LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H983_LEIBR
TriTrypDb:
LbrM.17.1400 , LBRM2903_170020600 *
Length:
956

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H983
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H983

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 214 218 PF00656 0.344
CLV_C14_Caspase3-7 308 312 PF00656 0.508
CLV_C14_Caspase3-7 52 56 PF00656 0.487
CLV_C14_Caspase3-7 690 694 PF00656 0.648
CLV_NRD_NRD_1 135 137 PF00675 0.368
CLV_NRD_NRD_1 244 246 PF00675 0.462
CLV_NRD_NRD_1 394 396 PF00675 0.490
CLV_NRD_NRD_1 416 418 PF00675 0.616
CLV_NRD_NRD_1 444 446 PF00675 0.282
CLV_NRD_NRD_1 46 48 PF00675 0.355
CLV_NRD_NRD_1 484 486 PF00675 0.438
CLV_NRD_NRD_1 628 630 PF00675 0.336
CLV_PCSK_KEX2_1 135 137 PF00082 0.490
CLV_PCSK_KEX2_1 244 246 PF00082 0.470
CLV_PCSK_KEX2_1 394 396 PF00082 0.494
CLV_PCSK_KEX2_1 416 418 PF00082 0.616
CLV_PCSK_KEX2_1 444 446 PF00082 0.502
CLV_PCSK_KEX2_1 46 48 PF00082 0.538
CLV_PCSK_KEX2_1 482 484 PF00082 0.458
CLV_PCSK_KEX2_1 628 630 PF00082 0.431
CLV_PCSK_PC1ET2_1 482 484 PF00082 0.458
CLV_PCSK_PC7_1 240 246 PF00082 0.418
CLV_PCSK_PC7_1 390 396 PF00082 0.453
CLV_PCSK_SKI1_1 146 150 PF00082 0.495
CLV_PCSK_SKI1_1 192 196 PF00082 0.476
CLV_PCSK_SKI1_1 338 342 PF00082 0.458
CLV_PCSK_SKI1_1 361 365 PF00082 0.299
CLV_PCSK_SKI1_1 421 425 PF00082 0.457
CLV_PCSK_SKI1_1 458 462 PF00082 0.391
CLV_PCSK_SKI1_1 491 495 PF00082 0.435
CLV_PCSK_SKI1_1 537 541 PF00082 0.398
CLV_PCSK_SKI1_1 614 618 PF00082 0.316
CLV_PCSK_SKI1_1 645 649 PF00082 0.380
CLV_PCSK_SKI1_1 782 786 PF00082 0.438
CLV_PCSK_SKI1_1 91 95 PF00082 0.396
CLV_PCSK_SKI1_1 915 919 PF00082 0.533
CLV_PCSK_SKI1_1 952 956 PF00082 0.575
DEG_APCC_DBOX_1 135 143 PF00400 0.545
DEG_MDM2_SWIB_1 562 569 PF02201 0.383
DEG_Nend_UBRbox_2 1 3 PF02207 0.536
DOC_CKS1_1 329 334 PF01111 0.592
DOC_CYCLIN_RxL_1 485 497 PF00134 0.412
DOC_CYCLIN_RxL_1 782 795 PF00134 0.518
DOC_CYCLIN_yCln2_LP_2 185 191 PF00134 0.536
DOC_MAPK_gen_1 666 676 PF00069 0.310
DOC_MAPK_HePTP_8 33 45 PF00069 0.535
DOC_MAPK_HePTP_8 493 505 PF00069 0.414
DOC_MAPK_HePTP_8 838 850 PF00069 0.280
DOC_MAPK_MEF2A_6 160 168 PF00069 0.380
DOC_MAPK_MEF2A_6 20 27 PF00069 0.483
DOC_MAPK_MEF2A_6 204 212 PF00069 0.437
DOC_MAPK_MEF2A_6 36 45 PF00069 0.577
DOC_MAPK_MEF2A_6 496 505 PF00069 0.407
DOC_MAPK_MEF2A_6 669 676 PF00069 0.520
DOC_MAPK_MEF2A_6 841 850 PF00069 0.279
DOC_MAPK_NFAT4_5 20 28 PF00069 0.331
DOC_MAPK_NFAT4_5 669 677 PF00069 0.523
DOC_PP2B_LxvP_1 220 223 PF13499 0.451
DOC_PP2B_LxvP_1 5 8 PF13499 0.415
DOC_USP7_MATH_1 123 127 PF00917 0.522
DOC_USP7_MATH_1 812 816 PF00917 0.501
DOC_USP7_MATH_1 866 870 PF00917 0.526
DOC_USP7_UBL2_3 111 115 PF12436 0.530
DOC_USP7_UBL2_3 478 482 PF12436 0.442
DOC_WW_Pin1_4 184 189 PF00397 0.553
DOC_WW_Pin1_4 319 324 PF00397 0.564
DOC_WW_Pin1_4 328 333 PF00397 0.502
DOC_WW_Pin1_4 373 378 PF00397 0.515
DOC_WW_Pin1_4 6 11 PF00397 0.515
DOC_WW_Pin1_4 80 85 PF00397 0.479
LIG_14-3-3_CanoR_1 146 151 PF00244 0.384
LIG_14-3-3_CanoR_1 204 209 PF00244 0.507
LIG_14-3-3_CanoR_1 361 366 PF00244 0.417
LIG_14-3-3_CanoR_1 381 386 PF00244 0.469
LIG_14-3-3_CanoR_1 430 436 PF00244 0.480
LIG_Actin_WH2_2 599 616 PF00022 0.424
LIG_APCC_ABBA_1 672 677 PF00400 0.543
LIG_BIR_III_4 596 600 PF00653 0.496
LIG_BRCT_BRCA1_1 428 432 PF00533 0.433
LIG_BRCT_BRCA1_1 433 437 PF00533 0.379
LIG_BRCT_BRCA1_1 594 598 PF00533 0.447
LIG_BRCT_BRCA1_1 850 854 PF00533 0.529
LIG_Clathr_ClatBox_1 147 151 PF01394 0.277
LIG_CtBP_PxDLS_1 295 299 PF00389 0.488
LIG_deltaCOP1_diTrp_1 630 638 PF00928 0.361
LIG_deltaCOP1_diTrp_1 830 839 PF00928 0.443
LIG_eIF4E_1 365 371 PF01652 0.405
LIG_FHA_1 20 26 PF00498 0.400
LIG_FHA_1 205 211 PF00498 0.482
LIG_FHA_1 264 270 PF00498 0.338
LIG_FHA_1 405 411 PF00498 0.404
LIG_FHA_1 418 424 PF00498 0.468
LIG_FHA_1 649 655 PF00498 0.417
LIG_FHA_1 669 675 PF00498 0.228
LIG_FHA_2 24 30 PF00498 0.570
LIG_FHA_2 306 312 PF00498 0.513
LIG_FHA_2 362 368 PF00498 0.412
LIG_FHA_2 457 463 PF00498 0.405
LIG_FHA_2 50 56 PF00498 0.486
LIG_FHA_2 728 734 PF00498 0.739
LIG_FHA_2 81 87 PF00498 0.460
LIG_GBD_Chelix_1 62 70 PF00786 0.531
LIG_LIR_Gen_1 207 216 PF02991 0.389
LIG_LIR_Gen_1 400 410 PF02991 0.406
LIG_LIR_Gen_1 446 452 PF02991 0.348
LIG_LIR_Gen_1 462 468 PF02991 0.434
LIG_LIR_Gen_1 469 474 PF02991 0.390
LIG_LIR_Gen_1 543 552 PF02991 0.396
LIG_LIR_Gen_1 584 594 PF02991 0.415
LIG_LIR_Nem_3 207 212 PF02991 0.394
LIG_LIR_Nem_3 400 406 PF02991 0.427
LIG_LIR_Nem_3 429 435 PF02991 0.383
LIG_LIR_Nem_3 446 450 PF02991 0.368
LIG_LIR_Nem_3 462 467 PF02991 0.404
LIG_LIR_Nem_3 469 473 PF02991 0.392
LIG_LIR_Nem_3 543 548 PF02991 0.406
LIG_LIR_Nem_3 565 569 PF02991 0.335
LIG_LIR_Nem_3 584 589 PF02991 0.335
LIG_LIR_Nem_3 704 710 PF02991 0.602
LIG_LIR_Nem_3 908 913 PF02991 0.528
LIG_LIR_Nem_3 932 937 PF02991 0.340
LIG_MLH1_MIPbox_1 428 432 PF16413 0.451
LIG_NRBOX 143 149 PF00104 0.469
LIG_PCNA_APIM_2 14 20 PF02747 0.346
LIG_PCNA_yPIPBox_3 272 284 PF02747 0.374
LIG_Pex14_1 634 638 PF04695 0.379
LIG_Pex14_2 437 441 PF04695 0.477
LIG_Pex14_2 562 566 PF04695 0.396
LIG_PTB_Apo_2 32 39 PF02174 0.439
LIG_PTB_Apo_2 556 563 PF02174 0.399
LIG_PTB_Phospho_1 32 38 PF10480 0.313
LIG_REV1ctd_RIR_1 192 200 PF16727 0.476
LIG_RPA_C_Fungi 390 402 PF08784 0.447
LIG_SH2_CRK 545 549 PF00017 0.461
LIG_SH2_CRK 571 575 PF00017 0.447
LIG_SH2_CRK 707 711 PF00017 0.687
LIG_SH2_CRK 90 94 PF00017 0.530
