Hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H960_LEIBR

TriTrypDb:

LbrM.17.1160 , LBRM2903_170018500

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H960

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H960

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	33
GO:0016787	hydrolase activity	2	33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	270	272	PF00675	0.296
CLV_NRD_NRD_1	43	45	PF00675	0.576
CLV_PCSK_KEX2_1	270	272	PF00082	0.323
CLV_PCSK_KEX2_1	43	45	PF00082	0.451
CLV_PCSK_SKI1_1	164	168	PF00082	0.312
CLV_PCSK_SKI1_1	210	214	PF00082	0.198
CLV_PCSK_SKI1_1	236	240	PF00082	0.286
CLV_PCSK_SKI1_1	43	47	PF00082	0.529
CLV_PCSK_SKI1_1	65	69	PF00082	0.428
DEG_APCC_DBOX_1	269	277	PF00400	0.393
DEG_SPOP_SBC_1	14	18	PF00917	0.467
DOC_AGCK_PIF_2	247	252	PF00069	0.151
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.151
DOC_MAPK_gen_1	26	34	PF00069	0.391
DOC_MAPK_MEF2A_6	210	217	PF00069	0.191
DOC_MAPK_MEF2A_6	319	326	PF00069	0.411
DOC_PP1_RVXF_1	232	238	PF00149	0.394
DOC_PP1_RVXF_1	348	355	PF00149	0.356
DOC_PP2B_LxvP_1	135	138	PF13499	0.297
DOC_PP4_FxxP_1	74	77	PF00568	0.351
DOC_USP7_MATH_1	139	143	PF00917	0.371
DOC_USP7_MATH_1	14	18	PF00917	0.672
DOC_USP7_MATH_1	204	208	PF00917	0.381
DOC_USP7_MATH_1	297	301	PF00917	0.312
DOC_WW_Pin1_4	126	131	PF00397	0.346
DOC_WW_Pin1_4	16	21	PF00397	0.587
DOC_WW_Pin1_4	306	311	PF00397	0.477
LIG_14-3-3_CanoR_1	305	311	PF00244	0.454
LIG_14-3-3_CanoR_1	378	384	PF00244	0.307
LIG_14-3-3_CanoR_1	59	67	PF00244	0.421
LIG_BIR_III_4	158	162	PF00653	0.394
LIG_FHA_1	222	228	PF00498	0.225
LIG_FHA_2	120	126	PF00498	0.328
LIG_FHA_2	149	155	PF00498	0.309
LIG_FHA_2	61	67	PF00498	0.397
LIG_HP1_1	322	326	PF01393	0.394
LIG_IRF3_LxIS_1	162	169	PF10401	0.307
LIG_LIR_Apic_2	125	130	PF02991	0.394
LIG_LIR_Apic_2	207	211	PF02991	0.211
LIG_LIR_Apic_2	72	77	PF02991	0.387
LIG_LIR_Gen_1	30	39	PF02991	0.559
LIG_LIR_Gen_1	51	61	PF02991	0.442
LIG_LIR_Gen_1	68	77	PF02991	0.253
LIG_LIR_Nem_3	244	250	PF02991	0.311
LIG_LIR_Nem_3	30	34	PF02991	0.591
LIG_LIR_Nem_3	51	57	PF02991	0.404
LIG_LIR_Nem_3	68	74	PF02991	0.275
LIG_NRBOX	213	219	PF00104	0.151
LIG_Pex14_1	95	99	PF04695	0.258
LIG_REV1ctd_RIR_1	235	243	PF16727	0.212
LIG_SH2_GRB2like	113	116	PF00017	0.301
LIG_SH2_PTP2	31	34	PF00017	0.474
LIG_SH2_STAP1	250	254	PF00017	0.339
LIG_SH2_STAT5	109	112	PF00017	0.274
LIG_SH2_STAT5	150	153	PF00017	0.316
LIG_SH2_STAT5	31	34	PF00017	0.474
LIG_SH2_STAT5	360	363	PF00017	0.408
LIG_SH3_3	258	264	PF00018	0.277
LIG_SH3_3	329	335	PF00018	0.289
LIG_SH3_3	349	355	PF00018	0.326
LIG_SH3_3	74	80	PF00018	0.423
LIG_SUMO_SIM_par_1	21	27	PF11976	0.352
LIG_UBA3_1	162	167	PF00899	0.257
LIG_WRC_WIRS_1	71	76	PF05994	0.340
MOD_CK1_1	306	312	PF00069	0.308
MOD_CK1_1	314	320	PF00069	0.324
MOD_CK1_1	380	386	PF00069	0.511
MOD_CK2_1	139	145	PF00069	0.335
MOD_CK2_1	24	30	PF00069	0.425
MOD_CK2_1	298	304	PF00069	0.176
