Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Organic solute transport protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H985_LEIBR

TriTrypDb:

LbrM.17.1420 , LBRM2903_170020800

Length:

446

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H985

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H985

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.458
CLV_NRD_NRD_1	157	159	PF00675	0.241
CLV_NRD_NRD_1	87	89	PF00675	0.298
CLV_PCSK_KEX2_1	157	159	PF00082	0.340
CLV_PCSK_KEX2_1	239	241	PF00082	0.551
CLV_PCSK_KEX2_1	288	290	PF00082	0.477
CLV_PCSK_KEX2_1	417	419	PF00082	0.438
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.467
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.477
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.438
CLV_PCSK_SKI1_1	158	162	PF00082	0.229
CLV_PCSK_SKI1_1	404	408	PF00082	0.441
DEG_APCC_DBOX_1	105	113	PF00400	0.267
DEG_SCF_FBW7_1	304	310	PF00400	0.448
DEG_SPOP_SBC_1	307	311	PF00917	0.438
DEG_SPOP_SBC_1	370	374	PF00917	0.589
DOC_CKS1_1	304	309	PF01111	0.593
DOC_CKS1_1	55	60	PF01111	0.286
DOC_CYCLIN_RxL_1	155	165	PF00134	0.276
DOC_CYCLIN_RxL_1	400	411	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.248
DOC_MAPK_FxFP_2	413	416	PF00069	0.370
DOC_MAPK_gen_1	140	150	PF00069	0.155
DOC_MAPK_gen_1	157	163	PF00069	0.235
DOC_MAPK_gen_1	167	175	PF00069	0.230
DOC_MAPK_MEF2A_6	167	175	PF00069	0.233
DOC_PP4_FxxP_1	187	190	PF00568	0.379
DOC_PP4_FxxP_1	194	197	PF00568	0.357
DOC_PP4_FxxP_1	212	215	PF00568	0.424
DOC_PP4_FxxP_1	218	221	PF00568	0.511
DOC_PP4_FxxP_1	301	304	PF00568	0.521
DOC_PP4_FxxP_1	367	370	PF00568	0.458
DOC_PP4_FxxP_1	413	416	PF00568	0.593
DOC_USP7_MATH_1	169	173	PF00917	0.287
DOC_USP7_MATH_1	232	236	PF00917	0.536
DOC_USP7_MATH_1	256	260	PF00917	0.649
DOC_USP7_MATH_1	287	291	PF00917	0.528
DOC_USP7_MATH_1	29	33	PF00917	0.281
DOC_USP7_MATH_1	308	312	PF00917	0.615
DOC_USP7_MATH_1	361	365	PF00917	0.638
DOC_USP7_UBL2_3	400	404	PF12436	0.367
DOC_WW_Pin1_4	193	198	PF00397	0.369
DOC_WW_Pin1_4	234	239	PF00397	0.279
DOC_WW_Pin1_4	258	263	PF00397	0.511
DOC_WW_Pin1_4	300	305	PF00397	0.594
DOC_WW_Pin1_4	54	59	PF00397	0.267
LIG_14-3-3_CanoR_1	131	141	PF00244	0.393
LIG_14-3-3_CanoR_1	143	149	PF00244	0.313
LIG_14-3-3_CanoR_1	157	161	PF00244	0.216
LIG_14-3-3_CanoR_1	170	174	PF00244	0.208
LIG_14-3-3_CanoR_1	289	298	PF00244	0.539
LIG_14-3-3_CanoR_1	317	325	PF00244	0.362
