UDP-sugar pyrophosphorylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-sugar pyrophosphorylase

Species:

Leishmania braziliensis

UniProt:

A4H971_LEIBR

TriTrypDb:

LbrM.17.1270 , LBRM2903_170019800

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H971

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H971

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	1
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	1
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009225	nucleotide-sugar metabolic process	4	1
GO:0009226	nucleotide-sugar biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046349	amino sugar biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	6	5
GO:0070569	uridylyltransferase activity	5	10
GO:0000166	nucleotide binding	3	1
GO:0002134	UTP binding	4	1
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	6	1
GO:0005488	binding	1	1
GO:0017103	UTP:galactose-1-phosphate uridylyltransferase activity	7	1
GO:0019103	pyrimidine nucleotide binding	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0032553	ribonucleotide binding	3	1
GO:0032557	pyrimidine ribonucleotide binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043763	UTP:glucose-1-phosphate uridylyltransferase regulator activity	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.674
CLV_C14_Caspase3-7	583	587	PF00656	0.401
CLV_C14_Caspase3-7	616	620	PF00656	0.449
CLV_MEL_PAP_1	424	430	PF00089	0.413
CLV_NRD_NRD_1	112	114	PF00675	0.246
CLV_NRD_NRD_1	218	220	PF00675	0.215
CLV_NRD_NRD_1	393	395	PF00675	0.525
CLV_NRD_NRD_1	466	468	PF00675	0.428
CLV_NRD_NRD_1	96	98	PF00675	0.452
CLV_PCSK_KEX2_1	393	395	PF00082	0.525
CLV_PCSK_KEX2_1	465	467	PF00082	0.429
CLV_PCSK_KEX2_1	96	98	PF00082	0.455
CLV_PCSK_SKI1_1	114	118	PF00082	0.235
CLV_PCSK_SKI1_1	466	470	PF00082	0.408
DEG_APCC_DBOX_1	464	472	PF00400	0.409
DEG_COP1_1	375	383	PF00400	0.412
DOC_AGCK_PIF_1	425	430	PF00069	0.323
DOC_ANK_TNKS_1	466	473	PF00023	0.369
DOC_CDC14_PxL_1	88	96	PF14671	0.449
DOC_MAPK_gen_1	113	120	PF00069	0.368
DOC_MAPK_gen_1	465	475	PF00069	0.347
DOC_MAPK_HePTP_8	463	475	PF00069	0.366
DOC_MAPK_MEF2A_6	113	120	PF00069	0.362
DOC_MAPK_MEF2A_6	466	475	PF00069	0.354
DOC_MAPK_MEF2A_6	493	500	PF00069	0.243
DOC_PP2B_LxvP_1	16	19	PF13499	0.287
DOC_PP2B_LxvP_1	186	189	PF13499	0.452
DOC_PP2B_LxvP_1	82	85	PF13499	0.399
DOC_PP4_FxxP_1	383	386	PF00568	0.382
DOC_PP4_FxxP_1	396	399	PF00568	0.483
DOC_PP4_FxxP_1	517	520	PF00568	0.434
DOC_PP4_FxxP_1	89	92	PF00568	0.444
DOC_USP7_MATH_1	250	254	PF00917	0.315
DOC_USP7_MATH_1	288	292	PF00917	0.401
DOC_USP7_MATH_1	303	307	PF00917	0.392
DOC_USP7_MATH_1	332	336	PF00917	0.445
DOC_USP7_MATH_1	4	8	PF00917	0.500
DOC_USP7_MATH_1	577	581	PF00917	0.445
DOC_USP7_MATH_1	611	615	PF00917	0.407
DOC_USP7_MATH_1	624	628	PF00917	0.408
DOC_USP7_UBL2_3	216	220	PF12436	0.431
DOC_WW_Pin1_4	350	355	PF00397	0.460
LIG_14-3-3_CanoR_1	113	117	PF00244	0.515
LIG_14-3-3_CanoR_1	127	137	PF00244	0.480
LIG_14-3-3_CanoR_1	393	397	PF00244	0.525
LIG_14-3-3_CanoR_1	427	431	PF00244	0.321
LIG_14-3-3_CanoR_1	528	532	PF00244	0.298
LIG_14-3-3_CanoR_1	96	104	PF00244	0.328
LIG_Actin_WH2_2	181	197	PF00022	0.469
LIG_Actin_WH2_2	352	367	PF00022	0.440
LIG_Actin_WH2_2	456	471	PF00022	0.406
LIG_AP2alpha_2	319	321	PF02296	0.383
LIG_BIR_II_1	1	5	PF00653	0.441
LIG_BRCT_BRCA1_1	264	268	PF00533	0.354
LIG_CtBP_PxDLS_1	281	285	PF00389	0.282
LIG_EVH1_2	85	89	PF00568	0.433
LIG_FHA_1	107	113	PF00498	0.520
LIG_FHA_1	143	149	PF00498	0.498
LIG_FHA_1	175	181	PF00498	0.442
LIG_FHA_1	275	281	PF00498	0.287
LIG_FHA_1	302	308	PF00498	0.433
LIG_FHA_1	359	365	PF00498	0.266
LIG_FHA_1	528	534	PF00498	0.416
LIG_FHA_1	58	64	PF00498	0.288
LIG_FHA_2	100	106	PF00498	0.513
LIG_FHA_2	167	173	PF00498	0.432
LIG_FHA_2	31	37	PF00498	0.480
LIG_FHA_2	377	383	PF00498	0.297
LIG_FHA_2	421	427	PF00498	0.406
LIG_FHA_2	452	458	PF00498	0.220
LIG_FHA_2	604	610	PF00498	0.411
LIG_GBD_Chelix_1	120	128	PF00786	0.215
LIG_LIR_Apic_2	382	386	PF02991	0.381
LIG_LIR_Apic_2	395	399	PF02991	0.447
LIG_LIR_Apic_2	515	520	PF02991	0.413
LIG_LIR_Gen_1	115	124	PF02991	0.432
LIG_LIR_Gen_1	162	172	PF02991	0.458
LIG_LIR_Gen_1	293	303	PF02991	0.355
LIG_LIR_Gen_1	327	334	PF02991	0.342
LIG_LIR_Gen_1	423	433	PF02991	0.315
LIG_LIR_Gen_1	76	87	PF02991	0.393
LIG_LIR_LC3C_4	529	533	PF02991	0.202
LIG_LIR_Nem_3	115	120	PF02991	0.432
LIG_LIR_Nem_3	145	150	PF02991	0.498
LIG_LIR_Nem_3	293	299	PF02991	0.347
LIG_LIR_Nem_3	327	331	PF02991	0.335
LIG_LIR_Nem_3	350	355	PF02991	0.381
LIG_LIR_Nem_3	423	428	PF02991	0.304
LIG_LIR_Nem_3	429	433	PF02991	0.272
LIG_LIR_Nem_3	457	463	PF02991	0.319
LIG_LIR_Nem_3	76	82	PF02991	0.414
LIG_PTB_Apo_2	322	329	PF02174	0.393
LIG_PTB_Apo_2	382	389	PF02174	0.367
LIG_PTB_Phospho_1	322	328	PF10480	0.386
LIG_PTB_Phospho_1	382	388	PF10480	0.424
LIG_SH2_CRK	130	134	PF00017	0.458
LIG_SH2_CRK	430	434	PF00017	0.286
LIG_SH2_SRC	430	433	PF00017	0.280
LIG_SH2_STAP1	263	267	PF00017	0.282
LIG_SH2_STAP1	369	373	PF00017	0.216
LIG_SH2_STAT3	150	153	PF00017	0.374
LIG_SH2_STAT3	461	464	PF00017	0.405
LIG_SH2_STAT5	147	150	PF00017	0.415
LIG_SH2_STAT5	151	154	PF00017	0.415
LIG_SH2_STAT5	451	454	PF00017	0.312
LIG_SH2_STAT5	561	564	PF00017	0.377
LIG_SH2_STAT5	62	65	PF00017	0.305
LIG_SH3_3	132	138	PF00018	0.458
LIG_SH3_3	275	281	PF00018	0.269
LIG_SH3_3	297	303	PF00018	0.335
LIG_SH3_3	343	349	PF00018	0.466
LIG_SH3_3	550	556	PF00018	0.431
LIG_SUMO_SIM_anti_2	408	417	PF11976	0.306
LIG_SUMO_SIM_par_1	495	501	PF11976	0.285
LIG_SUMO_SIM_par_1	529	534	PF11976	0.312
LIG_TYR_ITIM	128	133	PF00017	0.432
LIG_UBA3_1	309	315	PF00899	0.235
LIG_WRC_WIRS_1	578	583	PF05994	0.362
MOD_CK1_1	170	176	PF00069	0.420
MOD_CK1_1	2	8	PF00069	0.405
MOD_CK1_1	242	248	PF00069	0.421
MOD_CK1_1	358	364	PF00069	0.317
MOD_CK1_1	376	382	PF00069	0.368
MOD_CK1_1	389	395	PF00069	0.496
MOD_CK1_1	436	442	PF00069	0.362
MOD_CK1_1	478	484	PF00069	0.237
MOD_CK1_1	506	512	PF00069	0.372
MOD_CK1_1	580	586	PF00069	0.543
MOD_CK2_1	30	36	PF00069	0.393
MOD_CK2_1	376	382	PF00069	0.312
MOD_CK2_1	420	426	PF00069	0.400
MOD_CK2_1	451	457	PF00069	0.225
MOD_CK2_1	476	482	PF00069	0.452
MOD_CK2_1	99	105	PF00069	0.391
MOD_GlcNHglycan	204	207	PF01048	0.269
