Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H963_LEIBR

TriTrypDb:

LbrM.17.1190 , LBRM2903_170018800

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H963

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H963

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.390
CLV_C14_Caspase3-7	383	387	PF00656	0.558
CLV_C14_Caspase3-7	475	479	PF00656	0.633
CLV_C14_Caspase3-7	496	500	PF00656	0.447
CLV_C14_Caspase3-7	536	540	PF00656	0.527
CLV_C14_Caspase3-7	682	686	PF00656	0.565
CLV_NRD_NRD_1	528	530	PF00675	0.534
CLV_NRD_NRD_1	680	682	PF00675	0.542
CLV_PCSK_KEX2_1	530	532	PF00082	0.533
CLV_PCSK_KEX2_1	680	682	PF00082	0.542
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.533
CLV_PCSK_SKI1_1	4	8	PF00082	0.439
CLV_PCSK_SKI1_1	406	410	PF00082	0.724
CLV_PCSK_SKI1_1	52	56	PF00082	0.537
CLV_PCSK_SKI1_1	656	660	PF00082	0.506
DEG_Nend_UBRbox_3	1	3	PF02207	0.436
DEG_SPOP_SBC_1	114	118	PF00917	0.649
DEG_SPOP_SBC_1	119	123	PF00917	0.590
DEG_SPOP_SBC_1	206	210	PF00917	0.425
DEG_SPOP_SBC_1	321	325	PF00917	0.648
DEG_SPOP_SBC_1	471	475	PF00917	0.553
DOC_ANK_TNKS_1	680	687	PF00023	0.545
DOC_CDC14_PxL_1	424	432	PF14671	0.495
DOC_CKS1_1	135	140	PF01111	0.666
DOC_CKS1_1	410	415	PF01111	0.650
DOC_CKS1_1	696	701	PF01111	0.559
DOC_CYCLIN_RxL_1	1	10	PF00134	0.391
DOC_CYCLIN_RxL_1	279	290	PF00134	0.516
DOC_CYCLIN_RxL_1	401	412	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.559
DOC_MAPK_gen_1	102	112	PF00069	0.556
DOC_MAPK_MEF2A_6	105	112	PF00069	0.464
DOC_MAPK_MEF2A_6	350	358	PF00069	0.695
DOC_MAPK_MEF2A_6	46	55	PF00069	0.349
DOC_PP2B_LxvP_1	343	346	PF13499	0.583
DOC_USP7_MATH_1	114	118	PF00917	0.601
DOC_USP7_MATH_1	291	295	PF00917	0.555
DOC_USP7_MATH_1	360	364	PF00917	0.765
DOC_USP7_MATH_1	434	438	PF00917	0.612
DOC_USP7_MATH_1	729	733	PF00917	0.642
DOC_USP7_MATH_2	692	698	PF00917	0.562
DOC_WW_Pin1_4	120	125	PF00397	0.550
DOC_WW_Pin1_4	134	139	PF00397	0.639
DOC_WW_Pin1_4	409	414	PF00397	0.651
DOC_WW_Pin1_4	418	423	PF00397	0.576
DOC_WW_Pin1_4	542	547	PF00397	0.569
DOC_WW_Pin1_4	565	570	PF00397	0.597
DOC_WW_Pin1_4	695	700	PF00397	0.712
DOC_WW_Pin1_4	732	737	PF00397	0.655
LIG_14-3-3_CanoR_1	102	112	PF00244	0.644
LIG_14-3-3_CanoR_1	271	279	PF00244	0.528
LIG_14-3-3_CanoR_1	300	304	PF00244	0.397
LIG_14-3-3_CanoR_1	318	327	PF00244	0.522
LIG_14-3-3_CanoR_1	371	375	PF00244	0.577
LIG_14-3-3_CanoR_1	390	395	PF00244	0.555
LIG_14-3-3_CanoR_1	618	622	PF00244	0.498
LIG_Actin_WH2_2	640	658	PF00022	0.391
LIG_BIR_III_4	499	503	PF00653	0.475
LIG_BIR_III_4	570	574	PF00653	0.484
