Putative META domain containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

META domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H951_LEIBR

TriTrypDb:

LbrM.17.1070 , LBRM2903_170017300

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H951

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H951

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034599	cellular response to oxidative stress	4	1
GO:0034605	cellular response to heat	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0062197	cellular response to chemical stress	4	1
GO:0070887	cellular response to chemical stimulus	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.456
CLV_PCSK_SKI1_1	328	332	PF00082	0.493
CLV_PCSK_SKI1_1	353	357	PF00082	0.394
CLV_PCSK_SKI1_1	373	377	PF00082	0.205
CLV_PCSK_SKI1_1	95	99	PF00082	0.304
DOC_ANK_TNKS_1	136	143	PF00023	0.427
DOC_CYCLIN_RxL_1	92	101	PF00134	0.329
DOC_MAPK_MEF2A_6	243	250	PF00069	0.498
DOC_MAPK_MEF2A_6	412	419	PF00069	0.450
DOC_USP7_MATH_1	178	182	PF00917	0.540
DOC_USP7_MATH_1	284	288	PF00917	0.454
DOC_USP7_MATH_1	71	75	PF00917	0.504
LIG_14-3-3_CanoR_1	219	226	PF00244	0.598
LIG_14-3-3_CanoR_1	388	392	PF00244	0.437
LIG_Actin_WH2_2	83	101	PF00022	0.450
LIG_AP2alpha_1	83	87	PF02296	0.450
LIG_BIR_II_1	1	5	PF00653	0.392
LIG_BIR_III_2	440	444	PF00653	0.515
LIG_BRCT_BRCA1_1	103	107	PF00533	0.463
LIG_BRCT_BRCA1_1	189	193	PF00533	0.452
LIG_BRCT_BRCA1_1	351	355	PF00533	0.329
LIG_BRCT_BRCA1_1	79	83	PF00533	0.507
LIG_BRCT_BRCA1_2	189	195	PF00533	0.309
LIG_Clathr_ClatBox_1	182	186	PF01394	0.475
LIG_deltaCOP1_diTrp_1	371	376	PF00928	0.335
LIG_FHA_1	147	153	PF00498	0.449
LIG_FHA_1	171	177	PF00498	0.386
LIG_FHA_1	212	218	PF00498	0.427
LIG_FHA_1	24	30	PF00498	0.414
LIG_FHA_1	269	275	PF00498	0.337
LIG_FHA_1	62	68	PF00498	0.253
LIG_FHA_1	8	14	PF00498	0.367
LIG_FHA_2	1	7	PF00498	0.560
LIG_FHA_2	172	178	PF00498	0.464
LIG_FHA_2	222	228	PF00498	0.525
LIG_FHA_2	291	297	PF00498	0.510
LIG_GBD_Chelix_1	89	97	PF00786	0.350
LIG_LIR_Gen_1	103	113	PF02991	0.511
LIG_LIR_Gen_1	326	337	PF02991	0.523
LIG_LIR_Gen_1	85	93	PF02991	0.450
LIG_LIR_Nem_3	103	108	PF02991	0.358
LIG_LIR_Nem_3	326	332	PF02991	0.513
LIG_LIR_Nem_3	371	377	PF02991	0.358
LIG_LIR_Nem_3	85	90	PF02991	0.450
LIG_NRBOX	92	98	PF00104	0.253
LIG_PCNA_yPIPBox_3	219	230	PF02747	0.314
LIG_PCNA_yPIPBox_3	353	367	PF02747	0.253
LIG_PDZ_Class_3	439	444	PF00595	0.442
LIG_Pex14_2	193	197	PF04695	0.467
LIG_Pex14_2	303	307	PF04695	0.348
LIG_Pex14_2	83	87	PF04695	0.399
LIG_SH2_GRB2like	406	409	PF00017	0.253
LIG_SH2_GRB2like	52	55	PF00017	0.410
LIG_SH2_SRC	52	55	PF00017	0.253
LIG_SH2_STAT5	11	14	PF00017	0.450
LIG_SH2_STAT5	230	233	PF00017	0.392
LIG_SH2_STAT5	350	353	PF00017	0.450
LIG_SH2_STAT5	413	416	PF00017	0.541
