Hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H961_LEIBR

TriTrypDb:

LbrM.17.1170 , LBRM2903_170018600

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H961

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H961

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.639
CLV_C14_Caspase3-7	449	453	PF00656	0.656
CLV_C14_Caspase3-7	553	557	PF00656	0.540
CLV_NRD_NRD_1	216	218	PF00675	0.417
CLV_NRD_NRD_1	232	234	PF00675	0.269
CLV_NRD_NRD_1	309	311	PF00675	0.457
CLV_NRD_NRD_1	463	465	PF00675	0.657
CLV_NRD_NRD_1	608	610	PF00675	0.482
CLV_PCSK_KEX2_1	209	211	PF00082	0.434
CLV_PCSK_KEX2_1	216	218	PF00082	0.307
CLV_PCSK_KEX2_1	232	234	PF00082	0.400
CLV_PCSK_KEX2_1	309	311	PF00082	0.527
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.309
CLV_PCSK_SKI1_1	136	140	PF00082	0.231
CLV_PCSK_SKI1_1	193	197	PF00082	0.312
CLV_PCSK_SKI1_1	209	213	PF00082	0.312
CLV_PCSK_SKI1_1	313	317	PF00082	0.642
CLV_PCSK_SKI1_1	355	359	PF00082	0.523
CLV_PCSK_SKI1_1	549	553	PF00082	0.684
CLV_PCSK_SKI1_1	90	94	PF00082	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.303
DEG_SCF_FBW7_1	639	646	PF00400	0.546
DEG_SPOP_SBC_1	151	155	PF00917	0.312
DEG_SPOP_SBC_1	455	459	PF00917	0.586
DEG_SPOP_SBC_1	486	490	PF00917	0.502
DEG_SPOP_SBC_1	511	515	PF00917	0.501
DEG_SPOP_SBC_1	555	559	PF00917	0.624
DOC_CYCLIN_RxL_1	272	281	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.312
DOC_MAPK_DCC_7	79	87	PF00069	0.231
DOC_MAPK_gen_1	208	215	PF00069	0.312
DOC_MAPK_gen_1	79	87	PF00069	0.321
DOC_MAPK_MEF2A_6	594	602	PF00069	0.527
DOC_MAPK_MEF2A_6	79	87	PF00069	0.388
DOC_PP2B_LxvP_1	117	120	PF13499	0.312
DOC_PP2B_LxvP_1	139	142	PF13499	0.312
DOC_PP2B_LxvP_1	172	175	PF13499	0.231
DOC_PP2B_LxvP_1	244	247	PF13499	0.326
DOC_PP2B_LxvP_1	420	423	PF13499	0.515
DOC_PP2B_LxvP_1	85	88	PF13499	0.312
DOC_PP4_FxxP_1	22	25	PF00568	0.380
DOC_PP4_FxxP_1	369	372	PF00568	0.484
DOC_USP7_MATH_1	315	319	PF00917	0.645
DOC_USP7_MATH_1	348	352	PF00917	0.558
DOC_USP7_MATH_1	385	389	PF00917	0.536
DOC_USP7_MATH_1	436	440	PF00917	0.546
DOC_USP7_MATH_1	455	459	PF00917	0.551
DOC_USP7_MATH_1	478	482	PF00917	0.574
DOC_USP7_MATH_1	487	491	PF00917	0.462
DOC_USP7_MATH_1	511	515	PF00917	0.645
DOC_USP7_MATH_1	524	528	PF00917	0.531
DOC_USP7_MATH_1	555	559	PF00917	0.660
DOC_USP7_MATH_1	561	565	PF00917	0.724
DOC_USP7_MATH_1	625	629	PF00917	0.670
DOC_USP7_MATH_1	641	645	PF00917	0.542
DOC_USP7_MATH_1	716	720	PF00917	0.538
DOC_WW_Pin1_4	376	381	PF00397	0.544
DOC_WW_Pin1_4	468	473	PF00397	0.521
DOC_WW_Pin1_4	639	644	PF00397	0.547
LIG_14-3-3_CanoR_1	144	149	PF00244	0.352
LIG_14-3-3_CanoR_1	177	182	PF00244	0.401
LIG_14-3-3_CanoR_1	188	193	PF00244	0.256
