Protein SDA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein SDA1

Gene product:

NUC130/3NT domain/SDA1, putative

Species:

Leishmania braziliensis

UniProt:

A4H993_LEIBR

TriTrypDb:

LbrM.17.1500 , LBRM2903_170022000

Length:

865

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H993

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H993

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	11
GO:0000055	ribosomal large subunit export from nucleus	4	11
GO:0006810	transport	3	11
GO:0006913	nucleocytoplasmic transport	5	11
GO:0006996	organelle organization	4	11
GO:0007010	cytoskeleton organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0030029	actin filament-based process	2	11
GO:0030036	actin cytoskeleton organization	3	11
GO:0031503	protein-containing complex localization	2	11
GO:0033036	macromolecule localization	2	11
GO:0033750	ribosome localization	3	11
GO:0042273	ribosomal large subunit biogenesis	5	11
GO:0044085	cellular component biogenesis	3	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051168	nuclear export	6	11
GO:0051169	nuclear transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051640	organelle localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0051656	establishment of organelle localization	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.413
CLV_C14_Caspase3-7	503	507	PF00656	0.298
CLV_C14_Caspase3-7	523	527	PF00656	0.306
CLV_C14_Caspase3-7	532	536	PF00656	0.255
CLV_C14_Caspase3-7	571	575	PF00656	0.438
CLV_C14_Caspase3-7	605	609	PF00656	0.374
CLV_C14_Caspase3-7	614	618	PF00656	0.334
CLV_C14_Caspase3-7	639	643	PF00656	0.197
CLV_NRD_NRD_1	130	132	PF00675	0.381
CLV_NRD_NRD_1	142	144	PF00675	0.364
CLV_NRD_NRD_1	157	159	PF00675	0.379
CLV_NRD_NRD_1	18	20	PF00675	0.424
CLV_NRD_NRD_1	189	191	PF00675	0.408
CLV_NRD_NRD_1	275	277	PF00675	0.484
CLV_NRD_NRD_1	792	794	PF00675	0.359
CLV_NRD_NRD_1	802	804	PF00675	0.303
CLV_PCSK_FUR_1	16	20	PF00082	0.443
CLV_PCSK_FUR_1	858	862	PF00082	0.324
CLV_PCSK_KEX2_1	18	20	PF00082	0.424
CLV_PCSK_KEX2_1	188	190	PF00082	0.405
CLV_PCSK_KEX2_1	262	264	PF00082	0.453
CLV_PCSK_KEX2_1	268	270	PF00082	0.447
CLV_PCSK_KEX2_1	275	277	PF00082	0.464
CLV_PCSK_KEX2_1	412	414	PF00082	0.391
CLV_PCSK_KEX2_1	582	584	PF00082	0.347
CLV_PCSK_KEX2_1	753	755	PF00082	0.330
CLV_PCSK_KEX2_1	777	779	PF00082	0.305
CLV_PCSK_KEX2_1	818	820	PF00082	0.261
CLV_PCSK_KEX2_1	827	829	PF00082	0.324
CLV_PCSK_KEX2_1	860	862	PF00082	0.324
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.453
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.447
