DBR1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H947_LEIBR

TriTrypDb:

LbrM.17.1030 , LBRM2903_170016900

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H947

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H947

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006397	mRNA processing	7	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0016071	mRNA metabolic process	6	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0008380	RNA splicing	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	6
GO:0004519	endonuclease activity	5	6
GO:0004521	RNA endonuclease activity	5	6
GO:0004540	RNA nuclease activity	4	6
GO:0008419	RNA lariat debranching enzyme activity	7	6
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	6
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.218
CLV_NRD_NRD_1	214	216	PF00675	0.333
CLV_NRD_NRD_1	402	404	PF00675	0.434
CLV_NRD_NRD_1	492	494	PF00675	0.595
CLV_NRD_NRD_1	497	499	PF00675	0.600
CLV_PCSK_FUR_1	400	404	PF00082	0.386
CLV_PCSK_KEX2_1	214	216	PF00082	0.371
CLV_PCSK_KEX2_1	402	404	PF00082	0.386
CLV_PCSK_KEX2_1	492	494	PF00082	0.595
CLV_PCSK_KEX2_1	497	499	PF00082	0.600
CLV_PCSK_KEX2_1	77	79	PF00082	0.392
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.386
CLV_PCSK_PC7_1	493	499	PF00082	0.511
CLV_PCSK_PC7_1	73	79	PF00082	0.386
CLV_PCSK_SKI1_1	288	292	PF00082	0.356
CLV_PCSK_SKI1_1	348	352	PF00082	0.306
CLV_PCSK_SKI1_1	437	441	PF00082	0.402
CLV_PCSK_SKI1_1	447	451	PF00082	0.502
CLV_PCSK_SKI1_1	463	467	PF00082	0.249
CLV_Separin_Metazoa	409	413	PF03568	0.392
DEG_ODPH_VHL_1	458	471	PF01847	0.470
DEG_SCF_FBW7_1	241	246	PF00400	0.218
DEG_SCF_FBW7_1	583	590	PF00400	0.539
DEG_SPOP_SBC_1	33	37	PF00917	0.686
DEG_SPOP_SBC_1	534	538	PF00917	0.616
DEG_SPOP_SBC_1	545	549	PF00917	0.641
DEG_SPOP_SBC_1	582	586	PF00917	0.711
DEG_SPOP_SBC_1	594	598	PF00917	0.685
DOC_MAPK_gen_1	348	358	PF00069	0.298
DOC_MAPK_gen_1	400	410	PF00069	0.392
DOC_MAPK_gen_1	77	83	PF00069	0.380
DOC_MAPK_MEF2A_6	402	410	PF00069	0.396
DOC_PP2B_LxvP_1	457	460	PF13499	0.434
DOC_PP4_FxxP_1	157	160	PF00568	0.298
DOC_PP4_FxxP_1	186	189	PF00568	0.386
DOC_USP7_MATH_1	117	121	PF00917	0.396
DOC_USP7_MATH_1	150	154	PF00917	0.298
DOC_USP7_MATH_1	206	210	PF00917	0.392
DOC_USP7_MATH_1	22	26	PF00917	0.555
DOC_USP7_MATH_1	27	31	PF00917	0.704
DOC_USP7_MATH_1	324	328	PF00917	0.530
