Putative L-gulonolactone oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

L-galactonolactone oxidase, putative

Species:

Leishmania braziliensis

UniProt:

A4H992_LEIBR

TriTrypDb:

LbrM.17.1490 , LBRM2903_170021800

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0020022	acidocalcisome	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H992

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H992

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0005996	monosaccharide metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006766	vitamin metabolic process	3	1
GO:0006767	water-soluble vitamin metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009110	vitamin biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016051	carbohydrate biosynthetic process	4	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0019852	L-ascorbic acid metabolic process	4	1
GO:0019853	L-ascorbic acid biosynthetic process	5	1
GO:0042364	water-soluble vitamin biosynthetic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046364	monosaccharide biosynthetic process	4	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901334	lactone metabolic process	4	1
GO:1901336	lactone biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003885	D-arabinono-1,4-lactone oxidase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050105	L-gulonolactone oxidase activity	5	5
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0071949	FAD binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0010181	FMN binding	4	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	2
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	2
GO:0032553	ribonucleotide binding	3	1
GO:0050024	L-galactonolactone oxidase activity	5	2
GO:0097367	carbohydrate derivative binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.377
CLV_C14_Caspase3-7	275	279	PF00656	0.720
CLV_NRD_NRD_1	469	471	PF00675	0.330
CLV_PCSK_KEX2_1	462	464	PF00082	0.351
CLV_PCSK_KEX2_1	468	470	PF00082	0.380
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.337
CLV_PCSK_SKI1_1	141	145	PF00082	0.373
CLV_PCSK_SKI1_1	200	204	PF00082	0.463
CLV_PCSK_SKI1_1	286	290	PF00082	0.317
CLV_PCSK_SKI1_1	462	466	PF00082	0.257
CLV_PCSK_SKI1_1	83	87	PF00082	0.267
DEG_COP1_1	231	242	PF00400	0.371
DEG_MDM2_SWIB_1	477	485	PF02201	0.263
DEG_SPOP_SBC_1	277	281	PF00917	0.428
DOC_CYCLIN_yCln2_LP_2	380	386	PF00134	0.403
DOC_MAPK_MEF2A_6	375	382	PF00069	0.357
DOC_MAPK_MEF2A_6	402	411	PF00069	0.263
DOC_MAPK_MEF2A_6	98	107	PF00069	0.343
DOC_MAPK_NFAT4_5	375	383	PF00069	0.403
DOC_PP1_RVXF_1	185	191	PF00149	0.488
DOC_PP1_RVXF_1	33	40	PF00149	0.178
DOC_PP2B_LxvP_1	3	6	PF13499	0.416
DOC_PP4_FxxP_1	388	391	PF00568	0.448
DOC_USP7_MATH_1	125	129	PF00917	0.323
DOC_USP7_MATH_1	264	268	PF00917	0.522
DOC_USP7_MATH_1	277	281	PF00917	0.610
DOC_USP7_UBL2_3	286	290	PF12436	0.428
