Hydrolase, alpha/beta fold family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase, alpha/beta fold family-like protein

Species:

Leishmania braziliensis

UniProt:

A4H956_LEIBR

TriTrypDb:

LbrM.17.1120 , LBRM2903_170018100

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 36
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H956

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H956

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	35
GO:0016787	hydrolase activity	2	35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.342
CLV_NRD_NRD_1	257	259	PF00675	0.428
CLV_NRD_NRD_1	267	269	PF00675	0.457
CLV_PCSK_KEX2_1	257	259	PF00082	0.423
CLV_PCSK_KEX2_1	267	269	PF00082	0.399
CLV_PCSK_SKI1_1	111	115	PF00082	0.236
CLV_PCSK_SKI1_1	172	176	PF00082	0.205
CLV_PCSK_SKI1_1	267	271	PF00082	0.404
CLV_PCSK_SKI1_1	42	46	PF00082	0.446
DOC_CDC14_PxL_1	269	277	PF14671	0.360
DOC_CKS1_1	104	109	PF01111	0.402
DOC_MAPK_DCC_7	267	277	PF00069	0.257
DOC_MAPK_gen_1	267	277	PF00069	0.421
DOC_MAPK_MEF2A_6	268	277	PF00069	0.318
DOC_PP1_RVXF_1	299	306	PF00149	0.442
DOC_USP7_MATH_1	116	120	PF00917	0.322
DOC_USP7_MATH_1	347	351	PF00917	0.586
DOC_WW_Pin1_4	103	108	PF00397	0.352
DOC_WW_Pin1_4	349	354	PF00397	0.603
LIG_14-3-3_CanoR_1	170	175	PF00244	0.289
LIG_BIR_III_4	135	139	PF00653	0.398
LIG_FHA_1	104	110	PF00498	0.309
LIG_FHA_1	272	278	PF00498	0.291
LIG_FHA_1	346	352	PF00498	0.442
LIG_FHA_2	126	132	PF00498	0.306
LIG_FHA_2	350	356	PF00498	0.550
LIG_FHA_2	38	44	PF00498	0.400
LIG_FHA_2	97	103	PF00498	0.333
LIG_GBD_Chelix_1	61	69	PF00786	0.434
LIG_Integrin_RGD_1	221	223	PF01839	0.305
LIG_LIR_Apic_2	102	107	PF02991	0.398
LIG_LIR_Gen_1	194	201	PF02991	0.514
LIG_LIR_Gen_1	29	38	PF02991	0.449
LIG_LIR_Nem_3	135	140	PF02991	0.396
LIG_LIR_Nem_3	29	34	PF02991	0.415
LIG_LIR_Nem_3	315	320	PF02991	0.385
LIG_LIR_Nem_3	45	51	PF02991	0.347
LIG_Pex14_1	191	195	PF04695	0.282
LIG_Pex14_1	72	76	PF04695	0.244
LIG_SH2_CRK	104	108	PF00017	0.323
LIG_SH2_CRK	48	52	PF00017	0.459
LIG_SH2_GRB2like	90	93	PF00017	0.307
LIG_SH2_NCK_1	104	108	PF00017	0.158
LIG_SH2_STAT5	104	107	PF00017	0.149
LIG_SH2_STAT5	127	130	PF00017	0.280
LIG_SH2_STAT5	178	181	PF00017	0.149
LIG_SH3_3	198	204	PF00018	0.546
LIG_SH3_3	51	57	PF00018	0.413
LIG_TRAF2_1	205	208	PF00917	0.322
LIG_TYR_ITIM	46	51	PF00017	0.448
MOD_CK1_1	202	208	PF00069	0.450
MOD_CK1_1	342	348	PF00069	0.676
MOD_CK2_1	116	122	PF00069	0.352
MOD_CK2_1	202	208	PF00069	0.300
MOD_CK2_1	349	355	PF00069	0.557
MOD_CK2_1	37	43	PF00069	0.350
MOD_GlcNHglycan	181	184	PF01048	0.340
MOD_GlcNHglycan	201	204	PF01048	0.452
MOD_GlcNHglycan	342	345	PF01048	0.647
MOD_GSK3_1	172	179	PF00069	0.282
MOD_GSK3_1	187	194	PF00069	0.199
MOD_GSK3_1	335	342	PF00069	0.514
MOD_GSK3_1	345	352	PF00069	0.496
MOD_GSK3_1	92	99	PF00069	0.317
MOD_LATS_1	185	191	PF00433	0.287
MOD_N-GLC_1	237	242	PF02516	0.298
MOD_NEK2_1	1	6	PF00069	0.466
MOD_NEK2_1	151	156	PF00069	0.350
MOD_NEK2_1	280	285	PF00069	0.344
MOD_NEK2_1	308	313	PF00069	0.420
MOD_NEK2_1	65	70	PF00069	0.375
MOD_NEK2_2	144	149	PF00069	0.149
MOD_PKA_2	339	345	PF00069	0.422
MOD_PKA_2	92	98	PF00069	0.338
MOD_Plk_1	354	360	PF00069	0.446
MOD_Plk_1	42	48	PF00069	0.360
MOD_Plk_4	1	7	PF00069	0.555
MOD_Plk_4	125	131	PF00069	0.303
MOD_Plk_4	172	178	PF00069	0.252
MOD_Plk_4	215	221	PF00069	0.403
MOD_Plk_4	271	277	PF00069	0.319
MOD_Plk_4	280	286	PF00069	0.346
MOD_Plk_4	65	71	PF00069	0.392
MOD_ProDKin_1	103	109	PF00069	0.352
MOD_ProDKin_1	349	355	PF00069	0.604
MOD_SUMO_rev_2	319	326	PF00179	0.225
MOD_SUMO_rev_2	332	336	PF00179	0.268
TRG_DiLeu_BaEn_3	207	213	PF01217	0.241
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.356
TRG_ENDOCYTIC_2	317	320	PF00928	0.474
TRG_ENDOCYTIC_2	48	51	PF00928	0.341
TRG_ER_diArg_1	256	258	PF00400	0.390
TRG_ER_diArg_1	266	268	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	34%	84%
A0A0N0P3S4	Leptomonas seymouri	38%	99%
A0A0N1PA10	Leptomonas seymouri	44%	100%
A0A0N1PCQ2	Leptomonas seymouri	66%	100%
A0A0S4JQB3	Bodo saltans	37%	100%
A0A1X0NSR3	Trypanosomatidae	37%	81%
A0A1X0NSS6	Trypanosomatidae	45%	100%
A0A1X0NT85	Trypanosomatidae	32%	73%
A0A3Q8IAY1	Leishmania donovani	41%	92%
A0A3R7KKJ0	Trypanosoma rangeli	45%	100%
A0A3S5IRR1	Trypanosoma rangeli	31%	89%
A0A3S7WUJ3	Leishmania donovani	57%	100%
A0A3S7WUK0	Leishmania donovani	33%	84%
A0A3S7X1K2	Leishmania donovani	45%	100%
A0A422NS41	Trypanosoma rangeli	38%	84%
A1JMX1	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	24%	100%
A4H959	Leishmania braziliensis	33%	84%
A4H960	Leishmania braziliensis	38%	92%
A4HGL0	Leishmania braziliensis	46%	100%
A4HXH8	Leishmania infantum	57%	100%
A4HXI1	Leishmania infantum	33%	84%
A4HXI2	Leishmania infantum	41%	92%
A4I3N6	Leishmania infantum	45%	100%
A4JPX5	Burkholderia vietnamiensis (strain G4 / LMG 22486)	23%	100%
B0SW62	Caulobacter sp. (strain K31)	27%	100%
C5CN82	Variovorax paradoxus (strain S110)	25%	100%
C9Y0S4	Cronobacter turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827 / z3032)	26%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	90%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	83%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	92%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
P00632	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	25%	100%
Q400K3	Pseudomonas putida	27%	100%
Q48MQ7	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	28%	100%
Q4Q8A8	Leishmania major	44%	100%
Q4QE86	Leishmania major	40%	100%
Q4QE87	Leishmania major	33%	100%
Q4QE90	Leishmania major	55%	100%
Q54528	Streptomyces purpurascens	28%	100%
Q54809	Streptomyces peucetius	27%	100%
Q55217	Streptomyces sp. (strain C5)	27%	100%
V5AZB9	Trypanosoma cruzi	38%	84%
V5BER0	Trypanosoma cruzi	45%	100%
V5BNU9	Trypanosoma cruzi	29%	89%