LIG_Clathr_ClatBox_1	492	496	PF01394	0.440
LIG_deltaCOP1_diTrp_1	645	651	PF00928	0.474
LIG_FHA_1	142	148	PF00498	0.574
LIG_FHA_1	150	156	PF00498	0.640
LIG_FHA_1	207	213	PF00498	0.574
LIG_FHA_1	21	27	PF00498	0.390
LIG_FHA_1	339	345	PF00498	0.644
LIG_FHA_1	419	425	PF00498	0.581
LIG_FHA_1	472	478	PF00498	0.704
LIG_FHA_1	60	66	PF00498	0.419
LIG_FHA_1	702	708	PF00498	0.587
LIG_FHA_1	710	716	PF00498	0.477
LIG_FHA_1	8	14	PF00498	0.538
LIG_FHA_2	228	234	PF00498	0.379
LIG_FHA_2	398	404	PF00498	0.514
LIG_FHA_2	454	460	PF00498	0.521
LIG_FHA_2	696	702	PF00498	0.556
LIG_Integrin_RGD_1	683	685	PF01839	0.553
LIG_LIR_Apic_2	704	708	PF02991	0.511
LIG_LIR_Gen_1	130	138	PF02991	0.692
LIG_LIR_Gen_1	144	150	PF02991	0.430
LIG_LIR_Gen_1	392	402	PF02991	0.497
LIG_LIR_Gen_1	649	659	PF02991	0.549
LIG_LIR_Nem_3	130	135	PF02991	0.698
LIG_LIR_Nem_3	144	148	PF02991	0.427
LIG_LIR_Nem_3	392	397	PF02991	0.498
LIG_LIR_Nem_3	398	402	PF02991	0.481
LIG_LIR_Nem_3	649	654	PF02991	0.542
LIG_MYND_3	427	431	PF01753	0.494
LIG_NRBOX	282	288	PF00104	0.428
LIG_SH2_CRK	132	136	PF00017	0.597
LIG_SH2_NCK_1	145	149	PF00017	0.500
LIG_SH2_NCK_1	41	45	PF00017	0.506
LIG_SH2_STAP1	39	43	PF00017	0.402
LIG_SH2_STAP1	70	74	PF00017	0.344
LIG_SH2_STAT5	225	228	PF00017	0.414
LIG_SH2_STAT5	315	318	PF00017	0.478
LIG_SH2_STAT5	399	402	PF00017	0.497
LIG_SH3_3	200	206	PF00018	0.734
LIG_SH3_3	566	572	PF00018	0.652
LIG_SH3_3	693	699	PF00018	0.698
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.557
LIG_SUMO_SIM_anti_2	486	492	PF11976	0.550
LIG_SUMO_SIM_par_1	146	152	PF11976	0.603
LIG_TRAF2_1	380	383	PF00917	0.604
LIG_TRAF2_1	437	440	PF00917	0.385
MOD_CDK_SPK_2	120	125	PF00069	0.504
MOD_CK1_1	115	121	PF00069	0.675
MOD_CK1_1	207	213	PF00069	0.559
MOD_CK1_1	385	391	PF00069	0.573
MOD_CK1_1	411	417	PF00069	0.645
MOD_CK1_1	454	460	PF00069	0.555
MOD_CK1_1	469	475	PF00069	0.655
MOD_CK1_1	545	551	PF00069	0.576
MOD_CK1_1	587	593	PF00069	0.694
MOD_CK1_1	732	738	PF00069	0.654
MOD_CK1_1	92	98	PF00069	0.531
MOD_CK2_1	161	167	PF00069	0.734
MOD_CK2_1	169	175	PF00069	0.786
MOD_CK2_1	377	383	PF00069	0.601
MOD_CK2_1	434	440	PF00069	0.410
MOD_CK2_1	530	536	PF00069	0.523
MOD_CMANNOS	648	651	PF00535	0.458
MOD_GlcNHglycan	105	108	PF01048	0.595
MOD_GlcNHglycan	177	180	PF01048	0.594
MOD_GlcNHglycan	230	233	PF01048	0.509
MOD_GlcNHglycan	256	259	PF01048	0.489
MOD_GlcNHglycan	293	296	PF01048	0.584
MOD_GlcNHglycan	328	331	PF01048	0.570
MOD_GlcNHglycan	413	416	PF01048	0.619
MOD_GlcNHglycan	485	488	PF01048	0.454
MOD_GlcNHglycan	586	589	PF01048	0.682
