Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H974_LEIBR

TriTrypDb:

LbrM.17.1310 , LBRM2903_170020300

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H974

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H974

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.685
CLV_C14_Caspase3-7	46	50	PF00656	0.568
CLV_C14_Caspase3-7	463	467	PF00656	0.583
CLV_C14_Caspase3-7	586	590	PF00656	0.593
CLV_C14_Caspase3-7	61	65	PF00656	0.533
CLV_NRD_NRD_1	15	17	PF00675	0.597
CLV_NRD_NRD_1	157	159	PF00675	0.569
CLV_NRD_NRD_1	212	214	PF00675	0.737
CLV_NRD_NRD_1	245	247	PF00675	0.839
CLV_NRD_NRD_1	27	29	PF00675	0.565
CLV_NRD_NRD_1	275	277	PF00675	0.553
CLV_NRD_NRD_1	278	280	PF00675	0.477
CLV_NRD_NRD_1	451	453	PF00675	0.701
CLV_NRD_NRD_1	457	459	PF00675	0.756
CLV_NRD_NRD_1	618	620	PF00675	0.583
CLV_NRD_NRD_1	639	641	PF00675	0.715
CLV_NRD_NRD_1	671	673	PF00675	0.821
CLV_NRD_NRD_1	677	679	PF00675	0.730
CLV_NRD_NRD_1	701	703	PF00675	0.760
CLV_NRD_NRD_1	735	737	PF00675	0.648
CLV_NRD_NRD_1	761	763	PF00675	0.748
CLV_NRD_NRD_1	83	85	PF00675	0.576
CLV_PCSK_FUR_1	13	17	PF00082	0.585
CLV_PCSK_FUR_1	276	280	PF00082	0.433
CLV_PCSK_KEX2_1	15	17	PF00082	0.597
CLV_PCSK_KEX2_1	157	159	PF00082	0.569
CLV_PCSK_KEX2_1	212	214	PF00082	0.746
CLV_PCSK_KEX2_1	245	247	PF00082	0.839
CLV_PCSK_KEX2_1	27	29	PF00082	0.609
CLV_PCSK_KEX2_1	275	277	PF00082	0.535
CLV_PCSK_KEX2_1	278	280	PF00082	0.477
CLV_PCSK_KEX2_1	300	302	PF00082	0.626
CLV_PCSK_KEX2_1	375	377	PF00082	0.660
CLV_PCSK_KEX2_1	451	453	PF00082	0.701
CLV_PCSK_KEX2_1	457	459	PF00082	0.756
CLV_PCSK_KEX2_1	618	620	PF00082	0.583
CLV_PCSK_KEX2_1	638	640	PF00082	0.669
CLV_PCSK_KEX2_1	671	673	PF00082	0.821
CLV_PCSK_KEX2_1	677	679	PF00082	0.730
CLV_PCSK_KEX2_1	701	703	PF00082	0.760
CLV_PCSK_KEX2_1	735	737	PF00082	0.648
CLV_PCSK_KEX2_1	760	762	PF00082	0.764
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.565
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.504
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.574
CLV_PCSK_PC7_1	697	703	PF00082	0.757
CLV_PCSK_SKI1_1	628	632	PF00082	0.610
CLV_PCSK_SKI1_1	685	689	PF00082	0.717
CLV_PCSK_SKI1_1	762	766	PF00082	0.584
DEG_Nend_UBRbox_1	1	4	PF02207	0.692
DEG_SPOP_SBC_1	575	579	PF00917	0.648
DOC_MAPK_MEF2A_6	564	572	PF00069	0.604
DOC_MIT_MIM_1	378	387	PF04212	0.564
DOC_PP1_RVXF_1	257	264	PF00149	0.520
DOC_PP2B_LxvP_1	122	125	PF13499	0.749
DOC_PP4_FxxP_1	114	117	PF00568	0.714
DOC_PP4_FxxP_1	263	266	PF00568	0.497
DOC_USP7_MATH_1	257	261	PF00917	0.547
DOC_USP7_MATH_1	341	345	PF00917	0.553
DOC_USP7_MATH_1	496	500	PF00917	0.807
DOC_USP7_MATH_1	556	560	PF00917	0.722
DOC_USP7_MATH_1	58	62	PF00917	0.603
DOC_USP7_MATH_1	614	618	PF00917	0.691
DOC_USP7_MATH_1	679	683	PF00917	0.657
DOC_USP7_MATH_1	740	744	PF00917	0.588
DOC_USP7_MATH_1	764	768	PF00917	0.743
DOC_USP7_MATH_1	769	773	PF00917	0.696
DOC_USP7_MATH_1	846	850	PF00917	0.550
DOC_WW_Pin1_4	113	118	PF00397	0.799
DOC_WW_Pin1_4	179	184	PF00397	0.774
DOC_WW_Pin1_4	262	267	PF00397	0.499
DOC_WW_Pin1_4	362	367	PF00397	0.490
DOC_WW_Pin1_4	47	52	PF00397	0.633
DOC_WW_Pin1_4	475	480	PF00397	0.718
DOC_WW_Pin1_4	489	494	PF00397	0.529
DOC_WW_Pin1_4	509	514	PF00397	0.638
DOC_WW_Pin1_4	612	617	PF00397	0.591
DOC_WW_Pin1_4	621	626	PF00397	0.559
DOC_WW_Pin1_4	704	709	PF00397	0.768
DOC_WW_Pin1_4	736	741	PF00397	0.773
DOC_WW_Pin1_4	745	750	PF00397	0.690
DOC_WW_Pin1_4	754	759	PF00397	0.592
DOC_WW_Pin1_4	809	814	PF00397	0.542
LIG_14-3-3_CanoR_1	103	111	PF00244	0.728
LIG_14-3-3_CanoR_1	13	23	PF00244	0.578
LIG_14-3-3_CanoR_1	198	203	PF00244	0.680
LIG_14-3-3_CanoR_1	222	230	PF00244	0.664
LIG_14-3-3_CanoR_1	245	252	PF00244	0.672
LIG_14-3-3_CanoR_1	537	546	PF00244	0.686
LIG_14-3-3_CanoR_1	564	572	PF00244	0.589
LIG_14-3-3_CanoR_1	574	582	PF00244	0.814
LIG_14-3-3_CanoR_1	639	646	PF00244	0.644
LIG_14-3-3_CanoR_1	677	687	PF00244	0.763
LIG_14-3-3_CanoR_1	701	710	PF00244	0.675
LIG_14-3-3_CanoR_1	735	739	PF00244	0.714
LIG_14-3-3_CanoR_1	760	768	PF00244	0.614
LIG_14-3-3_CanoR_1	774	783	PF00244	0.660
LIG_14-3-3_CanoR_1	797	805	PF00244	0.545
LIG_14-3-3_CanoR_1	821	825	PF00244	0.676
LIG_BRCT_BRCA1_1	243	247	PF00533	0.631
LIG_BRCT_BRCA1_1	259	263	PF00533	0.490
LIG_BRCT_BRCA1_1	747	751	PF00533	0.573
LIG_DLG_GKlike_1	198	206	PF00625	0.564
LIG_EH1_1	720	728	PF00400	0.579
LIG_FHA_1	262	268	PF00498	0.498
LIG_FHA_1	363	369	PF00498	0.480
LIG_FHA_1	577	583	PF00498	0.766
LIG_FHA_1	679	685	PF00498	0.692
LIG_FHA_1	763	769	PF00498	0.758
LIG_FHA_1	799	805	PF00498	0.704
LIG_FHA_1	852	858	PF00498	0.543
LIG_FHA_2	38	44	PF00498	0.566
LIG_FHA_2	461	467	PF00498	0.586
LIG_FHA_2	576	582	PF00498	0.611
LIG_FHA_2	584	590	PF00498	0.571
LIG_LIR_Apic_2	113	117	PF02991	0.644
LIG_LIR_Apic_2	260	266	PF02991	0.507
LIG_LIR_Apic_2	624	629	PF02991	0.564
LIG_LIR_Gen_1	748	758	PF02991	0.573
LIG_LIR_Nem_3	50	56	PF02991	0.559
LIG_LIR_Nem_3	748	754	PF02991	0.573
LIG_MLH1_MIPbox_1	747	751	PF16413	0.573
LIG_NRBOX	43	49	PF00104	0.569
LIG_NRBOX	852	858	PF00104	0.543
LIG_PDZ_Class_1	857	862	PF00595	0.538
LIG_Pex14_1	820	824	PF04695	0.552
LIG_SH2_GRB2like	503	506	PF00017	0.569
