Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H975_LEIBR

TriTrypDb:

LbrM.17.1320 , LBRM2903_170021200

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H975

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H975

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	160	166	PF00089	0.352
CLV_NRD_NRD_1	10	12	PF00675	0.506
CLV_NRD_NRD_1	171	173	PF00675	0.361
CLV_NRD_NRD_1	214	216	PF00675	0.513
CLV_NRD_NRD_1	292	294	PF00675	0.541
CLV_PCSK_KEX2_1	10	12	PF00082	0.506
CLV_PCSK_KEX2_1	214	216	PF00082	0.513
CLV_Separin_Metazoa	112	116	PF03568	0.603
DEG_ODPH_VHL_1	160	171	PF01847	0.581
DEG_SCF_FBW7_2	106	112	PF00400	0.596
DEG_SPOP_SBC_1	81	85	PF00917	0.634
DOC_CKS1_1	106	111	PF01111	0.726
DOC_CKS1_1	150	155	PF01111	0.557
DOC_CKS1_1	220	225	PF01111	0.335
DOC_PP1_RVXF_1	138	144	PF00149	0.568
DOC_PP1_RVXF_1	171	178	PF00149	0.517
DOC_PP1_RVXF_1	240	246	PF00149	0.332
DOC_USP7_MATH_1	236	240	PF00917	0.438
DOC_USP7_MATH_1	266	270	PF00917	0.398
DOC_USP7_MATH_1	43	47	PF00917	0.698
DOC_USP7_MATH_1	58	62	PF00917	0.702
DOC_USP7_MATH_1	81	85	PF00917	0.674
DOC_USP7_MATH_1	99	103	PF00917	0.583
DOC_USP7_UBL2_3	179	183	PF12436	0.517
DOC_WW_Pin1_4	105	110	PF00397	0.705
DOC_WW_Pin1_4	149	154	PF00397	0.554
DOC_WW_Pin1_4	17	22	PF00397	0.609
DOC_WW_Pin1_4	219	224	PF00397	0.351
DOC_WW_Pin1_4	68	73	PF00397	0.620
LIG_14-3-3_CanoR_1	172	178	PF00244	0.624
LIG_14-3-3_CanoR_1	242	246	PF00244	0.392
LIG_BIR_III_4	131	135	PF00653	0.533
LIG_BIR_III_4	66	70	PF00653	0.630
LIG_eIF4E_1	191	197	PF01652	0.260
LIG_FHA_1	124	130	PF00498	0.545
LIG_FHA_1	238	244	PF00498	0.350
LIG_FHA_1	58	64	PF00498	0.617
LIG_FHA_2	105	111	PF00498	0.619
LIG_FHA_2	29	35	PF00498	0.633
LIG_LIR_Apic_2	147	153	PF02991	0.549
LIG_LIR_Gen_1	188	199	PF02991	0.260
LIG_LIR_Nem_3	176	180	PF02991	0.496
LIG_LIR_Nem_3	188	194	PF02991	0.211
LIG_LYPXL_yS_3	184	187	PF13949	0.507
LIG_NRP_CendR_1	293	295	PF00754	0.547
LIG_Pex14_1	204	208	PF04695	0.211
LIG_SH2_CRK	150	154	PF00017	0.584
LIG_SH2_CRK	166	170	PF00017	0.508
LIG_SH2_GRB2like	191	194	PF00017	0.260
LIG_SH2_NCK_1	166	170	PF00017	0.672
LIG_SH2_PTP2	191	194	PF00017	0.410
LIG_SH2_SRC	191	194	PF00017	0.260
LIG_SH2_STAT5	136	139	PF00017	0.536
LIG_SH2_STAT5	191	194	PF00017	0.260
LIG_SH2_STAT5	270	273	PF00017	0.318
LIG_SH3_3	138	144	PF00018	0.549
LIG_SH3_3	69	75	PF00018	0.646
LIG_SH3_3	91	97	PF00018	0.656
LIG_TYR_ITIM	189	194	PF00017	0.233
MOD_CK1_1	22	28	PF00069	0.742
MOD_CK1_1	57	63	PF00069	0.614
MOD_CK2_1	28	34	PF00069	0.634
MOD_GlcNHglycan	102	105	PF01048	0.513
MOD_GlcNHglycan	21	24	PF01048	0.510
MOD_GlcNHglycan	27	30	PF01048	0.526
MOD_GlcNHglycan	45	48	PF01048	0.535
MOD_GlcNHglycan	55	59	PF01048	0.461
MOD_GlcNHglycan	60	63	PF01048	0.458
MOD_GSK3_1	100	107	PF00069	0.750
MOD_GSK3_1	15	22	PF00069	0.669
MOD_GSK3_1	237	244	PF00069	0.447
MOD_GSK3_1	25	32	PF00069	0.701
MOD_GSK3_1	266	273	PF00069	0.422
MOD_GSK3_1	50	57	PF00069	0.747
MOD_GSK3_1	82	89	PF00069	0.707
MOD_N-GLC_1	15	20	PF02516	0.411
MOD_N-GLC_1	237	242	PF02516	0.577
MOD_NEK2_1	12	17	PF00069	0.664
MOD_PIKK_1	237	243	PF00454	0.356
MOD_PKA_2	185	191	PF00069	0.388
MOD_PKA_2	241	247	PF00069	0.460
MOD_PKA_2	37	43	PF00069	0.674
MOD_Plk_1	266	272	PF00069	0.455
MOD_Plk_1	5	11	PF00069	0.608
MOD_Plk_2-3	286	292	PF00069	0.337
MOD_Plk_4	173	179	PF00069	0.510
MOD_Plk_4	266	272	PF00069	0.337
MOD_ProDKin_1	105	111	PF00069	0.700
MOD_ProDKin_1	149	155	PF00069	0.554
MOD_ProDKin_1	17	23	PF00069	0.611
MOD_ProDKin_1	219	225	PF00069	0.353
MOD_ProDKin_1	68	74	PF00069	0.618
MOD_SUMO_for_1	132	135	PF00179	0.537
MOD_SUMO_rev_2	269	278	PF00179	0.399
TRG_DiLeu_BaEn_1	249	254	PF01217	0.321
TRG_ENDOCYTIC_2	166	169	PF00928	0.543
TRG_ENDOCYTIC_2	184	187	PF00928	0.599
TRG_ENDOCYTIC_2	191	194	PF00928	0.296
TRG_ER_diArg_1	213	215	PF00400	0.313
TRG_ER_diArg_1	292	295	PF00400	0.346
TRG_ER_diArg_1	9	11	PF00400	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J6W1	Bodo saltans	58%	100%
A0A422NAT4	Trypanosoma rangeli	50%	100%