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.464
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.391
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.347
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.330
CLV_PCSK_PC1ET2_1	777	779	PF00082	0.305
CLV_PCSK_PC1ET2_1	818	820	PF00082	0.324
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.324
CLV_PCSK_PC1ET2_1	860	862	PF00082	0.416
CLV_PCSK_PC7_1	408	414	PF00082	0.371
CLV_PCSK_SKI1_1	132	136	PF00082	0.376
CLV_PCSK_SKI1_1	214	218	PF00082	0.358
CLV_PCSK_SKI1_1	255	259	PF00082	0.493
CLV_PCSK_SKI1_1	265	269	PF00082	0.425
CLV_PCSK_SKI1_1	272	276	PF00082	0.404
CLV_PCSK_SKI1_1	717	721	PF00082	0.377
CLV_PCSK_SKI1_1	853	857	PF00082	0.329
CLV_PCSK_SKI1_1	94	98	PF00082	0.292
CLV_Separin_Metazoa	79	83	PF03568	0.449
DEG_APCC_DBOX_1	217	225	PF00400	0.382
DEG_APCC_DBOX_1	6	14	PF00400	0.421
DEG_APCC_DBOX_1	818	826	PF00400	0.324
DEG_SPOP_SBC_1	707	711	PF00917	0.423
DOC_CDC14_PxL_1	483	491	PF14671	0.299
DOC_MAPK_DCC_7	290	298	PF00069	0.418
DOC_MAPK_gen_1	126	135	PF00069	0.389
DOC_MAPK_gen_1	249	256	PF00069	0.380
DOC_MAPK_gen_1	462	471	PF00069	0.197
DOC_MAPK_HePTP_8	174	186	PF00069	0.356
DOC_MAPK_MEF2A_6	177	186	PF00069	0.352
DOC_MAPK_MEF2A_6	68	76	PF00069	0.416
DOC_PP1_RVXF_1	851	858	PF00149	0.324
DOC_PP2B_LxvP_1	222	225	PF13499	0.432
DOC_PP2B_LxvP_1	340	343	PF13499	0.531
DOC_PP4_MxPP_1	373	376	PF00568	0.417
DOC_SPAK_OSR1_1	319	323	PF12202	0.388
DOC_USP7_MATH_1	522	526	PF00917	0.448
DOC_USP7_MATH_1	542	546	PF00917	0.341
DOC_USP7_MATH_1	593	597	PF00917	0.397
DOC_USP7_MATH_1	673	677	PF00917	0.415
DOC_USP7_MATH_1	700	704	PF00917	0.368
DOC_USP7_UBL2_3	128	132	PF12436	0.504
DOC_USP7_UBL2_3	249	253	PF12436	0.455
DOC_USP7_UBL2_3	255	259	PF12436	0.458
DOC_USP7_UBL2_3	794	798	PF12436	0.347
DOC_USP7_UBL2_3	804	808	PF12436	0.302
DOC_USP7_UBL2_3	848	852	PF12436	0.325
DOC_USP7_UBL2_3	856	860	PF12436	0.326
DOC_WW_Pin1_4	207	212	PF00397	0.460
LIG_14-3-3_CanoR_1	158	164	PF00244	0.427
LIG_14-3-3_CanoR_1	189	198	PF00244	0.480
LIG_14-3-3_CanoR_1	226	231	PF00244	0.619
LIG_14-3-3_CanoR_1	332	340	PF00244	0.393
LIG_14-3-3_CanoR_1	36	43	PF00244	0.515
LIG_14-3-3_CanoR_1	394	402	PF00244	0.537
LIG_14-3-3_CanoR_1	698	703	PF00244	0.246
LIG_14-3-3_CanoR_1	717	724	PF00244	0.305
LIG_14-3-3_CanoR_1	793	801	PF00244	0.416
LIG_Actin_WH2_2	69	84	PF00022	0.416
LIG_APCC_ABBA_1	446	451	PF00400	0.324
LIG_APCC_ABBA_1	770	775	PF00400	0.197
LIG_BIR_III_2	588	592	PF00653	0.197
LIG_BRCT_BRCA1_1	161	165	PF00533	0.282
LIG_BRCT_BRCA1_1	316	320	PF00533	0.472
