544	552	PF00069	0.324
DOC_MAPK_NFAT4_5	293	301	PF00069	0.471
DOC_PP1_RVXF_1	586	592	PF00149	0.363
DOC_PP2B_LxvP_1	101	104	PF13499	0.730
DOC_PP2B_LxvP_1	29	32	PF13499	0.700
DOC_SPAK_OSR1_1	590	594	PF12202	0.464
DOC_USP7_MATH_1	128	132	PF00917	0.640
DOC_USP7_MATH_1	223	227	PF00917	0.557
DOC_USP7_MATH_1	268	272	PF00917	0.604
DOC_USP7_MATH_1	315	319	PF00917	0.699
DOC_USP7_MATH_1	398	402	PF00917	0.572
DOC_USP7_MATH_1	4	8	PF00917	0.589
DOC_USP7_UBL2_3	532	536	PF12436	0.342
DOC_WW_Pin1_4	118	123	PF00397	0.732
DOC_WW_Pin1_4	143	148	PF00397	0.716
DOC_WW_Pin1_4	155	160	PF00397	0.610
DOC_WW_Pin1_4	233	238	PF00397	0.722
LIG_14-3-3_CanoR_1	117	122	PF00244	0.747
LIG_14-3-3_CanoR_1	18	23	PF00244	0.633
LIG_14-3-3_CanoR_1	198	204	PF00244	0.633
LIG_14-3-3_CanoR_1	221	230	PF00244	0.722
LIG_14-3-3_CanoR_1	356	364	PF00244	0.554
LIG_14-3-3_CanoR_1	577	586	PF00244	0.501
LIG_14-3-3_CanoR_1	601	607	PF00244	0.586
LIG_14-3-3_CanoR_1	624	629	PF00244	0.631
LIG_Actin_WH2_2	603	619	PF00022	0.365
LIG_CaM_IQ_9	345	360	PF13499	0.482
LIG_CaM_IQ_9	443	458	PF13499	0.482
LIG_CaM_IQ_9	480	496	PF13499	0.482
LIG_CaM_IQ_9	564	580	PF13499	0.526
LIG_deltaCOP1_diTrp_1	328	334	PF00928	0.615
LIG_FHA_1	119	125	PF00498	0.776
LIG_FHA_1	57	63	PF00498	0.738
LIG_FHA_1	96	102	PF00498	0.683
LIG_FHA_2	130	136	PF00498	0.563
LIG_FHA_2	176	182	PF00498	0.485
LIG_Integrin_RGD_1	233	235	PF01839	0.770
LIG_LIR_Gen_1	11	19	PF02991	0.467
LIG_LIR_Gen_1	236	247	PF02991	0.518
LIG_LIR_Gen_1	65	75	PF02991	0.585
LIG_LIR_Nem_3	11	16	PF02991	0.532
LIG_LIR_Nem_3	157	163	PF02991	0.467
LIG_LIR_Nem_3	21	25	PF02991	0.542
LIG_LIR_Nem_3	236	242	PF02991	0.523
LIG_LIR_Nem_3	43	49	PF02991	0.738
LIG_LIR_Nem_3	485	490	PF02991	0.534
LIG_LIR_Nem_3	543	548	PF02991	0.583
LIG_LIR_Nem_3	65	71	PF02991	0.586
LIG_PCNA_yPIPBox_3	9	23	PF02747	0.603
LIG_REV1ctd_RIR_1	410	420	PF16727	0.526
LIG_RPA_C_Fungi	353	365	PF08784	0.388
LIG_SH2_CRK	13	17	PF00017	0.421
LIG_SH2_SRC	320	323	PF00017	0.643
LIG_SH2_STAP1	524	528	PF00017	0.506
LIG_SH2_STAP1	546	550	PF00017	0.551
LIG_SH2_STAT3	430	433	PF00017	0.370
LIG_SH2_STAT3	490	493	PF00017	0.477
LIG_SH2_STAT5	204	207	PF00017	0.614
LIG_SH2_STAT5	320	323	PF00017	0.643
LIG_SH3_1	136	142	PF00018	0.566
LIG_SH3_2	145	150	PF14604	0.565
LIG_SH3_3	131	137	PF00018	0.727
LIG_SH3_3	139	145	PF00018	0.748
LIG_SH3_3	156	162	PF00018	0.672
LIG_SH3_3	169	175	PF00018	0.358
LIG_SH3_CIN85_PxpxPR_1	145	150	PF14604	0.565
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.637
LIG_SUMO_SIM_par_1	372	377	PF11976	0.363
LIG_TRAF2_1	207	210	PF00917	0.675
LIG_UBA3_1	15	23	PF00899	0.550
LIG_UBA3_1	296	304	PF00899	0.490
LIG_UBA3_1	92	96	PF00899	0.456
LIG_Vh1_VBS_1	1	19	PF01044	0.433
LIG_WRC_WIRS_1	22	27	PF05994	0.547
LIG_WRC_WIRS_1	244	249	PF05994	0.511
LIG_WW_3	147	151	PF00397	0.568
MOD_CDK_SPxxK_3	143	150	PF00069	0.564
MOD_CK1_1	158	164	PF00069	0.633
MOD_CK1_1	226	232	PF00069	0.647
MOD_CK1_1	47	53	PF00069	0.680
MOD_CK1_1	58	64	PF00069	0.664
MOD_CK2_1	129	135	PF00069	0.801
MOD_CK2_1	175	181	PF00069	0.434
MOD_CK2_1	268	274	PF00069	0.706
MOD_CK2_1	402	408	PF00069	0.408
