Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H962_LEIBR

TriTrypDb:

LbrM.17.1180 , LBRM2903_170018700

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H962

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H962

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.493
CLV_NRD_NRD_1	127	129	PF00675	0.505
CLV_NRD_NRD_1	212	214	PF00675	0.465
CLV_NRD_NRD_1	263	265	PF00675	0.523
CLV_PCSK_KEX2_1	10	12	PF00082	0.493
CLV_PCSK_KEX2_1	127	129	PF00082	0.505
CLV_PCSK_KEX2_1	143	145	PF00082	0.533
CLV_PCSK_KEX2_1	212	214	PF00082	0.465
CLV_PCSK_KEX2_1	263	265	PF00082	0.527
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.420
CLV_PCSK_SKI1_1	120	124	PF00082	0.506
CLV_PCSK_SKI1_1	130	134	PF00082	0.506
CLV_PCSK_SKI1_1	14	18	PF00082	0.647
CLV_PCSK_SKI1_1	207	211	PF00082	0.452
CLV_PCSK_SKI1_1	344	348	PF00082	0.662
CLV_PCSK_SKI1_1	401	405	PF00082	0.395
DEG_SCF_FBW7_1	438	445	PF00400	0.548
DOC_CKS1_1	231	236	PF01111	0.629
DOC_CYCLIN_RxL_1	127	135	PF00134	0.777
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.660
DOC_MAPK_gen_1	127	133	PF00069	0.775
DOC_MAPK_gen_1	263	271	PF00069	0.697
DOC_PP1_RVXF_1	128	134	PF00149	0.743
DOC_PP2B_LxvP_1	113	116	PF13499	0.642
DOC_PP2B_LxvP_1	167	170	PF13499	0.686
DOC_PP2B_LxvP_1	379	382	PF13499	0.509
DOC_USP7_MATH_1	192	196	PF00917	0.696
DOC_USP7_MATH_1	2	6	PF00917	0.713
DOC_USP7_MATH_1	275	279	PF00917	0.698
DOC_USP7_MATH_1	329	333	PF00917	0.380
DOC_USP7_MATH_1	412	416	PF00917	0.509
DOC_USP7_MATH_1	59	63	PF00917	0.701
DOC_WW_Pin1_4	230	235	PF00397	0.703
DOC_WW_Pin1_4	438	443	PF00397	0.544
LIG_14-3-3_CanoR_1	10	16	PF00244	0.802
LIG_14-3-3_CanoR_1	120	129	PF00244	0.704
LIG_14-3-3_CanoR_1	186	190	PF00244	0.660
LIG_14-3-3_CanoR_1	28	34	PF00244	0.735
LIG_14-3-3_CanoR_1	311	319	PF00244	0.548
LIG_14-3-3_CanoR_1	65	72	PF00244	0.678
LIG_APCC_ABBA_1	269	274	PF00400	0.641
LIG_BRCT_BRCA1_1	198	202	PF00533	0.761
LIG_deltaCOP1_diTrp_1	88	95	PF00928	0.651
LIG_eIF4E_1	39	45	PF01652	0.621
LIG_FHA_1	249	255	PF00498	0.722
LIG_FHA_1	286	292	PF00498	0.619
LIG_FHA_1	304	310	PF00498	0.564
LIG_FHA_1	368	374	PF00498	0.430
LIG_FHA_1	376	382	PF00498	0.314
LIG_FHA_1	39	45	PF00498	0.621
LIG_FHA_1	443	449	PF00498	0.569
LIG_FHA_1	97	103	PF00498	0.621
LIG_FHA_2	121	127	PF00498	0.700
LIG_FHA_2	257	263	PF00498	0.633
LIG_FHA_2	412	418	PF00498	0.366
LIG_LIR_Apic_2	228	234	PF02991	0.633
LIG_LIR_Gen_1	38	46	PF02991	0.774
LIG_LIR_Nem_3	242	248	PF02991	0.639
LIG_LIR_Nem_3	88	92	PF02991	0.726
LIG_LYPXL_yS_3	164	167	PF13949	0.662
LIG_PDZ_Class_2	447	452	PF00595	0.590
LIG_Pex14_1	189	193	PF04695	0.752
LIG_Pex14_1	398	402	PF04695	0.658
LIG_PTB_Apo_2	171	178	PF02174	0.671
LIG_PTB_Apo_2	33	40	PF02174	0.749
LIG_PTB_Phospho_1	171	177	PF10480	0.667
LIG_PTB_Phospho_1	33	39	PF10480	0.616
LIG_SH2_CRK	177	181	PF00017	0.693
LIG_SH2_CRK	246	250	PF00017	0.724
LIG_SH2_CRK	388	392	PF00017	0.411
LIG_SH3_2	208	213	PF14604	0.654
LIG_SH3_3	205	211	PF00018	0.671
LIG_SH3_3	346	352	PF00018	0.367
LIG_SUMO_SIM_anti_2	417	422	PF11976	0.413
LIG_SUMO_SIM_par_1	372	378	PF11976	0.366
LIG_TRAF2_1	123	126	PF00917	0.700
LIG_TRAF2_1	293	296	PF00917	0.595
LIG_TYR_ITIM	162	167	PF00017	0.566
MOD_CK2_1	120	126	PF00069	0.622
MOD_CK2_1	200	206	PF00069	0.678
MOD_CK2_1	290	296	PF00069	0.715
MOD_CK2_1	360	366	PF00069	0.630
MOD_GlcNHglycan	216	219	PF01048	0.763
MOD_GlcNHglycan	220	223	PF01048	0.741
MOD_GlcNHglycan	299	302	PF01048	0.507
MOD_GlcNHglycan	392	395	PF01048	0.509
MOD_GlcNHglycan	66	69	PF01048	0.794
MOD_GlcNHglycan	82	85	PF01048	0.621
MOD_GSK3_1	10	17	PF00069	0.774
MOD_GSK3_1	175	182	PF00069	0.600
MOD_GSK3_1	192	199	PF00069	0.512
MOD_GSK3_1	214	221	PF00069	0.612
MOD_GSK3_1	277	284	PF00069	0.547
MOD_GSK3_1	358	365	PF00069	0.494
MOD_GSK3_1	438	445	PF00069	0.708
MOD_GSK3_1	93	100	PF00069	0.536
MOD_N-GLC_1	218	223	PF02516	0.559
MOD_N-GLC_1	302	307	PF02516	0.498
MOD_N-GLC_1	438	443	PF02516	0.688
MOD_NEK2_1	132	137	PF00069	0.740
MOD_NEK2_1	15	20	PF00069	0.727
MOD_NEK2_1	255	260	PF00069	0.793
MOD_NEK2_1	367	372	PF00069	0.327
MOD_NEK2_1	411	416	PF00069	0.411
MOD_NEK2_1	98	103	PF00069	0.602
MOD_PIKK_1	329	335	PF00454	0.411
MOD_PKA_1	10	16	PF00069	0.578
MOD_PKA_2	139	145	PF00069	0.509
MOD_PKA_2	185	191	PF00069	0.588
MOD_PKA_2	27	33	PF00069	0.796
MOD_PKA_2	297	303	PF00069	0.471
MOD_PKA_2	310	316	PF00069	0.357
MOD_PKA_2	54	60	PF00069	0.800
MOD_PKA_2	64	70	PF00069	0.597
MOD_PKA_2	9	15	PF00069	0.720
MOD_Plk_1	442	448	PF00069	0.714
MOD_Plk_4	180	186	PF00069	0.558
MOD_ProDKin_1	230	236	PF00069	0.628
MOD_ProDKin_1	438	444	PF00069	0.691
TRG_DiLeu_BaEn_2	303	309	PF01217	0.443
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.692
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.514
TRG_ENDOCYTIC_2	164	167	PF00928	0.574
TRG_ENDOCYTIC_2	321	324	PF00928	0.411
TRG_ENDOCYTIC_2	388	391	PF00928	0.411
TRG_ENDOCYTIC_2	39	42	PF00928	0.512
TRG_ENDOCYTIC_2	408	411	PF00928	0.183
TRG_ER_diArg_1	127	130	PF00400	0.634
TRG_ER_diArg_1	155	158	PF00400	0.708
TRG_ER_diArg_1	211	213	PF00400	0.579
TRG_ER_diArg_1	404	407	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D5	Leptomonas seymouri	49%	72%
A0A3Q8IAR6	Leishmania donovani	64%	86%
A4HXI4	Leishmania infantum	64%	86%
E9AR79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	98%
Q4QE84	Leishmania major	61%	100%