Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H989_LEIBR

TriTrypDb:

LbrM.17.1460 , LBRM2903_170021500

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H989

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H989

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	116	120	PF00082	0.338
DEG_APCC_DBOX_1	79	87	PF00400	0.598
DEG_SPOP_SBC_1	58	62	PF00917	0.634
DOC_AGCK_PIF_2	103	108	PF00069	0.559
DOC_CDC14_PxL_1	50	58	PF14671	0.650
DOC_MAPK_MEF2A_6	49	58	PF00069	0.595
DOC_PP2B_LxvP_1	203	206	PF13499	0.595
DOC_WW_Pin1_4	109	114	PF00397	0.600
DOC_WW_Pin1_4	130	135	PF00397	0.411
LIG_14-3-3_CanoR_1	59	68	PF00244	0.714
LIG_CtBP_PxDLS_1	232	236	PF00389	0.612
LIG_eIF4E_1	152	158	PF01652	0.242
LIG_FHA_1	198	204	PF00498	0.621
LIG_FHA_1	62	68	PF00498	0.629
LIG_FHA_2	74	80	PF00498	0.518
LIG_LIR_Apic_2	150	155	PF02991	0.353
LIG_LIR_Gen_1	107	113	PF02991	0.574
LIG_LIR_Gen_1	76	86	PF02991	0.545
LIG_LIR_Nem_3	101	106	PF02991	0.569
LIG_LIR_Nem_3	107	111	PF02991	0.597
LIG_LIR_Nem_3	213	219	PF02991	0.602
LIG_LIR_Nem_3	5	11	PF02991	0.626
LIG_LIR_Nem_3	76	81	PF02991	0.539
LIG_PCNA_TLS_4	180	187	PF02747	0.486
LIG_PDZ_Class_2	236	241	PF00595	0.657
LIG_SH2_CRK	152	156	PF00017	0.242
LIG_SH2_CRK	97	101	PF00017	0.578
LIG_SH2_NCK_1	108	112	PF00017	0.563
LIG_SH2_SRC	108	111	PF00017	0.598
LIG_SH2_SRC	219	222	PF00017	0.644
LIG_SH2_STAP1	22	26	PF00017	0.597
LIG_SH2_STAT3	22	25	PF00017	0.727
LIG_SH2_STAT5	194	197	PF00017	0.587
LIG_SH2_STAT5	219	222	PF00017	0.644
LIG_SH2_STAT5	75	78	PF00017	0.521
LIG_SH3_1	12	18	PF00018	0.653
LIG_SH3_2	85	90	PF14604	0.527
LIG_SH3_3	12	18	PF00018	0.570
LIG_SH3_3	141	147	PF00018	0.240
LIG_SH3_3	203	209	PF00018	0.595
LIG_SH3_3	82	88	PF00018	0.560
LIG_TRAF2_1	112	115	PF00917	0.517
MOD_CDK_SPxxK_3	109	116	PF00069	0.593
MOD_CK1_1	225	231	PF00069	0.609
MOD_CK1_1	61	67	PF00069	0.690
MOD_CK2_1	109	115	PF00069	0.594
MOD_CK2_1	73	79	PF00069	0.545
MOD_GlcNHglycan	51	54	PF01048	0.466
MOD_GSK3_1	57	64	PF00069	0.706
MOD_NEK2_1	174	179	PF00069	0.600
MOD_NEK2_2	147	152	PF00069	0.447
MOD_PIKK_1	174	180	PF00454	0.613
MOD_PIKK_1	225	231	PF00454	0.605
MOD_PKA_2	58	64	PF00069	0.628
MOD_Plk_2-3	73	79	PF00069	0.530
MOD_Plk_4	147	153	PF00069	0.459
MOD_Plk_4	3	9	PF00069	0.594
MOD_Plk_4	73	79	PF00069	0.555
MOD_ProDKin_1	109	115	PF00069	0.594
MOD_ProDKin_1	130	136	PF00069	0.411
MOD_SUMO_for_1	29	32	PF00179	0.567
MOD_SUMO_rev_2	109	118	PF00179	0.557
TRG_DiLeu_BaEn_1	79	84	PF01217	0.599
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.231
TRG_ENDOCYTIC_2	108	111	PF00928	0.585
TRG_ENDOCYTIC_2	97	100	PF00928	0.565
TRG_ER_diArg_1	209	212	PF00400	0.675
TRG_ER_diArg_1	91	94	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ4	Leptomonas seymouri	80%	100%
A0A0S4J5W5	Bodo saltans	51%	100%
A0A1X0NSN8	Trypanosomatidae	61%	98%
A0A3Q8I9U7	Leishmania donovani	92%	100%
A0A422NB46	Trypanosoma rangeli	68%	100%
A4HXL0	Leishmania infantum	92%	100%
C9ZPA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ARA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QE57	Leishmania major	92%	100%
V5AZF8	Trypanosoma cruzi	70%	100%