Cytochrome b5 heme-binding domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H991_LEIBR

TriTrypDb:

LbrM.17.1480 , LBRM2903_170021700

Length:

219

Annotations

LeishMANIAdb annotations

This cluster contains a high variety of cytochrome b5 homologs. Although all membrane-anchored, some use the N-terminal [type-III] while others the C-terminal TM helix [type-IV]. The heme domain is assumed to be cytoplasmic.. Localization: ER (by homology) / Mitochondrial outer membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H991

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H991

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0020037	heme binding	4	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	215	219	PF00082	0.705
DEG_SPOP_SBC_1	2	6	PF00917	0.634
DOC_MAPK_MEF2A_6	154	163	PF00069	0.433
DOC_MAPK_MEF2A_6	49	57	PF00069	0.339
DOC_PP1_RVXF_1	26	33	PF00149	0.622
DOC_PP4_FxxP_1	199	202	PF00568	0.320
DOC_USP7_MATH_1	2	6	PF00917	0.634
DOC_USP7_MATH_1	7	11	PF00917	0.625
DOC_USP7_MATH_1	94	98	PF00917	0.635
DOC_USP7_UBL2_3	21	25	PF12436	0.639
DOC_WW_Pin1_4	103	108	PF00397	0.539
DOC_WW_Pin1_4	13	18	PF00397	0.653
DOC_WW_Pin1_4	3	8	PF00397	0.632
DOC_WW_Pin1_4	96	101	PF00397	0.613
LIG_14-3-3_CanoR_1	144	150	PF00244	0.433
LIG_14-3-3_CanoR_1	19	25	PF00244	0.694
LIG_14-3-3_CanoR_1	28	33	PF00244	0.596
LIG_14-3-3_CanoR_1	71	76	PF00244	0.429
LIG_APCC_ABBA_1	109	114	PF00400	0.420
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BRCT_BRCA1_1	71	75	PF00533	0.411
LIG_EH1_1	210	218	PF00400	0.400
LIG_FHA_1	104	110	PF00498	0.607
LIG_FHA_1	25	31	PF00498	0.621
LIG_FHA_2	144	150	PF00498	0.352
LIG_FHA_2	153	159	PF00498	0.287
LIG_Integrin_isoDGR_2	47	49	PF01839	0.383
LIG_LIR_Gen_1	157	168	PF02991	0.433
LIG_LIR_Gen_1	194	202	PF02991	0.347
LIG_LIR_Gen_1	31	41	PF02991	0.621
LIG_LIR_Gen_1	72	81	PF02991	0.420
LIG_LIR_Nem_3	157	163	PF02991	0.433
LIG_LIR_Nem_3	194	199	PF02991	0.347
LIG_LIR_Nem_3	31	36	PF02991	0.621
LIG_LIR_Nem_3	72	76	PF02991	0.425
LIG_PCNA_PIPBox_1	192	201	PF02747	0.433
LIG_PCNA_PIPBox_1	26	35	PF02747	0.620
LIG_PCNA_yPIPBox_3	19	33	PF02747	0.632
LIG_SH2_NCK_1	131	135	PF00017	0.329
LIG_SH2_STAP1	126	130	PF00017	0.466
LIG_SH2_STAT5	145	148	PF00017	0.324
LIG_SH3_3	172	178	PF00018	0.433
LIG_SH3_3	73	79	PF00018	0.518
LIG_Sin3_3	54	61	PF02671	0.339
LIG_TRAF2_1	146	149	PF00917	0.433
LIG_WRC_WIRS_1	29	34	PF05994	0.621
LIG_WRC_WIRS_1	70	75	PF05994	0.492
MOD_CDC14_SPxK_1	16	19	PF00782	0.652
MOD_CDK_SPxK_1	13	19	PF00069	0.657
MOD_CK1_1	31	37	PF00069	0.623
MOD_CK2_1	143	149	PF00069	0.352
MOD_GlcNHglycan	170	173	PF01048	0.633
MOD_GlcNHglycan	96	99	PF01048	0.697
MOD_GSK3_1	13	20	PF00069	0.623
MOD_GSK3_1	24	31	PF00069	0.585
MOD_GSK3_1	3	10	PF00069	0.636
MOD_GSK3_1	96	103	PF00069	0.598
MOD_N-GLC_1	168	173	PF02516	0.615
MOD_N-GLC_2	210	212	PF02516	0.466
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	130	135	PF00069	0.328
MOD_NEK2_1	168	173	PF00069	0.433
MOD_NEK2_1	24	29	PF00069	0.583
MOD_NEK2_1	8	13	PF00069	0.627
MOD_PIKK_1	143	149	PF00454	0.352
MOD_PIKK_1	152	158	PF00454	0.287
MOD_PKA_2	143	149	PF00069	0.433
MOD_PKA_2	94	100	PF00069	0.467
MOD_Plk_1	168	174	PF00069	0.415
MOD_Plk_4	191	197	PF00069	0.334
MOD_Plk_4	28	34	PF00069	0.622
MOD_ProDKin_1	103	109	PF00069	0.538
MOD_ProDKin_1	13	19	PF00069	0.653
MOD_ProDKin_1	3	9	PF00069	0.634
MOD_ProDKin_1	96	102	PF00069	0.612
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.308
TRG_ER_diArg_1	36	39	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.705
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUN9	Leishmania donovani	60%	100%
A4HXL2	Leishmania infantum	60%	100%
E9ARA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QE55	Leishmania major	60%	100%