LIG_14-3-3_CanoR_1	337	346	PF00244	0.414
LIG_14-3-3_CanoR_1	393	399	PF00244	0.532
LIG_14-3-3_CanoR_1	81	87	PF00244	0.304
LIG_APCC_ABBA_1	346	351	PF00400	0.561
LIG_BIR_II_1	1	5	PF00653	0.348
LIG_BRCT_BRCA1_1	183	187	PF00533	0.357
LIG_BRCT_BRCA1_1	363	367	PF00533	0.461
LIG_EVH1_1	225	229	PF00568	0.508
LIG_FHA_1	145	151	PF00498	0.155
LIG_FHA_1	293	299	PF00498	0.687
LIG_FHA_1	371	377	PF00498	0.686
LIG_FHA_1	393	399	PF00498	0.550
LIG_FHA_2	433	439	PF00498	0.473
LIG_LIR_Apic_2	184	190	PF02991	0.295
LIG_LIR_Apic_2	192	197	PF02991	0.361
LIG_LIR_Apic_2	217	221	PF02991	0.438
LIG_LIR_Apic_2	299	304	PF02991	0.523
LIG_LIR_Apic_2	364	370	PF02991	0.457
LIG_LIR_Apic_2	411	416	PF02991	0.587
LIG_LIR_Gen_1	152	161	PF02991	0.228
LIG_LIR_Gen_1	5	15	PF02991	0.270
LIG_LIR_Gen_1	92	103	PF02991	0.347
LIG_LIR_Nem_3	44	50	PF02991	0.451
LIG_LIR_Nem_3	5	11	PF02991	0.271
LIG_LIR_Nem_3	92	98	PF02991	0.387
LIG_PDZ_Class_3	441	446	PF00595	0.565
LIG_Pex14_2	47	51	PF04695	0.303
LIG_PTB_Apo_2	244	251	PF02174	0.237
LIG_Rb_pABgroove_1	85	93	PF01858	0.292
LIG_REV1ctd_RIR_1	161	171	PF16727	0.292
LIG_SH2_CRK	91	95	PF00017	0.347
LIG_SH2_NCK_1	253	257	PF00017	0.376
LIG_SH2_NCK_1	62	66	PF00017	0.339
LIG_SH2_NCK_1	91	95	PF00017	0.372
LIG_SH2_STAP1	253	257	PF00017	0.441
LIG_SH2_STAP1	321	325	PF00017	0.473
LIG_SH2_STAP1	91	95	PF00017	0.378
LIG_SH2_STAT3	327	330	PF00017	0.568
LIG_SH2_STAT5	188	191	PF00017	0.469
LIG_SH2_STAT5	208	211	PF00017	0.255
LIG_SH2_STAT5	327	330	PF00017	0.476
LIG_SH3_3	223	229	PF00018	0.366
LIG_SH3_3	301	307	PF00018	0.724
LIG_SH3_3	384	390	PF00018	0.665
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.346
LIG_SUMO_SIM_anti_2	438	445	PF11976	0.488
LIG_SUMO_SIM_par_1	107	113	PF11976	0.243
LIG_SUMO_SIM_par_1	438	445	PF11976	0.455
LIG_TRAF2_1	136	139	PF00917	0.243
LIG_TRAF2_1	340	343	PF00917	0.576
LIG_TYR_ITIM	93	98	PF00017	0.395
MOD_CDC14_SPxK_1	237	240	PF00782	0.288
MOD_CDK_SPK_2	234	239	PF00069	0.279
MOD_CDK_SPxK_1	234	240	PF00069	0.284
MOD_CK1_1	292	298	PF00069	0.686
MOD_CK1_1	303	309	PF00069	0.543
MOD_CK1_1	311	317	PF00069	0.470
MOD_CK1_1	374	380	PF00069	0.531
MOD_CK1_1	63	69	PF00069	0.298
MOD_CK1_1	75	81	PF00069	0.112
MOD_CK1_1	83	89	PF00069	0.201
MOD_CK2_1	132	138	PF00069	0.402
MOD_CK2_1	337	343	PF00069	0.605
MOD_CK2_1	352	358	PF00069	0.656
MOD_GlcNHglycan	134	137	PF01048	0.276
MOD_GlcNHglycan	183	186	PF01048	0.348
