LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H949_LEIBR
TriTrypDb:
LbrM.17.1050 , LBRM2903_170017100
Length:
118

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H949
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H949

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 105 107 PF00675 0.497
CLV_NRD_NRD_1 36 38 PF00675 0.566
CLV_NRD_NRD_1 92 94 PF00675 0.496
CLV_PCSK_KEX2_1 104 106 PF00082 0.534
CLV_PCSK_KEX2_1 38 40 PF00082 0.548
CLV_PCSK_KEX2_1 84 86 PF00082 0.569
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.548
CLV_PCSK_PC1ET2_1 84 86 PF00082 0.569
CLV_PCSK_SKI1_1 7 11 PF00082 0.739
CLV_PCSK_SKI1_1 87 91 PF00082 0.514
DOC_USP7_UBL2_3 25 29 PF12436 0.688
DOC_USP7_UBL2_3 63 67 PF12436 0.708
DOC_USP7_UBL2_3 90 94 PF12436 0.524
DOC_WW_Pin1_4 24 29 PF00397 0.618
LIG_14-3-3_CanoR_1 45 52 PF00244 0.679
LIG_14-3-3_CanoR_1 7 13 PF00244 0.706
LIG_BRCT_BRCA1_1 74 78 PF00533 0.657
LIG_LIR_Gen_1 75 82 PF02991 0.659
LIG_LIR_Nem_3 75 81 PF02991 0.634
LIG_SH2_STAP1 107 111 PF00017 0.414
LIG_SH2_STAT5 107 110 PF00017 0.410
LIG_SUMO_SIM_anti_2 11 16 PF11976 0.744
MOD_CDK_SPK_2 24 29 PF00069 0.618
MOD_CK1_1 44 50 PF00069 0.665
MOD_Cter_Amidation 23 26 PF01082 0.704
MOD_GSK3_1 13 20 PF00069 0.544
MOD_GSK3_1 52 59 PF00069 0.633
MOD_NEK2_1 31 36 PF00069 0.539
MOD_NEK2_1 52 57 PF00069 0.563
MOD_PIKK_1 62 68 PF00454 0.543
MOD_PKA_1 105 111 PF00069 0.415
MOD_PKA_2 105 111 PF00069 0.522
MOD_PKA_2 31 37 PF00069 0.557
MOD_PKA_2 44 50 PF00069 0.421
MOD_PKB_1 39 47 PF00069 0.597
MOD_Plk_1 52 58 PF00069 0.566
MOD_ProDKin_1 24 30 PF00069 0.616
TRG_ER_diArg_1 103 106 PF00400 0.548
TRG_ER_diArg_1 39 42 PF00400 0.479
TRG_NLS_Bipartite_1 25 42 PF00514 0.655
TRG_NLS_MonoExtC_3 36 41 PF00514 0.648
TRG_NLS_MonoExtN_4 35 42 PF00514 0.570

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4KMF1 Bodo saltans 46% 83%
A0A1X0NKS3 Trypanosomatidae 57% 98%
A0A3Q8IAX0 Leishmania donovani 82% 100%
A4HXG3 Leishmania infantum 82% 100%
C9ZNE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 93%
E9AR58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QEA5 Leishmania major 85% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS