Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H948_LEIBR

TriTrypDb:

LbrM.17.1040 , LBRM2903_170017000

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H948

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H948

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.486
CLV_NRD_NRD_1	162	164	PF00675	0.563
CLV_NRD_NRD_1	246	248	PF00675	0.564
CLV_NRD_NRD_1	249	251	PF00675	0.640
CLV_NRD_NRD_1	26	28	PF00675	0.657
CLV_NRD_NRD_1	375	377	PF00675	0.426
CLV_NRD_NRD_1	398	400	PF00675	0.391
CLV_NRD_NRD_1	59	61	PF00675	0.627
CLV_NRD_NRD_1	74	76	PF00675	0.606
CLV_PCSK_FUR_1	162	166	PF00082	0.549
CLV_PCSK_FUR_1	247	251	PF00082	0.709
CLV_PCSK_KEX2_1	129	131	PF00082	0.496
CLV_PCSK_KEX2_1	162	164	PF00082	0.582
CLV_PCSK_KEX2_1	248	250	PF00082	0.635
CLV_PCSK_KEX2_1	375	377	PF00082	0.426
CLV_PCSK_KEX2_1	398	400	PF00082	0.391
CLV_PCSK_KEX2_1	58	60	PF00082	0.623
CLV_PCSK_KEX2_1	74	76	PF00082	0.564
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.496
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.652
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.635
CLV_PCSK_SKI1_1	189	193	PF00082	0.625
CLV_PCSK_SKI1_1	194	198	PF00082	0.594
CLV_PCSK_SKI1_1	324	328	PF00082	0.592
CLV_PCSK_SKI1_1	483	487	PF00082	0.551
CLV_PCSK_SKI1_1	506	510	PF00082	0.545
CLV_PCSK_SKI1_1	560	564	PF00082	0.516
CLV_PCSK_SKI1_1	60	64	PF00082	0.590
DEG_SCF_TRCP1_1	362	368	PF00400	0.351
DEG_SPOP_SBC_1	257	261	PF00917	0.673
DEG_SPOP_SBC_1	401	405	PF00917	0.281
DEG_SPOP_SBC_1	99	103	PF00917	0.742
DOC_ANK_TNKS_1	269	276	PF00023	0.539
DOC_CKS1_1	490	495	PF01111	0.469
DOC_CYCLIN_RxL_1	171	182	PF00134	0.561
DOC_CYCLIN_RxL_1	565	573	PF00134	0.292
DOC_CYCLIN_yCln2_LP_2	520	526	PF00134	0.557
DOC_MAPK_DCC_7	531	540	PF00069	0.511
DOC_MAPK_gen_1	171	180	PF00069	0.556
DOC_MAPK_gen_1	201	209	PF00069	0.539
DOC_MAPK_gen_1	375	382	PF00069	0.395
DOC_MAPK_HePTP_8	528	540	PF00069	0.402
DOC_MAPK_MEF2A_6	531	540	PF00069	0.399
DOC_PP1_RVXF_1	174	181	PF00149	0.567
DOC_PP2B_LxvP_1	575	578	PF13499	0.613
DOC_PP4_FxxP_1	114	117	PF00568	0.514
DOC_PP4_FxxP_1	311	314	PF00568	0.551
DOC_PP4_FxxP_1	374	377	PF00568	0.411
DOC_USP7_MATH_1	100	104	PF00917	0.625
DOC_USP7_MATH_1	132	136	PF00917	0.534
DOC_USP7_MATH_1	258	262	PF00917	0.774
DOC_USP7_MATH_1	320	324	PF00917	0.593