LIG_SH2_CRK 934 938 PF00017 0.472
LIG_SH2_NCK_1 38 42 PF00017 0.434
LIG_SH2_NCK_1 433 437 PF00017 0.386
LIG_SH2_NCK_1 799 803 PF00017 0.445
LIG_SH2_STAP1 433 437 PF00017 0.385
LIG_SH2_STAP1 464 468 PF00017 0.455
LIG_SH2_STAP1 545 549 PF00017 0.408
LIG_SH2_STAP1 799 803 PF00017 0.431
LIG_SH2_STAT3 946 949 PF00017 0.345
LIG_SH2_STAT5 365 368 PF00017 0.388
LIG_SH2_STAT5 431 434 PF00017 0.368
LIG_SH2_STAT5 551 554 PF00017 0.456
LIG_SH2_STAT5 637 640 PF00017 0.379
LIG_SH2_STAT5 682 685 PF00017 0.537
LIG_SH3_3 178 184 PF00018 0.363
LIG_SH3_3 289 295 PF00018 0.551
LIG_SH3_3 326 332 PF00018 0.551
LIG_SH3_3 432 438 PF00018 0.367
LIG_SH3_3 495 501 PF00018 0.407
LIG_SH3_3 745 751 PF00018 0.580
LIG_SH3_3 790 796 PF00018 0.425
LIG_SUMO_SIM_anti_2 844 852 PF11976 0.287
LIG_SUMO_SIM_par_1 146 151 PF11976 0.276
LIG_SUMO_SIM_par_1 2 9 PF11976 0.445
LIG_SUMO_SIM_par_1 340 347 PF11976 0.291
LIG_TRAF2_1 223 226 PF00917 0.573
LIG_TRAF2_1 26 29 PF00917 0.578
LIG_TRAF2_1 730 733 PF00917 0.751
LIG_TRAF2_1 923 926 PF00917 0.520
LIG_TYR_ITIM 569 574 PF00017 0.447
LIG_TYR_ITIM 705 710 PF00017 0.715
LIG_TYR_ITIM 88 93 PF00017 0.332
LIG_UBA3_1 164 173 PF00899 0.479
LIG_WRC_WIRS_1 813 818 PF05994 0.515
MOD_CDC14_SPxK_1 187 190 PF00782 0.530
MOD_CDK_SPxK_1 184 190 PF00069 0.548
MOD_CK1_1 126 132 PF00069 0.732
MOD_CK1_1 202 208 PF00069 0.476
MOD_CK1_1 286 292 PF00069 0.527
MOD_CK2_1 23 29 PF00069 0.538
MOD_CK2_1 294 300 PF00069 0.689
MOD_CK2_1 361 367 PF00069 0.421
MOD_CK2_1 6 12 PF00069 0.487
MOD_CK2_1 727 733 PF00069 0.710
MOD_CK2_1 80 86 PF00069 0.474
MOD_CMANNOS 518 521 PF00535 0.431
MOD_CMANNOS 631 634 PF00535 0.396
MOD_GlcNHglycan 177 180 PF01048 0.595
MOD_GlcNHglycan 258 261 PF01048 0.420
MOD_GlcNHglycan 285 288 PF01048 0.462
MOD_GlcNHglycan 413 416 PF01048 0.507
MOD_GlcNHglycan 580 584 PF01048 0.337
MOD_GlcNHglycan 63 66 PF01048 0.537
MOD_GlcNHglycan 690 693 PF01048 0.512
MOD_GlcNHglycan 754 757 PF01048 0.574
MOD_GlcNHglycan 78 81 PF01048 0.252
MOD_GlcNHglycan 855 859 PF01048 0.332
MOD_GlcNHglycan 868 871 PF01048 0.449
MOD_GSK3_1 119 126 PF00069 0.686
MOD_GSK3_1 19 26 PF00069 0.480
MOD_GSK3_1 45 52 PF00069 0.413
MOD_GSK3_1 452 459 PF00069 0.454
MOD_GSK3_1 76 83 PF00069 0.510
MOD_GSK3_1 868 875 PF00069 0.675
MOD_GSK3_1 887 894 PF00069 0.720
MOD_N-GLC_1 76 81 PF02516 0.397
MOD_NEK2_1 199 204 PF00069 0.427
MOD_NEK2_1 256 261 PF00069 0.527
MOD_NEK2_1 283 288 PF00069 0.587
MOD_NEK2_1 3 8 PF00069 0.450
MOD_NEK2_1 45 50 PF00069 0.596
MOD_NEK2_1 452 457 PF00069 0.413
MOD_NEK2_1 854 859 PF00069 0.488
MOD_NEK2_2 570 575 PF00069 0.447
MOD_NEK2_2 812 817 PF00069 0.510
MOD_PIKK_1 618 624 PF00454 0.438
MOD_PKA_2 19 25 PF00069 0.379