MOD_GlcNHglycan	286	289	PF01048	0.338
MOD_GlcNHglycan	438	441	PF01048	0.331
MOD_GlcNHglycan	506	509	PF01048	0.405
MOD_GlcNHglycan	582	585	PF01048	0.497
MOD_GlcNHglycan	613	616	PF01048	0.640
MOD_GlcNHglycan	626	629	PF01048	0.711
MOD_GlcNHglycan	73	76	PF01048	0.548
MOD_GSK3_1	138	145	PF00069	0.463
MOD_GSK3_1	166	173	PF00069	0.434
MOD_GSK3_1	241	248	PF00069	0.614
MOD_GSK3_1	276	283	PF00069	0.298
MOD_GSK3_1	284	291	PF00069	0.338
MOD_GSK3_1	332	339	PF00069	0.360
MOD_GSK3_1	576	583	PF00069	0.436
MOD_GSK3_1	609	616	PF00069	0.623
MOD_GSK3_1	95	102	PF00069	0.497
MOD_N-GLC_1	143	148	PF02516	0.252
MOD_N-GLC_1	232	237	PF02516	0.336
MOD_N-GLC_1	294	299	PF02516	0.287
MOD_N-GLC_1	587	592	PF02516	0.304
MOD_NEK2_1	112	117	PF00069	0.458
MOD_NEK2_1	128	133	PF00069	0.364
MOD_NEK2_1	202	207	PF00069	0.462
MOD_NEK2_1	294	299	PF00069	0.377
MOD_NEK2_1	364	369	PF00069	0.384
MOD_NEK2_1	373	378	PF00069	0.349
MOD_NEK2_1	503	508	PF00069	0.416
MOD_NEK2_1	600	605	PF00069	0.494
MOD_NEK2_2	129	134	PF00069	0.452
MOD_NEK2_2	232	237	PF00069	0.502
MOD_NEK2_2	571	576	PF00069	0.384
MOD_PIKK_1	57	63	PF00454	0.212
MOD_PKA_2	112	118	PF00069	0.427
MOD_PKA_2	347	353	PF00069	0.471
MOD_PKA_2	373	379	PF00069	0.407
MOD_PKA_2	392	398	PF00069	0.609
MOD_PKA_2	426	432	PF00069	0.338
MOD_PKA_2	527	533	PF00069	0.356
MOD_PKA_2	71	77	PF00069	0.501
MOD_PKA_2	95	101	PF00069	0.444
MOD_Plk_1	143	149	PF00069	0.452
MOD_Plk_1	174	180	PF00069	0.525
MOD_Plk_1	232	238	PF00069	0.525
MOD_Plk_1	288	294	PF00069	0.340
MOD_Plk_1	481	487	PF00069	0.438
MOD_Plk_1	600	606	PF00069	0.349
MOD_Plk_1	99	105	PF00069	0.379
MOD_Plk_4	112	118	PF00069	0.432
MOD_Plk_4	143	149	PF00069	0.462
MOD_Plk_4	226	232	PF00069	0.432
MOD_Plk_4	250	256	PF00069	0.364
MOD_Plk_4	262	268	PF00069	0.491
MOD_Plk_4	358	364	PF00069	0.304
MOD_Plk_4	401	407	PF00069	0.300
MOD_Plk_4	420	426	PF00069	0.400
MOD_Plk_4	512	518	PF00069	0.333
MOD_Plk_4	527	533	PF00069	0.424
MOD_Plk_4	603	609	PF00069	0.428
MOD_ProDKin_1	350	356	PF00069	0.448
MOD_SUMO_rev_2	212	218	PF00179	0.357
TRG_AP2beta_CARGO_1	457	467	PF09066	0.366
TRG_DiLeu_BaEn_1	305	310	PF01217	0.308
TRG_DiLeu_BaEn_1	438	443	PF01217	0.313
TRG_DiLeu_BaEn_2	263	269	PF01217	0.337
TRG_DiLeu_LyEn_5	83	88	PF01217	0.447
TRG_ENDOCYTIC_2	130	133	PF00928	0.432
TRG_ENDOCYTIC_2	263	266	PF00928	0.287
TRG_ENDOCYTIC_2	328	331	PF00928	0.342
TRG_ENDOCYTIC_2	430	433	PF00928	0.280
TRG_ER_diArg_1	465	467	PF00400	0.320
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.367
TRG_PTS1	627	630	PF00515	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W2	Leptomonas seymouri	66%	98%
A0A0S4IQX2	Bodo saltans	34%	83%
A0A1X0NSQ3	Trypanosomatidae	50%	100%
A0A3R7KRK2	Trypanosoma rangeli	48%	100%
A0A3S7WUL7	Leishmania donovani	83%	100%
A2YGP6	Oryza sativa subsp. indica	32%	100%
A4HXJ3	Leishmania infantum	83%	100%
E9AR88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q09WE7	Glycine max	34%	100%
Q0GZS3	Cucumis melo	35%	100%
Q4QE75	Leishmania major	84%	100%
Q5W915	Pisum sativum	34%	100%
Q5Z8Y4	Oryza sativa subsp. japonica	32%	100%
Q9C5I1	Arabidopsis thaliana	35%	100%
V5DFP2	Trypanosoma cruzi	49%	100%