Hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H959_LEIBR

TriTrypDb:

LbrM.17.1150 , LBRM2903_170018400

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H959

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H959

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	34
GO:0016787	hydrolase activity	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.340
CLV_NRD_NRD_1	404	406	PF00675	0.571
CLV_PCSK_KEX2_1	276	278	PF00082	0.248
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.297
CLV_PCSK_SKI1_1	269	273	PF00082	0.305
CLV_PCSK_SKI1_1	286	290	PF00082	0.310
DEG_APCC_DBOX_1	285	293	PF00400	0.391
DEG_SPOP_SBC_1	207	211	PF00917	0.400
DEG_SPOP_SBC_1	414	418	PF00917	0.429
DOC_CKS1_1	4	9	PF01111	0.434
DOC_MAPK_gen_1	273	281	PF00069	0.358
DOC_MAPK_gen_1	302	310	PF00069	0.311
DOC_MAPK_MEF2A_6	49	57	PF00069	0.288
DOC_PP2B_LxvP_1	10	13	PF13499	0.723
DOC_PP2B_LxvP_1	292	295	PF13499	0.346
DOC_PP2B_LxvP_1	335	338	PF13499	0.237
DOC_PP2B_PxIxI_1	337	343	PF00149	0.204
DOC_USP7_MATH_1	413	417	PF00917	0.633
DOC_USP7_UBL2_3	248	252	PF12436	0.373
DOC_WW_Pin1_4	185	190	PF00397	0.318
DOC_WW_Pin1_4	220	225	PF00397	0.459
DOC_WW_Pin1_4	3	8	PF00397	0.660
DOC_WW_Pin1_4	330	335	PF00397	0.240
DOC_WW_Pin1_4	47	52	PF00397	0.424
DOC_WW_Pin1_4	58	63	PF00397	0.321
LIG_14-3-3_CanoR_1	175	182	PF00244	0.286
LIG_14-3-3_CanoR_1	30	38	PF00244	0.410
LIG_14-3-3_CanoR_1	302	310	PF00244	0.328
LIG_14-3-3_CanoR_1	324	334	PF00244	0.452
LIG_14-3-3_CanoR_1	356	362	PF00244	0.316
LIG_14-3-3_CanoR_1	382	386	PF00244	0.236
LIG_Actin_WH2_2	366	384	PF00022	0.147
LIG_APCC_ABBA_1	169	174	PF00400	0.147
LIG_APCC_ABBA_1	239	244	PF00400	0.147
LIG_APCC_ABBAyCdc20_2	238	244	PF00400	0.147
LIG_BIR_III_4	140	144	PF00653	0.402
LIG_BRCT_BRCA1_1	21	25	PF00533	0.515
LIG_FHA_1	109	115	PF00498	0.428
LIG_FHA_1	123	129	PF00498	0.414
LIG_FHA_1	337	343	PF00498	0.241
LIG_FHA_1	4	10	PF00498	0.502
LIG_FHA_2	125	131	PF00498	0.288
LIG_FHA_2	193	199	PF00498	0.147
LIG_FHA_2	92	98	PF00498	0.324
LIG_LIR_Gen_1	201	207	PF02991	0.407
LIG_LIR_Gen_1	244	253	PF02991	0.401
LIG_LIR_Gen_1	261	267	PF02991	0.460
LIG_LIR_Gen_1	384	393	PF02991	0.401
LIG_LIR_Gen_1	77	85	PF02991	0.452
LIG_LIR_Nem_3	110	116	PF02991	0.312
LIG_LIR_Nem_3	140	145	PF02991	0.386
LIG_LIR_Nem_3	201	205	PF02991	0.373
LIG_LIR_Nem_3	244	249	PF02991	0.425
LIG_LIR_Nem_3	261	265	PF02991	0.269