LIG_SH2_SRC	503	506	PF00017	0.569
LIG_SH2_STAT5	503	506	PF00017	0.586
LIG_SH3_1	173	179	PF00018	0.570
LIG_SH3_2	176	181	PF14604	0.573
LIG_SH3_2	830	835	PF14604	0.718
LIG_SH3_3	173	179	PF00018	0.660
LIG_SH3_3	476	482	PF00018	0.566
LIG_SH3_3	490	496	PF00018	0.519
LIG_SH3_3	52	58	PF00018	0.606
LIG_SH3_3	569	575	PF00018	0.744
LIG_SH3_3	667	673	PF00018	0.766
LIG_SH3_3	827	833	PF00018	0.709
LIG_SUMO_SIM_anti_2	849	855	PF11976	0.550
LIG_SUMO_SIM_par_1	264	270	PF11976	0.488
MOD_CDC14_SPxK_1	512	515	PF00782	0.577
MOD_CDC14_SPxK_1	757	760	PF00782	0.573
MOD_CDK_SPxK_1	475	481	PF00069	0.717
MOD_CDK_SPxK_1	509	515	PF00069	0.573
MOD_CDK_SPxK_1	612	618	PF00069	0.583
MOD_CDK_SPxK_1	754	760	PF00069	0.624
MOD_CDK_SPxxK_3	612	619	PF00069	0.583
MOD_CDK_SPxxK_3	621	628	PF00069	0.553
MOD_CDK_SPxxK_3	704	711	PF00069	0.756
MOD_CDK_SPxxK_3	754	761	PF00069	0.576
MOD_CK1_1	105	111	PF00069	0.650
MOD_CK1_1	118	124	PF00069	0.566
MOD_CK1_1	148	154	PF00069	0.749
MOD_CK1_1	17	23	PF00069	0.786
MOD_CK1_1	197	203	PF00069	0.710
MOD_CK1_1	215	221	PF00069	0.541
MOD_CK1_1	239	245	PF00069	0.598
MOD_CK1_1	265	271	PF00069	0.566
MOD_CK1_1	342	348	PF00069	0.511
MOD_CK1_1	362	368	PF00069	0.513
MOD_CK1_1	420	426	PF00069	0.719
MOD_CK1_1	460	466	PF00069	0.587
MOD_CK1_1	514	520	PF00069	0.656
MOD_CK1_1	540	546	PF00069	0.611
MOD_CK1_1	559	565	PF00069	0.707
MOD_CK1_1	598	604	PF00069	0.789
MOD_CK1_1	621	627	PF00069	0.675
MOD_CK1_1	642	648	PF00069	0.577
MOD_CK1_1	664	670	PF00069	0.690
MOD_CK1_1	686	692	PF00069	0.701
MOD_CK1_1	700	706	PF00069	0.671
MOD_CK1_1	713	719	PF00069	0.649
MOD_CK1_1	76	82	PF00069	0.662
MOD_CK1_1	772	778	PF00069	0.610
MOD_CK1_1	808	814	PF00069	0.638
MOD_CK2_1	855	861	PF00069	0.539
MOD_Cter_Amidation	13	16	PF01082	0.589
MOD_Cter_Amidation	758	761	PF01082	0.566
MOD_DYRK1A_RPxSP_1	736	740	PF00069	0.648
MOD_GlcNHglycan	104	107	PF01048	0.588
MOD_GlcNHglycan	147	150	PF01048	0.708
MOD_GlcNHglycan	208	211	PF01048	0.729
MOD_GlcNHglycan	214	217	PF01048	0.674
MOD_GlcNHglycan	225	228	PF01048	0.535
MOD_GlcNHglycan	240	244	PF01048	0.670
MOD_GlcNHglycan	341	344	PF01048	0.716
MOD_GlcNHglycan	350	353	PF01048	0.601
MOD_GlcNHglycan	419	422	PF01048	0.687
MOD_GlcNHglycan	445	448	PF01048	0.708
MOD_GlcNHglycan	498	501	PF01048	0.794
MOD_GlcNHglycan	525	528	PF01048	0.722
MOD_GlcNHglycan	558	561	PF01048	0.761
MOD_GlcNHglycan	604	607	PF01048	0.776
MOD_GlcNHglycan	620	623	PF01048	0.646
MOD_GlcNHglycan	648	651	PF01048	0.731
MOD_GlcNHglycan	663	666	PF01048	0.698
MOD_GlcNHglycan	703	706	PF01048	0.599
