Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H973_LEIBR

TriTrypDb:

LbrM.17.1290 , LBRM2903_170020000

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H973

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H973

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	557	561	PF00656	0.580
CLV_C14_Caspase3-7	679	683	PF00656	0.664
CLV_MEL_PAP_1	487	493	PF00089	0.370
CLV_NRD_NRD_1	107	109	PF00675	0.663
CLV_NRD_NRD_1	489	491	PF00675	0.616
CLV_NRD_NRD_1	612	614	PF00675	0.670
CLV_NRD_NRD_1	720	722	PF00675	0.711
CLV_NRD_NRD_1	830	832	PF00675	0.531
CLV_NRD_NRD_1	837	839	PF00675	0.547
CLV_NRD_NRD_1	884	886	PF00675	0.629
CLV_PCSK_FUR_1	718	722	PF00082	0.665
CLV_PCSK_KEX2_1	107	109	PF00082	0.663
CLV_PCSK_KEX2_1	488	490	PF00082	0.623
CLV_PCSK_KEX2_1	612	614	PF00082	0.635
CLV_PCSK_KEX2_1	718	720	PF00082	0.714
CLV_PCSK_KEX2_1	830	832	PF00082	0.531
CLV_PCSK_KEX2_1	837	839	PF00082	0.547
CLV_PCSK_KEX2_1	883	885	PF00082	0.631
CLV_PCSK_PC7_1	484	490	PF00082	0.643
CLV_PCSK_PC7_1	608	614	PF00082	0.582
CLV_PCSK_PC7_1	880	886	PF00082	0.576
CLV_PCSK_SKI1_1	264	268	PF00082	0.580
CLV_PCSK_SKI1_1	369	373	PF00082	0.511
CLV_PCSK_SKI1_1	446	450	PF00082	0.533
CLV_PCSK_SKI1_1	484	488	PF00082	0.515
CLV_PCSK_SKI1_1	552	556	PF00082	0.468
CLV_PCSK_SKI1_1	651	655	PF00082	0.642
CLV_PCSK_SKI1_1	663	667	PF00082	0.521
CLV_PCSK_SKI1_1	68	72	PF00082	0.404
CLV_PCSK_SKI1_1	812	816	PF00082	0.554
CLV_PCSK_SKI1_1	830	834	PF00082	0.583
CLV_PCSK_SKI1_1	898	902	PF00082	0.608
DEG_ODPH_VHL_1	249	262	PF01847	0.551
DEG_SCF_FBW7_1	759	766	PF00400	0.597
DEG_SPOP_SBC_1	49	53	PF00917	0.575
DEG_SPOP_SBC_1	534	538	PF00917	0.544
DEG_SPOP_SBC_1	795	799	PF00917	0.541
DOC_CDC14_PxL_1	137	145	PF14671	0.540
DOC_CYCLIN_yCln2_LP_2	289	292	PF00134	0.575
DOC_MAPK_MEF2A_6	298	307	PF00069	0.554
DOC_MAPK_MEF2A_6	40	47	PF00069	0.539
DOC_MAPK_MEF2A_6	502	510	PF00069	0.408
DOC_MAPK_MEF2A_6	590	597	PF00069	0.557
DOC_MAPK_MEF2A_6	68	76	PF00069	0.420
DOC_MAPK_RevD_3	708	721	PF00069	0.561
DOC_PP1_RVXF_1	449	456	PF00149	0.386
DOC_PP2B_LxvP_1	289	292	PF13499	0.621
DOC_PP2B_LxvP_1	710	713	PF13499	0.540
DOC_PP4_FxxP_1	418	421	PF00568	0.513
DOC_SPAK_OSR1_1	646	650	PF12202	0.542
DOC_USP7_MATH_1	127	131	PF00917	0.607
DOC_USP7_MATH_1	142	146	PF00917	0.579
DOC_USP7_MATH_1	195	199	PF00917	0.581
DOC_USP7_MATH_1	281	285	PF00917	0.602
DOC_USP7_MATH_1	329	333	PF00917	0.761
DOC_USP7_MATH_1	382	386	PF00917	0.580
DOC_USP7_MATH_1	388	392	PF00917	0.563
DOC_USP7_MATH_1	475	479	PF00917	0.442
DOC_USP7_MATH_1	534	538	PF00917	0.544
DOC_USP7_MATH_1	554	558	PF00917	0.423
DOC_USP7_MATH_1	561	565	PF00917	0.506
DOC_USP7_MATH_1	588	592	PF00917	0.790
DOC_USP7_MATH_1	625	629	PF00917	0.704
DOC_USP7_MATH_1	640	644	PF00917	0.564
DOC_USP7_MATH_1	665	669	PF00917	0.651
DOC_USP7_MATH_1	690	694	PF00917	0.571
DOC_USP7_MATH_1	782	786	PF00917	0.599
DOC_USP7_MATH_1	795	799	PF00917	0.541
DOC_USP7_MATH_1	82	86	PF00917	0.603
DOC_USP7_MATH_1	896	900	PF00917	0.642
DOC_USP7_MATH_1	99	103	PF00917	0.495
DOC_WW_Pin1_4	18	23	PF00397	0.458
DOC_WW_Pin1_4	226	231	PF00397	0.651
DOC_WW_Pin1_4	28	33	PF00397	0.569
DOC_WW_Pin1_4	325	330	PF00397	0.784
DOC_WW_Pin1_4	378	383	PF00397	0.567
DOC_WW_Pin1_4	538	543	PF00397	0.504
DOC_WW_Pin1_4	570	575	PF00397	0.719
DOC_WW_Pin1_4	579	584	PF00397	0.622
DOC_WW_Pin1_4	759	764	PF00397	0.630
LIG_14-3-3_CanoR_1	107	116	PF00244	0.663
LIG_14-3-3_CanoR_1	144	148	PF00244	0.512
LIG_14-3-3_CanoR_1	162	167	PF00244	0.497
LIG_14-3-3_CanoR_1	274	282	PF00244	0.561
LIG_14-3-3_CanoR_1	417	421	PF00244	0.505
LIG_14-3-3_CanoR_1	533	542	PF00244	0.605
LIG_14-3-3_CanoR_1	720	728	PF00244	0.631
LIG_14-3-3_CanoR_1	830	839	PF00244	0.544
LIG_14-3-3_CanoR_1	873	879	PF00244	0.548
LIG_14-3-3_CanoR_1	898	903	PF00244	0.574
LIG_APCC_Cbox_2	909	915	PF00515	0.614
LIG_BRCT_BRCA1_1	414	418	PF00533	0.583
LIG_BRCT_BRCA1_1	671	675	PF00533	0.545
LIG_BRCT_BRCA1_1	796	800	PF00533	0.549
LIG_Clathr_ClatBox_1	594	598	PF01394	0.546
LIG_EVH1_1	290	294	PF00568	0.572
LIG_FHA_1	111	117	PF00498	0.578
LIG_FHA_1	166	172	PF00498	0.594
LIG_FHA_1	179	185	PF00498	0.524
LIG_FHA_1	195	201	PF00498	0.530
LIG_FHA_1	255	261	PF00498	0.568
LIG_FHA_1	440	446	PF00498	0.454
LIG_FHA_1	69	75	PF00498	0.575
LIG_FHA_1	723	729	PF00498	0.562
LIG_FHA_1	831	837	PF00498	0.592
LIG_FHA_2	370	376	PF00498	0.571
LIG_FHA_2	388	394	PF00498	0.609
LIG_FHA_2	50	56	PF00498	0.530
LIG_GSK3_LRP6_1	226	231	PF00069	0.560
LIG_Integrin_RGD_1	866	868	PF01839	0.499
LIG_LIR_Apic_2	415	421	PF02991	0.545
LIG_LIR_Apic_2	877	882	PF02991	0.589
LIG_LIR_Gen_1	197	207	PF02991	0.549
LIG_LIR_Gen_1	563	574	PF02991	0.562
LIG_LIR_Gen_1	743	752	PF02991	0.611
LIG_LIR_Nem_3	197	202	PF02991	0.554
LIG_LIR_Nem_3	563	569	PF02991	0.556
LIG_LIR_Nem_3	743	747	PF02991	0.612
LIG_MYND_1	287	291	PF01753	0.638
LIG_PDZ_Class_3	917	922	PF00595	0.538
LIG_SH2_CRK	224	228	PF00017	0.566
LIG_SH2_CRK	879	883	PF00017	0.651