LIG_LIR_Nem_3	384	388	PF02991	0.400
LIG_LIR_Nem_3	44	48	PF02991	0.358
LIG_LIR_Nem_3	77	83	PF02991	0.299
LIG_NRBOX	69	75	PF00104	0.249
LIG_PDZ_Class_1	424	429	PF00595	0.694
LIG_SH2_CRK	118	122	PF00017	0.306
LIG_SH2_CRK	80	84	PF00017	0.474
LIG_SH2_GRB2like	280	283	PF00017	0.156
LIG_SH2_PTP2	385	388	PF00017	0.483
LIG_SH2_SRC	116	119	PF00017	0.204
LIG_SH2_SRC	242	245	PF00017	0.147
LIG_SH2_SRC	280	283	PF00017	0.232
LIG_SH2_STAP1	116	120	PF00017	0.406
LIG_SH2_STAP1	214	218	PF00017	0.399
LIG_SH2_STAP1	242	246	PF00017	0.400
LIG_SH2_STAP1	260	264	PF00017	0.274
LIG_SH2_STAT5	113	116	PF00017	0.400
LIG_SH2_STAT5	132	135	PF00017	0.306
LIG_SH2_STAT5	280	283	PF00017	0.246
LIG_SH2_STAT5	336	339	PF00017	0.377
LIG_SH2_STAT5	385	388	PF00017	0.460
LIG_SH3_3	15	21	PF00018	0.604
LIG_SH3_3	345	351	PF00018	0.282
LIG_SH3_3	45	51	PF00018	0.414
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.418
LIG_SxIP_EBH_1	356	368	PF03271	0.206
LIG_TRAF2_1	223	226	PF00917	0.400
LIG_UBA3_1	199	208	PF00899	0.352
LIG_WRC_WIRS_1	199	204	PF05994	0.269
LIG_WRC_WIRS_1	42	47	PF05994	0.300
MOD_CDK_SPxxK_3	220	227	PF00069	0.147
MOD_CK1_1	107	113	PF00069	0.307
MOD_CK1_1	183	189	PF00069	0.285
MOD_CK1_1	201	207	PF00069	0.214
MOD_CK1_1	258	264	PF00069	0.251
MOD_CK1_1	416	422	PF00069	0.709
MOD_CK1_1	5	11	PF00069	0.698
MOD_CK2_1	124	130	PF00069	0.339
MOD_CK2_1	220	226	PF00069	0.369
MOD_Cter_Amidation	403	406	PF01082	0.414
MOD_DYRK1A_RPxSP_1	220	224	PF00069	0.147
MOD_GlcNHglycan	210	213	PF01048	0.375
MOD_GlcNHglycan	253	256	PF01048	0.349
MOD_GlcNHglycan	328	331	PF01048	0.412
MOD_GlcNHglycan	409	412	PF01048	0.590
MOD_GlcNHglycan	76	79	PF01048	0.453
MOD_GSK3_1	104	111	PF00069	0.313
MOD_GSK3_1	177	184	PF00069	0.266
MOD_GSK3_1	251	258	PF00069	0.366
MOD_GSK3_1	304	311	PF00069	0.350
MOD_GSK3_1	320	327	PF00069	0.415
MOD_N-GLC_1	320	325	PF02516	0.207
MOD_NEK2_1	108	113	PF00069	0.396
MOD_NEK2_1	155	160	PF00069	0.336
MOD_NEK2_1	177	182	PF00069	0.276
MOD_NEK2_1	275	280	PF00069	0.299
MOD_NEK2_1	373	378	PF00069	0.380
MOD_NEK2_1	381	386	PF00069	0.384
MOD_NEK2_1	74	79	PF00069	0.407
MOD_NEK2_2	124	129	PF00069	0.204
MOD_PIKK_1	175	181	PF00454	0.373
MOD_PIKK_1	308	314	PF00454	0.451
MOD_PK_1	304	310	PF00069	0.406
MOD_PKA_2	19	25	PF00069	0.363
MOD_PKA_2	303	309	PF00069	0.395
MOD_PKA_2	31	37	PF00069	0.425
MOD_PKA_2	381	387	PF00069	0.449
MOD_PKA_2	91	97	PF00069	0.313
MOD_PKB_1	302	310	PF00069	0.204
MOD_Plk_2-3	130	136	PF00069	0.270
MOD_Plk_4	109	115	PF00069	0.372
MOD_Plk_4	14	20	PF00069	0.354
MOD_Plk_4	164	170	PF00069	0.265
MOD_Plk_4	177	183	PF00069	0.246
MOD_Plk_4	198	204	PF00069	0.361
MOD_Plk_4	336	342	PF00069	0.281
MOD_Plk_4	357	363	PF00069	0.314
MOD_Plk_4	373	379	PF00069	0.373
MOD_Plk_4	381	387	PF00069	0.390
MOD_Plk_4	5	11	PF00069	0.540
MOD_Plk_4	69	75	PF00069	0.411
MOD_ProDKin_1	185	191	PF00069	0.318
MOD_ProDKin_1	220	226	PF00069	0.459
MOD_ProDKin_1	3	9	PF00069	0.660
MOD_ProDKin_1	330	336	PF00069	0.240
MOD_ProDKin_1	47	53	PF00069	0.415
MOD_ProDKin_1	58	64	PF00069	0.321
MOD_SUMO_for_1	212	215	PF00179	0.147
TRG_DiLeu_BaEn_4	225	231	PF01217	0.400
TRG_ENDOCYTIC_2	118	121	PF00928	0.281
TRG_ENDOCYTIC_2	385	388	PF00928	0.500
TRG_ENDOCYTIC_2	42	45	PF00928	0.312
TRG_ENDOCYTIC_2	80	83	PF00928	0.328
TRG_ER_diArg_1	227	230	PF00400	0.370
TRG_ER_diArg_1	301	304	PF00400	0.368
TRG_ER_diArg_1	37	40	PF00400	0.434
TRG_ER_diArg_1	402	405	PF00400	0.548
TRG_NES_CRM1_1	299	313	PF08389	0.142
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.147
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	65%	100%
A0A0N0P3S4	Leptomonas seymouri	34%	100%
A0A0N1PA10	Leptomonas seymouri	29%	100%
A0A0N1PCQ2	Leptomonas seymouri	30%	100%
A0A0S4JQB3	Bodo saltans	31%	100%
A0A0S4KKL9	Bodo saltans	27%	81%
A0A1X0NSR3	Trypanosomatidae	31%	96%
A0A1X0NSS6	Trypanosomatidae	31%	100%
A0A1X0NT85	Trypanosomatidae	32%	87%
A0A3Q8IAY1	Leishmania donovani	36%	100%
A0A3S5IRR1	Trypanosoma rangeli	39%	100%
A0A3S7WUJ3	Leishmania donovani	30%	100%
A0A3S7WUK0	Leishmania donovani	79%	100%
A0A3S7X1K2	Leishmania donovani	31%	100%
A0A422NS41	Trypanosoma rangeli	31%	100%
A4H956	Leishmania braziliensis	33%	89%
A4H960	Leishmania braziliensis	36%	100%
A4HGL0	Leishmania braziliensis	31%	100%
A4HXH8	Leishmania infantum	31%	100%
A4HXI1	Leishmania infantum	79%	100%
A4HXI2	Leishmania infantum	36%	100%
A4I3N6	Leishmania infantum	31%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q8A8	Leishmania major	31%	95%
Q4QE86	Leishmania major	36%	100%
Q4QE87	Leishmania major	77%	100%
Q4QE90	Leishmania major	31%	90%
Q54528	Streptomyces purpurascens	26%	100%
V5AZB9	Trypanosoma cruzi	31%	100%
V5BER0	Trypanosoma cruzi	32%	100%
V5BNU9	Trypanosoma cruzi	33%	100%