DOC_USP7_UBL2_3	98	102	PF12436	0.178
DOC_WW_Pin1_4	240	245	PF00397	0.609
DOC_WW_Pin1_4	255	260	PF00397	0.633
DOC_WW_Pin1_4	394	399	PF00397	0.263
DOC_WW_Pin1_4	484	489	PF00397	0.405
DOC_WW_Pin1_4	52	57	PF00397	0.263
LIG_14-3-3_CanoR_1	325	331	PF00244	0.415
LIG_14-3-3_CanoR_1	387	391	PF00244	0.373
LIG_14-3-3_CanoR_1	402	410	PF00244	0.174
LIG_14-3-3_CanoR_1	83	92	PF00244	0.241
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_Clathr_ClatBox_1	66	70	PF01394	0.346
LIG_CSL_BTD_1	221	224	PF09270	0.283
LIG_deltaCOP1_diTrp_1	303	307	PF00928	0.382
LIG_deltaCOP1_diTrp_1	459	464	PF00928	0.353
LIG_FHA_1	179	185	PF00498	0.418
LIG_FHA_1	203	209	PF00498	0.433
LIG_FHA_1	249	255	PF00498	0.555
LIG_FHA_1	279	285	PF00498	0.546
LIG_FHA_1	28	34	PF00498	0.378
LIG_FHA_1	292	298	PF00498	0.368
LIG_FHA_1	402	408	PF00498	0.286
LIG_FHA_2	155	161	PF00498	0.287
LIG_FHA_2	26	32	PF00498	0.315
LIG_FHA_2	387	393	PF00498	0.298
LIG_LIR_Apic_2	385	391	PF02991	0.353
LIG_LIR_Gen_1	343	352	PF02991	0.281
LIG_LIR_Gen_1	364	373	PF02991	0.336
LIG_LIR_Gen_1	8	18	PF02991	0.429
LIG_LIR_LC3C_4	280	285	PF02991	0.382
LIG_LIR_Nem_3	227	233	PF02991	0.380
LIG_LIR_Nem_3	343	347	PF02991	0.281
LIG_LIR_Nem_3	364	369	PF02991	0.336
LIG_LIR_Nem_3	403	409	PF02991	0.264
LIG_LIR_Nem_3	459	464	PF02991	0.293
LIG_LIR_Nem_3	8	13	PF02991	0.433
LIG_LYPXL_S_1	311	315	PF13949	0.328
LIG_LYPXL_yS_3	312	315	PF13949	0.328
LIG_MYND_1	313	317	PF01753	0.293
LIG_PALB2_WD40_1	477	485	PF16756	0.403
LIG_Pex14_1	442	446	PF04695	0.263
LIG_Pex14_2	344	348	PF04695	0.263
LIG_Pex14_2	382	386	PF04695	0.266
LIG_Pex14_2	477	481	PF04695	0.263
LIG_PTB_Apo_2	317	324	PF02174	0.279
LIG_PTB_Apo_2	476	483	PF02174	0.403
LIG_PTB_Phospho_1	317	323	PF10480	0.279
LIG_SH2_CRK	323	327	PF00017	0.239
LIG_SH2_CRK	328	332	PF00017	0.231
LIG_SH2_GRB2like	318	321	PF00017	0.298
LIG_SH2_NCK_1	328	332	PF00017	0.194
LIG_SH2_STAT5	113	116	PF00017	0.323
LIG_SH2_STAT5	139	142	PF00017	0.298
LIG_SH2_STAT5	291	294	PF00017	0.424
LIG_SH2_STAT5	318	321	PF00017	0.302
LIG_SH3_2	244	249	PF14604	0.463
LIG_SH3_3	190	196	PF00018	0.431
LIG_SH3_3	241	247	PF00018	0.646
LIG_SH3_3	256	262	PF00018	0.605
LIG_SUMO_SIM_par_1	73	80	PF11976	0.324
LIG_UBA3_1	151	159	PF00899	0.266
MOD_CDC14_SPxK_1	246	249	PF00782	0.462
MOD_CDC14_SPxK_1	487	490	PF00782	0.482
MOD_CDK_SPK_2	240	245	PF00069	0.609
MOD_CDK_SPxK_1	243	249	PF00069	0.735
MOD_CDK_SPxK_1	255	261	PF00069	0.692
MOD_CDK_SPxK_1	484	490	PF00069	0.459
MOD_CK1_1	112	118	PF00069	0.436
MOD_CK1_1	232	238	PF00069	0.321
MOD_CK1_1	243	249	PF00069	0.715
MOD_CK1_1	271	277	PF00069	0.742
MOD_CK1_1	279	285	PF00069	0.503
MOD_CK1_1	394	400	PF00069	0.403
MOD_CK1_1	55	61	PF00069	0.323
MOD_CK1_1	77	83	PF00069	0.403
MOD_CK1_1	8	14	PF00069	0.455
MOD_CK2_1	25	31	PF00069	0.280
MOD_CK2_1	334	340	PF00069	0.331
MOD_CMANNOS	304	307	PF00535	0.382
MOD_GlcNHglycan	128	131	PF01048	0.263
MOD_GlcNHglycan	275	278	PF01048	0.752
MOD_GlcNHglycan	328	331	PF01048	0.317
MOD_GlcNHglycan	336	339	PF01048	0.273
MOD_GSK3_1	109	116	PF00069	0.272
MOD_GSK3_1	121	128	PF00069	0.245
MOD_GSK3_1	191	198	PF00069	0.285
MOD_GSK3_1	260	267	PF00069	0.648
MOD_GSK3_1	273	280	PF00069	0.604
MOD_GSK3_1	480	487	PF00069	0.365
MOD_GSK3_1	55	62	PF00069	0.315
MOD_GSK3_1	70	77	PF00069	0.269
MOD_N-GLC_1	271	276	PF02516	0.763
MOD_N-GLC_1	491	496	PF02516	0.377
MOD_NEK2_1	151	156	PF00069	0.343
MOD_NEK2_1	248	253	PF00069	0.728
MOD_NEK2_1	386	391	PF00069	0.357
MOD_NEK2_1	39	44	PF00069	0.353
MOD_PIKK_1	191	197	PF00454	0.430
MOD_PIKK_1	39	45	PF00454	0.337
MOD_PK_1	74	80	PF00069	0.279
MOD_PKA_2	248	254	PF00069	0.468
MOD_PKA_2	386	392	PF00069	0.274
MOD_PKA_2	401	407	PF00069	0.231
MOD_PKA_2	419	425	PF00069	0.263
MOD_PKA_2	8	14	PF00069	0.516
MOD_Plk_1	178	184	PF00069	0.461
MOD_Plk_1	302	308	PF00069	0.395
MOD_Plk_2-3	340	346	PF00069	0.279
MOD_Plk_4	109	115	PF00069	0.263
MOD_Plk_4	279	285	PF00069	0.573
MOD_ProDKin_1	240	246	PF00069	0.612
MOD_ProDKin_1	255	261	PF00069	0.634
MOD_ProDKin_1	394	400	PF00069	0.263
MOD_ProDKin_1	484	490	PF00069	0.408
MOD_ProDKin_1	52	58	PF00069	0.263
TRG_ENDOCYTIC_2	233	236	PF00928	0.490
TRG_ENDOCYTIC_2	312	315	PF00928	0.272
TRG_ENDOCYTIC_2	323	326	PF00928	0.196
TRG_ENDOCYTIC_2	426	429	PF00928	0.271
TRG_ER_diArg_1	412	415	PF00400	0.293
TRG_ER_diArg_1	467	470	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA41	Leptomonas seymouri	61%	93%
A0A0S4J5V1	Bodo saltans	43%	91%
A0A1X0NU47	Trypanosomatidae	42%	90%
A0A3S5H719	Leishmania donovani	83%	100%
A0A422NB30	Trypanosoma rangeli	45%	98%
A4HXL3	Leishmania infantum	82%	100%
C9ZPA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	96%
E9ARA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
O47881	Brassica oleracea	23%	83%
O93852	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	89%
P10867	Rattus norvegicus	27%	100%
P54783	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	95%
P58710	Mus musculus	26%	100%
P9WIT2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	100%
P9WIT3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	100%
Q2QXY1	Oryza sativa subsp. japonica	24%	85%
Q2RAP0	Oryza sativa subsp. japonica	23%	85%
Q3ZC33	Bos taurus	27%	100%
Q4QE54	Leishmania major	81%	100%
Q6BZA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	20%	89%
Q6CG88	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	95%
Q6CSY3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	95%
Q6FS20	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	22%	95%
Q752Y3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	22%	94%
Q7SGY1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	90%
Q8HXW0	Sus scrofa	27%	100%
Q90YK3	Scyliorhinus torazame	25%	100%
Q9HDX8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9SU56	Arabidopsis thaliana	23%	82%
V5BEU1	Trypanosoma cruzi	45%	90%