Mak10 subunit, NatC N-terminal acetyltransferase-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mak10 subunit, NatC N(alpha)-terminal acetyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H953_LEIBR

TriTrypDb:

LbrM.17.1090 , LBRM2903_170017600

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031248	protein acetyltransferase complex	3	12
GO:0031414	N-terminal protein acetyltransferase complex	4	12
GO:0031417	NatC complex	5	12
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902493	acetyltransferase complex	4	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H953

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H953

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	12
GO:0006474	N-terminal protein amino acid acetylation	5	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0017196	N-terminal peptidyl-methionine acetylation	6	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018206	peptidyl-methionine modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0031365	N-terminal protein amino acid modification	5	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043543	protein acylation	5	12
GO:0044238	primary metabolic process	2	12
GO:0051604	protein maturation	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.404
CLV_C14_Caspase3-7	579	583	PF00656	0.418
CLV_NRD_NRD_1	204	206	PF00675	0.306
CLV_NRD_NRD_1	349	351	PF00675	0.391
CLV_NRD_NRD_1	409	411	PF00675	0.423
CLV_NRD_NRD_1	435	437	PF00675	0.344
CLV_NRD_NRD_1	592	594	PF00675	0.496
CLV_NRD_NRD_1	679	681	PF00675	0.394
CLV_NRD_NRD_1	685	687	PF00675	0.411
CLV_NRD_NRD_1	737	739	PF00675	0.472
CLV_PCSK_KEX2_1	220	222	PF00082	0.499
CLV_PCSK_KEX2_1	349	351	PF00082	0.398
CLV_PCSK_KEX2_1	357	359	PF00082	0.332
CLV_PCSK_KEX2_1	409	411	PF00082	0.423
CLV_PCSK_KEX2_1	435	437	PF00082	0.344
CLV_PCSK_KEX2_1	547	549	PF00082	0.463
CLV_PCSK_KEX2_1	685	687	PF00082	0.452
CLV_PCSK_KEX2_1	736	738	PF00082	0.502
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.499
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.344
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.547
CLV_PCSK_SKI1_1	102	106	PF00082	0.412
CLV_PCSK_SKI1_1	140	144	PF00082	0.403
CLV_PCSK_SKI1_1	151	155	PF00082	0.497
CLV_PCSK_SKI1_1	206	210	PF00082	0.346
CLV_PCSK_SKI1_1	287	291	PF00082	0.321
CLV_PCSK_SKI1_1	349	353	PF00082	0.523
CLV_PCSK_SKI1_1	397	401	PF00082	0.481
CLV_PCSK_SKI1_1	617	621	PF00082	0.529
DEG_APCC_DBOX_1	123	131	PF00400	0.462
DEG_APCC_DBOX_1	139	147	PF00400	0.385
DEG_APCC_DBOX_1	348	356	PF00400	0.383
DEG_APCC_DBOX_1	592	600	PF00400	0.390
DEG_APCC_DBOX_1	639	647	PF00400	0.369
DEG_APCC_KENBOX_2	525	529	PF00400	0.398
DEG_SCF_TRCP1_1	60	65	PF00400	0.338
DEG_SPOP_SBC_1	153	157	PF00917	0.494
DEG_SPOP_SBC_1	191	195	PF00917	0.439
DOC_ANK_TNKS_1	684	691	PF00023	0.501
DOC_CKS1_1	267	272	PF01111	0.557
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	166	169	PF00134	0.593