DOC_USP7_MATH_1	337	341	PF00917	0.569
DOC_USP7_MATH_1	34	38	PF00917	0.769
DOC_USP7_MATH_1	40	44	PF00917	0.589
DOC_USP7_MATH_1	545	549	PF00917	0.695
DOC_USP7_MATH_1	582	586	PF00917	0.543
DOC_USP7_MATH_1	592	596	PF00917	0.526
DOC_USP7_UBL2_3	279	283	PF12436	0.316
DOC_WW_Pin1_4	18	23	PF00397	0.708
DOC_WW_Pin1_4	239	244	PF00397	0.338
DOC_WW_Pin1_4	322	327	PF00397	0.511
DOC_WW_Pin1_4	36	41	PF00397	0.654
DOC_WW_Pin1_4	469	474	PF00397	0.462
DOC_WW_Pin1_4	483	488	PF00397	0.607
DOC_WW_Pin1_4	546	551	PF00397	0.679
DOC_WW_Pin1_4	583	588	PF00397	0.593
DOC_WW_Pin1_4	604	609	PF00397	0.589
LIG_14-3-3_CanoR_1	365	373	PF00244	0.218
LIG_14-3-3_CanoR_1	389	396	PF00244	0.298
LIG_14-3-3_CanoR_1	412	418	PF00244	0.494
LIG_14-3-3_CanoR_1	492	500	PF00244	0.513
LIG_Actin_WH2_2	218	234	PF00022	0.218
LIG_APCC_ABBA_1	568	573	PF00400	0.712
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BRCT_BRCA1_1	182	186	PF00533	0.298
LIG_BRCT_BRCA1_1	339	343	PF00533	0.386
LIG_BRCT_BRCA1_1	413	417	PF00533	0.386
LIG_FHA_1	134	140	PF00498	0.298
LIG_FHA_1	226	232	PF00498	0.386
LIG_FHA_1	236	242	PF00498	0.263
LIG_FHA_1	294	300	PF00498	0.280
LIG_FHA_1	339	345	PF00498	0.312
LIG_FHA_1	390	396	PF00498	0.386
LIG_FHA_1	460	466	PF00498	0.371
LIG_FHA_1	535	541	PF00498	0.654
LIG_FHA_1	563	569	PF00498	0.661
LIG_FHA_1	578	584	PF00498	0.538
LIG_FHA_1	92	98	PF00498	0.218
LIG_FHA_2	170	176	PF00498	0.344
LIG_FHA_2	355	361	PF00498	0.377
LIG_FHA_2	483	489	PF00498	0.526
LIG_FHA_2	91	97	PF00498	0.392
LIG_GBD_Chelix_1	3	11	PF00786	0.619
LIG_LIR_Apic_2	183	189	PF02991	0.331
LIG_LIR_Apic_2	190	194	PF02991	0.267
LIG_LIR_Gen_1	340	350	PF02991	0.303
LIG_LIR_Gen_1	357	364	PF02991	0.275
LIG_LIR_Gen_1	404	413	PF02991	0.392
LIG_LIR_Gen_1	569	576	PF02991	0.588
LIG_LIR_Nem_3	104	109	PF02991	0.381
LIG_LIR_Nem_3	111	115	PF02991	0.344
LIG_LIR_Nem_3	152	157	PF02991	0.301
LIG_LIR_Nem_3	340	346	PF02991	0.303
LIG_LIR_Nem_3	357	361	PF02991	0.275
LIG_LIR_Nem_3	404	410	PF02991	0.464
LIG_LIR_Nem_3	46	51	PF02991	0.381
LIG_LIR_Nem_3	569	574	PF02991	0.598
LIG_LIR_Nem_3	87	91	PF02991	0.333
LIG_LYPXL_SIV_4	223	231	PF13949	0.218
LIG_Pex14_1	44	48	PF04695	0.513
LIG_Pex14_2	278	282	PF04695	0.392
LIG_SH2_CRK	106	110	PF00017	0.400
LIG_SH2_CRK	191	195	PF00017	0.333
LIG_SH2_NCK_1	116	120	PF00017	0.386
LIG_SH2_NCK_1	191	195	PF00017	0.333
LIG_SH2_SRC	116	119	PF00017	0.386
