EOG090X0431

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

EOG090X0431

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H958_LEIBR

TriTrypDb:

LbrM.17.1140 , LBRM2903_170018300

Length:

830

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H958

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H958

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	543	547	PF00656	0.419
CLV_C14_Caspase3-7	649	653	PF00656	0.427
CLV_MEL_PAP_1	118	124	PF00089	0.672
CLV_NRD_NRD_1	302	304	PF00675	0.691
CLV_NRD_NRD_1	426	428	PF00675	0.631
CLV_NRD_NRD_1	435	437	PF00675	0.557
CLV_NRD_NRD_1	530	532	PF00675	0.343
CLV_NRD_NRD_1	763	765	PF00675	0.434
CLV_PCSK_KEX2_1	441	443	PF00082	0.587
CLV_PCSK_KEX2_1	530	532	PF00082	0.343
CLV_PCSK_KEX2_1	763	765	PF00082	0.434
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.587
CLV_PCSK_SKI1_1	54	58	PF00082	0.507
CLV_PCSK_SKI1_1	582	586	PF00082	0.327
CLV_PCSK_SKI1_1	679	683	PF00082	0.425
CLV_PCSK_SKI1_1	721	725	PF00082	0.382
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DOC_MAPK_FxFP_2	252	255	PF00069	0.514
DOC_MAPK_gen_1	441	447	PF00069	0.583
DOC_MAPK_gen_1	530	536	PF00069	0.338
DOC_MAPK_MEF2A_6	802	811	PF00069	0.406
DOC_PP2B_PxIxI_1	497	503	PF00149	0.521
DOC_PP4_FxxP_1	222	225	PF00568	0.629
DOC_PP4_FxxP_1	252	255	PF00568	0.514
DOC_PP4_FxxP_1	97	100	PF00568	0.595
DOC_SPAK_OSR1_1	617	621	PF12202	0.421
DOC_USP7_MATH_1	241	245	PF00917	0.643
DOC_USP7_MATH_1	327	331	PF00917	0.631
DOC_USP7_MATH_1	465	469	PF00917	0.685
DOC_USP7_MATH_1	576	580	PF00917	0.381
DOC_USP7_UBL2_3	437	441	PF12436	0.592
DOC_WW_Pin1_4	494	499	PF00397	0.539
DOC_WW_Pin1_4	59	64	PF00397	0.511
DOC_WW_Pin1_4	623	628	PF00397	0.344
DOC_WW_Pin1_4	660	665	PF00397	0.484
DOC_WW_Pin1_4	75	80	PF00397	0.770
DOC_WW_Pin1_4	817	822	PF00397	0.471
LIG_14-3-3_CanoR_1	176	181	PF00244	0.661
LIG_14-3-3_CanoR_1	209	217	PF00244	0.661
LIG_14-3-3_CanoR_1	335	341	PF00244	0.672
LIG_14-3-3_CanoR_1	427	432	PF00244	0.641
LIG_14-3-3_CanoR_1	436	445	PF00244	0.646
LIG_14-3-3_CanoR_1	530	536	PF00244	0.506
LIG_14-3-3_CanoR_1	730	738	PF00244	0.413
LIG_14-3-3_CanoR_1	795	800	PF00244	0.493
LIG_BIR_III_2	404	408	PF00653	0.665
LIG_BRCT_BRCA1_1	589	593	PF00533	0.502
LIG_BRCT_BRCA1_1	61	65	PF00533	0.510
LIG_BRCT_BRCA1_1	625	629	PF00533	0.342
LIG_BRCT_BRCA1_1	694	698	PF00533	0.327
LIG_deltaCOP1_diTrp_1	570	574	PF00928	0.392
LIG_DLG_GKlike_1	476	484	PF00625	0.380
LIG_EVH1_2	614	618	PF00568	0.466
LIG_FHA_1	287	293	PF00498	0.553
LIG_FHA_1	360	366	PF00498	0.689
LIG_FHA_1	479	485	PF00498	0.500
LIG_FHA_1	673	679	PF00498	0.400
LIG_FHA_1	776	782	PF00498	0.441
LIG_FHA_2	269	275	PF00498	0.515
LIG_FHA_2	589	595	PF00498	0.443
LIG_FHA_2	620	626	PF00498	0.415
LIG_LIR_Apic_2	221	225	PF02991	0.628
LIG_LIR_Apic_2	660	664	PF02991	0.318
LIG_LIR_Apic_2	95	100	PF02991	0.593
LIG_LIR_Gen_1	109	118	PF02991	0.668
LIG_LIR_Gen_1	140	148	PF02991	0.695
LIG_LIR_Gen_1	569	580	PF02991	0.340
LIG_LIR_Gen_1	646	655	PF02991	0.341
LIG_LIR_Gen_1	745	754	PF02991	0.419
LIG_LIR_Nem_3	140	144	PF02991	0.819
LIG_LIR_Nem_3	179	183	PF02991	0.518
LIG_LIR_Nem_3	218	222	PF02991	0.621
LIG_LIR_Nem_3	569	575	PF02991	0.346
LIG_LIR_Nem_3	626	632	PF02991	0.333
LIG_LIR_Nem_3	646	650	PF02991	0.347
LIG_LIR_Nem_3	745	751	PF02991	0.440
LIG_PALB2_WD40_1	567	575	PF16756	0.400
LIG_PDZ_Class_1	825	830	PF00595	0.438
LIG_PTB_Apo_2	174	181	PF02174	0.551
LIG_PTB_Apo_2	82	89	PF02174	0.660
LIG_PTB_Phospho_1	174	180	PF10480	0.553
LIG_SH2_CRK	180	184	PF00017	0.515
LIG_SH2_CRK	661	665	PF00017	0.326
LIG_SH2_CRK	709	713	PF00017	0.361
LIG_SH2_GRB2like	527	530	PF00017	0.446
LIG_SH2_NCK_1	305	309	PF00017	0.519
LIG_SH2_STAT3	36	39	PF00017	0.666
LIG_SH2_STAT5	314	317	PF00017	0.505
LIG_SH2_STAT5	446	449	PF00017	0.621
LIG_SH2_STAT5	527	530	PF00017	0.446
LIG_SH2_STAT5	6	9	PF00017	0.632
LIG_SH2_STAT5	638	641	PF00017	0.388
LIG_SH2_STAT5	661	664	PF00017	0.315
LIG_SH2_STAT5	750	753	PF00017	0.399
LIG_SH3_3	281	287	PF00018	0.567
LIG_SH3_3	4	10	PF00018	0.472
LIG_SH3_3	55	61	PF00018	0.566
LIG_SH3_3	714	720	PF00018	0.431
LIG_SUMO_SIM_anti_2	805	811	PF11976	0.458
LIG_SUMO_SIM_par_1	497	503	PF11976	0.532
LIG_SUMO_SIM_par_1	619	626	PF11976	0.306
LIG_TRAF2_1	540	543	PF00917	0.450
LIG_TRAF2_1	665	668	PF00917	0.386
LIG_TYR_ITIM	707	712	PF00017	0.363
LIG_WRC_WIRS_1	107	112	PF05994	0.679
LIG_WRC_WIRS_1	122	127	PF05994	0.610
LIG_WRC_WIRS_1	219	224	PF05994	0.630
MOD_CK1_1	109	115	PF00069	0.652
MOD_CK1_1	140	146	PF00069	0.747
MOD_CK1_1	163	169	PF00069	0.560
MOD_CK1_1	179	185	PF00069	0.790
MOD_CK1_1	208	214	PF00069	0.606
MOD_CK1_1	215	221	PF00069	0.644
MOD_CK1_1	231	237	PF00069	0.691
MOD_CK1_1	244	250	PF00069	0.613
MOD_CK1_1	297	303	PF00069	0.614
MOD_CK1_1	408	414	PF00069	0.727
MOD_CK1_1	468	474	PF00069	0.629
MOD_CK1_1	537	543	PF00069	0.446
MOD_CK1_1	684	690	PF00069	0.435
MOD_CK1_1	72	78	PF00069	0.525
MOD_CK1_1	731	737	PF00069	0.388
MOD_CK2_1	537	543	PF00069	0.479
MOD_CK2_1	588	594	PF00069	0.406
MOD_CK2_1	619	625	PF00069	0.424
MOD_CK2_1	662	668	PF00069	0.369
MOD_CK2_1	684	690	PF00069	0.497
MOD_CK2_1	755	761	PF00069	0.440
MOD_CMANNOS	571	574	PF00535	0.322
MOD_Cter_Amidation	425	428	PF01082	0.672
MOD_GlcNHglycan	155	158	PF01048	0.679
MOD_GlcNHglycan	161	165	PF01048	0.638
MOD_GlcNHglycan	169	172	PF01048	0.555
MOD_GlcNHglycan	211	214	PF01048	0.592
MOD_GlcNHglycan	256	259	PF01048	0.701
MOD_GlcNHglycan	289	292	PF01048	0.770
MOD_GlcNHglycan	296	299	PF01048	0.731
MOD_GlcNHglycan	411	414	PF01048	0.600
MOD_GlcNHglycan	467	470	PF01048	0.681
MOD_GlcNHglycan	491	495	PF01048	0.399
MOD_GlcNHglycan	50	53	PF01048	0.724
MOD_GlcNHglycan	664	667	PF01048	0.445
MOD_GlcNHglycan	686	689	PF01048	0.470
MOD_GlcNHglycan	69	72	PF01048	0.503
MOD_GlcNHglycan	699	702	PF01048	0.313
MOD_GlcNHglycan	74	77	PF01048	0.505
MOD_GlcNHglycan	768	771	PF01048	0.441
MOD_GSK3_1	139	146	PF00069	0.793
MOD_GSK3_1	163	170	PF00069	0.575
MOD_GSK3_1	205	212	PF00069	0.640
MOD_GSK3_1	264	271	PF00069	0.763
MOD_GSK3_1	405	412	PF00069	0.692
MOD_GSK3_1	432	439	PF00069	0.633
MOD_GSK3_1	464	471	PF00069	0.620
MOD_GSK3_1	490	497	PF00069	0.438
MOD_GSK3_1	566	573	PF00069	0.370
MOD_GSK3_1	619	626	PF00069	0.360
MOD_GSK3_1	680	687	PF00069	0.404
MOD_GSK3_1	693	700	PF00069	0.196
MOD_GSK3_1	728	735	PF00069	0.405
MOD_GSK3_1	746	753	PF00069	0.342
MOD_GSK3_1	755	762	PF00069	0.393
MOD_N-GLC_1	176	181	PF02516	0.669
MOD_N-GLC_1	432	437	PF02516	0.527
MOD_N-GLC_1	92	97	PF02516	0.537
MOD_N-GLC_2	472	474	PF02516	0.522
MOD_NEK2_1	160	165	PF00069	0.674
MOD_NEK2_1	228	233	PF00069	0.610
MOD_NEK2_1	326	331	PF00069	0.558
MOD_NEK2_1	484	489	PF00069	0.364
MOD_NEK2_1	490	495	PF00069	0.388
MOD_NEK2_1	588	593	PF00069	0.407
MOD_NEK2_1	595	600	PF00069	0.297
MOD_NEK2_1	723	728	PF00069	0.418
MOD_NEK2_2	147	152	PF00069	0.516
MOD_NEK2_2	186	191	PF00069	0.699
MOD_PIKK_1	163	169	PF00454	0.685
MOD_PIKK_1	327	333	PF00454	0.667
MOD_PIKK_1	334	340	PF00454	0.769
MOD_PIKK_1	588	594	PF00454	0.460
MOD_PIKK_1	681	687	PF00454	0.489
MOD_PIKK_1	77	83	PF00454	0.518
MOD_PK_1	303	309	PF00069	0.635
MOD_PK_1	427	433	PF00069	0.639
MOD_PK_1	69	75	PF00069	0.524
MOD_PKA_1	303	309	PF00069	0.684
MOD_PKA_1	427	433	PF00069	0.608
MOD_PKA_1	436	442	PF00069	0.562
MOD_PKA_2	208	214	PF00069	0.697
MOD_PKA_2	334	340	PF00069	0.794
MOD_PKA_2	529	535	PF00069	0.501
MOD_PKA_2	566	572	PF00069	0.434
MOD_PKA_2	755	761	PF00069	0.539
MOD_Plk_1	176	182	PF00069	0.666
MOD_Plk_1	241	247	PF00069	0.595
MOD_Plk_1	593	599	PF00069	0.327
MOD_Plk_4	186	192	PF00069	0.664
MOD_Plk_4	223	229	PF00069	0.505
MOD_Plk_4	484	490	PF00069	0.382
MOD_Plk_4	693	699	PF00069	0.327
MOD_Plk_4	723	729	PF00069	0.423
MOD_Plk_4	84	90	PF00069	0.679
MOD_ProDKin_1	494	500	PF00069	0.530
MOD_ProDKin_1	59	65	PF00069	0.515
MOD_ProDKin_1	623	629	PF00069	0.341
MOD_ProDKin_1	660	666	PF00069	0.485
MOD_ProDKin_1	75	81	PF00069	0.770
MOD_ProDKin_1	817	823	PF00069	0.478
TRG_DiLeu_BaEn_1	805	810	PF01217	0.447
TRG_ENDOCYTIC_2	180	183	PF00928	0.639
TRG_ENDOCYTIC_2	219	222	PF00928	0.565
TRG_ENDOCYTIC_2	5	8	PF00928	0.629
TRG_ENDOCYTIC_2	709	712	PF00928	0.360
TRG_ENDOCYTIC_2	725	728	PF00928	0.365
TRG_ER_diArg_1	763	765	PF00400	0.415
TRG_ER_diArg_1	794	797	PF00400	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHP8	Leptomonas seymouri	58%	100%
A0A1X0NU85	Trypanosomatidae	37%	100%
A0A3S7WUI6	Leishmania donovani	77%	100%
A4HXI0	Leishmania infantum	79%	100%
E9AR75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QE88	Leishmania major	78%	99%