MOD_GlcNHglycan	717	720	PF01048	0.596
MOD_GlcNHglycan	729	732	PF01048	0.588
MOD_GlcNHglycan	762	765	PF01048	0.754
MOD_GlcNHglycan	774	777	PF01048	0.606
MOD_GlcNHglycan	787	790	PF01048	0.562
MOD_GlcNHglycan	838	841	PF01048	0.729
MOD_GSK3_1	14	21	PF00069	0.659
MOD_GSK3_1	145	152	PF00069	0.729
MOD_GSK3_1	194	201	PF00069	0.744
MOD_GSK3_1	202	209	PF00069	0.657
MOD_GSK3_1	221	228	PF00069	0.674
MOD_GSK3_1	241	248	PF00069	0.712
MOD_GSK3_1	257	264	PF00069	0.643
MOD_GSK3_1	33	40	PF00069	0.518
MOD_GSK3_1	344	351	PF00069	0.532
MOD_GSK3_1	357	364	PF00069	0.528
MOD_GSK3_1	460	467	PF00069	0.684
MOD_GSK3_1	505	512	PF00069	0.745
MOD_GSK3_1	514	521	PF00069	0.686
MOD_GSK3_1	523	530	PF00069	0.681
MOD_GSK3_1	559	566	PF00069	0.706
MOD_GSK3_1	583	590	PF00069	0.800
MOD_GSK3_1	598	605	PF00069	0.640
MOD_GSK3_1	614	621	PF00069	0.606
MOD_GSK3_1	624	631	PF00069	0.613
MOD_GSK3_1	638	645	PF00069	0.558
MOD_GSK3_1	679	686	PF00069	0.657
MOD_GSK3_1	696	703	PF00069	0.639
MOD_GSK3_1	711	718	PF00069	0.629
MOD_GSK3_1	736	743	PF00069	0.662
MOD_GSK3_1	745	752	PF00069	0.706
MOD_GSK3_1	760	767	PF00069	0.602
MOD_GSK3_1	772	779	PF00069	0.605
MOD_GSK3_1	804	811	PF00069	0.622
MOD_GSK3_1	851	858	PF00069	0.547
MOD_N-GLC_1	126	131	PF02516	0.718
MOD_N-GLC_1	198	203	PF02516	0.739
MOD_N-GLC_1	468	473	PF02516	0.578
MOD_N-GLC_1	518	523	PF02516	0.639
MOD_N-GLC_1	754	759	PF02516	0.748
MOD_N-GLC_1	808	813	PF02516	0.558
MOD_N-GLC_1	846	851	PF02516	0.551
MOD_NEK2_1	102	107	PF00069	0.575
MOD_NEK2_1	202	207	PF00069	0.631
MOD_NEK2_1	267	272	PF00069	0.495
MOD_NEK2_1	417	422	PF00069	0.651
MOD_NEK2_1	427	432	PF00069	0.505
MOD_NEK2_1	563	568	PF00069	0.757
MOD_NEK2_1	661	666	PF00069	0.601
MOD_NEK2_1	68	73	PF00069	0.576
MOD_NEK2_1	683	688	PF00069	0.602
MOD_NEK2_1	726	731	PF00069	0.786
MOD_NEK2_1	805	810	PF00069	0.552
MOD_NEK2_1	836	841	PF00069	0.732
MOD_NEK2_2	769	774	PF00069	0.725
MOD_PIKK_1	115	121	PF00454	0.648
MOD_PIKK_1	245	251	PF00454	0.662
MOD_PIKK_1	252	258	PF00454	0.662
MOD_PIKK_1	483	489	PF00454	0.573
MOD_PIKK_1	563	569	PF00454	0.751
MOD_PIKK_1	653	659	PF00454	0.587
MOD_PIKK_1	741	747	PF00454	0.574
MOD_PK_1	278	284	PF00069	0.579
MOD_PK_1	671	677	PF00069	0.764
MOD_PKA_1	212	218	PF00069	0.735
MOD_PKA_1	245	251	PF00069	0.741
MOD_PKA_1	278	284	PF00069	0.404
MOD_PKA_1	457	463	PF00069	0.766
MOD_PKA_1	618	624	PF00069	0.585
MOD_PKA_1	638	644	PF00069	0.658
MOD_PKA_1	671	677	PF00069	0.764
MOD_PKA_1	701	707	PF00069	0.747
MOD_PKA_1	760	766	PF00069	0.754
MOD_PKA_1	84	90	PF00069	0.582
MOD_PKA_2	102	108	PF00069	0.754
MOD_PKA_2	14	20	PF00069	0.610
