Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H976_LEIBR

TriTrypDb:

LbrM.17.1330

Length:

1052

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H976

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H976

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.661
CLV_C14_Caspase3-7	65	69	PF00656	0.488
CLV_C14_Caspase3-7	718	722	PF00656	0.329
CLV_NRD_NRD_1	1047	1049	PF00675	0.415
CLV_NRD_NRD_1	168	170	PF00675	0.448
CLV_NRD_NRD_1	176	178	PF00675	0.433
CLV_NRD_NRD_1	705	707	PF00675	0.455
CLV_NRD_NRD_1	805	807	PF00675	0.495
CLV_NRD_NRD_1	855	857	PF00675	0.525
CLV_NRD_NRD_1	861	863	PF00675	0.622
CLV_NRD_NRD_1	899	901	PF00675	0.500
CLV_PCSK_FUR_1	174	178	PF00082	0.478
CLV_PCSK_KEX2_1	1047	1049	PF00082	0.449
CLV_PCSK_KEX2_1	168	170	PF00082	0.448
CLV_PCSK_KEX2_1	176	178	PF00082	0.433
CLV_PCSK_KEX2_1	381	383	PF00082	0.475
CLV_PCSK_KEX2_1	525	527	PF00082	0.667
CLV_PCSK_KEX2_1	680	682	PF00082	0.549
CLV_PCSK_KEX2_1	705	707	PF00082	0.455
CLV_PCSK_KEX2_1	805	807	PF00082	0.495
CLV_PCSK_KEX2_1	855	857	PF00082	0.494
CLV_PCSK_KEX2_1	861	863	PF00082	0.591
CLV_PCSK_KEX2_1	899	901	PF00082	0.466
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.475
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.667
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.549
CLV_PCSK_SKI1_1	107	111	PF00082	0.585
CLV_PCSK_SKI1_1	169	173	PF00082	0.507
CLV_PCSK_SKI1_1	589	593	PF00082	0.529
CLV_PCSK_SKI1_1	780	784	PF00082	0.301
CLV_PCSK_SKI1_1	806	810	PF00082	0.571
CLV_PCSK_SKI1_1	838	842	PF00082	0.407
CLV_PCSK_SKI1_1	843	847	PF00082	0.380
CLV_PCSK_SKI1_1	953	957	PF00082	0.518
DEG_APCC_DBOX_1	566	574	PF00400	0.495
DEG_MDM2_SWIB_1	846	853	PF02201	0.474
DEG_SPOP_SBC_1	41	45	PF00917	0.389
DEG_SPOP_SBC_1	447	451	PF00917	0.556
DEG_SPOP_SBC_1	559	563	PF00917	0.631
DEG_SPOP_SBC_1	824	828	PF00917	0.362
DOC_ANK_TNKS_1	525	532	PF00023	0.781
DOC_CKS1_1	742	747	PF01111	0.522
DOC_CKS1_1	931	936	PF01111	0.546
DOC_CYCLIN_RxL_1	104	113	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	607	613	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	639	645	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.505
DOC_MAPK_DCC_7	567	575	PF00069	0.488
DOC_MAPK_gen_1	225	232	PF00069	0.520
DOC_MAPK_gen_1	586	596	PF00069	0.468
DOC_MAPK_gen_1	679	685	PF00069	0.500
DOC_MAPK_gen_1	899	910	PF00069	0.503
DOC_MAPK_MEF2A_6	332	340	PF00069	0.645
DOC_MAPK_MEF2A_6	567	575	PF00069	0.488
DOC_MAPK_MEF2A_6	586	594	PF00069	0.519
DOC_MAPK_MEF2A_6	727	736	PF00069	0.490
DOC_MAPK_MEF2A_6	753	760	PF00069	0.391
DOC_PP1_RVXF_1	356	362	PF00149	0.561
DOC_PP1_RVXF_1	836	843	PF00149	0.424
