Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H972_LEIBR

TriTrypDb:

LbrM.17.1280 , LBRM2903_170019900

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H972

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H972

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.731
CLV_C14_Caspase3-7	59	63	PF00656	0.548
CLV_NRD_NRD_1	145	147	PF00675	0.751
CLV_NRD_NRD_1	188	190	PF00675	0.580
CLV_NRD_NRD_1	201	203	PF00675	0.546
CLV_NRD_NRD_1	549	551	PF00675	0.723
CLV_NRD_NRD_1	556	558	PF00675	0.629
CLV_NRD_NRD_1	588	590	PF00675	0.728
CLV_PCSK_FUR_1	143	147	PF00082	0.652
CLV_PCSK_KEX2_1	143	145	PF00082	0.625
CLV_PCSK_KEX2_1	19	21	PF00082	0.579
CLV_PCSK_KEX2_1	201	203	PF00082	0.635
CLV_PCSK_KEX2_1	205	207	PF00082	0.687
CLV_PCSK_KEX2_1	366	368	PF00082	0.583
CLV_PCSK_KEX2_1	556	558	PF00082	0.650
CLV_PCSK_KEX2_1	588	590	PF00082	0.728
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.499
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.718
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.583
CLV_PCSK_PC7_1	201	207	PF00082	0.586
CLV_PCSK_SKI1_1	249	253	PF00082	0.794
CLV_PCSK_SKI1_1	374	378	PF00082	0.559
CLV_PCSK_SKI1_1	589	593	PF00082	0.513
CLV_PCSK_SKI1_1	7	11	PF00082	0.573
CLV_PCSK_SKI1_1	84	88	PF00082	0.548
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DEG_SPOP_SBC_1	219	223	PF00917	0.672
DEG_SPOP_SBC_1	382	386	PF00917	0.700
DOC_CKS1_1	535	540	PF01111	0.498
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	592	598	PF00134	0.547
DOC_MAPK_DCC_7	254	263	PF00069	0.733
DOC_MAPK_gen_1	19	27	PF00069	0.499
DOC_MAPK_gen_1	91	99	PF00069	0.492
DOC_MAPK_MEF2A_6	254	263	PF00069	0.733
DOC_MAPK_MEF2A_6	93	101	PF00069	0.482
DOC_PP2B_LxvP_1	123	126	PF13499	0.764
DOC_PP2B_LxvP_1	450	453	PF13499	0.548
DOC_USP7_MATH_1	167	171	PF00917	0.609
DOC_USP7_MATH_1	211	215	PF00917	0.776
DOC_USP7_MATH_1	316	320	PF00917	0.637
DOC_USP7_MATH_1	382	386	PF00917	0.788
DOC_USP7_MATH_1	397	401	PF00917	0.556
DOC_USP7_MATH_1	403	407	PF00917	0.669
DOC_USP7_MATH_1	51	55	PF00917	0.571
DOC_USP7_UBL2_3	362	366	PF12436	0.589
DOC_WW_Pin1_4	279	284	PF00397	0.837
DOC_WW_Pin1_4	351	356	PF00397	0.861
DOC_WW_Pin1_4	360	365	PF00397	0.709
DOC_WW_Pin1_4	534	539	PF00397	0.506
LIG_14-3-3_CanoR_1	159	164	PF00244	0.714
LIG_14-3-3_CanoR_1	346	356	PF00244	0.691
LIG_14-3-3_CanoR_1	374	382	PF00244	0.580
LIG_14-3-3_CanoR_1	399	403	PF00244	0.657
LIG_14-3-3_CanoR_1	429	435	PF00244	0.619
LIG_14-3-3_CanoR_1	459	466	PF00244	0.771
LIG_14-3-3_CanoR_1	484	488	PF00244	0.474
LIG_14-3-3_CanoR_1	570	575	PF00244	0.664
LIG_14-3-3_CanoR_1	84	89	PF00244	0.537
LIG_BIR_III_4	412	416	PF00653	0.701
LIG_BRCT_BRCA1_1	601	605	PF00533	0.741
LIG_CSL_BTD_1	379	382	PF09270	0.547
LIG_FHA_1	1	7	PF00498	0.750
LIG_FHA_1	183	189	PF00498	0.669
LIG_FHA_1	221	227	PF00498	0.685
LIG_FHA_1	452	458	PF00498	0.561
LIG_FHA_1	468	474	PF00498	0.654
LIG_FHA_1	543	549	PF00498	0.607
LIG_FHA_1	573	579	PF00498	0.439
LIG_FHA_1	591	597	PF00498	0.445
LIG_FHA_1	83	89	PF00498	0.654
LIG_FHA_2	327	333	PF00498	0.608
LIG_FHA_2	453	459	PF00498	0.817
LIG_FHA_2	522	528	PF00498	0.516
LIG_FHA_2	571	577	PF00498	0.437
LIG_FHA_2	85	91	PF00498	0.564
LIG_HP1_1	259	263	PF01393	0.730
LIG_Integrin_isoDGR_2	196	198	PF01839	0.588
LIG_LIR_Gen_1	114	125	PF02991	0.751
LIG_LIR_Gen_1	303	312	PF02991	0.550
LIG_LIR_Nem_3	105	111	PF02991	0.693
LIG_LIR_Nem_3	114	120	PF02991	0.676
LIG_LIR_Nem_3	303	308	PF02991	0.550
LIG_NRBOX	543	549	PF00104	0.748
LIG_PDZ_Class_1	604	609	PF00595	0.523
LIG_SH2_NCK_1	518	522	PF00017	0.495
LIG_SH2_SRC	286	289	PF00017	0.793
LIG_SH2_STAP1	505	509	PF00017	0.710
LIG_SH3_3	253	259	PF00018	0.778
LIG_SH3_3	286	292	PF00018	0.781
LIG_SH3_3	330	336	PF00018	0.653
LIG_SH3_3	460	466	PF00018	0.527
LIG_SH3_3	530	536	PF00018	0.802
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.509
LIG_SUMO_SIM_par_1	384	392	PF11976	0.536
LIG_TRAF2_1	488	491	PF00917	0.716
MOD_CDK_SPxK_1	360	366	PF00069	0.590
MOD_CDK_SPxxK_3	360	367	PF00069	0.734
MOD_CK1_1	157	163	PF00069	0.625
MOD_CK1_1	170	176	PF00069	0.587
MOD_CK1_1	214	220	PF00069	0.687
MOD_CK1_1	303	309	PF00069	0.784
MOD_CK1_1	354	360	PF00069	0.860
MOD_CK1_1	375	381	PF00069	0.755
MOD_CK1_1	386	392	PF00069	0.556
MOD_CK1_1	398	404	PF00069	0.585
MOD_CK1_1	430	436	PF00069	0.701
MOD_CK1_1	534	540	PF00069	0.531
MOD_CK1_1	54	60	PF00069	0.584
MOD_CK2_1	316	322	PF00069	0.667
MOD_CK2_1	326	332	PF00069	0.582
MOD_CK2_1	452	458	PF00069	0.742
MOD_CK2_1	516	522	PF00069	0.561
MOD_CK2_1	570	576	PF00069	0.439
MOD_GlcNHglycan	165	168	PF01048	0.564
MOD_GlcNHglycan	245	248	PF01048	0.568
MOD_GlcNHglycan	36	40	PF01048	0.787
MOD_GlcNHglycan	391	394	PF01048	0.740
MOD_GlcNHglycan	416	419	PF01048	0.567
MOD_GlcNHglycan	601	604	PF01048	0.772
MOD_GlcNHglycan	75	78	PF01048	0.706
MOD_GSK3_1	153	160	PF00069	0.607
MOD_GSK3_1	163	170	PF00069	0.621
MOD_GSK3_1	188	195	PF00069	0.821
MOD_GSK3_1	211	218	PF00069	0.700
MOD_GSK3_1	300	307	PF00069	0.758
MOD_GSK3_1	312	319	PF00069	0.628
MOD_GSK3_1	347	354	PF00069	0.736
MOD_GSK3_1	35	42	PF00069	0.798
MOD_GSK3_1	382	389	PF00069	0.695
MOD_GSK3_1	403	410	PF00069	0.607
MOD_GSK3_1	493	500	PF00069	0.484
MOD_GSK3_1	51	58	PF00069	0.555
MOD_GSK3_1	82	89	PF00069	0.694
MOD_N-GLC_1	358	363	PF02516	0.595
MOD_N-GLC_1	403	408	PF02516	0.568
MOD_N-GLC_1	430	435	PF02516	0.555
MOD_N-GLC_1	599	604	PF02516	0.675
MOD_NEK2_1	1	6	PF00069	0.717
MOD_NEK2_1	154	159	PF00069	0.534
MOD_NEK2_1	163	168	PF00069	0.633
MOD_NEK2_1	300	305	PF00069	0.778
MOD_NEK2_1	312	317	PF00069	0.611
MOD_NEK2_1	388	393	PF00069	0.642
MOD_NEK2_1	53	58	PF00069	0.741
MOD_NEK2_2	316	321	PF00069	0.542
MOD_NEK2_2	39	44	PF00069	0.527
MOD_PIKK_1	422	428	PF00454	0.555
MOD_PIKK_1	531	537	PF00454	0.528
MOD_PIKK_1	590	596	PF00454	0.491
MOD_PKA_2	158	164	PF00069	0.651
MOD_PKA_2	188	194	PF00069	0.581
MOD_PKA_2	398	404	PF00069	0.552
MOD_PKA_2	458	464	PF00069	0.809
MOD_PKA_2	483	489	PF00069	0.549
MOD_PKA_2	569	575	PF00069	0.664
MOD_PKB_1	597	605	PF00069	0.516
MOD_Plk_1	118	124	PF00069	0.511
MOD_Plk_1	170	176	PF00069	0.530
MOD_Plk_1	430	436	PF00069	0.556
MOD_Plk_1	542	548	PF00069	0.480
MOD_Plk_4	118	124	PF00069	0.566
MOD_Plk_4	170	176	PF00069	0.799
MOD_Plk_4	383	389	PF00069	0.537
MOD_Plk_4	542	548	PF00069	0.597
MOD_ProDKin_1	279	285	PF00069	0.839
MOD_ProDKin_1	351	357	PF00069	0.861
MOD_ProDKin_1	360	366	PF00069	0.709
MOD_ProDKin_1	534	540	PF00069	0.502
TRG_DiLeu_BaEn_1	543	548	PF01217	0.747
TRG_DiLeu_BaEn_1	587	592	PF01217	0.463
TRG_ENDOCYTIC_2	108	111	PF00928	0.626
TRG_ENDOCYTIC_2	286	289	PF00928	0.702
TRG_ER_diArg_1	143	146	PF00400	0.758
TRG_ER_diArg_1	473	476	PF00400	0.657
TRG_ER_diArg_1	556	558	PF00400	0.650
TRG_ER_diArg_1	596	599	PF00400	0.678
TRG_NES_CRM1_1	543	555	PF08389	0.591
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	589	594	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUL8	Leishmania donovani	55%	100%
A4HXJ4	Leishmania infantum	55%	100%
E9AR89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q4QE74	Leishmania major	54%	99%