LIG_14-3-3_CanoR_1	210	216	PF00244	0.444
LIG_14-3-3_CanoR_1	217	221	PF00244	0.312
LIG_14-3-3_CanoR_1	447	454	PF00244	0.542
LIG_Actin_WH2_2	182	199	PF00022	0.318
LIG_BRCT_BRCA1_1	710	714	PF00533	0.538
LIG_CSL_BTD_1	433	436	PF09270	0.509
LIG_DLG_GKlike_1	188	195	PF00625	0.312
LIG_DLG_GKlike_1	216	224	PF00625	0.364
LIG_FHA_1	143	149	PF00498	0.307
LIG_FHA_1	417	423	PF00498	0.603
LIG_FHA_1	477	483	PF00498	0.520
LIG_FHA_1	489	495	PF00498	0.471
LIG_FHA_1	649	655	PF00498	0.559
LIG_FHA_1	683	689	PF00498	0.523
LIG_FHA_2	178	184	PF00498	0.384
LIG_FHA_2	318	324	PF00498	0.635
LIG_FHA_2	678	684	PF00498	0.595
LIG_FHA_2	70	76	PF00498	0.352
LIG_LIR_Apic_2	368	372	PF02991	0.647
LIG_LIR_Gen_1	108	119	PF02991	0.349
LIG_LIR_Gen_1	415	423	PF02991	0.660
LIG_LIR_Gen_1	514	524	PF02991	0.599
LIG_LIR_Gen_1	656	667	PF02991	0.494
LIG_LIR_Gen_1	718	723	PF02991	0.669
LIG_LIR_Nem_3	108	114	PF02991	0.315
LIG_LIR_Nem_3	415	420	PF02991	0.655
LIG_LIR_Nem_3	496	500	PF02991	0.738
LIG_LIR_Nem_3	514	520	PF02991	0.576
LIG_LIR_Nem_3	656	662	PF02991	0.492
LIG_NRBOX	191	197	PF00104	0.312
LIG_PCNA_yPIPBox_3	173	185	PF02747	0.312
LIG_Pex14_1	45	49	PF04695	0.352
LIG_Pex14_2	286	290	PF04695	0.363
LIG_SH2_CRK	198	202	PF00017	0.388
LIG_SH2_CRK	273	277	PF00017	0.388
LIG_SH2_CRK	417	421	PF00017	0.660
LIG_SH2_GRB2like	63	66	PF00017	0.312
LIG_SH2_NCK_1	198	202	PF00017	0.388
LIG_SH2_STAP1	273	277	PF00017	0.312
LIG_SH2_STAT5	206	209	PF00017	0.314
LIG_SH2_STAT5	285	288	PF00017	0.380
LIG_SH2_STAT5	59	62	PF00017	0.338
LIG_SH2_STAT5	607	610	PF00017	0.553
LIG_SH3_2	433	438	PF14604	0.514
LIG_SH3_3	155	161	PF00018	0.312
LIG_SH3_3	254	260	PF00018	0.312
LIG_SH3_3	388	394	PF00018	0.610
LIG_SH3_3	397	403	PF00018	0.604
LIG_SH3_3	425	431	PF00018	0.611
LIG_SH3_3	472	478	PF00018	0.509
LIG_SH3_3	505	511	PF00018	0.556
LIG_SH3_3	518	524	PF00018	0.518
LIG_SH3_3	597	603	PF00018	0.488
LIG_SH3_3	657	663	PF00018	0.489
LIG_SUMO_SIM_par_1	275	281	PF11976	0.312
LIG_TRAF2_1	603	606	PF00917	0.539
LIG_TRAF2_2	100	105	PF00917	0.388
LIG_TRFH_1	198	202	PF08558	0.388
LIG_TRFH_1	662	666	PF08558	0.494
LIG_TYR_ITIM	271	276	PF00017	0.388
LIG_UBA3_1	276	280	PF00899	0.312
LIG_UBA3_1	499	507	PF00899	0.510
LIG_WW_3	174	178	PF00397	0.388
MOD_CDK_SPxxK_3	376	383	PF00069	0.612
MOD_CK1_1	147	153	PF00069	0.341
MOD_CK1_1	219	225	PF00069	0.227
MOD_CK1_1	326	332	PF00069	0.699
MOD_CK1_1	349	355	PF00069	0.548
MOD_CK1_1	446	452	PF00069	0.605
MOD_CK1_1	488	494	PF00069	0.514
MOD_CK1_1	557	563	PF00069	0.625
MOD_CK1_1	614	620	PF00069	0.607
MOD_CK1_1	671	677	PF00069	0.579
MOD_CK1_1	689	695	PF00069	0.616
MOD_CK1_1	708	714	PF00069	0.601
MOD_CK2_1	177	183	PF00069	0.384
MOD_CK2_1	362	368	PF00069	0.642