MOD_CK2_1	466	472	PF00069	0.355
MOD_CK2_1	602	608	PF00069	0.363
MOD_Cter_Amidation	575	578	PF01082	0.366
MOD_GlcNHglycan	163	166	PF01048	0.641
MOD_GlcNHglycan	175	178	PF01048	0.575
MOD_GlcNHglycan	249	252	PF01048	0.725
MOD_GlcNHglycan	272	278	PF01048	0.480
MOD_GlcNHglycan	29	32	PF01048	0.541
MOD_GlcNHglycan	317	320	PF01048	0.626
MOD_GlcNHglycan	342	345	PF01048	0.477
MOD_GlcNHglycan	376	379	PF01048	0.594
MOD_GlcNHglycan	400	403	PF01048	0.673
MOD_GlcNHglycan	46	49	PF01048	0.648
MOD_GSK3_1	109	116	PF00069	0.748
MOD_GSK3_1	14	21	PF00069	0.554
MOD_GSK3_1	154	161	PF00069	0.698
MOD_GSK3_1	229	236	PF00069	0.625
MOD_GSK3_1	243	250	PF00069	0.626
MOD_GSK3_1	394	401	PF00069	0.596
MOD_GSK3_1	4	11	PF00069	0.564
MOD_GSK3_1	478	485	PF00069	0.360
MOD_GSK3_1	577	584	PF00069	0.459
MOD_GSK3_1	58	65	PF00069	0.689
MOD_GSK3_1	91	98	PF00069	0.619
MOD_N-GLC_1	221	226	PF02516	0.489
MOD_NEK2_1	242	247	PF00069	0.514
MOD_NEK2_1	300	305	PF00069	0.725
MOD_NEK2_1	330	335	PF00069	0.665
MOD_NEK2_1	372	377	PF00069	0.573
MOD_NEK2_1	482	487	PF00069	0.432
MOD_NEK2_1	75	80	PF00069	0.674
MOD_NEK2_1	91	96	PF00069	0.605
MOD_NEK2_2	223	228	PF00069	0.508
MOD_OFUCOSY	479	486	PF10250	0.434
MOD_PIKK_1	5	11	PF00454	0.594
MOD_PIKK_1	577	583	PF00454	0.375
MOD_PIKK_1	62	68	PF00454	0.542
MOD_PK_1	602	608	PF00069	0.509
MOD_PK_1	617	623	PF00069	0.368
MOD_PKA_1	117	123	PF00069	0.528
MOD_PKA_1	577	583	PF00069	0.531
MOD_PKA_2	379	385	PF00069	0.540
MOD_PKA_2	55	61	PF00069	0.687
MOD_PKA_2	577	583	PF00069	0.545
MOD_PKA_2	584	590	PF00069	0.585
MOD_PKB_1	600	608	PF00069	0.366
MOD_Plk_1	242	248	PF00069	0.514
MOD_Plk_1	36	42	PF00069	0.543
MOD_Plk_1	403	409	PF00069	0.515
MOD_Plk_1	581	587	PF00069	0.369
MOD_Plk_1	617	623	PF00069	0.368
MOD_Plk_1	62	68	PF00069	0.658
MOD_Plk_1	75	81	PF00069	0.707
MOD_Plk_4	109	115	PF00069	0.759
MOD_Plk_4	199	205	PF00069	0.443
MOD_Plk_4	306	312	PF00069	0.493
MOD_Plk_4	36	42	PF00069	0.573
MOD_Plk_4	478	484	PF00069	0.360
MOD_Plk_4	8	14	PF00069	0.512
MOD_ProDKin_1	118	124	PF00069	0.734
MOD_ProDKin_1	143	149	PF00069	0.717
MOD_ProDKin_1	155	161	PF00069	0.601
MOD_ProDKin_1	233	239	PF00069	0.723
MOD_SUMO_for_1	278	281	PF00179	0.632
TRG_ENDOCYTIC_2	13	16	PF00928	0.540
TRG_ENDOCYTIC_2	22	25	PF00928	0.533
TRG_ER_diArg_1	230	233	PF00400	0.539
TRG_ER_diArg_1	355	358	PF00400	0.351
TRG_ER_diArg_1	383	385	PF00400	0.509
TRG_ER_diArg_1	424	427	PF00400	0.423
TRG_ER_diArg_1	487	489	PF00400	0.436
TRG_ER_diArg_1	497	500	PF00400	0.402
TRG_ER_diArg_1	510	513	PF00400	0.509
TRG_ER_diArg_1	522	524	PF00400	0.488
TRG_ER_diArg_1	588	591	PF00400	0.562
TRG_ER_diArg_1	600	602	PF00400	0.585
TRG_ER_diArg_1	640	642	PF00400	0.406
TRG_NLS_MonoExtC_3	422	427	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D9	Leptomonas seymouri	47%	87%
A0A0S4J9A9	Bodo saltans	27%	73%
A0A1X0NSM4	Trypanosomatidae	28%	84%
A0A3R7K6T1	Trypanosoma rangeli	29%	87%
A0A3S7WUM7	Leishmania donovani	66%	94%
A4HXL6	Leishmania infantum	66%	81%
E9ARB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	77%
Q4QE51	Leishmania major	67%	100%
V5DFR3	Trypanosoma cruzi	29%	100%