DOC_PP1_RVXF_1	845	851	PF00149	0.366
DOC_PP2B_LxvP_1	476	479	PF13499	0.491
DOC_PP2B_LxvP_1	7	10	PF13499	0.403
DOC_USP7_MATH_1	1022	1026	PF00917	0.589
DOC_USP7_MATH_1	3	7	PF00917	0.509
DOC_USP7_MATH_1	447	451	PF00917	0.645
DOC_USP7_MATH_1	452	456	PF00917	0.713
DOC_USP7_MATH_1	611	615	PF00917	0.655
DOC_USP7_MATH_1	700	704	PF00917	0.572
DOC_USP7_MATH_2	19	25	PF00917	0.319
DOC_WW_Pin1_4	1035	1040	PF00397	0.470
DOC_WW_Pin1_4	142	147	PF00397	0.736
DOC_WW_Pin1_4	31	36	PF00397	0.603
DOC_WW_Pin1_4	469	474	PF00397	0.732
DOC_WW_Pin1_4	542	547	PF00397	0.722
DOC_WW_Pin1_4	606	611	PF00397	0.759
DOC_WW_Pin1_4	638	643	PF00397	0.596
DOC_WW_Pin1_4	644	649	PF00397	0.470
DOC_WW_Pin1_4	741	746	PF00397	0.543
DOC_WW_Pin1_4	790	795	PF00397	0.560
DOC_WW_Pin1_4	826	831	PF00397	0.577
DOC_WW_Pin1_4	86	91	PF00397	0.631
DOC_WW_Pin1_4	927	932	PF00397	0.544
LIG_14-3-3_CanoR_1	453	461	PF00244	0.708
LIG_14-3-3_CanoR_1	574	580	PF00244	0.569
LIG_14-3-3_CanoR_1	61	67	PF00244	0.414
LIG_14-3-3_CanoR_1	753	757	PF00244	0.507
LIG_14-3-3_CanoR_1	775	784	PF00244	0.564
LIG_14-3-3_CanoR_1	805	815	PF00244	0.415
LIG_14-3-3_CanoR_1	834	842	PF00244	0.424
LIG_14-3-3_CanoR_1	945	952	PF00244	0.507
LIG_14-3-3_CanoR_1	953	962	PF00244	0.506
LIG_Actin_WH2_2	493	510	PF00022	0.382
LIG_APCC_ABBA_1	1001	1006	PF00400	0.477
LIG_APCC_ABBA_1	185	190	PF00400	0.312
LIG_APCC_ABBA_1	889	894	PF00400	0.543
LIG_APCC_ABBAyCdc20_2	107	113	PF00400	0.343
LIG_BIR_III_2	634	638	PF00653	0.603
LIG_BIR_III_4	181	185	PF00653	0.282
LIG_CaM_IQ_9	848	864	PF13499	0.322
LIG_Clathr_ClatBox_1	994	998	PF01394	0.404
LIG_deltaCOP1_diTrp_1	77	86	PF00928	0.610
LIG_EH1_1	587	595	PF00400	0.593
LIG_EH1_1	988	996	PF00400	0.410
LIG_eIF4E_1	588	594	PF01652	0.531
LIG_FHA_1	165	171	PF00498	0.422
LIG_FHA_1	41	47	PF00498	0.561
LIG_FHA_1	415	421	PF00498	0.590
LIG_FHA_1	432	438	PF00498	0.444
LIG_FHA_1	465	471	PF00498	0.732
LIG_FHA_1	652	658	PF00498	0.465
LIG_FHA_1	680	686	PF00498	0.560
LIG_FHA_1	742	748	PF00498	0.561
LIG_FHA_1	753	759	PF00498	0.438
LIG_FHA_1	808	814	PF00498	0.429
LIG_FHA_1	817	823	PF00498	0.435
LIG_FHA_1	97	103	PF00498	0.577
LIG_FHA_1	998	1004	PF00498	0.413
LIG_FHA_2	187	193	PF00498	0.478
LIG_FHA_2	234	240	PF00498	0.427
LIG_FHA_2	369	375	PF00498	0.552
LIG_FHA_2	410	416	PF00498	0.776
LIG_FHA_2	42	48	PF00498	0.621
LIG_FHA_2	478	484	PF00498	0.490
LIG_FHA_2	504	510	PF00498	0.653
LIG_Integrin_isoDGR_2	263	265	PF01839	0.516
LIG_LIR_Apic_2	716	720	PF02991	0.477
LIG_LIR_Apic_2	920	926	PF02991	0.330
LIG_LIR_Gen_1	360	369	PF02991	0.493
LIG_LIR_Gen_1	545	555	PF02991	0.551
LIG_LIR_Gen_1	652	661	PF02991	0.555