LIG_SH3_3	64	70	PF00018	0.253
LIG_SUMO_SIM_par_1	413	418	PF11976	0.441
LIG_TRAF2_1	130	133	PF00917	0.625
LIG_TRAF2_1	280	283	PF00917	0.410
LIG_TRAF2_1	293	296	PF00917	0.277
LIG_TRAF2_1	70	73	PF00917	0.410
LIG_WRC_WIRS_1	232	237	PF05994	0.450
LIG_WRC_WIRS_1	247	252	PF05994	0.450
MOD_CK1_1	111	117	PF00069	0.500
MOD_CK1_1	211	217	PF00069	0.311
MOD_CK1_1	60	66	PF00069	0.541
MOD_CK2_1	171	177	PF00069	0.481
MOD_CK2_1	221	227	PF00069	0.401
MOD_CK2_1	277	283	PF00069	0.411
MOD_CK2_1	290	296	PF00069	0.295
MOD_CK2_1	313	319	PF00069	0.338
MOD_CK2_1	392	398	PF00069	0.371
MOD_GlcNHglycan	203	206	PF01048	0.516
MOD_GlcNHglycan	300	303	PF01048	0.262
MOD_GlcNHglycan	315	318	PF01048	0.334
MOD_GSK3_1	107	114	PF00069	0.394
MOD_GSK3_1	152	159	PF00069	0.404
MOD_GSK3_1	19	26	PF00069	0.424
MOD_GSK3_1	207	214	PF00069	0.397
MOD_GSK3_1	290	297	PF00069	0.383
MOD_GSK3_1	34	41	PF00069	0.440
MOD_GSK3_1	342	349	PF00069	0.440
MOD_GSK3_1	57	64	PF00069	0.392
MOD_GSK3_1	7	14	PF00069	0.329
MOD_GSK3_1	71	78	PF00069	0.436
MOD_N-GLC_1	101	106	PF02516	0.498
MOD_N-GLC_1	201	206	PF02516	0.542
MOD_N-GLC_1	377	382	PF02516	0.334
MOD_N-GLC_1	65	70	PF02516	0.359
MOD_NEK2_1	107	112	PF00069	0.539
MOD_NEK2_1	156	161	PF00069	0.366
MOD_NEK2_1	171	176	PF00069	0.550
MOD_NEK2_1	221	226	PF00069	0.390
MOD_NEK2_1	285	290	PF00069	0.391
MOD_NEK2_1	46	51	PF00069	0.424
MOD_NEK2_1	61	66	PF00069	0.277
MOD_NEK2_1	98	103	PF00069	0.409
MOD_NEK2_2	246	251	PF00069	0.253
MOD_NEK2_2	25	30	PF00069	0.450
MOD_PIKK_1	171	177	PF00454	0.544
MOD_PIKK_1	219	225	PF00454	0.434
MOD_PIKK_1	377	383	PF00454	0.253
MOD_PKA_2	156	162	PF00069	0.317
MOD_PKA_2	268	274	PF00069	0.447
MOD_PKA_2	387	393	PF00069	0.400
MOD_PKA_2	46	52	PF00069	0.416
MOD_Plk_1	101	107	PF00069	0.450
MOD_Plk_1	178	184	PF00069	0.525
MOD_Plk_1	258	264	PF00069	0.447
MOD_Plk_1	318	324	PF00069	0.345
MOD_Plk_1	415	421	PF00069	0.381
MOD_Plk_1	75	81	PF00069	0.406
MOD_Plk_4	178	184	PF00069	0.586
MOD_Plk_4	38	44	PF00069	0.441
MOD_SUMO_for_1	355	358	PF00179	0.450
MOD_SUMO_rev_2	14	21	PF00179	0.350
MOD_SUMO_rev_2	294	299	PF00179	0.526
MOD_SUMO_rev_2	369	375	PF00179	0.396
TRG_DiLeu_BaEn_1	203	208	PF01217	0.514
TRG_DiLeu_BaEn_1	358	363	PF01217	0.450
TRG_DiLeu_BaEn_1	92	97	PF01217	0.278
TRG_DiLeu_BaEn_4	294	300	PF01217	0.410
TRG_DiLeu_LyEn_5	92	97	PF01217	0.253
TRG_NES_CRM1_1	77	92	PF08389	0.450
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L4	Leptomonas seymouri	61%	100%
A0A1X0NSU0	Trypanosomatidae	36%	100%
A0A3Q8IAQ3	Leishmania donovani	80%	100%
A0A422NH16	Trypanosoma rangeli	33%	100%
A4HXG5	Leishmania infantum	81%	100%
C9ZP52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AR60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QEA3	Leishmania major	82%	100%