Putative translation initiation factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit b

Species:

Leishmania braziliensis

UniProt:

A4H988_LEIBR

TriTrypDb:

LbrM.17.1450 , LBRM2903_170021100

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H988

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H988

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0031369	translation initiation factor binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	406	412	PF00089	0.207
CLV_NRD_NRD_1	163	165	PF00675	0.487
CLV_NRD_NRD_1	33	35	PF00675	0.508
CLV_NRD_NRD_1	633	635	PF00675	0.515
CLV_NRD_NRD_1	699	701	PF00675	0.579
CLV_PCSK_KEX2_1	162	164	PF00082	0.554
CLV_PCSK_KEX2_1	23	25	PF00082	0.466
CLV_PCSK_KEX2_1	33	35	PF00082	0.416
CLV_PCSK_KEX2_1	436	438	PF00082	0.315
CLV_PCSK_KEX2_1	458	460	PF00082	0.315
CLV_PCSK_KEX2_1	633	635	PF00082	0.476
CLV_PCSK_KEX2_1	642	644	PF00082	0.501
CLV_PCSK_KEX2_1	699	701	PF00082	0.580
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.466
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.315
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.315
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.480
CLV_PCSK_PC7_1	29	35	PF00082	0.566
CLV_PCSK_PC7_1	432	438	PF00082	0.315
CLV_PCSK_SKI1_1	24	28	PF00082	0.396
CLV_PCSK_SKI1_1	262	266	PF00082	0.438
CLV_PCSK_SKI1_1	322	326	PF00082	0.497
CLV_PCSK_SKI1_1	387	391	PF00082	0.264
CLV_PCSK_SKI1_1	511	515	PF00082	0.306
CLV_PCSK_SKI1_1	577	581	PF00082	0.298
CLV_PCSK_SKI1_1	608	612	PF00082	0.426
CLV_PCSK_SKI1_1	642	646	PF00082	0.490
CLV_PCSK_SKI1_1	654	658	PF00082	0.541
CLV_PCSK_SKI1_1	8	12	PF00082	0.447
DOC_CKS1_1	250	255	PF01111	0.509
DOC_CYCLIN_RxL_1	602	615	PF00134	0.364
DOC_MAPK_gen_1	265	275	PF00069	0.412
DOC_PP1_RVXF_1	225	231	PF00149	0.522
DOC_PP4_FxxP_1	334	337	PF00568	0.465
DOC_PP4_FxxP_1	496	499	PF00568	0.475
DOC_USP7_MATH_1	222	226	PF00917	0.513
DOC_USP7_MATH_1	288	292	PF00917	0.365
DOC_USP7_MATH_1	302	306	PF00917	0.491
DOC_USP7_MATH_1	366	370	PF00917	0.466
DOC_USP7_UBL2_3	479	483	PF12436	0.477
DOC_USP7_UBL2_3	576	580	PF12436	0.532
DOC_WW_Pin1_4	17	22	PF00397	0.469
DOC_WW_Pin1_4	239	244	PF00397	0.338
DOC_WW_Pin1_4	249	254	PF00397	0.358
LIG_14-3-3_CanoR_1	285	293	PF00244	0.482
LIG_14-3-3_CanoR_1	409	415	PF00244	0.407
LIG_APCC_ABBA_1	226	231	PF00400	0.521
LIG_APCC_ABBA_1	273	278	PF00400	0.557
LIG_APCC_ABBA_1	517	522	PF00400	0.407
LIG_CSL_BTD_1	398	401	PF09270	0.464
LIG_deltaCOP1_diTrp_1	145	153	PF00928	0.355
LIG_deltaCOP1_diTrp_1	278	286	PF00928	0.378
LIG_deltaCOP1_diTrp_1	396	405	PF00928	0.567
LIG_deltaCOP1_diTrp_1	540	548	PF00928	0.469
LIG_FHA_1	231	237	PF00498	0.466
LIG_FHA_1	318	324	PF00498	0.422
LIG_FHA_1	467	473	PF00498	0.489
LIG_FHA_1	52	58	PF00498	0.483
LIG_FHA_2	250	256	PF00498	0.420
LIG_FHA_2	391	397	PF00498	0.515
LIG_FHA_2	48	54	PF00498	0.577
LIG_FHA_2	522	528	PF00498	0.529
LIG_FHA_2	535	541	PF00498	0.423
LIG_FHA_2	568	574	PF00498	0.567
LIG_FHA_2	657	663	PF00498	0.584
LIG_LIR_Apic_2	103	109	PF02991	0.527
LIG_LIR_Apic_2	333	337	PF02991	0.468
LIG_LIR_Apic_2	493	499	PF02991	0.475
LIG_LIR_Gen_1	245	253	PF02991	0.364
LIG_LIR_Gen_1	404	410	PF02991	0.542
LIG_LIR_Gen_1	451	457	PF02991	0.567
LIG_LIR_Gen_1	692	702	PF02991	0.623
LIG_LIR_Gen_1	90	99	PF02991	0.435
LIG_LIR_LC3C_4	289	294	PF02991	0.485
LIG_LIR_Nem_3	145	151	PF02991	0.349
LIG_LIR_Nem_3	245	250	PF02991	0.357
LIG_LIR_Nem_3	298	303	PF02991	0.364
LIG_LIR_Nem_3	343	347	PF02991	0.378
LIG_LIR_Nem_3	404	408	PF02991	0.542
LIG_LIR_Nem_3	416	421	PF02991	0.390
LIG_LIR_Nem_3	451	456	PF02991	0.567
LIG_LIR_Nem_3	544	550	PF02991	0.544
LIG_LIR_Nem_3	667	672	PF02991	0.520
LIG_LIR_Nem_3	692	697	PF02991	0.618
LIG_LIR_Nem_3	90	96	PF02991	0.415
LIG_NRP_CendR_1	708	709	PF00754	0.543
LIG_Pex14_2	144	148	PF04695	0.362
LIG_Pex14_2	27	31	PF04695	0.505
LIG_SH2_CRK	694	698	PF00017	0.616
LIG_SH2_PTP2	106	109	PF00017	0.606
LIG_SH2_PTP2	247	250	PF00017	0.433
LIG_SH2_SRC	106	109	PF00017	0.656
LIG_SH2_SRC	247	250	PF00017	0.467
LIG_SH2_STAP1	614	618	PF00017	0.378
LIG_SH2_STAT5	106	109	PF00017	0.606
LIG_SH2_STAT5	247	250	PF00017	0.345
LIG_SH2_STAT5	316	319	PF00017	0.581
LIG_SH2_STAT5	354	357	PF00017	0.490
LIG_SH2_STAT5	418	421	PF00017	0.531
LIG_SH2_STAT5	439	442	PF00017	0.552
LIG_SH2_STAT5	547	550	PF00017	0.567
LIG_SH2_STAT5	569	572	PF00017	0.567
LIG_SH2_STAT5	640	643	PF00017	0.504
LIG_SH3_3	102	108	PF00018	0.653
LIG_SH3_3	193	199	PF00018	0.459
LIG_SH3_3	247	253	PF00018	0.432
LIG_SH3_3	586	592	PF00018	0.444
LIG_SUMO_SIM_anti_2	255	260	PF11976	0.479
LIG_SUMO_SIM_anti_2	289	296	PF11976	0.484
LIG_TRAF2_1	635	638	PF00917	0.599
LIG_TRAF2_1	659	662	PF00917	0.585
LIG_TRAF2_1	681	684	PF00917	0.534
LIG_TRAF2_1	95	98	PF00917	0.518
LIG_TYR_ITSM	296	303	PF00017	0.344
LIG_TYR_ITSM	690	697	PF00017	0.615
LIG_UBA3_1	258	266	PF00899	0.529
LIG_UBA3_1	474	479	PF00899	0.574
LIG_WW_1	561	564	PF00397	0.407
MOD_CDK_SPK_2	249	254	PF00069	0.452
MOD_CDK_SPxK_1	17	23	PF00069	0.470
MOD_CDK_SPxxK_3	17	24	PF00069	0.467
MOD_CDK_SPxxK_3	239	246	PF00069	0.360
MOD_CK1_1	140	146	PF00069	0.449
MOD_CK1_1	330	336	PF00069	0.444
MOD_CK1_1	529	535	PF00069	0.511
MOD_CK1_1	63	69	PF00069	0.425
MOD_CK2_1	209	215	PF00069	0.508
MOD_CK2_1	239	245	PF00069	0.338
MOD_CK2_1	47	53	PF00069	0.501
MOD_CK2_1	534	540	PF00069	0.567
MOD_CK2_1	551	557	PF00069	0.458
MOD_CK2_1	567	573	PF00069	0.512
MOD_CK2_1	632	638	PF00069	0.658
MOD_CK2_1	656	662	PF00069	0.567
MOD_CK2_1	91	97	PF00069	0.509
MOD_CMANNOS	150	153	PF00535	0.486
MOD_GlcNHglycan	139	142	PF01048	0.521
MOD_GlcNHglycan	186	189	PF01048	0.522
MOD_GlcNHglycan	191	194	PF01048	0.488
MOD_GlcNHglycan	286	289	PF01048	0.461
MOD_GlcNHglycan	304	307	PF01048	0.451
MOD_GlcNHglycan	329	332	PF01048	0.506
MOD_GlcNHglycan	490	493	PF01048	0.288
MOD_GlcNHglycan	531	534	PF01048	0.298
MOD_GlcNHglycan	57	60	PF01048	0.518
MOD_GlcNHglycan	84	87	PF01048	0.522
MOD_GlcNHglycan	93	96	PF01048	0.470
MOD_GSK3_1	201	208	PF00069	0.453
MOD_GSK3_1	284	291	PF00069	0.484
MOD_GSK3_1	326	333	PF00069	0.445
MOD_GSK3_1	409	416	PF00069	0.488
MOD_GSK3_1	47	54	PF00069	0.526
MOD_GSK3_1	486	493	PF00069	0.491
MOD_GSK3_1	652	659	PF00069	0.467
MOD_GSK3_1	82	89	PF00069	0.411
MOD_N-GLC_1	17	22	PF02516	0.488
MOD_NEK2_1	137	142	PF00069	0.464
MOD_NEK2_1	189	194	PF00069	0.474
MOD_NEK2_1	209	214	PF00069	0.364
MOD_NEK2_1	390	395	PF00069	0.567
MOD_NEK2_1	466	471	PF00069	0.551
MOD_NEK2_1	509	514	PF00069	0.501
MOD_NEK2_1	567	572	PF00069	0.544
MOD_NEK2_1	606	611	PF00069	0.628
MOD_NEK2_1	82	87	PF00069	0.524
MOD_NEK2_2	222	227	PF00069	0.520
MOD_NEK2_2	551	556	PF00069	0.567
MOD_PIKK_1	209	215	PF00454	0.364
MOD_PIKK_1	347	353	PF00454	0.452
MOD_PIKK_1	593	599	PF00454	0.587
MOD_PK_1	254	260	PF00069	0.439
MOD_PKA_1	164	170	PF00069	0.581
MOD_PKA_2	173	179	PF00069	0.571
MOD_PKA_2	284	290	PF00069	0.480
MOD_PKA_2	408	414	PF00069	0.407
MOD_PKA_2	431	437	PF00069	0.567
MOD_PKA_2	632	638	PF00069	0.521
MOD_PKA_2	91	97	PF00069	0.481
MOD_PKB_1	162	170	PF00069	0.616
MOD_Plk_1	230	236	PF00069	0.443
MOD_Plk_1	254	260	PF00069	0.379
MOD_Plk_1	288	294	PF00069	0.376
MOD_Plk_1	509	515	PF00069	0.488
MOD_Plk_1	521	527	PF00069	0.488
MOD_Plk_1	556	562	PF00069	0.534
MOD_Plk_1	652	658	PF00069	0.408
MOD_Plk_2-3	274	280	PF00069	0.553
MOD_Plk_2-3	521	527	PF00069	0.567
MOD_Plk_4	205	211	PF00069	0.437
MOD_Plk_4	288	294	PF00069	0.357
MOD_Plk_4	401	407	PF00069	0.567
MOD_Plk_4	509	515	PF00069	0.488
MOD_Plk_4	590	596	PF00069	0.566
MOD_Plk_4	606	612	PF00069	0.444
MOD_Plk_4	652	658	PF00069	0.408
MOD_ProDKin_1	17	23	PF00069	0.470
MOD_ProDKin_1	239	245	PF00069	0.338
MOD_ProDKin_1	249	255	PF00069	0.359
MOD_SUMO_rev_2	176	185	PF00179	0.548
MOD_SUMO_rev_2	596	603	PF00179	0.484
TRG_DiLeu_BaEn_1	118	123	PF01217	0.647
TRG_DiLeu_BaEn_1	319	324	PF01217	0.474
TRG_DiLeu_BaEn_1	386	391	PF01217	0.361
TRG_DiLeu_BaEn_4	652	658	PF01217	0.408
TRG_ENDOCYTIC_2	206	209	PF00928	0.461
TRG_ENDOCYTIC_2	247	250	PF00928	0.339
TRG_ENDOCYTIC_2	300	303	PF00928	0.543
TRG_ENDOCYTIC_2	418	421	PF00928	0.464
TRG_ENDOCYTIC_2	547	550	PF00928	0.560
TRG_ENDOCYTIC_2	564	567	PF00928	0.450
TRG_ENDOCYTIC_2	694	697	PF00928	0.619
TRG_ER_diArg_1	161	164	PF00400	0.569
TRG_ER_diArg_1	33	35	PF00400	0.545
TRG_NES_CRM1_1	231	245	PF08389	0.498
TRG_NLS_MonoExtN_4	262	269	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P842	Leptomonas seymouri	79%	100%
A0A0S4JDX9	Bodo saltans	33%	97%
A0A1X0NUD9	Trypanosomatidae	45%	100%
A0A3R7NH08	Trypanosoma rangeli	45%	100%
A0A3S7WUM3	Leishmania donovani	94%	100%
A1CS92	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	22%	96%
A1D558	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	21%	96%
A2Q908	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	22%	96%
A3LY29	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	22%	100%
A4HXK6	Leishmania infantum	94%	100%
A4QZL9	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	95%
A5DR43	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	24%	96%
A5E5Y8	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	24%	100%
A6SFQ6	Botryotinia fuckeliana (strain B05.10)	22%	95%
A6ZPJ1	Saccharomyces cerevisiae (strain YJM789)	24%	93%
A7EHM8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	22%	95%
A7TKF2	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	24%	98%
A8WX15	Caenorhabditis briggsae	23%	99%
B0W562	Culex quinquefasciatus	23%	100%
B0XRG7	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	21%	96%
B3ME25	Drosophila ananassae	22%	100%
B3NMI5	Drosophila erecta	22%	100%
B4GAY7	Drosophila persimilis	23%	100%
B4HMV9	Drosophila sechellia	23%	100%
B4J6D5	Drosophila grimshawi	22%	100%
B4KNN9	Drosophila mojavensis	22%	100%
B4LM71	Drosophila virilis	22%	100%
B4MQL8	Drosophila willistoni	23%	100%
B4P5F7	Drosophila yakuba	22%	100%
B4QB88	Drosophila simulans	23%	100%
B5E081	Drosophila pseudoobscura pseudoobscura	23%	100%
C9ZP96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ARA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P06103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	93%
P0CN44	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	94%
P0CN45	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	94%
P56821	Nicotiana tabacum	22%	99%
Q0CN46	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	21%	96%
Q0E940	Drosophila melanogaster	23%	100%
Q0IEY3	Aedes aegypti	23%	100%
Q10425	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	98%
Q1DI97	Coccidioides immitis (strain RS)	23%	96%
Q1HDZ5	Bombyx mori	26%	100%
Q2GM53	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	22%	95%
Q2URB7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	22%	96%
Q4P6G4	Ustilago maydis (strain 521 / FGSC 9021)	24%	95%
Q4QE62	Leishmania major	95%	100%
Q4WKL7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	21%	96%
Q54QW1	Dictyostelium discoideum	22%	100%
Q569Z1	Xenopus laevis	26%	100%
Q5AGV4	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	96%
Q5BGH1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	96%
Q6BLY5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	99%
Q6C1H8	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	99%
Q6CY34	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	97%
Q6FM92	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	22%	99%
Q758X9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	96%
Q7PZY1	Anopheles gambiae	23%	100%
Q7S464	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	95%
Q9C5Z1	Arabidopsis thaliana	23%	100%
Q9XWI6	Caenorhabditis elegans	24%	98%
V5AZD7	Trypanosoma cruzi	45%	100%