LIG_BRCT_BRCA1_1	62	66	PF00533	0.319
LIG_BRCT_BRCA1_1	795	799	PF00533	0.416
LIG_BRCT_BRCA1_2	62	68	PF00533	0.319
LIG_FAT_LD_1	306	314	PF03623	0.369
LIG_FHA_1	113	119	PF00498	0.482
LIG_FHA_1	134	140	PF00498	0.477
LIG_FHA_1	195	201	PF00498	0.368
LIG_FHA_1	208	214	PF00498	0.345
LIG_FHA_1	358	364	PF00498	0.383
LIG_FHA_1	399	405	PF00498	0.349
LIG_FHA_1	51	57	PF00498	0.398
LIG_FHA_1	571	577	PF00498	0.197
LIG_FHA_1	629	635	PF00498	0.332
LIG_FHA_1	7	13	PF00498	0.429
LIG_FHA_2	15	21	PF00498	0.424
LIG_FHA_2	404	410	PF00498	0.359
LIG_FHA_2	515	521	PF00498	0.409
LIG_FHA_2	582	588	PF00498	0.260
LIG_FHA_2	605	611	PF00498	0.371
LIG_FHA_2	612	618	PF00498	0.347
LIG_FHA_2	718	724	PF00498	0.377
LIG_FHA_2	810	816	PF00498	0.324
LIG_Integrin_RGD_1	433	435	PF01839	0.305
LIG_Integrin_RGD_1	504	506	PF01839	0.197
LIG_LIR_Apic_2	349	354	PF02991	0.391
LIG_LIR_Gen_1	162	173	PF02991	0.500
LIG_LIR_Gen_1	480	491	PF02991	0.255
LIG_LIR_Gen_1	535	546	PF02991	0.416
LIG_LIR_Gen_1	619	628	PF02991	0.197
LIG_LIR_Gen_1	679	689	PF02991	0.376
LIG_LIR_Gen_1	721	732	PF02991	0.294
LIG_LIR_Nem_3	113	119	PF02991	0.373
LIG_LIR_Nem_3	451	456	PF02991	0.315
LIG_LIR_Nem_3	480	486	PF02991	0.255
LIG_LIR_Nem_3	490	496	PF02991	0.339
LIG_LIR_Nem_3	535	541	PF02991	0.416
LIG_LIR_Nem_3	619	624	PF02991	0.197
LIG_LIR_Nem_3	679	685	PF02991	0.376
LIG_LIR_Nem_3	721	727	PF02991	0.294
LIG_LRP6_Inhibitor_1	402	408	PF00058	0.360
LIG_LYPXL_S_1	452	456	PF13949	0.305
LIG_LYPXL_yS_3	453	456	PF13949	0.305
LIG_MYND_1	454	458	PF01753	0.305
LIG_MYND_1	557	561	PF01753	0.347
LIG_PALB2_WD40_1	677	685	PF16756	0.449
LIG_Pex14_2	116	120	PF04695	0.375
LIG_PTB_Apo_2	46	53	PF02174	0.434
LIG_REV1ctd_RIR_1	117	125	PF16727	0.266
LIG_SH2_GRB2like	326	329	PF00017	0.358
LIG_SH2_NCK_1	483	487	PF00017	0.299
LIG_SH2_NCK_1	621	625	PF00017	0.197
LIG_SH2_SRC	326	329	PF00017	0.358
LIG_SH2_STAT3	278	281	PF00017	0.596
LIG_SH2_STAT3	429	432	PF00017	0.274
LIG_SH2_STAT5	326	329	PF00017	0.351
LIG_SH2_STAT5	483	486	PF00017	0.299
LIG_SH2_STAT5	58	61	PF00017	0.328
LIG_SH3_3	142	148	PF00018	0.317
LIG_SH3_3	536	542	PF00018	0.404
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.324
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.363
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.413
LIG_SUMO_SIM_par_1	180	185	PF11976	0.349
LIG_SUMO_SIM_par_1	193	202	PF11976	0.380
LIG_SUMO_SIM_par_1	360	366	PF11976	0.391
LIG_TRAF2_1	545	548	PF00917	0.433
LIG_TYR_ITIM	324	329	PF00017	0.360
LIG_TYR_ITIM	491	496	PF00017	0.410
LIG_UBA3_1	101	107	PF00899	0.412
LIG_UBA3_1	309	315	PF00899	0.340