MOD_Cter_Amidation	268	271	PF01082	0.212
MOD_GlcNHglycan	202	205	PF01048	0.395
MOD_GlcNHglycan	281	285	PF01048	0.320
MOD_GlcNHglycan	300	303	PF01048	0.355
MOD_GlcNHglycan	306	309	PF01048	0.380
MOD_GlcNHglycan	379	382	PF01048	0.378
MOD_GSK3_1	10	17	PF00069	0.732
MOD_GSK3_1	200	207	PF00069	0.283
MOD_GSK3_1	276	283	PF00069	0.418
MOD_GSK3_1	291	298	PF00069	0.285
MOD_GSK3_1	311	318	PF00069	0.451
MOD_GSK3_1	380	387	PF00069	0.509
MOD_GSK3_1	65	72	PF00069	0.456
MOD_N-GLC_1	295	300	PF02516	0.198
MOD_N-GLC_1	88	93	PF02516	0.212
MOD_NEK2_1	15	20	PF00069	0.513
MOD_NEK2_1	166	171	PF00069	0.309
MOD_NEK2_1	193	198	PF00069	0.314
MOD_NEK2_1	199	204	PF00069	0.293
MOD_NEK2_1	311	316	PF00069	0.311
MOD_NEK2_1	384	389	PF00069	0.609
MOD_NEK2_1	69	74	PF00069	0.509
MOD_NEK2_1	88	93	PF00069	0.388
MOD_NEK2_1	94	99	PF00069	0.387
MOD_NEK2_2	21	26	PF00069	0.351
MOD_PIKK_1	166	172	PF00454	0.212
MOD_PIKK_1	262	268	PF00454	0.166
MOD_PKA_2	291	297	PF00069	0.452
MOD_PKA_2	304	310	PF00069	0.367
MOD_PKA_2	377	383	PF00069	0.391
MOD_Plk_1	312	318	PF00069	0.459
MOD_Plk_1	65	71	PF00069	0.346
MOD_Plk_1	88	94	PF00069	0.419
MOD_Plk_2-3	226	232	PF00069	0.394
MOD_Plk_4	226	232	PF00069	0.402
MOD_Plk_4	89	95	PF00069	0.427
MOD_ProDKin_1	126	132	PF00069	0.346
MOD_ProDKin_1	16	22	PF00069	0.578
MOD_ProDKin_1	306	312	PF00069	0.477
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.151
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.394
TRG_ENDOCYTIC_2	31	34	PF00928	0.334
TRG_ENDOCYTIC_2	71	74	PF00928	0.350
TRG_ER_diArg_1	233	236	PF00400	0.409
TRG_ER_diArg_1	42	44	PF00400	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	35%	90%
A0A0N0P3S4	Leptomonas seymouri	61%	100%
A0A0N1PA10	Leptomonas seymouri	39%	100%
A0A0N1PCQ2	Leptomonas seymouri	42%	100%
A0A0S4JQB3	Bodo saltans	35%	100%
A0A1X0NSR3	Trypanosomatidae	35%	87%
A0A1X0NSS6	Trypanosomatidae	40%	100%
A0A3Q8IAY1	Leishmania donovani	76%	100%
A0A3R7KKJ0	Trypanosoma rangeli	37%	100%
A0A3S5IRR1	Trypanosoma rangeli	34%	96%
A0A3S7WUJ3	Leishmania donovani	36%	100%
A0A3S7WUK0	Leishmania donovani	37%	90%
A0A3S7X1K2	Leishmania donovani	40%	100%
A0A422NS41	Trypanosoma rangeli	36%	91%
A4H956	Leishmania braziliensis	38%	100%
A4H959	Leishmania braziliensis	36%	100%
A4HGL0	Leishmania braziliensis	41%	100%
A4HXH8	Leishmania infantum	36%	100%
A4HXI1	Leishmania infantum	36%	90%
A4HXI2	Leishmania infantum	76%	100%
A4I3N6	Leishmania infantum	40%	100%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	90%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4Q8A8	Leishmania major	37%	91%
Q4QE86	Leishmania major	77%	100%
Q4QE87	Leishmania major	35%	100%
Q4QE90	Leishmania major	36%	95%
Q54528	Streptomyces purpurascens	29%	100%
Q54809	Streptomyces peucetius	29%	100%
Q55217	Streptomyces sp. (strain C5)	30%	100%
V5AZB9	Trypanosoma cruzi	35%	91%
V5BER0	Trypanosoma cruzi	38%	100%
V5BNU9	Trypanosoma cruzi	30%	96%