LIG_LIR_Gen_1	68	77	PF02991	0.490
LIG_LIR_Gen_1	786	797	PF02991	0.501
LIG_LIR_Gen_1	907	918	PF02991	0.450
LIG_LIR_Gen_1	972	982	PF02991	0.480
LIG_LIR_Nem_3	104	109	PF02991	0.483
LIG_LIR_Nem_3	21	26	PF02991	0.445
LIG_LIR_Nem_3	360	364	PF02991	0.498
LIG_LIR_Nem_3	501	507	PF02991	0.623
LIG_LIR_Nem_3	545	551	PF02991	0.561
LIG_LIR_Nem_3	652	656	PF02991	0.541
LIG_LIR_Nem_3	68	74	PF02991	0.436
LIG_LIR_Nem_3	786	792	PF02991	0.501
LIG_LIR_Nem_3	844	849	PF02991	0.465
LIG_LIR_Nem_3	907	913	PF02991	0.460
LIG_LIR_Nem_3	972	977	PF02991	0.452
LIG_MYND_1	891	895	PF01753	0.482
LIG_NRBOX	844	850	PF00104	0.464
LIG_Pex14_2	842	846	PF04695	0.475
LIG_Rb_pABgroove_1	1027	1035	PF01858	0.431
LIG_REV1ctd_RIR_1	23	31	PF16727	0.364
LIG_REV1ctd_RIR_1	502	512	PF16727	0.411
LIG_REV1ctd_RIR_1	839	847	PF16727	0.527
LIG_SH2_CRK	1042	1046	PF00017	0.472
LIG_SH2_CRK	588	592	PF00017	0.543
LIG_SH2_CRK	653	657	PF00017	0.547
LIG_SH2_CRK	686	690	PF00017	0.401
LIG_SH2_NCK_1	923	927	PF00017	0.380
LIG_SH2_SRC	748	751	PF00017	0.406
LIG_SH2_SRC	921	924	PF00017	0.534
LIG_SH2_STAP1	653	657	PF00017	0.470
LIG_SH2_STAP1	98	102	PF00017	0.306
LIG_SH2_STAT5	1002	1005	PF00017	0.478
LIG_SH2_STAT5	291	294	PF00017	0.406
LIG_SH2_STAT5	49	52	PF00017	0.407
LIG_SH2_STAT5	496	499	PF00017	0.563
LIG_SH2_STAT5	548	551	PF00017	0.604
LIG_SH2_STAT5	583	586	PF00017	0.610
LIG_SH2_STAT5	653	656	PF00017	0.532
LIG_SH2_STAT5	70	73	PF00017	0.461
LIG_SH2_STAT5	748	751	PF00017	0.352
LIG_SH2_STAT5	921	924	PF00017	0.479
LIG_SH2_STAT5	932	935	PF00017	0.511
LIG_SH2_STAT5	940	943	PF00017	0.507
LIG_SH2_STAT5	951	954	PF00017	0.578
LIG_SH2_STAT5	98	101	PF00017	0.443
LIG_SH3_1	928	934	PF00018	0.560
LIG_SH3_3	32	38	PF00018	0.489
LIG_SH3_3	602	608	PF00018	0.641
LIG_SH3_3	642	648	PF00018	0.737
LIG_SH3_3	733	739	PF00018	0.483
LIG_SH3_3	744	750	PF00018	0.449
LIG_SH3_3	884	890	PF00018	0.514
LIG_SH3_3	928	934	PF00018	0.560
LIG_SUMO_SIM_anti_2	1023	1031	PF11976	0.443
LIG_SUMO_SIM_anti_2	728	734	PF11976	0.569
LIG_SUMO_SIM_anti_2	812	817	PF11976	0.437
LIG_SUMO_SIM_anti_2	992	998	PF11976	0.407
LIG_SUMO_SIM_par_1	781	786	PF11976	0.501
LIG_SUMO_SIM_par_1	992	998	PF11976	0.407
LIG_TRAF2_1	159	162	PF00917	0.527
LIG_TRAF2_1	946	949	PF00917	0.573
LIG_UBA3_1	282	289	PF00899	0.286
LIG_WRC_WIRS_1	974	979	PF05994	0.528
MOD_CDK_SPK_2	1035	1040	PF00069	0.470
MOD_CDK_SPK_2	469	474	PF00069	0.606
MOD_CDK_SPK_2	790	795	PF00069	0.406
MOD_CK1_1	101	107	PF00069	0.303
MOD_CK1_1	145	151	PF00069	0.721
MOD_CK1_1	153	159	PF00069	0.548
MOD_CK1_1	28	34	PF00069	0.659
MOD_CK1_1	328	334	PF00069	0.599
MOD_CK1_1	468	474	PF00069	0.607