DOC_USP7_MATH_1	350	354	PF00917	0.692
DOC_USP7_MATH_1	360	364	PF00917	0.393
DOC_USP7_MATH_1	73	77	PF00917	0.653
DOC_USP7_MATH_1	88	92	PF00917	0.642
DOC_USP7_MATH_2	496	502	PF00917	0.452
DOC_WW_Pin1_4	263	268	PF00397	0.657
DOC_WW_Pin1_4	310	315	PF00397	0.541
DOC_WW_Pin1_4	367	372	PF00397	0.484
DOC_WW_Pin1_4	451	456	PF00397	0.476
DOC_WW_Pin1_4	486	491	PF00397	0.456
DOC_WW_Pin1_4	69	74	PF00397	0.600
LIG_14-3-3_CanoR_1	399	409	PF00244	0.416
LIG_14-3-3_CanoR_1	450	455	PF00244	0.669
LIG_14-3-3_CanoR_1	483	489	PF00244	0.460
LIG_14-3-3_CanoR_1	59	69	PF00244	0.602
LIG_APCC_ABBA_1	177	182	PF00400	0.591
LIG_APCC_ABBAyCdc20_2	176	182	PF00400	0.582
LIG_BRCT_BRCA1_1	132	136	PF00533	0.617
LIG_BRCT_BRCA1_1	296	300	PF00533	0.464
LIG_BRCT_BRCA1_1	334	338	PF00533	0.621
LIG_BRCT_BRCA1_1	362	366	PF00533	0.602
LIG_BRCT_BRCA1_1	511	515	PF00533	0.364
LIG_FHA_1	17	23	PF00498	0.728
LIG_FHA_1	225	231	PF00498	0.662
LIG_FHA_1	257	263	PF00498	0.747
LIG_FHA_1	264	270	PF00498	0.508
LIG_FHA_1	525	531	PF00498	0.543
LIG_FHA_2	344	350	PF00498	0.728
LIG_FHA_2	490	496	PF00498	0.629
LIG_GBD_Chelix_1	546	554	PF00786	0.441
LIG_LIR_Apic_2	112	117	PF02991	0.511
LIG_LIR_Apic_2	308	314	PF02991	0.443
LIG_LIR_Apic_2	340	344	PF02991	0.447
LIG_LIR_Apic_2	372	377	PF02991	0.452
LIG_LIR_Gen_1	195	205	PF02991	0.524
LIG_LIR_Gen_1	363	374	PF02991	0.533
LIG_LIR_Gen_1	522	533	PF02991	0.563
LIG_LIR_Nem_3	151	155	PF02991	0.658
LIG_LIR_Nem_3	195	200	PF02991	0.521
LIG_LIR_Nem_3	297	303	PF02991	0.442
LIG_LIR_Nem_3	335	341	PF02991	0.665
LIG_LIR_Nem_3	394	400	PF02991	0.376
LIG_LIR_Nem_3	522	528	PF02991	0.554
LIG_LIR_Nem_3	79	84	PF02991	0.708
LIG_MYND_1	407	411	PF01753	0.551
LIG_NRBOX	324	330	PF00104	0.586
LIG_PCNA_yPIPBox_3	293	304	PF02747	0.511
LIG_Pex14_2	338	342	PF04695	0.675
LIG_SH2_CRK	525	529	PF00017	0.425
LIG_SH2_GRB2like	221	224	PF00017	0.551
LIG_SH2_GRB2like	480	483	PF00017	0.413
LIG_SH2_NCK_1	155	159	PF00017	0.664
LIG_SH2_PTP2	412	415	PF00017	0.493
LIG_SH2_STAT3	10	13	PF00017	0.463
LIG_SH2_STAT5	104	107	PF00017	0.746
LIG_SH2_STAT5	202	205	PF00017	0.529
LIG_SH2_STAT5	221	224	PF00017	0.551
LIG_SH2_STAT5	341	344	PF00017	0.693
LIG_SH2_STAT5	412	415	PF00017	0.488
LIG_SH2_STAT5	480	483	PF00017	0.418
LIG_SH2_STAT5	533	536	PF00017	0.422
LIG_SH2_STAT5	574	577	PF00017	0.585
LIG_SH3_2	70	75	PF14604	0.717
LIG_SH3_3	147	153	PF00018	0.696
LIG_SH3_3	408	414	PF00018	0.403
LIG_SH3_3	487	493	PF00018	0.541
LIG_SH3_3	67	73	PF00018	0.691
LIG_SH3_3	81	87	PF00018	0.711
LIG_SH3_CIN85_PxpxPR_1	69	74	PF14604	0.712
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.467
LIG_SUMO_SIM_par_1	19	25	PF11976	0.467
LIG_SUMO_SIM_par_1	327	332	PF11976	0.575
LIG_SUMO_SIM_par_1	378	383	PF11976	0.395
LIG_SUMO_SIM_par_1	457	464	PF11976	0.419
LIG_TRAF2_1	278	281	PF00917	0.539
LIG_TRAF2_1	416	419	PF00917	0.641
LIG_TYR_ITIM	410	415	PF00017	0.425
LIG_UBA3_1	22	28	PF00899	0.533
LIG_UBA3_1	381	388	PF00899	0.557
MOD_CDC14_SPxK_1	72	75	PF00782	0.658
MOD_CDK_SPK_2	451	456	PF00069	0.476
MOD_CDK_SPK_2	69	74	PF00069	0.694
MOD_CDK_SPxK_1	69	75	PF00069	0.659
MOD_CDK_SPxxK_3	263	270	PF00069	0.537
MOD_CK1_1	151	157	PF00069	0.622
MOD_CK1_1	30	36	PF00069	0.642
MOD_CK1_1	332	338	PF00069	0.615
MOD_CK1_1	425	431	PF00069	0.740
MOD_CK1_1	454	460	PF00069	0.530
MOD_CK1_1	464	470	PF00069	0.357
MOD_CK1_1	489	495	PF00069	0.588
MOD_CK1_1	76	82	PF00069	0.657
MOD_CK1_1	89	95	PF00069	0.661
MOD_CK2_1	100	106	PF00069	0.585
MOD_CK2_1	125	131	PF00069	0.647
MOD_CK2_1	138	144	PF00069	0.505
MOD_CK2_1	343	349	PF00069	0.712
MOD_CK2_1	489	495	PF00069	0.584
MOD_CK2_1	498	504	PF00069	0.479
MOD_Cter_Amidation	160	163	PF01082	0.422
MOD_GlcNHglycan	271	274	PF01048	0.763
MOD_GlcNHglycan	317	320	PF01048	0.587
MOD_GlcNHglycan	34	37	PF01048	0.724
MOD_GlcNHglycan	362	365	PF01048	0.606
MOD_GlcNHglycan	424	427	PF01048	0.743
MOD_GlcNHglycan	445	449	PF01048	0.705
MOD_GlcNHglycan	466	469	PF01048	0.490
MOD_GlcNHglycan	550	553	PF01048	0.435
MOD_GlcNHglycan	75	78	PF01048	0.641
MOD_GSK3_1	138	145	PF00069	0.536
MOD_GSK3_1	27	34	PF00069	0.685
MOD_GSK3_1	280	287	PF00069	0.699
MOD_GSK3_1	320	327	PF00069	0.514
MOD_GSK3_1	329	336	PF00069	0.457
MOD_GSK3_1	350	357	PF00069	0.634
MOD_GSK3_1	360	367	PF00069	0.396
MOD_GSK3_1	425	432	PF00069	0.669
MOD_GSK3_1	450	457	PF00069	0.667
MOD_GSK3_1	484	491	PF00069	0.469
MOD_GSK3_1	511	518	PF00069	0.386
MOD_GSK3_1	69	76	PF00069	0.594
MOD_GSK3_1	82	89	PF00069	0.615
MOD_N-GLC_1	123	128	PF02516	0.523
MOD_N-GLC_1	332	337	PF02516	0.509
MOD_N-GLC_1	89	94	PF02516	0.665
MOD_NEK2_1	294	299	PF00069	0.604
MOD_NEK2_1	329	334	PF00069	0.630
MOD_NEK2_1	365	370	PF00069	0.584
MOD_NEK2_1	400	405	PF00069	0.330
MOD_NEK2_1	484	489	PF00069	0.422
MOD_NEK2_1	509	514	PF00069	0.426
MOD_NEK2_1	515	520	PF00069	0.424
MOD_NEK2_1	524	529	PF00069	0.436
MOD_NEK2_1	82	87	PF00069	0.697
MOD_PIKK_1	380	386	PF00454	0.379
MOD_PIKK_1	388	394	PF00454	0.405
MOD_PIKK_1	427	433	PF00454	0.638
MOD_PIKK_1	515	521	PF00454	0.498
MOD_PKA_1	138	144	PF00069	0.474
MOD_PKA_1	27	33	PF00069	0.554
MOD_PKA_2	11	17	PF00069	0.622
MOD_PKA_2	118	124	PF00069	0.625
MOD_PKA_2	269	275	PF00069	0.613
MOD_PKA_2	350	356	PF00069	0.710
MOD_PKA_2	73	79	PF00069	0.643
MOD_PKB_1	163	171	PF00069	0.417
MOD_PKB_1	58	66	PF00069	0.479
MOD_Plk_2-3	498	504	PF00069	0.630
MOD_Plk_4	100	106	PF00069	0.509
MOD_Plk_4	132	138	PF00069	0.569
MOD_Plk_4	17	23	PF00069	0.462
MOD_Plk_4	258	264	PF00069	0.790
MOD_Plk_4	295	301	PF00069	0.406
MOD_Plk_4	324	330	PF00069	0.529
MOD_Plk_4	337	343	PF00069	0.506
MOD_Plk_4	369	375	PF00069	0.545
MOD_Plk_4	511	517	PF00069	0.360
MOD_Plk_4	562	568	PF00069	0.472
MOD_ProDKin_1	263	269	PF00069	0.656
MOD_ProDKin_1	310	316	PF00069	0.538
MOD_ProDKin_1	367	373	PF00069	0.483
MOD_ProDKin_1	451	457	PF00069	0.466
MOD_ProDKin_1	486	492	PF00069	0.469
MOD_ProDKin_1	69	75	PF00069	0.602
MOD_SUMO_for_1	170	173	PF00179	0.620
MOD_SUMO_rev_2	224	233	PF00179	0.546
MOD_SUMO_rev_2	498	508	PF00179	0.632
MOD_SUMO_rev_2	556	562	PF00179	0.578
TRG_AP2beta_CARGO_1	195	204	PF09066	0.524
TRG_DiLeu_BaEn_3	172	178	PF01217	0.549
TRG_ENDOCYTIC_2	412	415	PF00928	0.422
TRG_ENDOCYTIC_2	473	476	PF00928	0.426
TRG_ENDOCYTIC_2	525	528	PF00928	0.424
TRG_ER_diArg_1	162	165	PF00400	0.603
TRG_ER_diArg_1	247	250	PF00400	0.700
TRG_ER_diArg_1	374	376	PF00400	0.431
TRG_ER_diArg_1	397	399	PF00400	0.386
TRG_ER_diArg_1	57	60	PF00400	0.614
TRG_ER_diArg_1	73	75	PF00400	0.647
TRG_NLS_MonoCore_2	246	251	PF00514	0.694
TRG_NLS_MonoExtN_4	247	252	PF00514	0.715
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	568	573	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD84	Leptomonas seymouri	62%	100%
A0A1X0NST3	Trypanosomatidae	45%	100%
A0A3S5IR66	Trypanosoma rangeli	44%	100%
A0A3S7WUG6	Leishmania donovani	80%	100%
A4HXG2	Leishmania infantum	80%	100%
C9ZP42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AR57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QEA6	Leishmania major	79%	100%
V5AQX9	Trypanosoma cruzi	47%	100%