MOD_GlcNHglycan	289	292	PF01048	0.463
MOD_GlcNHglycan	295	298	PF01048	0.659
MOD_GlcNHglycan	318	321	PF01048	0.641
MOD_GlcNHglycan	339	342	PF01048	0.497
MOD_GlcNHglycan	354	357	PF01048	0.720
MOD_GlcNHglycan	378	381	PF01048	0.548
MOD_GlcNHglycan	419	423	PF01048	0.641
MOD_GlcNHglycan	63	66	PF01048	0.301
MOD_GSK3_1	152	159	PF00069	0.398
MOD_GSK3_1	289	296	PF00069	0.731
MOD_GSK3_1	303	310	PF00069	0.626
MOD_GSK3_1	333	340	PF00069	0.547
MOD_GSK3_1	352	359	PF00069	0.642
MOD_GSK3_1	370	377	PF00069	0.623
MOD_GSK3_1	424	431	PF00069	0.589
MOD_N-GLC_1	374	379	PF02516	0.649
MOD_N-GLC_1	75	80	PF02516	0.262
MOD_NEK2_1	112	117	PF00069	0.271
MOD_NEK2_1	144	149	PF00069	0.378
MOD_NEK2_1	156	161	PF00069	0.363
MOD_NEK2_1	174	179	PF00069	0.260
MOD_NEK2_1	331	336	PF00069	0.645
MOD_NEK2_1	394	399	PF00069	0.495
MOD_NEK2_1	61	66	PF00069	0.386
MOD_NEK2_1	74	79	PF00069	0.286
MOD_PKA_2	156	162	PF00069	0.327
MOD_PKA_2	169	175	PF00069	0.235
MOD_PKA_2	190	196	PF00069	0.432
MOD_PKA_2	243	249	PF00069	0.332
MOD_PKA_2	278	284	PF00069	0.542
MOD_PKA_2	316	322	PF00069	0.373
MOD_PKA_2	392	398	PF00069	0.505
MOD_PKA_2	80	86	PF00069	0.289
MOD_Plk_1	112	118	PF00069	0.233
MOD_Plk_1	75	81	PF00069	0.242
MOD_Plk_1	83	89	PF00069	0.255
MOD_Plk_4	169	175	PF00069	0.231
MOD_Plk_4	190	196	PF00069	0.328
MOD_Plk_4	308	314	PF00069	0.427
MOD_Plk_4	34	40	PF00069	0.277
MOD_Plk_4	394	400	PF00069	0.382
MOD_Plk_4	63	69	PF00069	0.393
MOD_Plk_4	75	81	PF00069	0.138
MOD_ProDKin_1	193	199	PF00069	0.377
MOD_ProDKin_1	234	240	PF00069	0.284
MOD_ProDKin_1	258	264	PF00069	0.517
MOD_ProDKin_1	300	306	PF00069	0.592
MOD_ProDKin_1	54	60	PF00069	0.267
MOD_SUMO_for_1	416	419	PF00179	0.431
MOD_SUMO_rev_2	172	179	PF00179	0.243
TRG_ENDOCYTIC_2	100	103	PF00928	0.201
TRG_ENDOCYTIC_2	91	94	PF00928	0.263
TRG_ENDOCYTIC_2	95	98	PF00928	0.236
TRG_ER_diArg_1	156	158	PF00400	0.262
TRG_NES_CRM1_1	5	16	PF08389	0.295
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P0	Leptomonas seymouri	50%	97%
A0A0S4JB79	Bodo saltans	34%	100%
A0A1X0NSP8	Trypanosomatidae	36%	100%
A0A3R7MAW0	Trypanosoma rangeli	36%	100%
A0A3S7WUM8	Leishmania donovani	72%	99%
A4HXK3	Leishmania infantum	71%	99%
C9ZP93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AR98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q29S00	Bos taurus	33%	100%
Q4QE65	Leishmania major	71%	100%
V5BNX0	Trypanosoma cruzi	36%	100%