MOD_CK2_1	487	493	PF00069	0.568
MOD_CK2_1	498	504	PF00069	0.620
MOD_CK2_1	689	695	PF00069	0.575
MOD_CK2_1	69	75	PF00069	0.312
MOD_GlcNHglycan	221	224	PF01048	0.276
MOD_GlcNHglycan	313	316	PF01048	0.582
MOD_GlcNHglycan	317	320	PF01048	0.653
MOD_GlcNHglycan	325	328	PF01048	0.658
MOD_GlcNHglycan	346	351	PF01048	0.597
MOD_GlcNHglycan	42	45	PF01048	0.231
MOD_GlcNHglycan	424	427	PF01048	0.746
MOD_GlcNHglycan	458	461	PF01048	0.596
MOD_GlcNHglycan	466	471	PF01048	0.510
MOD_GlcNHglycan	526	529	PF01048	0.569
MOD_GlcNHglycan	559	562	PF01048	0.631
MOD_GlcNHglycan	576	579	PF01048	0.539
MOD_GlcNHglycan	643	646	PF01048	0.576
MOD_GlcNHglycan	670	673	PF01048	0.570
MOD_GlcNHglycan	695	698	PF01048	0.569
MOD_GSK3_1	142	149	PF00069	0.345
MOD_GSK3_1	211	218	PF00069	0.312
MOD_GSK3_1	311	318	PF00069	0.554
MOD_GSK3_1	418	425	PF00069	0.758
MOD_GSK3_1	443	450	PF00069	0.585
MOD_GSK3_1	555	562	PF00069	0.589
MOD_GSK3_1	570	577	PF00069	0.579
MOD_GSK3_1	610	617	PF00069	0.593
MOD_GSK3_1	621	628	PF00069	0.678
MOD_GSK3_1	639	646	PF00069	0.728
MOD_GSK3_1	682	689	PF00069	0.629
MOD_GSK3_1	701	708	PF00069	0.520
MOD_N-GLC_1	177	182	PF02516	0.312
MOD_NEK2_1	125	130	PF00069	0.350
MOD_NEK2_1	146	151	PF00069	0.338
MOD_NEK2_1	152	157	PF00069	0.299
MOD_NEK2_1	211	216	PF00069	0.444
MOD_NEK2_1	290	295	PF00069	0.388
MOD_NEK2_1	362	367	PF00069	0.565
MOD_NEK2_1	40	45	PF00069	0.399
MOD_NEK2_1	443	448	PF00069	0.585
MOD_NEK2_1	454	459	PF00069	0.672
MOD_NEK2_1	49	54	PF00069	0.296
MOD_PIKK_1	357	363	PF00454	0.504
MOD_PIKK_1	611	617	PF00454	0.527
MOD_PIKK_1	708	714	PF00454	0.544
MOD_PKA_1	216	222	PF00069	0.302
MOD_PKA_2	215	221	PF00069	0.322
MOD_PKA_2	446	452	PF00069	0.545
MOD_PKA_2	543	549	PF00069	0.668
MOD_Plk_1	142	148	PF00069	0.312
MOD_Plk_1	177	183	PF00069	0.312
MOD_Plk_1	701	707	PF00069	0.532
MOD_Plk_4	147	153	PF00069	0.317
MOD_Plk_4	290	296	PF00069	0.369
MOD_Plk_4	49	55	PF00069	0.332
MOD_Plk_4	701	707	PF00069	0.532
MOD_ProDKin_1	376	382	PF00069	0.535
MOD_ProDKin_1	468	474	PF00069	0.523
MOD_ProDKin_1	639	645	PF00069	0.546
MOD_SUMO_for_1	437	440	PF00179	0.520
MOD_SUMO_rev_2	347	357	PF00179	0.628
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.388
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.523
TRG_ENDOCYTIC_2	19	22	PF00928	0.392
TRG_ENDOCYTIC_2	273	276	PF00928	0.317
TRG_ENDOCYTIC_2	417	420	PF00928	0.660
TRG_ER_diArg_1	215	217	PF00400	0.422
TRG_ER_diArg_1	231	233	PF00400	0.269
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI2	Leptomonas seymouri	55%	90%
A0A3Q8IAT8	Leishmania donovani	69%	100%
A4HXI3	Leishmania infantum	69%	91%
E9AR78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QE85	Leishmania major	69%	98%