MOD_GlcNHglycan	7	10	PF01048	0.535
MOD_GSK3_1	114	121	PF00069	0.611
MOD_GSK3_1	130	137	PF00069	0.681
MOD_GSK3_1	201	208	PF00069	0.638
MOD_GSK3_1	223	230	PF00069	0.429
MOD_GSK3_1	322	329	PF00069	0.648
MOD_GSK3_1	385	392	PF00069	0.626
MOD_GSK3_1	418	425	PF00069	0.684
MOD_GSK3_1	450	457	PF00069	0.590
MOD_GSK3_1	462	469	PF00069	0.693
MOD_GSK3_1	479	486	PF00069	0.486
MOD_GSK3_1	81	88	PF00069	0.522
MOD_N-GLC_1	418	423	PF02516	0.526
MOD_N-GLC_1	523	528	PF02516	0.509
MOD_N-GLC_2	278	280	PF02516	0.373
MOD_NEK2_1	227	232	PF00069	0.461
MOD_NEK2_1	299	304	PF00069	0.543
MOD_NEK2_1	395	400	PF00069	0.560
MOD_NEK2_1	408	413	PF00069	0.663
MOD_NEK2_1	466	471	PF00069	0.697
MOD_NEK2_1	5	10	PF00069	0.546
MOD_NEK2_1	504	509	PF00069	0.633
MOD_NEK2_1	551	556	PF00069	0.595
MOD_NEK2_1	668	673	PF00069	0.577
MOD_NEK2_2	223	228	PF00069	0.329
MOD_NEK2_2	260	265	PF00069	0.505
MOD_PIKK_1	422	428	PF00454	0.529
MOD_PKA_1	530	536	PF00069	0.523
MOD_PKA_2	270	276	PF00069	0.561
MOD_PKA_2	299	305	PF00069	0.595
MOD_PKA_2	370	376	PF00069	0.591
MOD_PKA_2	389	395	PF00069	0.560
MOD_PKA_2	530	536	PF00069	0.523
MOD_PKA_2	584	590	PF00069	0.509
MOD_PKA_2	617	623	PF00069	0.496
MOD_Plk_1	385	391	PF00069	0.518
MOD_Plk_1	395	401	PF00069	0.467
MOD_Plk_1	402	408	PF00069	0.466
MOD_Plk_1	523	529	PF00069	0.557
MOD_Plk_1	574	580	PF00069	0.522
MOD_Plk_1	81	87	PF00069	0.373
MOD_Plk_2-3	377	383	PF00069	0.527
MOD_Plk_4	130	136	PF00069	0.596
MOD_Plk_4	207	213	PF00069	0.486
MOD_Plk_4	223	229	PF00069	0.423
MOD_Plk_4	390	396	PF00069	0.687
MOD_Plk_4	504	510	PF00069	0.401
MOD_ProDKin_1	120	126	PF00069	0.545
MOD_ProDKin_1	134	140	PF00069	0.637
MOD_ProDKin_1	409	415	PF00069	0.650
MOD_ProDKin_1	418	424	PF00069	0.577
MOD_ProDKin_1	542	548	PF00069	0.556
MOD_ProDKin_1	565	571	PF00069	0.598
MOD_ProDKin_1	695	701	PF00069	0.712
MOD_ProDKin_1	732	738	PF00069	0.654
MOD_SUMO_rev_2	454	463	PF00179	0.522
TRG_DiLeu_BaEn_4	367	373	PF01217	0.543
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.515
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.528
TRG_ENDOCYTIC_2	132	135	PF00928	0.598
TRG_ENDOCYTIC_2	145	148	PF00928	0.495
TRG_ENDOCYTIC_2	225	228	PF00928	0.445
TRG_ER_diArg_1	404	407	PF00400	0.651
TRG_ER_diArg_1	528	531	PF00400	0.535
TRG_ER_diArg_1	743	746	PF00400	0.625
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIE2	Leptomonas seymouri	34%	100%
A0A3S5H715	Leishmania donovani	66%	100%
A4HXI5	Leishmania infantum	66%	100%
E9AR80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QE83	Leishmania major	68%	100%