LIG_SH2_STAT5	134	137	PF00017	0.324
LIG_SH2_STAT5	164	167	PF00017	0.333
LIG_SH2_STAT5	224	227	PF00017	0.392
LIG_SH2_STAT5	281	284	PF00017	0.365
LIG_SH2_STAT5	316	319	PF00017	0.444
LIG_SH2_STAT5	553	556	PF00017	0.707
LIG_SH3_1	191	197	PF00018	0.304
LIG_SH3_2	487	492	PF14604	0.699
LIG_SH3_3	191	197	PF00018	0.304
LIG_SH3_3	318	324	PF00018	0.464
LIG_SH3_3	470	476	PF00018	0.480
LIG_SH3_3	484	490	PF00018	0.605
LIG_SH3_3	522	528	PF00018	0.699
LIG_SH3_3	606	612	PF00018	0.615
LIG_SH3_4	279	286	PF00018	0.316
LIG_SUMO_SIM_par_1	168	175	PF11976	0.333
LIG_TRAF2_1	227	230	PF00917	0.218
LIG_UBA3_1	7	12	PF00899	0.633
LIG_WRC_WIRS_1	355	360	PF05994	0.361
LIG_WRC_WIRS_1	443	448	PF05994	0.325
LIG_WRPW_2	278	281	PF00400	0.298
LIG_WW_3	195	199	PF00397	0.392
LIG_WW_3	607	611	PF00397	0.710
MOD_CDK_SPxK_1	604	610	PF00069	0.549
MOD_CK1_1	120	126	PF00069	0.365
MOD_CK1_1	14	20	PF00069	0.633
MOD_CK1_1	169	175	PF00069	0.386
MOD_CK1_1	235	241	PF00069	0.360
MOD_CK1_1	369	375	PF00069	0.317
MOD_CK1_1	39	45	PF00069	0.536
MOD_CK1_1	391	397	PF00069	0.236
MOD_CK1_1	445	451	PF00069	0.530
MOD_CK1_1	536	542	PF00069	0.741
MOD_CK1_1	566	572	PF00069	0.588
MOD_CK1_1	578	584	PF00069	0.727
MOD_CK1_1	595	601	PF00069	0.660
MOD_CK2_1	231	237	PF00069	0.377
MOD_CK2_1	324	330	PF00069	0.552
MOD_CK2_1	40	46	PF00069	0.550
MOD_CK2_1	482	488	PF00069	0.500
MOD_CK2_1	566	572	PF00069	0.720
MOD_CK2_1	615	621	PF00069	0.677
MOD_CK2_1	64	70	PF00069	0.400
MOD_Cter_Amidation	495	498	PF01082	0.514
MOD_Cter_Amidation	75	78	PF01082	0.333
MOD_GlcNHglycan	121	125	PF01048	0.405
MOD_GlcNHglycan	13	16	PF01048	0.713
MOD_GlcNHglycan	182	185	PF01048	0.414
MOD_GlcNHglycan	208	211	PF01048	0.333
MOD_GlcNHglycan	29	32	PF01048	0.690
MOD_GlcNHglycan	326	329	PF01048	0.609
MOD_GlcNHglycan	36	39	PF01048	0.622
MOD_GlcNHglycan	374	377	PF01048	0.324
MOD_GlcNHglycan	447	450	PF01048	0.539
MOD_GlcNHglycan	452	455	PF01048	0.521
MOD_GlcNHglycan	565	568	PF01048	0.797
MOD_GlcNHglycan	580	583	PF01048	0.598
MOD_GlcNHglycan	597	600	PF01048	0.723
MOD_GSK3_1	165	172	PF00069	0.392
MOD_GSK3_1	18	25	PF00069	0.563
MOD_GSK3_1	231	238	PF00069	0.400
MOD_GSK3_1	239	246	PF00069	0.462
MOD_GSK3_1	29	36	PF00069	0.674
MOD_GSK3_1	322	329	PF00069	0.519
MOD_GSK3_1	368	375	PF00069	0.300
MOD_GSK3_1	529	536	PF00069	0.680
MOD_GSK3_1	562	569	PF00069	0.599
MOD_GSK3_1	574	581	PF00069	0.731
MOD_GSK3_1	583	590	PF00069	0.662
MOD_GSK3_1	594	601	PF00069	0.491
MOD_GSK3_1	7	14	PF00069	0.604
MOD_LATS_1	527	533	PF00433	0.714
MOD_N-GLC_1	420	425	PF02516	0.333
MOD_N-GLC_1	578	583	PF02516	0.536
MOD_N-GLC_2	66	68	PF02516	0.218
MOD_NEK2_1	165	170	PF00069	0.333
MOD_NEK2_1	231	236	PF00069	0.418
MOD_NEK2_1	317	322	PF00069	0.338
MOD_NEK2_1	396	401	PF00069	0.433
MOD_NEK2_1	411	416	PF00069	0.230
MOD_NEK2_1	535	540	PF00069	0.578
MOD_NEK2_1	620	625	PF00069	0.639
MOD_NEK2_2	133	138	PF00069	0.298
MOD_PIKK_1	225	231	PF00454	0.386
MOD_PIKK_1	554	560	PF00454	0.694
MOD_PIKK_1	621	627	PF00454	0.615
MOD_PK_1	232	238	PF00069	0.218
MOD_PKA_2	225	231	PF00069	0.386
MOD_PKA_2	388	394	PF00069	0.298
MOD_PKA_2	411	417	PF00069	0.358
MOD_PKA_2	450	456	PF00069	0.513
MOD_PKA_2	491	497	PF00069	0.523
MOD_PKA_2	512	518	PF00069	0.671
MOD_PKA_2	72	78	PF00069	0.392
MOD_PKA_2	91	97	PF00069	0.218
MOD_Plk_1	120	126	PF00069	0.218
MOD_Plk_1	317	323	PF00069	0.391
MOD_Plk_1	420	426	PF00069	0.333
MOD_Plk_1	578	584	PF00069	0.538
MOD_Plk_4	133	139	PF00069	0.298
MOD_Plk_4	166	172	PF00069	0.386
MOD_Plk_4	354	360	PF00069	0.392
MOD_Plk_4	391	397	PF00069	0.364
MOD_Plk_4	566	572	PF00069	0.756
MOD_Plk_4	615	621	PF00069	0.677
MOD_ProDKin_1	18	24	PF00069	0.710
MOD_ProDKin_1	239	245	PF00069	0.338
MOD_ProDKin_1	322	328	PF00069	0.519
MOD_ProDKin_1	36	42	PF00069	0.645
MOD_ProDKin_1	469	475	PF00069	0.473
MOD_ProDKin_1	483	489	PF00069	0.611
MOD_ProDKin_1	546	552	PF00069	0.681
MOD_ProDKin_1	583	589	PF00069	0.592
MOD_ProDKin_1	604	610	PF00069	0.589
TRG_DiLeu_BaEn_1	144	149	PF01217	0.392
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.392
TRG_ENDOCYTIC_2	106	109	PF00928	0.342
TRG_ENDOCYTIC_2	116	119	PF00928	0.371
TRG_ENDOCYTIC_2	134	137	PF00928	0.183
TRG_ENDOCYTIC_2	154	157	PF00928	0.162
TRG_ER_diArg_1	213	215	PF00400	0.333
TRG_ER_diArg_1	362	365	PF00400	0.392
TRG_ER_diArg_1	400	403	PF00400	0.386
TRG_ER_diArg_1	491	493	PF00400	0.537
TRG_ER_diArg_1	497	499	PF00400	0.487
TRG_ER_diArg_1	528	531	PF00400	0.710
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYD2	Leptomonas seymouri	51%	100%
A0A3R7KE78	Trypanosoma rangeli	52%	100%
A0A3S5H711	Leishmania donovani	81%	100%
A4HXG1	Leishmania infantum	81%	100%
C9ZP39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AR56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QEA7	Leishmania major	82%	98%