LIG_UBA3_1	422	430	PF00899	0.289
LIG_UBA3_1	822	827	PF00899	0.324
MOD_CDK_SPxxK_3	207	214	PF00069	0.452
MOD_CK1_1	207	213	PF00069	0.422
MOD_CK1_1	38	44	PF00069	0.518
MOD_CK1_1	392	398	PF00069	0.435
MOD_CK1_1	507	513	PF00069	0.327
MOD_CK1_1	635	641	PF00069	0.197
MOD_CK1_1	676	682	PF00069	0.414
MOD_CK1_1	701	707	PF00069	0.356
MOD_CK1_1	708	714	PF00069	0.360
MOD_CK1_1	736	742	PF00069	0.324
MOD_CK2_1	258	264	PF00069	0.495
MOD_CK2_1	332	338	PF00069	0.381
MOD_CK2_1	403	409	PF00069	0.359
MOD_CK2_1	507	513	PF00069	0.451
MOD_CK2_1	514	520	PF00069	0.307
MOD_CK2_1	522	528	PF00069	0.407
MOD_CK2_1	541	547	PF00069	0.159
MOD_CK2_1	581	587	PF00069	0.207
MOD_CK2_1	604	610	PF00069	0.344
MOD_CK2_1	622	628	PF00069	0.360
MOD_CK2_1	648	654	PF00069	0.401
MOD_CK2_1	674	680	PF00069	0.387
MOD_CK2_1	794	800	PF00069	0.324
MOD_CK2_1	809	815	PF00069	0.324
MOD_GlcNHglycan	365	368	PF01048	0.467
MOD_GlcNHglycan	38	41	PF01048	0.512
MOD_GlcNHglycan	395	398	PF01048	0.545
MOD_GlcNHglycan	517	520	PF01048	0.406
MOD_GlcNHglycan	544	547	PF01048	0.417
MOD_GlcNHglycan	567	570	PF01048	0.386
MOD_GlcNHglycan	604	607	PF01048	0.307
MOD_GlcNHglycan	642	645	PF01048	0.380
MOD_GlcNHglycan	652	658	PF01048	0.263
MOD_GSK3_1	108	115	PF00069	0.409
MOD_GSK3_1	133	140	PF00069	0.387
MOD_GSK3_1	159	166	PF00069	0.285
MOD_GSK3_1	190	197	PF00069	0.494
MOD_GSK3_1	389	396	PF00069	0.394
MOD_GSK3_1	477	484	PF00069	0.387
MOD_GSK3_1	504	511	PF00069	0.330
MOD_GSK3_1	520	527	PF00069	0.448
MOD_GSK3_1	598	605	PF00069	0.362
MOD_GSK3_1	622	629	PF00069	0.414
MOD_GSK3_1	698	705	PF00069	0.257
MOD_GSK3_1	708	715	PF00069	0.279
MOD_GSK3_1	804	811	PF00069	0.347
MOD_LATS_1	34	40	PF00433	0.388
MOD_N-GLC_1	14	19	PF02516	0.419
MOD_N-GLC_1	542	547	PF02516	0.235
MOD_N-GLC_1	565	570	PF02516	0.388
MOD_N-GLC_1	673	678	PF02516	0.373
MOD_N-GLC_1	691	696	PF02516	0.399
MOD_N-GLC_1	809	814	PF02516	0.306
MOD_NEK2_1	133	138	PF00069	0.386
MOD_NEK2_1	163	168	PF00069	0.396
MOD_NEK2_1	267	272	PF00069	0.580
MOD_NEK2_1	35	40	PF00069	0.393
MOD_NEK2_1	357	362	PF00069	0.398
MOD_NEK2_1	363	368	PF00069	0.360
MOD_NEK2_1	382	387	PF00069	0.362
MOD_NEK2_1	6	11	PF00069	0.437
MOD_NEK2_1	602	607	PF00069	0.433
MOD_NEK2_1	713	718	PF00069	0.382
MOD_NEK2_1	809	814	PF00069	0.344
MOD_NEK2_1	81	86	PF00069	0.362
MOD_NEK2_1	823	828	PF00069	0.324
MOD_NEK2_1	836	841	PF00069	0.291
MOD_NEK2_1	97	102	PF00069	0.228
MOD_NEK2_2	403	408	PF00069	0.356
MOD_PIKK_1	352	358	PF00454	0.405
MOD_PIKK_1	41	47	PF00454	0.512
MOD_PIKK_1	428	434	PF00454	0.206
MOD_PIKK_1	593	599	PF00454	0.428
MOD_PIKK_1	600	606	PF00454	0.400
MOD_PIKK_1	826	832	PF00454	0.345
MOD_PK_1	698	704	PF00069	0.410
MOD_PKA_1	258	264	PF00069	0.459
MOD_PKA_1	793	799	PF00069	0.342
MOD_PKA_1	804	810	PF00069	0.268
MOD_PKA_2	225	231	PF00069	0.598
MOD_PKA_2	35	41	PF00069	0.482
MOD_PKA_2	393	399	PF00069	0.557
MOD_PKA_2	6	12	PF00069	0.430
MOD_PKA_2	81	87	PF00069	0.410
MOD_PKA_2	842	848	PF00069	0.416
MOD_PKB_1	188	196	PF00069	0.502
MOD_Plk_1	112	118	PF00069	0.394
MOD_Plk_1	126	132	PF00069	0.419
MOD_Plk_1	194	200	PF00069	0.382
MOD_Plk_1	691	697	PF00069	0.197
MOD_Plk_2-3	194	200	PF00069	0.454
MOD_Plk_2-3	20	26	PF00069	0.547
MOD_Plk_2-3	520	526	PF00069	0.395
MOD_Plk_2-3	613	619	PF00069	0.373
MOD_Plk_2-3	622	628	PF00069	0.323
MOD_Plk_2-3	633	639	PF00069	0.256
MOD_Plk_2-3	648	654	PF00069	0.390
MOD_Plk_4	159	165	PF00069	0.284
MOD_Plk_4	38	44	PF00069	0.431
MOD_Plk_4	6	12	PF00069	0.430
MOD_Plk_4	97	103	PF00069	0.399
MOD_ProDKin_1	207	213	PF00069	0.452
MOD_SUMO_rev_2	425	431	PF00179	0.193
MOD_SUMO_rev_2	532	539	PF00179	0.232
MOD_SUMO_rev_2	849	857	PF00179	0.324
TRG_DiLeu_BaEn_4	663	669	PF01217	0.352
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.379
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.367
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.368
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.475
TRG_DiLeu_BaLyEn_6	714	719	PF01217	0.449
TRG_ENDOCYTIC_2	326	329	PF00928	0.356
TRG_ENDOCYTIC_2	345	348	PF00928	0.208
TRG_ENDOCYTIC_2	449	452	PF00928	0.312
TRG_ENDOCYTIC_2	453	456	PF00928	0.296
TRG_ENDOCYTIC_2	483	486	PF00928	0.302
TRG_ENDOCYTIC_2	493	496	PF00928	0.310
TRG_ENDOCYTIC_2	621	624	PF00928	0.197
TRG_ER_diArg_1	16	19	PF00400	0.442
TRG_ER_diArg_1	187	190	PF00400	0.391
TRG_ER_diArg_1	583	586	PF00400	0.414
TRG_NLS_Bipartite_1	793	809	PF00514	0.334
TRG_NLS_MonoCore_2	802	807	PF00514	0.316
TRG_NLS_MonoExtC_3	581	587	PF00514	0.346
TRG_NLS_MonoExtC_3	803	808	PF00514	0.320
TRG_NLS_MonoExtN_4	580	586	PF00514	0.381
TRG_NLS_MonoExtN_4	803	809	PF00514	0.325
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.119
TRG_Pf-PMV_PEXEL_1	717	721	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R9	Leptomonas seymouri	72%	100%
A0A1X0NT40	Trypanosomatidae	70%	100%
A0A3R7NHD4	Trypanosoma rangeli	66%	100%
A0A3S5H720	Leishmania donovani	84%	99%
A4HXL4	Leishmania infantum	84%	99%
C9ZPA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ARB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
P53313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q4QE53	Leishmania major	84%	99%
V5AZE5	Trypanosoma cruzi	64%	99%