LeishMANIAdb
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3-oxo-5-alpha-steroid 4-dehydrogenase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
3-oxo-5-alpha-steroid 4-dehydrogenase-like protein
Gene product:
3-oxo-5-alpha-steroid 4-dehydrogenase-like protein
Species:
Leishmania braziliensis
UniProt:
A4H965_LEIBR
TriTrypDb:
LbrM.17.1210 , LBRM2903_170019000 * , LBRM2903_170019100 *
Length:
539

Annotations

LeishMANIAdb annotations

Related to other eukaryotic steroid 5 alpha reductases. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4H965
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H965

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 7
GO:0008152 metabolic process 1 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity 5 6
GO:0016229 steroid dehydrogenase activity 3 6
GO:0016491 oxidoreductase activity 2 7
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 7
GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors 4 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 85 89 PF00656 0.681
CLV_NRD_NRD_1 298 300 PF00675 0.298
CLV_NRD_NRD_1 359 361 PF00675 0.593
CLV_NRD_NRD_1 530 532 PF00675 0.278
CLV_PCSK_KEX2_1 300 302 PF00082 0.293
CLV_PCSK_KEX2_1 358 360 PF00082 0.594
CLV_PCSK_PC1ET2_1 300 302 PF00082 0.293
CLV_PCSK_PC7_1 296 302 PF00082 0.290
CLV_PCSK_SKI1_1 531 535 PF00082 0.346
CLV_Separin_Metazoa 456 460 PF03568 0.387
DEG_SCF_FBW7_1 286 293 PF00400 0.580
DEG_SPOP_SBC_1 386 390 PF00917 0.603
DEG_SPOP_SBC_1 460 464 PF00917 0.463
DOC_CYCLIN_yCln2_LP_2 233 239 PF00134 0.471
DOC_MAPK_MEF2A_6 125 134 PF00069 0.331
DOC_PP1_RVXF_1 137 143 PF00149 0.424
DOC_PP2B_LxvP_1 134 137 PF13499 0.487
DOC_PP2B_LxvP_1 233 236 PF13499 0.383
DOC_SPAK_OSR1_1 116 120 PF12202 0.512
DOC_USP7_MATH_1 290 294 PF00917 0.674
DOC_USP7_MATH_1 44 48 PF00917 0.244
DOC_USP7_MATH_1 460 464 PF00917 0.463
DOC_WW_Pin1_4 144 149 PF00397 0.367
DOC_WW_Pin1_4 178 183 PF00397 0.416
DOC_WW_Pin1_4 286 291 PF00397 0.693
LIG_14-3-3_CanoR_1 116 122 PF00244 0.411
LIG_14-3-3_CanoR_1 133 137 PF00244 0.336
LIG_14-3-3_CanoR_1 139 143 PF00244 0.327
LIG_14-3-3_CanoR_1 459 469 PF00244 0.411
LIG_14-3-3_CanoR_1 99 103 PF00244 0.444
LIG_Actin_WH2_2 100 118 PF00022 0.512
LIG_BRCT_BRCA1_1 290 294 PF00533 0.598
LIG_BRCT_BRCA1_1 336 340 PF00533 0.512
LIG_BRCT_BRCA1_1 409 413 PF00533 0.227
LIG_BRCT_BRCA1_1 46 50 PF00533 0.244
LIG_BRCT_BRCA1_1 99 103 PF00533 0.524
LIG_deltaCOP1_diTrp_1 58 65 PF00928 0.748
LIG_FHA_1 104 110 PF00498 0.431
LIG_FHA_1 16 22 PF00498 0.411
LIG_FHA_1 328 334 PF00498 0.244
LIG_FHA_1 427 433 PF00498 0.385
LIG_FHA_1 5 11 PF00498 0.448
LIG_FHA_2 449 455 PF00498 0.471
LIG_FHA_2 519 525 PF00498 0.618
LIG_GBD_Chelix_1 449 457 PF00786 0.506
LIG_Integrin_isoDGR_2 257 259 PF01839 0.361
LIG_LIR_Apic_2 228 232 PF02991 0.371
LIG_LIR_Gen_1 111 119 PF02991 0.461
LIG_LIR_Gen_1 18 26 PF02991 0.478
LIG_LIR_Gen_1 251 260 PF02991 0.440
LIG_LIR_Gen_1 410 421 PF02991 0.227
LIG_LIR_Gen_1 429 437 PF02991 0.418
LIG_LIR_Gen_1 464 474 PF02991 0.487
LIG_LIR_Gen_1 524 534 PF02991 0.618
LIG_LIR_Nem_3 111 115 PF02991 0.461
LIG_LIR_Nem_3 160 164 PF02991 0.366
LIG_LIR_Nem_3 18 22 PF02991 0.478
LIG_LIR_Nem_3 201 206 PF02991 0.409
LIG_LIR_Nem_3 251 256 PF02991 0.411
LIG_LIR_Nem_3 351 355 PF02991 0.384
LIG_LIR_Nem_3 410 416 PF02991 0.227
LIG_LIR_Nem_3 427 431 PF02991 0.346
LIG_LIR_Nem_3 463 469 PF02991 0.499
LIG_LIR_Nem_3 498 502 PF02991 0.411
LIG_LIR_Nem_3 524 529 PF02991 0.556
LIG_LYPXL_yS_3 161 164 PF13949 0.486
LIG_NRBOX 214 220 PF00104 0.447
LIG_PCNA_PIPBox_1 249 258 PF02747 0.471
LIG_Pex14_1 323 327 PF04695 0.284
LIG_Pex14_2 294 298 PF04695 0.592
LIG_SH2_CRK 155 159 PF00017 0.278
LIG_SH2_CRK 405 409 PF00017 0.346
LIG_SH2_CRK 526 530 PF00017 0.618
LIG_SH2_PTP2 112 115 PF00017 0.244
LIG_SH2_PTP2 431 434 PF00017 0.346
LIG_SH2_SRC 353 356 PF00017 0.274
LIG_SH2_SRC 431 434 PF00017 0.418
LIG_SH2_STAP1 33 37 PF00017 0.332
LIG_SH2_STAP1 518 522 PF00017 0.618
LIG_SH2_STAT3 73 76 PF00017 0.728
LIG_SH2_STAT5 112 115 PF00017 0.244
LIG_SH2_STAT5 224 227 PF00017 0.365
LIG_SH2_STAT5 24 27 PF00017 0.411
LIG_SH2_STAT5 253 256 PF00017 0.411
LIG_SH2_STAT5 288 291 PF00017 0.695
LIG_SH2_STAT5 329 332 PF00017 0.312
LIG_SH2_STAT5 35 38 PF00017 0.437
LIG_SH2_STAT5 353 356 PF00017 0.394
LIG_SH2_STAT5 431 434 PF00017 0.346
LIG_SH2_STAT5 502 505 PF00017 0.411
LIG_SH2_STAT5 526 529 PF00017 0.618
LIG_SH3_3 116 122 PF00018 0.364
LIG_SH3_4 371 378 PF00018 0.417
LIG_SUMO_SIM_anti_2 106 111 PF11976 0.244
LIG_SUMO_SIM_par_1 105 111 PF11976 0.512
LIG_SUMO_SIM_par_1 242 247 PF11976 0.412
LIG_SUMO_SIM_par_1 431 436 PF11976 0.255
LIG_TRAF2_1 68 71 PF00917 0.752
LIG_TYR_ITIM 110 115 PF00017 0.286
LIG_TYR_ITIM 153 158 PF00017 0.481
LIG_TYR_ITIM 159 164 PF00017 0.579
LIG_TYR_ITSM 427 434 PF00017 0.512
MOD_CK1_1 138 144 PF00069 0.469
MOD_CK1_1 170 176 PF00069 0.649
MOD_CK1_1 178 184 PF00069 0.620
MOD_CK1_1 195 201 PF00069 0.593
MOD_CK1_1 306 312 PF00069 0.572
MOD_CK1_1 376 382 PF00069 0.572
MOD_CK1_1 387 393 PF00069 0.613
MOD_CK1_1 436 442 PF00069 0.472
MOD_CK1_1 445 451 PF00069 0.517
MOD_CK1_1 462 468 PF00069 0.404
MOD_CK2_1 448 454 PF00069 0.550
MOD_CK2_1 482 488 PF00069 0.508
MOD_CK2_1 65 71 PF00069 0.434
MOD_CMANNOS 59 62 PF00535 0.667
MOD_Cter_Amidation 529 532 PF01082 0.286
MOD_GlcNHglycan 237 240 PF01048 0.378
MOD_GlcNHglycan 264 267 PF01048 0.581
MOD_GlcNHglycan 27 30 PF01048 0.638