MOD_CK1_1	542	548	PF00069	0.691
MOD_CK1_1	641	647	PF00069	0.481
MOD_CK1_1	826	832	PF00069	0.500
MOD_CK2_1	186	192	PF00069	0.501
MOD_CK2_1	320	326	PF00069	0.625
MOD_CK2_1	459	465	PF00069	0.690
MOD_CK2_1	477	483	PF00069	0.372
MOD_CK2_1	513	519	PF00069	0.732
MOD_CK2_1	537	543	PF00069	0.516
MOD_CK2_1	825	831	PF00069	0.552
MOD_Cter_Amidation	859	862	PF01082	0.646
MOD_GlcNHglycan	1023	1027	PF01048	0.570
MOD_GlcNHglycan	103	106	PF01048	0.517
MOD_GlcNHglycan	11	14	PF01048	0.453
MOD_GlcNHglycan	129	132	PF01048	0.472
MOD_GlcNHglycan	152	155	PF01048	0.630
MOD_GlcNHglycan	199	202	PF01048	0.643
MOD_GlcNHglycan	272	275	PF01048	0.617
MOD_GlcNHglycan	28	31	PF01048	0.519
MOD_GlcNHglycan	450	453	PF01048	0.768
MOD_GlcNHglycan	465	470	PF01048	0.706
MOD_GlcNHglycan	487	490	PF01048	0.511
MOD_GlcNHglycan	58	61	PF01048	0.508
MOD_GlcNHglycan	613	616	PF01048	0.795
MOD_GlcNHglycan	622	625	PF01048	0.543
MOD_GlcNHglycan	777	780	PF01048	0.304
MOD_GlcNHglycan	81	84	PF01048	0.491
MOD_GlcNHglycan	835	838	PF01048	0.456
MOD_GlcNHglycan	863	867	PF01048	0.678
MOD_GSK3_1	1005	1012	PF00069	0.607
MOD_GSK3_1	141	148	PF00069	0.704
MOD_GSK3_1	21	28	PF00069	0.499
MOD_GSK3_1	244	251	PF00069	0.419
MOD_GSK3_1	384	391	PF00069	0.774
MOD_GSK3_1	414	421	PF00069	0.603
MOD_GSK3_1	448	455	PF00069	0.599
MOD_GSK3_1	464	471	PF00069	0.764
MOD_GSK3_1	485	492	PF00069	0.550
MOD_GSK3_1	503	510	PF00069	0.475
MOD_GSK3_1	748	755	PF00069	0.564
MOD_GSK3_1	75	82	PF00069	0.488
MOD_GSK3_1	807	814	PF00069	0.435
MOD_GSK3_1	862	869	PF00069	0.540
MOD_GSK3_1	961	968	PF00069	0.321
MOD_N-GLC_1	244	249	PF02516	0.398
MOD_N-GLC_1	41	46	PF02516	0.373
MOD_N-GLC_1	775	780	PF02516	0.324
MOD_N-GLC_2	769	771	PF02516	0.301
MOD_NEK2_1	216	221	PF00069	0.591
MOD_NEK2_1	233	238	PF00069	0.290
MOD_NEK2_1	25	30	PF00069	0.638
MOD_NEK2_1	325	330	PF00069	0.576
MOD_NEK2_1	537	542	PF00069	0.761
MOD_NEK2_1	56	61	PF00069	0.428
MOD_NEK2_1	575	580	PF00069	0.376
MOD_NEK2_1	62	67	PF00069	0.393
MOD_NEK2_1	701	706	PF00069	0.646
MOD_NEK2_1	774	779	PF00069	0.501
MOD_NEK2_1	783	788	PF00069	0.501
MOD_NEK2_1	816	821	PF00069	0.444
MOD_NEK2_1	841	846	PF00069	0.446
MOD_NEK2_1	848	853	PF00069	0.391
MOD_NEK2_1	96	101	PF00069	0.476
MOD_NEK2_1	978	983	PF00069	0.417
MOD_NEK2_1	990	995	PF00069	0.408
MOD_NEK2_1	997	1002	PF00069	0.406
MOD_NEK2_2	183	188	PF00069	0.311
MOD_NEK2_2	414	419	PF00069	0.648
MOD_PIKK_1	489	495	PF00454	0.511
MOD_PIKK_1	618	624	PF00454	0.648
MOD_PIKK_1	651	657	PF00454	0.575
MOD_PIKK_1	693	699	PF00454	0.480
MOD_PIKK_1	816	822	PF00454	0.432
MOD_PIKK_1	848	854	PF00454	0.367
MOD_PIKK_1	944	950	PF00454	0.547
MOD_PIKK_1	954	960	PF00454	0.464
MOD_PIKK_1	96	102	PF00454	0.395
MOD_PK_1	513	519	PF00069	0.525
MOD_PKA_1	679	685	PF00069	0.600
MOD_PKA_1	899	905	PF00069	0.554
MOD_PKA_2	197	203	PF00069	0.681
MOD_PKA_2	233	239	PF00069	0.440
MOD_PKA_2	26	32	PF00069	0.444
MOD_PKA_2	452	458	PF00069	0.519
MOD_PKA_2	507	513	PF00069	0.474
MOD_PKA_2	573	579	PF00069	0.597
MOD_PKA_2	752	758	PF00069	0.471
MOD_PKA_2	774	780	PF00069	0.560
MOD_PKA_2	833	839	PF00069	0.420
MOD_PKA_2	899	905	PF00069	0.554
MOD_PKA_2	944	950	PF00069	0.305
MOD_Plk_1	1022	1028	PF00069	0.517
MOD_Plk_1	244	250	PF00069	0.537
MOD_Plk_1	325	331	PF00069	0.591
MOD_Plk_1	41	47	PF00069	0.364
MOD_Plk_1	414	420	PF00069	0.691
MOD_Plk_1	431	437	PF00069	0.438
MOD_Plk_1	465	471	PF00069	0.755
MOD_Plk_1	997	1003	PF00069	0.407
MOD_Plk_4	145	151	PF00069	0.636
MOD_Plk_4	320	326	PF00069	0.625
MOD_Plk_4	360	366	PF00069	0.597
MOD_Plk_4	432	438	PF00069	0.417
MOD_Plk_4	519	525	PF00069	0.785
MOD_Plk_4	656	662	PF00069	0.477
MOD_Plk_4	752	758	PF00069	0.491
MOD_Plk_4	973	979	PF00069	0.450
MOD_Plk_4	98	104	PF00069	0.402
MOD_Plk_4	990	996	PF00069	0.324
MOD_ProDKin_1	1035	1041	PF00069	0.466
MOD_ProDKin_1	142	148	PF00069	0.735
MOD_ProDKin_1	31	37	PF00069	0.605
MOD_ProDKin_1	469	475	PF00069	0.730
MOD_ProDKin_1	542	548	PF00069	0.716
MOD_ProDKin_1	606	612	PF00069	0.760
MOD_ProDKin_1	638	644	PF00069	0.592
MOD_ProDKin_1	741	747	PF00069	0.530
MOD_ProDKin_1	790	796	PF00069	0.560
MOD_ProDKin_1	826	832	PF00069	0.574
MOD_ProDKin_1	86	92	PF00069	0.631
MOD_ProDKin_1	927	933	PF00069	0.532
MOD_SUMO_rev_2	350	359	PF00179	0.332
TRG_DiLeu_BaEn_1	519	524	PF01217	0.565
TRG_DiLeu_BaEn_1	728	733	PF01217	0.526
TRG_DiLeu_BaEn_1	992	997	PF01217	0.407
TRG_DiLeu_BaEn_4	465	471	PF01217	0.528
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.519
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.376
TRG_ENDOCYTIC_2	1042	1045	PF00928	0.471
TRG_ENDOCYTIC_2	442	445	PF00928	0.595
TRG_ENDOCYTIC_2	548	551	PF00928	0.522
TRG_ENDOCYTIC_2	588	591	PF00928	0.553
TRG_ENDOCYTIC_2	653	656	PF00928	0.538
TRG_ENDOCYTIC_2	70	73	PF00928	0.465
TRG_ER_diArg_1	168	170	PF00400	0.446
TRG_ER_diArg_1	174	177	PF00400	0.436
TRG_ER_diArg_1	855	857	PF00400	0.407
TRG_ER_diArg_1	898	900	PF00400	0.506
TRG_NES_CRM1_1	992	1006	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R1	Leptomonas seymouri	56%	100%
A0A3Q8IE30	Leishmania donovani	72%	100%
A0A3R7LJI9	Trypanosoma rangeli	36%	100%
A4HXK8	Leishmania infantum	73%	100%
E9ARA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QE60	Leishmania major	73%	99%
V5BET6	Trypanosoma cruzi	34%	100%