MOD_PKA_2	197	203	PF00069	0.606
MOD_PKA_2	212	218	PF00069	0.694
MOD_PKA_2	221	227	PF00069	0.624
MOD_PKA_2	245	251	PF00069	0.720
MOD_PKA_2	26	32	PF00069	0.617
MOD_PKA_2	278	284	PF00069	0.404
MOD_PKA_2	325	331	PF00069	0.594
MOD_PKA_2	457	463	PF00069	0.769
MOD_PKA_2	530	536	PF00069	0.667
MOD_PKA_2	563	569	PF00069	0.808
MOD_PKA_2	587	593	PF00069	0.791
MOD_PKA_2	618	624	PF00069	0.600
MOD_PKA_2	638	644	PF00069	0.692
MOD_PKA_2	671	677	PF00069	0.764
MOD_PKA_2	696	702	PF00069	0.740
MOD_PKA_2	710	716	PF00069	0.616
MOD_PKA_2	734	740	PF00069	0.701
MOD_PKA_2	760	766	PF00069	0.754
MOD_PKA_2	805	811	PF00069	0.559
MOD_PKA_2	820	826	PF00069	0.595
MOD_PKA_2	83	89	PF00069	0.585
MOD_PKB_1	276	284	PF00069	0.447
MOD_PKB_1	760	768	PF00069	0.580
MOD_Plk_1	198	204	PF00069	0.749
MOD_Plk_1	285	291	PF00069	0.549
MOD_Plk_1	791	797	PF00069	0.516
MOD_Plk_1	815	821	PF00069	0.604
MOD_Plk_4	110	116	PF00069	0.577
MOD_Plk_4	118	124	PF00069	0.562
MOD_Plk_4	285	291	PF00069	0.549
MOD_Plk_4	679	685	PF00069	0.584
MOD_ProDKin_1	113	119	PF00069	0.800
MOD_ProDKin_1	179	185	PF00069	0.773
MOD_ProDKin_1	262	268	PF00069	0.498
MOD_ProDKin_1	362	368	PF00069	0.487
MOD_ProDKin_1	47	53	PF00069	0.635
MOD_ProDKin_1	475	481	PF00069	0.717
MOD_ProDKin_1	489	495	PF00069	0.530
MOD_ProDKin_1	509	515	PF00069	0.641
MOD_ProDKin_1	612	618	PF00069	0.591
MOD_ProDKin_1	621	627	PF00069	0.558
MOD_ProDKin_1	704	710	PF00069	0.770
MOD_ProDKin_1	736	742	PF00069	0.771
MOD_ProDKin_1	745	751	PF00069	0.692
MOD_ProDKin_1	754	760	PF00069	0.593
MOD_ProDKin_1	809	815	PF00069	0.539
MOD_SUMO_for_1	400	403	PF00179	0.398
MOD_SUMO_rev_2	403	413	PF00179	0.553
MOD_SUMO_rev_2	566	572	PF00179	0.575
MOD_SUMO_rev_2	77	87	PF00179	0.581
TRG_DiLeu_BaEn_1	403	408	PF01217	0.560
TRG_DiLeu_BaLyEn_6	827	832	PF01217	0.709
TRG_DiLeu_LyEn_5	403	408	PF01217	0.560
TRG_ENDOCYTIC_2	419	422	PF00928	0.602
TRG_ENDOCYTIC_2	53	56	PF00928	0.565
TRG_ER_diArg_1	13	16	PF00400	0.589
TRG_ER_diArg_1	172	175	PF00400	0.579
TRG_ER_diArg_1	245	247	PF00400	0.741
TRG_ER_diArg_1	404	407	PF00400	0.563
TRG_ER_diArg_1	450	452	PF00400	0.688
TRG_ER_diArg_1	457	459	PF00400	0.754
TRG_ER_diArg_1	670	672	PF00400	0.819
TRG_ER_diArg_1	677	679	PF00400	0.716
TRG_ER_diArg_1	760	762	PF00400	0.589
TRG_ER_diArg_1	780	783	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.769

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJI6	Leishmania donovani	55%	100%
A4HXJ7	Leishmania infantum	56%	100%
E9AR92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4QE71	Leishmania major	56%	98%