MOD_GlcNHglycan 281 284 PF01048 0.629
MOD_GlcNHglycan 308 311 PF01048 0.536
MOD_GlcNHglycan 336 339 PF01048 0.471
MOD_GlcNHglycan 375 378 PF01048 0.520
MOD_GlcNHglycan 389 392 PF01048 0.504
MOD_GlcNHglycan 409 412 PF01048 0.244
MOD_GlcNHglycan 435 438 PF01048 0.479
MOD_GlcNHglycan 46 49 PF01048 0.199
MOD_GlcNHglycan 484 487 PF01048 0.528
MOD_GlcNHglycan 84 87 PF01048 0.566
MOD_GSK3_1 169 176 PF00069 0.679
MOD_GSK3_1 191 198 PF00069 0.662
MOD_GSK3_1 231 238 PF00069 0.486
MOD_GSK3_1 244 251 PF00069 0.382
MOD_GSK3_1 272 279 PF00069 0.680
MOD_GSK3_1 286 293 PF00069 0.470
MOD_GSK3_1 304 311 PF00069 0.513
MOD_GSK3_1 363 370 PF00069 0.587
MOD_GSK3_1 386 393 PF00069 0.754
MOD_GSK3_1 435 442 PF00069 0.443
MOD_GSK3_1 461 468 PF00069 0.647
MOD_GSK3_1 482 489 PF00069 0.639
MOD_GSK3_1 84 91 PF00069 0.382
MOD_N-GLC_1 363 368 PF02516 0.453
MOD_N-GLC_1 39 44 PF02516 0.244
MOD_N-GLC_1 442 447 PF02516 0.541
MOD_NEK2_1 103 108 PF00069 0.454
MOD_NEK2_1 117 122 PF00069 0.604
MOD_NEK2_1 132 137 PF00069 0.618
MOD_NEK2_1 15 20 PF00069 0.512
MOD_NEK2_1 169 174 PF00069 0.473
MOD_NEK2_1 177 182 PF00069 0.485
MOD_NEK2_1 218 223 PF00069 0.281
MOD_NEK2_1 244 249 PF00069 0.404
MOD_NEK2_1 304 309 PF00069 0.494
MOD_NEK2_1 327 332 PF00069 0.419
MOD_NEK2_1 334 339 PF00069 0.482
MOD_NEK2_1 385 390 PF00069 0.733
MOD_NEK2_1 461 466 PF00069 0.534
MOD_NEK2_1 65 70 PF00069 0.670
MOD_NEK2_2 248 253 PF00069 0.411
MOD_PIKK_1 208 214 PF00454 0.486
MOD_PK_1 192 198 PF00069 0.453
MOD_PKA_2 132 138 PF00069 0.516
MOD_PKA_2 191 197 PF00069 0.469
MOD_PKA_2 524 530 PF00069 0.300
MOD_PKA_2 98 104 PF00069 0.289
MOD_Plk_1 192 198 PF00069 0.453
MOD_Plk_2-3 363 369 PF00069 0.460
MOD_Plk_4 138 144 PF00069 0.469
MOD_Plk_4 15 21 PF00069 0.512
MOD_Plk_4 198 204 PF00069 0.525
MOD_Plk_4 244 250 PF00069 0.439
MOD_Plk_4 290 296 PF00069 0.366
MOD_Plk_4 46 52 PF00069 0.285
MOD_Plk_4 462 468 PF00069 0.597
MOD_Plk_4 98 104 PF00069 0.342
MOD_ProDKin_1 144 150 PF00069 0.439
MOD_ProDKin_1 178 184 PF00069 0.514
MOD_ProDKin_1 286 292 PF00069 0.615
TRG_ENDOCYTIC_2 112 115 PF00928 0.512
TRG_ENDOCYTIC_2 155 158 PF00928 0.577
TRG_ENDOCYTIC_2 161 164 PF00928 0.492
TRG_ENDOCYTIC_2 253 256 PF00928 0.411
TRG_ENDOCYTIC_2 352 355 PF00928 0.473
TRG_ENDOCYTIC_2 431 434 PF00928 0.411
TRG_ENDOCYTIC_2 526 529 PF00928 0.411
TRG_ER_diArg_1 298 301 PF00400 0.332
TRG_ER_diArg_1 357 360 PF00400 0.460

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P837 Leptomonas seymouri 46% 100%
A0A3S7WUK3 Leishmania donovani 72% 100%
A4HXI7 Leishmania infantum 72% 100%
E9AR82 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
Q4QE81 Leishmania major 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS