MSP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MSP (Major sperm protein) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H978_LEIBR

TriTrypDb:

LbrM.17.1350 , LBRM2903_170020400

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	7
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H978

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H978

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022406	membrane docking	2	1
GO:0051179	localization	1	1
GO:0051640	organelle localization	2	1
GO:0051643	endoplasmic reticulum localization	3	1
GO:0061024	membrane organization	4	1
GO:0061817	endoplasmic reticulum-plasma membrane tethering	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090158	endoplasmic reticulum membrane organization	5	1
GO:0140056	organelle localization by membrane tethering	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	173	175	PF00082	0.459
CLV_PCSK_KEX2_1	263	265	PF00082	0.242
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.459
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.242
CLV_PCSK_SKI1_1	37	41	PF00082	0.396
DEG_Nend_UBRbox_2	1	3	PF02207	0.808
DEG_SPOP_SBC_1	201	205	PF00917	0.714
DOC_MAPK_gen_1	128	135	PF00069	0.594
DOC_MAPK_gen_1	37	47	PF00069	0.571
DOC_MAPK_MEF2A_6	263	270	PF00069	0.488
DOC_MAPK_MEF2A_6	88	97	PF00069	0.546
DOC_PP1_RVXF_1	241	248	PF00149	0.635
DOC_PP4_FxxP_1	184	187	PF00568	0.614
DOC_PP4_FxxP_1	54	57	PF00568	0.546
DOC_USP7_MATH_1	103	107	PF00917	0.546
DOC_USP7_MATH_1	195	199	PF00917	0.638
DOC_USP7_MATH_1	210	214	PF00917	0.733
DOC_USP7_MATH_1	220	224	PF00917	0.802
DOC_USP7_MATH_1	238	242	PF00917	0.664
DOC_USP7_MATH_1	321	325	PF00917	0.478
DOC_USP7_UBL2_3	254	258	PF12436	0.776
DOC_USP7_UBL2_3	40	44	PF12436	0.542
DOC_WW_Pin1_4	143	148	PF00397	0.628
DOC_WW_Pin1_4	16	21	PF00397	0.720
DOC_WW_Pin1_4	173	178	PF00397	0.686
DOC_WW_Pin1_4	206	211	PF00397	0.795
DOC_WW_Pin1_4	305	310	PF00397	0.480
DOC_WW_Pin1_4	9	14	PF00397	0.671
LIG_14-3-3_CanoR_1	105	111	PF00244	0.506
LIG_14-3-3_CanoR_1	128	134	PF00244	0.666
LIG_14-3-3_CanoR_1	37	47	PF00244	0.580
LIG_14-3-3_CanoR_1	4	8	PF00244	0.771
LIG_BRCT_BRCA1_1	243	247	PF00533	0.636
LIG_EVH1_2	55	59	PF00568	0.546
LIG_FHA_1	113	119	PF00498	0.560
LIG_FHA_1	216	222	PF00498	0.702
LIG_FHA_1	282	288	PF00498	0.459
LIG_FHA_2	107	113	PF00498	0.504
LIG_FHA_2	137	143	PF00498	0.582
LIG_FHA_2	170	176	PF00498	0.629
LIG_Integrin_RGD_1	157	159	PF01839	0.497
LIG_LIR_Apic_2	183	187	PF02991	0.684
LIG_LIR_Gen_1	104	113	PF02991	0.549
LIG_LIR_Gen_1	149	156	PF02991	0.613
LIG_LIR_Gen_1	188	197	PF02991	0.579
LIG_LIR_Nem_3	104	110	PF02991	0.549
LIG_LIR_Nem_3	149	154	PF02991	0.605
LIG_LIR_Nem_3	188	192	PF02991	0.630
LIG_MYND_1	143	147	PF01753	0.698
LIG_SH2_PTP2	189	192	PF00017	0.650
LIG_SH2_STAT3	312	315	PF00017	0.454
LIG_SH2_STAT5	170	173	PF00017	0.613
LIG_SH2_STAT5	189	192	PF00017	0.650
LIG_SH2_STAT5	89	92	PF00017	0.546
LIG_SH3_3	189	195	PF00018	0.678
LIG_SH3_3	322	328	PF00018	0.616
LIG_SH3_3	50	56	PF00018	0.543
LIG_SH3_3	87	93	PF00018	0.524
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.562
LIG_SUMO_SIM_anti_2	279	284	PF11976	0.512
LIG_SxIP_EBH_1	186	199	PF03271	0.577
LIG_WRC_WIRS_1	181	186	PF05994	0.685
LIG_WW_1	186	189	PF00397	0.630
MOD_CDK_SPK_2	143	148	PF00069	0.628
MOD_CK1_1	106	112	PF00069	0.546
MOD_CK1_1	202	208	PF00069	0.727
MOD_CK1_1	209	215	PF00069	0.737
MOD_CK1_1	223	229	PF00069	0.728
MOD_CK1_1	241	247	PF00069	0.575
MOD_CK1_1	311	317	PF00069	0.494
MOD_CK1_1	38	44	PF00069	0.712
MOD_CK2_1	247	253	PF00069	0.639
MOD_CK2_1	8	14	PF00069	0.794
MOD_GlcNHglycan	101	104	PF01048	0.333
MOD_GlcNHglycan	205	208	PF01048	0.638
MOD_GlcNHglycan	222	225	PF01048	0.524
MOD_GlcNHglycan	233	236	PF01048	0.429
MOD_GlcNHglycan	240	243	PF01048	0.448
MOD_GlcNHglycan	249	252	PF01048	0.419
MOD_GlcNHglycan	303	306	PF01048	0.765
MOD_GlcNHglycan	37	40	PF01048	0.552
MOD_GSK3_1	137	144	PF00069	0.672
MOD_GSK3_1	169	176	PF00069	0.659
MOD_GSK3_1	195	202	PF00069	0.701
MOD_GSK3_1	205	212	PF00069	0.737
MOD_GSK3_1	301	308	PF00069	0.523
MOD_GSK3_1	99	106	PF00069	0.594
MOD_N-GLC_1	213	218	PF02516	0.542
MOD_N-GLC_1	231	236	PF02516	0.556
MOD_N-GLC_1	70	75	PF02516	0.346
MOD_N-GLC_1	8	13	PF02516	0.563
MOD_NEK2_1	129	134	PF00069	0.572
MOD_NEK2_1	247	252	PF00069	0.638
MOD_NEK2_1	276	281	PF00069	0.294
MOD_NEK2_1	298	303	PF00069	0.511
MOD_NEK2_1	3	8	PF00069	0.625
MOD_NEK2_2	180	185	PF00069	0.685
MOD_PIKK_1	26	32	PF00454	0.715
MOD_PIKK_1	311	317	PF00454	0.573
MOD_PIKK_1	80	86	PF00454	0.626
MOD_PKA_2	129	135	PF00069	0.590
MOD_PKA_2	3	9	PF00069	0.773
MOD_Plk_2-3	137	143	PF00069	0.611
MOD_Plk_4	180	186	PF00069	0.630
MOD_Plk_4	3	9	PF00069	0.626
MOD_Plk_4	65	71	PF00069	0.442
MOD_ProDKin_1	143	149	PF00069	0.627
MOD_ProDKin_1	16	22	PF00069	0.719
MOD_ProDKin_1	173	179	PF00069	0.688
MOD_ProDKin_1	206	212	PF00069	0.796
MOD_ProDKin_1	305	311	PF00069	0.480
MOD_ProDKin_1	9	15	PF00069	0.672
MOD_SUMO_for_1	45	48	PF00179	0.546
TRG_DiLeu_BaEn_1	48	53	PF01217	0.546
TRG_ENDOCYTIC_2	189	192	PF00928	0.650
TRG_NES_CRM1_1	123	137	PF08389	0.501
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ1	Leptomonas seymouri	53%	97%
A0A3S5H717	Leishmania donovani	65%	77%
A4HXJ8	Leishmania infantum	65%	77%
E9AR93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	81%
Q4QE70	Leishmania major	65%	100%