CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidylyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H990_LEIBR

TriTrypDb:

LbrM.17.1470 , LBRM2903_170021600

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H990

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H990

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009435	NAD biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019359	nicotinamide nucleotide biosynthetic process	7	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019363	pyridine nucleotide biosynthetic process	6	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072525	pyridine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	2
GO:0004515	nicotinate-nucleotide adenylyltransferase activity	6	2
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	4
GO:0070566	adenylyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.510
CLV_PCSK_KEX2_1	67	69	PF00082	0.299
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.330
CLV_PCSK_SKI1_1	129	133	PF00082	0.365
CLV_PCSK_SKI1_1	164	168	PF00082	0.294
CLV_PCSK_SKI1_1	189	193	PF00082	0.266
CLV_PCSK_SKI1_1	278	282	PF00082	0.506
CLV_PCSK_SKI1_1	286	290	PF00082	0.441
CLV_PCSK_SKI1_1	76	80	PF00082	0.338
DEG_Nend_Nbox_1	1	3	PF02207	0.448
DOC_CKS1_1	36	41	PF01111	0.375
DOC_CYCLIN_RxL_1	186	194	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.247
DOC_PP1_RVXF_1	162	168	PF00149	0.488
DOC_PP4_FxxP_1	177	180	PF00568	0.464
DOC_PP4_FxxP_1	249	252	PF00568	0.530
DOC_PP4_FxxP_1	82	85	PF00568	0.481
DOC_USP7_MATH_1	280	284	PF00917	0.544
DOC_USP7_MATH_1	66	70	PF00917	0.542
DOC_WW_Pin1_4	35	40	PF00397	0.617
DOC_WW_Pin1_4	81	86	PF00397	0.464
LIG_14-3-3_CanoR_1	206	215	PF00244	0.474
LIG_14-3-3_CanoR_1	217	223	PF00244	0.495
LIG_14-3-3_CanoR_1	241	247	PF00244	0.499
LIG_14-3-3_CanoR_1	284	289	PF00244	0.389
LIG_APCC_ABBA_1	298	303	PF00400	0.435
LIG_BIR_III_4	88	92	PF00653	0.507
LIG_BRCT_BRCA1_1	211	215	PF00533	0.384
LIG_FHA_1	11	17	PF00498	0.532
LIG_FHA_1	128	134	PF00498	0.481
LIG_FHA_1	219	225	PF00498	0.568
LIG_FHA_1	36	42	PF00498	0.473
LIG_FHA_2	226	232	PF00498	0.505
LIG_LIR_Apic_2	176	180	PF02991	0.461
LIG_LIR_Apic_2	88	93	PF02991	0.537
LIG_LIR_Gen_1	212	223	PF02991	0.559
LIG_LIR_Gen_1	243	252	PF02991	0.535
LIG_LIR_LC3C_4	194	199	PF02991	0.537
LIG_LIR_Nem_3	128	134	PF02991	0.503
LIG_LIR_Nem_3	172	177	PF02991	0.465
LIG_LIR_Nem_3	193	198	PF02991	0.535
LIG_LIR_Nem_3	212	218	PF02991	0.535
LIG_LIR_Nem_3	243	249	PF02991	0.535
LIG_LIR_Nem_3	51	55	PF02991	0.467
LIG_MYND_1	39	43	PF01753	0.291
LIG_NRBOX	187	193	PF00104	0.481
LIG_PCNA_yPIPBox_3	278	289	PF02747	0.541
LIG_Pex14_2	174	178	PF04695	0.535
LIG_REV1ctd_RIR_1	129	139	PF16727	0.384
LIG_SH2_CRK	90	94	PF00017	0.535
LIG_SH2_STAP1	127	131	PF00017	0.512
LIG_SH2_STAP1	242	246	PF00017	0.504
LIG_SH2_STAT5	127	130	PF00017	0.442
LIG_SH2_STAT5	242	245	PF00017	0.515
LIG_TRAF2_1	136	139	PF00917	0.566
LIG_WRC_WIRS_1	174	179	PF05994	0.464
MOD_CK1_1	25	31	PF00069	0.628
MOD_CK1_1	35	41	PF00069	0.481
MOD_CK2_1	26	32	PF00069	0.696
MOD_GSK3_1	123	130	PF00069	0.418
MOD_GSK3_1	22	29	PF00069	0.583
MOD_GSK3_1	276	283	PF00069	0.397
MOD_N-GLC_1	207	212	PF02516	0.296
MOD_NEK2_1	1	6	PF00069	0.508
MOD_NEK2_1	173	178	PF00069	0.464
MOD_NEK2_1	191	196	PF00069	0.464
MOD_NEK2_1	240	245	PF00069	0.470
MOD_NEK2_2	127	132	PF00069	0.504
MOD_PIKK_1	32	38	PF00454	0.690
MOD_PKA_2	240	246	PF00069	0.495
MOD_ProDKin_1	35	41	PF00069	0.599
MOD_ProDKin_1	81	87	PF00069	0.464
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.568
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.496
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.184
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK8	Leptomonas seymouri	54%	100%
A0A0S4J2V8	Bodo saltans	39%	100%
A0A3Q8ICX3	Leishmania donovani	80%	100%
A0A3R7KAJ0	Trypanosoma rangeli	41%	100%
A4HXL1	Leishmania infantum	79%	100%
A4IH61	Xenopus tropicalis	26%	100%
E9ARA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q0DWH7	Oryza sativa subsp. japonica	30%	100%
Q0VD50	Bos taurus	31%	100%
Q4QE56	Leishmania major	77%	100%
Q96T66	Homo sapiens	28%	100%
Q99JR6	Mus musculus	28%	100%
Q9EPA7	Mus musculus	31%	100%
Q9HAN9	Homo sapiens	31%	100%
V5BNX9	Trypanosoma cruzi	40%	100%