LIG_SH2_GRB2like	566	569	PF00017	0.568
LIG_SH2_NCK_1	224	228	PF00017	0.566
LIG_SH2_SRC	224	227	PF00017	0.569
LIG_SH2_STAP1	120	124	PF00017	0.631
LIG_SH2_STAP1	50	54	PF00017	0.439
LIG_SH2_STAP1	699	703	PF00017	0.533
LIG_SH2_STAT5	155	158	PF00017	0.700
LIG_SH2_STAT5	50	53	PF00017	0.445
LIG_SH3_1	224	230	PF00018	0.564
LIG_SH3_2	227	232	PF14604	0.564
LIG_SH3_2	293	298	PF14604	0.563
LIG_SH3_3	157	163	PF00018	0.566
LIG_SH3_3	16	22	PF00018	0.551
LIG_SH3_3	217	223	PF00018	0.568
LIG_SH3_3	224	230	PF00018	0.546
LIG_SH3_3	285	291	PF00018	0.768
LIG_SH3_3	314	320	PF00018	0.595
LIG_SH3_3	332	338	PF00018	0.718
LIG_SH3_3	514	520	PF00018	0.628
LIG_SH3_3	536	542	PF00018	0.514
LIG_SH3_3	571	577	PF00018	0.747
LIG_SH3_3	580	586	PF00018	0.672
LIG_SH3_3	823	829	PF00018	0.519
LIG_SH3_3	83	89	PF00018	0.624
LIG_SUMO_SIM_anti_2	197	204	PF11976	0.553
LIG_SUMO_SIM_anti_2	44	49	PF11976	0.548
LIG_SUMO_SIM_anti_2	505	511	PF11976	0.512
LIG_SUMO_SIM_par_1	111	117	PF11976	0.487
LIG_SUMO_SIM_par_1	12	18	PF11976	0.566
LIG_SUMO_SIM_par_1	593	598	PF11976	0.547
LIG_SUMO_SIM_par_1	776	781	PF11976	0.564
LIG_TRAF2_1	338	341	PF00917	0.647
LIG_TRAF2_1	373	376	PF00917	0.530
LIG_TRAF2_1	64	67	PF00917	0.535
LIG_TRAF2_1	75	78	PF00917	0.499
LIG_TRAF2_1	825	828	PF00917	0.547
LIG_WRC_WIRS_1	196	201	PF05994	0.553
LIG_WRC_WIRS_1	555	560	PF05994	0.490
LIG_WW_2	293	296	PF00397	0.717
LIG_WW_3	573	577	PF00397	0.571
MOD_CDC14_SPxK_1	229	232	PF00782	0.661
MOD_CDC14_SPxK_1	573	576	PF00782	0.574
MOD_CDK_SPK_2	538	543	PF00069	0.504
MOD_CDK_SPxK_1	226	232	PF00069	0.654
MOD_CDK_SPxK_1	570	576	PF00069	0.572
MOD_CDK_SPxK_1	759	765	PF00069	0.544
MOD_CK1_1	102	108	PF00069	0.602
MOD_CK1_1	112	118	PF00069	0.495
MOD_CK1_1	130	136	PF00069	0.644
MOD_CK1_1	165	171	PF00069	0.705
MOD_CK1_1	242	248	PF00069	0.621
MOD_CK1_1	253	259	PF00069	0.678
MOD_CK1_1	275	281	PF00069	0.708
MOD_CK1_1	30	36	PF00069	0.666
MOD_CK1_1	535	541	PF00069	0.655
MOD_CK1_1	564	570	PF00069	0.720
MOD_CK1_1	645	651	PF00069	0.635
MOD_CK1_1	652	658	PF00069	0.609
MOD_CK1_1	683	689	PF00069	0.714
MOD_CK1_1	724	730	PF00069	0.710
MOD_CK1_1	743	749	PF00069	0.680
MOD_CK1_1	781	787	PF00069	0.706
MOD_CK1_1	798	804	PF00069	0.576
MOD_CK1_1	818	824	PF00069	0.494
MOD_CK1_1	845	851	PF00069	0.523
MOD_CK1_1	894	900	PF00069	0.584
MOD_CK2_1	28	34	PF00069	0.506
MOD_CK2_1	369	375	PF00069	0.505
MOD_CK2_1	388	394	PF00069	0.613
MOD_CK2_1	559	565	PF00069	0.674
MOD_CK2_1	665	671	PF00069	0.514
MOD_CK2_1	72	78	PF00069	0.445
MOD_CK2_1	818	824	PF00069	0.575
MOD_Cter_Amidation	610	613	PF01082	0.652
MOD_GlcNHglycan	101	105	PF01048	0.502
MOD_GlcNHglycan	129	132	PF01048	0.515
MOD_GlcNHglycan	244	247	PF01048	0.611
MOD_GlcNHglycan	34	38	PF01048	0.483
MOD_GlcNHglycan	401	404	PF01048	0.727
MOD_GlcNHglycan	414	417	PF01048	0.639
MOD_GlcNHglycan	477	480	PF01048	0.503
MOD_GlcNHglycan	521	524	PF01048	0.783
MOD_GlcNHglycan	604	607	PF01048	0.640
MOD_GlcNHglycan	609	612	PF01048	0.542
MOD_GlcNHglycan	671	674	PF01048	0.628
MOD_GlcNHglycan	682	685	PF01048	0.733
MOD_GlcNHglycan	692	695	PF01048	0.667
MOD_GlcNHglycan	732	735	PF01048	0.603
MOD_GlcNHglycan	773	776	PF01048	0.625
MOD_GlcNHglycan	780	783	PF01048	0.624
MOD_GlcNHglycan	817	820	PF01048	0.601
MOD_GlcNHglycan	82	85	PF01048	0.621
MOD_GlcNHglycan	893	896	PF01048	0.664
MOD_GlcNHglycan	898	901	PF01048	0.632
MOD_GSK3_1	108	115	PF00069	0.507
MOD_GSK3_1	165	172	PF00069	0.679
MOD_GSK3_1	174	181	PF00069	0.582
MOD_GSK3_1	234	241	PF00069	0.568
MOD_GSK3_1	24	31	PF00069	0.632
MOD_GSK3_1	250	257	PF00069	0.583
MOD_GSK3_1	260	267	PF00069	0.590
MOD_GSK3_1	272	279	PF00069	0.569
MOD_GSK3_1	325	332	PF00069	0.774
MOD_GSK3_1	347	354	PF00069	0.595
MOD_GSK3_1	378	385	PF00069	0.680
MOD_GSK3_1	388	395	PF00069	0.680
MOD_GSK3_1	412	419	PF00069	0.615
MOD_GSK3_1	534	541	PF00069	0.602
MOD_GSK3_1	560	567	PF00069	0.641
MOD_GSK3_1	638	645	PF00069	0.712
MOD_GSK3_1	649	656	PF00069	0.543
MOD_GSK3_1	665	672	PF00069	0.542
MOD_GSK3_1	676	683	PF00069	0.699
MOD_GSK3_1	68	75	PF00069	0.484
MOD_GSK3_1	722	729	PF00069	0.713
MOD_GSK3_1	730	737	PF00069	0.596
MOD_GSK3_1	759	766	PF00069	0.627
MOD_GSK3_1	767	774	PF00069	0.593
MOD_GSK3_1	778	785	PF00069	0.680
MOD_GSK3_1	794	801	PF00069	0.551
MOD_GSK3_1	814	821	PF00069	0.553
MOD_GSK3_1	894	901	PF00069	0.635
MOD_N-GLC_1	329	334	PF02516	0.745
MOD_N-GLC_1	388	393	PF02516	0.601
MOD_N-GLC_1	567	572	PF02516	0.569
MOD_N-GLC_1	99	104	PF02516	0.626
MOD_NEK2_1	136	141	PF00069	0.647
MOD_NEK2_1	143	148	PF00069	0.652
MOD_NEK2_1	178	183	PF00069	0.562
MOD_NEK2_1	282	287	PF00069	0.572
MOD_NEK2_1	392	397	PF00069	0.690
MOD_NEK2_1	508	513	PF00069	0.571
MOD_NEK2_1	532	537	PF00069	0.553
MOD_NEK2_1	653	658	PF00069	0.542
MOD_NEK2_1	72	77	PF00069	0.566
MOD_NEK2_1	764	769	PF00069	0.658
MOD_NEK2_1	780	785	PF00069	0.519
MOD_NEK2_1	796	801	PF00069	0.547
MOD_NEK2_1	815	820	PF00069	0.555
MOD_NEK2_1	886	891	PF00069	0.605
MOD_NEK2_2	554	559	PF00069	0.480
MOD_OFUCOSY	802	807	PF10250	0.537
MOD_PIKK_1	162	168	PF00454	0.545
MOD_PIKK_1	250	256	PF00454	0.699
MOD_PIKK_1	397	403	PF00454	0.596
MOD_PIKK_1	416	422	PF00454	0.504
MOD_PIKK_1	508	514	PF00454	0.553
MOD_PKA_1	830	836	PF00069	0.534
MOD_PKA_1	837	843	PF00069	0.550
MOD_PKA_2	143	149	PF00069	0.513
MOD_PKA_2	273	279	PF00069	0.568
MOD_PKA_2	416	422	PF00069	0.462
MOD_PKA_2	439	445	PF00069	0.493
MOD_PKA_2	455	461	PF00069	0.399
MOD_PKA_2	532	538	PF00069	0.639
MOD_PKA_2	607	613	PF00069	0.596
MOD_PKA_2	638	644	PF00069	0.571
MOD_PKA_2	645	651	PF00069	0.524
MOD_PKA_2	722	728	PF00069	0.725
MOD_PKA_2	764	770	PF00069	0.585
MOD_PKA_2	830	836	PF00069	0.534
MOD_PKA_2	837	843	PF00069	0.550
MOD_PKB_1	719	727	PF00069	0.589
MOD_Plk_1	116	122	PF00069	0.479
MOD_Plk_1	33	39	PF00069	0.478
MOD_Plk_1	388	394	PF00069	0.600
MOD_Plk_1	649	655	PF00069	0.652
MOD_Plk_4	143	149	PF00069	0.668
MOD_Plk_4	169	175	PF00069	0.573
MOD_Plk_4	195	201	PF00069	0.545
MOD_Plk_4	239	245	PF00069	0.672
MOD_Plk_4	671	677	PF00069	0.545
MOD_Plk_4	740	746	PF00069	0.608
MOD_Plk_4	82	88	PF00069	0.487
MOD_Plk_4	874	880	PF00069	0.562
MOD_ProDKin_1	18	24	PF00069	0.457
MOD_ProDKin_1	226	232	PF00069	0.654
MOD_ProDKin_1	28	34	PF00069	0.568
MOD_ProDKin_1	325	331	PF00069	0.784
MOD_ProDKin_1	378	384	PF00069	0.568
MOD_ProDKin_1	538	544	PF00069	0.502
MOD_ProDKin_1	570	576	PF00069	0.720
MOD_ProDKin_1	579	585	PF00069	0.622
MOD_ProDKin_1	759	765	PF00069	0.633
MOD_SUMO_for_1	373	376	PF00179	0.530
MOD_SUMO_for_1	523	526	PF00179	0.528
MOD_SUMO_for_1	704	707	PF00179	0.535
MOD_SUMO_rev_2	340	345	PF00179	0.558
TRG_DiLeu_BaEn_1	505	510	PF01217	0.447
TRG_DiLeu_BaEn_2	670	676	PF01217	0.542
TRG_DiLeu_BaEn_4	340	346	PF01217	0.641
TRG_DiLeu_BaEn_4	465	471	PF01217	0.542
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.575
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.490
TRG_ENDOCYTIC_2	566	569	PF00928	0.568
TRG_ER_diArg_1	487	490	PF00400	0.638
TRG_ER_diArg_1	612	614	PF00400	0.671
TRG_ER_diArg_1	644	647	PF00400	0.559
TRG_ER_diArg_1	717	720	PF00400	0.713
TRG_ER_diArg_1	829	831	PF00400	0.527
TRG_ER_diArg_1	836	838	PF00400	0.544
TRG_ER_diArg_1	882	885	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	858	862	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUT3	Leishmania donovani	59%	100%
A4HXJ5	Leishmania infantum	59%	100%
E9AR90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4QE73	Leishmania major	55%	100%