DOC_CYCLIN_yCln2_LP_2	511	517	PF00134	0.335
DOC_MAPK_gen_1	254	263	PF00069	0.393
DOC_MAPK_gen_1	547	553	PF00069	0.401
DOC_MAPK_gen_1	593	599	PF00069	0.532
DOC_MAPK_RevD_3	421	436	PF00069	0.369
DOC_PP1_RVXF_1	199	205	PF00149	0.294
DOC_PP1_RVXF_1	257	264	PF00149	0.394
DOC_PP2B_LxvP_1	166	169	PF13499	0.594
DOC_PP2B_LxvP_1	49	52	PF13499	0.485
DOC_PP4_MxPP_1	4	7	PF00568	0.615
DOC_USP7_MATH_1	175	179	PF00917	0.591
DOC_USP7_MATH_1	190	194	PF00917	0.403
DOC_USP7_MATH_1	197	201	PF00917	0.221
DOC_USP7_MATH_1	275	279	PF00917	0.507
DOC_USP7_MATH_1	323	327	PF00917	0.349
DOC_USP7_MATH_1	337	341	PF00917	0.364
DOC_USP7_MATH_1	576	580	PF00917	0.469
DOC_USP7_MATH_1	603	607	PF00917	0.421
DOC_USP7_MATH_1	629	633	PF00917	0.513
DOC_USP7_MATH_1	639	643	PF00917	0.475
DOC_USP7_MATH_1	669	673	PF00917	0.374
DOC_USP7_MATH_1	84	88	PF00917	0.563
DOC_WD40_RPTOR_TOS_1	499	504	PF00400	0.456
DOC_WW_Pin1_4	192	197	PF00397	0.416
DOC_WW_Pin1_4	266	271	PF00397	0.426
DOC_WW_Pin1_4	390	395	PF00397	0.416
LIG_14-3-3_CanoR_1	245	249	PF00244	0.545
LIG_14-3-3_CanoR_1	382	388	PF00244	0.383
LIG_14-3-3_CanoR_1	401	406	PF00244	0.238
LIG_14-3-3_CanoR_1	409	419	PF00244	0.303
LIG_14-3-3_CanoR_1	436	442	PF00244	0.541
LIG_14-3-3_CanoR_1	476	481	PF00244	0.451
LIG_14-3-3_CanoR_1	577	586	PF00244	0.347
LIG_14-3-3_CanoR_1	635	643	PF00244	0.521
LIG_Actin_WH2_2	376	393	PF00022	0.488
LIG_BRCT_BRCA1_1	535	539	PF00533	0.445
LIG_Clathr_ClatBox_1	299	303	PF01394	0.474
LIG_Clathr_ClatBox_1	420	424	PF01394	0.323
LIG_Clathr_ClatBox_1	607	611	PF01394	0.422
LIG_deltaCOP1_diTrp_1	15	25	PF00928	0.450
LIG_eIF4E_1	585	591	PF01652	0.443
LIG_eIF4E_1	69	75	PF01652	0.434
LIG_FHA_1	251	257	PF00498	0.290
LIG_FHA_1	269	275	PF00498	0.449
LIG_FHA_1	410	416	PF00498	0.334
LIG_FHA_1	451	457	PF00498	0.449
LIG_FHA_1	529	535	PF00498	0.487
LIG_FHA_1	692	698	PF00498	0.411
LIG_FHA_1	75	81	PF00498	0.571
LIG_FHA_2	15	21	PF00498	0.438
LIG_FHA_2	438	444	PF00498	0.540
LIG_FHA_2	505	511	PF00498	0.354
LIG_FXI_DFP_1	116	120	PF00024	0.445
LIG_LIR_Gen_1	115	123	PF02991	0.269
LIG_LIR_Gen_1	15	25	PF02991	0.572
LIG_LIR_Gen_1	161	171	PF02991	0.559
LIG_LIR_Gen_1	443	452	PF02991	0.388
LIG_LIR_Gen_1	97	106	PF02991	0.442
LIG_LIR_Nem_3	115	119	PF02991	0.271
LIG_LIR_Nem_3	15	21	PF02991	0.531
LIG_LIR_Nem_3	161	167	PF02991	0.516
LIG_LIR_Nem_3	284	289	PF02991	0.403
LIG_LIR_Nem_3	295	299	PF02991	0.335
LIG_LIR_Nem_3	313	318	PF02991	0.385
LIG_LIR_Nem_3	443	447	PF02991	0.388
LIG_LIR_Nem_3	97	101	PF02991	0.440
LIG_NRBOX	211	217	PF00104	0.451
LIG_NRBOX	70	76	PF00104	0.379
LIG_PDZ_Class_1	739	744	PF00595	0.610
LIG_Pex14_1	516	520	PF04695	0.328
LIG_Pex14_2	204	208	PF04695	0.416
LIG_Pex14_2	311	315	PF04695	0.371
LIG_SH2_CRK	110	114	PF00017	0.412
LIG_SH2_CRK	286	290	PF00017	0.395
LIG_SH2_CRK	359	363	PF00017	0.286
LIG_SH2_CRK	364	368	PF00017	0.360
LIG_SH2_CRK	622	626	PF00017	0.505
LIG_SH2_GRB2like	517	520	PF00017	0.346
LIG_SH2_NCK_1	110	114	PF00017	0.263
LIG_SH2_PTP2	98	101	PF00017	0.442
LIG_SH2_SRC	98	101	PF00017	0.442
LIG_SH2_STAP1	452	456	PF00017	0.413
LIG_SH2_STAP1	633	637	PF00017	0.410
LIG_SH2_STAP1	652	656	PF00017	0.395
LIG_SH2_STAT5	106	109	PF00017	0.302
LIG_SH2_STAT5	116	119	PF00017	0.213
LIG_SH2_STAT5	121	124	PF00017	0.279
LIG_SH2_STAT5	138	141	PF00017	0.290
LIG_SH2_STAT5	243	246	PF00017	0.596
LIG_SH2_STAT5	419	422	PF00017	0.306
LIG_SH2_STAT5	452	455	PF00017	0.430
LIG_SH2_STAT5	488	491	PF00017	0.352
LIG_SH2_STAT5	517	520	PF00017	0.397
LIG_SH2_STAT5	585	588	PF00017	0.448
LIG_SH2_STAT5	718	721	PF00017	0.412
LIG_SH2_STAT5	98	101	PF00017	0.347
LIG_SH3_2	320	325	PF14604	0.327
LIG_SH3_3	264	270	PF00018	0.414
LIG_SH3_3	317	323	PF00018	0.354
LIG_SH3_3	4	10	PF00018	0.654
LIG_SH3_3	719	725	PF00018	0.391
LIG_SUMO_SIM_anti_2	233	241	PF11976	0.430
LIG_SUMO_SIM_anti_2	502	507	PF11976	0.477
LIG_SUMO_SIM_par_1	478	485	PF11976	0.390
LIG_SUMO_SIM_par_1	595	601	PF11976	0.385
LIG_SUMO_SIM_par_1	606	611	PF11976	0.399
LIG_SUMO_SIM_par_1	91	97	PF11976	0.337
LIG_SxIP_EBH_1	547	557	PF03271	0.433
LIG_TRAF2_1	160	163	PF00917	0.457
LIG_TRFH_1	164	168	PF08558	0.549
LIG_TYR_ITIM	620	625	PF00017	0.499
LIG_UBA3_1	289	297	PF00899	0.356
LIG_UBA3_1	351	357	PF00899	0.438
LIG_UBA3_1	596	604	PF00899	0.396
LIG_WRC_WIRS_1	293	298	PF05994	0.458
LIG_WRC_WIRS_1	496	501	PF05994	0.365
MOD_CDK_SPxK_1	266	272	PF00069	0.427
MOD_CDK_SPxxK_3	390	397	PF00069	0.451
MOD_CK1_1	266	272	PF00069	0.427
MOD_CK1_1	295	301	PF00069	0.405
MOD_CK1_1	33	39	PF00069	0.484
MOD_CK1_1	451	457	PF00069	0.358
MOD_CK1_1	581	587	PF00069	0.445
MOD_CK1_1	606	612	PF00069	0.402
MOD_CK1_1	729	735	PF00069	0.446
MOD_CK1_1	82	88	PF00069	0.412
MOD_CK2_1	157	163	PF00069	0.410
MOD_CK2_1	175	181	PF00069	0.423
MOD_CK2_1	219	225	PF00069	0.440
MOD_CK2_1	47	53	PF00069	0.419
MOD_CK2_1	504	510	PF00069	0.329
MOD_GlcNHglycan	283	286	PF01048	0.525
MOD_GlcNHglycan	49	52	PF01048	0.461
MOD_GlcNHglycan	586	589	PF01048	0.428
MOD_GlcNHglycan	60	63	PF01048	0.525
MOD_GlcNHglycan	600	603	PF01048	0.416
MOD_GlcNHglycan	637	640	PF01048	0.448
MOD_GlcNHglycan	673	676	PF01048	0.568
MOD_GlcNHglycan	705	708	PF01048	0.411
MOD_GlcNHglycan	728	731	PF01048	0.514
MOD_GlcNHglycan	81	84	PF01048	0.369
MOD_GSK3_1	108	115	PF00069	0.482
MOD_GSK3_1	153	160	PF00069	0.381
MOD_GSK3_1	215	222	PF00069	0.417
MOD_GSK3_1	237	244	PF00069	0.286
MOD_GSK3_1	450	457	PF00069	0.402
MOD_GSK3_1	475	482	PF00069	0.369
MOD_GSK3_1	556	563	PF00069	0.411
MOD_GSK3_1	58	65	PF00069	0.495
MOD_GSK3_1	635	642	PF00069	0.483
MOD_LATS_1	100	106	PF00433	0.443
MOD_N-GLC_1	131	136	PF02516	0.404
MOD_N-GLC_1	157	162	PF02516	0.534
MOD_N-GLC_1	337	342	PF02516	0.500
MOD_N-GLC_1	527	532	PF02516	0.359
MOD_NEK2_1	112	117	PF00069	0.381
MOD_NEK2_1	154	159	PF00069	0.497
MOD_NEK2_1	215	220	PF00069	0.410
MOD_NEK2_1	263	268	PF00069	0.413
MOD_NEK2_1	351	356	PF00069	0.459
MOD_NEK2_1	422	427	PF00069	0.359
MOD_NEK2_1	437	442	PF00069	0.388
MOD_NEK2_1	534	539	PF00069	0.482
MOD_NEK2_1	556	561	PF00069	0.339
MOD_NEK2_1	670	675	PF00069	0.473
MOD_NEK2_1	691	696	PF00069	0.367
MOD_NEK2_1	731	736	PF00069	0.422
MOD_NEK2_2	64	69	PF00069	0.517
MOD_PIKK_1	504	510	PF00454	0.344
MOD_PIKK_1	74	80	PF00454	0.316
MOD_PKA_1	219	225	PF00069	0.492
MOD_PKA_1	409	415	PF00069	0.241
MOD_PKA_2	244	250	PF00069	0.445
MOD_PKA_2	409	415	PF00069	0.393
MOD_PKA_2	475	481	PF00069	0.407
MOD_PKA_2	560	566	PF00069	0.430
MOD_PKA_2	576	582	PF00069	0.368
MOD_PKA_2	639	645	PF00069	0.350
MOD_Plk_1	102	108	PF00069	0.438
MOD_Plk_1	14	20	PF00069	0.473
MOD_Plk_1	175	181	PF00069	0.532
MOD_Plk_1	31	37	PF00069	0.537
MOD_Plk_1	337	343	PF00069	0.501
MOD_Plk_1	448	454	PF00069	0.346
MOD_Plk_1	527	533	PF00069	0.425
MOD_Plk_1	581	587	PF00069	0.503
MOD_Plk_4	102	108	PF00069	0.463
MOD_Plk_4	112	118	PF00069	0.495
MOD_Plk_4	131	137	PF00069	0.321
MOD_Plk_4	210	216	PF00069	0.399
MOD_Plk_4	263	269	PF00069	0.528
MOD_Plk_4	295	301	PF00069	0.426
MOD_Plk_4	337	343	PF00069	0.414
MOD_Plk_4	422	428	PF00069	0.390
MOD_Plk_4	454	460	PF00069	0.341
MOD_Plk_4	476	482	PF00069	0.394
MOD_Plk_4	540	546	PF00069	0.442
MOD_Plk_4	581	587	PF00069	0.513
MOD_Plk_4	603	609	PF00069	0.418
MOD_Plk_4	64	70	PF00069	0.473
MOD_ProDKin_1	192	198	PF00069	0.407
MOD_ProDKin_1	266	272	PF00069	0.427
MOD_ProDKin_1	390	396	PF00069	0.415
MOD_SUMO_for_1	29	32	PF00179	0.528
MOD_SUMO_rev_2	246	256	PF00179	0.537
MOD_SUMO_rev_2	50	59	PF00179	0.420
MOD_SUMO_rev_2	587	596	PF00179	0.422
TRG_DiLeu_BaEn_1	162	167	PF01217	0.560
TRG_DiLeu_BaEn_1	233	238	PF01217	0.348
TRG_DiLeu_BaEn_1	592	597	PF01217	0.353
TRG_DiLeu_BaEn_2	394	400	PF01217	0.297
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.324
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.459
TRG_ENDOCYTIC_2	110	113	PF00928	0.409
TRG_ENDOCYTIC_2	116	119	PF00928	0.262
TRG_ENDOCYTIC_2	286	289	PF00928	0.322
TRG_ENDOCYTIC_2	364	367	PF00928	0.286
TRG_ENDOCYTIC_2	419	422	PF00928	0.437
TRG_ENDOCYTIC_2	517	520	PF00928	0.363
TRG_ENDOCYTIC_2	622	625	PF00928	0.505
TRG_ENDOCYTIC_2	98	101	PF00928	0.439
TRG_ER_diArg_1	201	204	PF00400	0.311
TRG_ER_diArg_1	349	351	PF00400	0.363
TRG_ER_diArg_1	408	410	PF00400	0.426
TRG_ER_diArg_1	435	437	PF00400	0.332
TRG_ER_diArg_1	684	686	PF00400	0.483
TRG_ER_diArg_1	735	738	PF00400	0.532
TRG_NES_CRM1_1	291	303	PF08389	0.465
TRG_NES_CRM1_1	494	508	PF08389	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y3	Leptomonas seymouri	78%	100%
A0A0S4IMZ6	Bodo saltans	32%	100%
A0A1X0NSS7	Trypanosomatidae	51%	100%
A0A3R7M3C6	Trypanosoma rangeli	48%	100%
A0A3S7WUK2	Leishmania donovani	91%	100%
A4HXH5	Leishmania infantum	91%	100%
C9ZP62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AR70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QE93	Leishmania major	90%	100%
V5D6H5	Trypanosoma cruzi	48%	100%