MOD_PKA_2 256 262 PF00069 0.446
MOD_PKA_2 45 51 PF00069 0.580
MOD_PKA_2 668 674 PF00069 0.440
MOD_PKB_1 359 367 PF00069 0.306
MOD_PKB_1 483 491 PF00069 0.432
MOD_PKB_1 936 944 PF00069 0.590
MOD_Plk_1 225 231 PF00069 0.449
MOD_Plk_1 263 269 PF00069 0.523
MOD_Plk_1 452 458 PF00069 0.454
MOD_Plk_1 676 682 PF00069 0.538
MOD_Plk_2-3 225 231 PF00069 0.501
MOD_Plk_2-3 668 674 PF00069 0.535
MOD_Plk_4 204 210 PF00069 0.447
MOD_Plk_4 264 270 PF00069 0.506
MOD_Plk_4 361 367 PF00069 0.421
MOD_Plk_4 381 387 PF00069 0.185
MOD_Plk_4 452 458 PF00069 0.491
MOD_Plk_4 602 608 PF00069 0.382
MOD_Plk_4 701 707 PF00069 0.466
MOD_ProDKin_1 184 190 PF00069 0.548
MOD_ProDKin_1 319 325 PF00069 0.562
MOD_ProDKin_1 328 334 PF00069 0.490
MOD_ProDKin_1 373 379 PF00069 0.511
MOD_ProDKin_1 6 12 PF00069 0.525
MOD_ProDKin_1 80 86 PF00069 0.474
MOD_SUMO_for_1 172 175 PF00179 0.529
MOD_SUMO_for_1 683 686 PF00179 0.592
MOD_SUMO_rev_2 108 117 PF00179 0.531
MOD_SUMO_rev_2 605 613 PF00179 0.561
TRG_DiLeu_BaEn_2 748 754 PF01217 0.469
TRG_DiLeu_BaEn_4 28 34 PF01217 0.530
TRG_DiLeu_BaEn_4 736 742 PF01217 0.691
TRG_DiLeu_BaLyEn_6 143 148 PF01217 0.376
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.482
TRG_DiLeu_BaLyEn_6 365 370 PF01217 0.389
TRG_ENDOCYTIC_2 38 41 PF00928 0.308
TRG_ENDOCYTIC_2 447 450 PF00928 0.442
TRG_ENDOCYTIC_2 464 467 PF00928 0.320
TRG_ENDOCYTIC_2 545 548 PF00928 0.414
TRG_ENDOCYTIC_2 571 574 PF00928 0.335
TRG_ENDOCYTIC_2 637 640 PF00928 0.379
TRG_ENDOCYTIC_2 707 710 PF00928 0.685
TRG_ENDOCYTIC_2 90 93 PF00928 0.509
TRG_ENDOCYTIC_2 934 937 PF00928 0.463
TRG_ER_diArg_1 189 192 PF00400 0.371
TRG_ER_diArg_1 271 274 PF00400 0.425
TRG_ER_diArg_1 359 362 PF00400 0.332
TRG_ER_diArg_1 387 390 PF00400 0.383
TRG_ER_diArg_1 393 395 PF00400 0.448
TRG_ER_diArg_1 443 445 PF00400 0.269
TRG_ER_diArg_1 45 47 PF00400 0.449
TRG_ER_diArg_1 483 485 PF00400 0.495
TRG_ER_diArg_1 773 776 PF00400 0.532
TRG_ER_diArg_1 943 946 PF00400 0.520
TRG_NES_CRM1_1 497 509 PF08389 0.529
TRG_NES_CRM1_1 60 76 PF08389 0.440
TRG_NES_CRM1_1 749 761 PF08389 0.622
TRG_Pf-PMV_PEXEL_1 146 151 PF00026 0.384
TRG_Pf-PMV_PEXEL_1 245 250 PF00026 0.360
TRG_Pf-PMV_PEXEL_1 368 372 PF00026 0.391
TRG_Pf-PMV_PEXEL_1 491 495 PF00026 0.424

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IA34 Leptomonas seymouri 69% 95%
A0A1X0NSN3 Trypanosomatidae 47% 98%
A0A3R7K6J2 Trypanosoma rangeli 52% 100%
A0A3S7WUL1 Leishmania donovani 82% 100%
A4HXK1 Leishmania infantum 82% 100%
C9ZP90 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AR96 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QE67 Leishmania major 81% 99%
V5AZD3 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS