Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H946_LEIBR

TriTrypDb:

LbrM.17.1020 , LBRM2903_170016800

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H946

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H946

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.552
CLV_C14_Caspase3-7	395	399	PF00656	0.601
CLV_NRD_NRD_1	179	181	PF00675	0.650
CLV_NRD_NRD_1	484	486	PF00675	0.655
CLV_PCSK_KEX2_1	179	181	PF00082	0.650
CLV_PCSK_KEX2_1	484	486	PF00082	0.644
CLV_PCSK_SKI1_1	30	34	PF00082	0.590
CLV_PCSK_SKI1_1	50	54	PF00082	0.499
CLV_PCSK_SKI1_1	502	506	PF00082	0.639
DEG_Nend_UBRbox_2	1	3	PF02207	0.554
DEG_SPOP_SBC_1	151	155	PF00917	0.608
DEG_SPOP_SBC_1	238	242	PF00917	0.567
DEG_SPOP_SBC_1	249	253	PF00917	0.517
DEG_SPOP_SBC_1	491	495	PF00917	0.660
DEG_SPOP_SBC_1	555	559	PF00917	0.623
DOC_PP2B_LxvP_1	57	60	PF13499	0.516
DOC_USP7_MATH_1	108	112	PF00917	0.596
DOC_USP7_MATH_1	145	149	PF00917	0.506
DOC_USP7_MATH_1	247	251	PF00917	0.622
DOC_USP7_MATH_1	293	297	PF00917	0.693
DOC_USP7_MATH_1	353	357	PF00917	0.582
DOC_USP7_MATH_1	46	50	PF00917	0.590
DOC_USP7_MATH_1	474	478	PF00917	0.740
DOC_USP7_MATH_1	486	490	PF00917	0.659
DOC_USP7_MATH_1	506	510	PF00917	0.599
DOC_USP7_MATH_1	583	587	PF00917	0.545
DOC_USP7_MATH_1	64	68	PF00917	0.569
DOC_WW_Pin1_4	120	125	PF00397	0.684
DOC_WW_Pin1_4	128	133	PF00397	0.602
DOC_WW_Pin1_4	15	20	PF00397	0.557
DOC_WW_Pin1_4	166	171	PF00397	0.585
DOC_WW_Pin1_4	230	235	PF00397	0.647
DOC_WW_Pin1_4	240	245	PF00397	0.657
DOC_WW_Pin1_4	307	312	PF00397	0.633
DOC_WW_Pin1_4	316	321	PF00397	0.632
DOC_WW_Pin1_4	358	363	PF00397	0.615
DOC_WW_Pin1_4	51	56	PF00397	0.697
DOC_WW_Pin1_4	62	67	PF00397	0.581
DOC_WW_Pin1_4	84	89	PF00397	0.531
LIG_14-3-3_CanoR_1	10	16	PF00244	0.603
LIG_14-3-3_CanoR_1	239	244	PF00244	0.656
LIG_14-3-3_CanoR_1	492	501	PF00244	0.667
LIG_14-3-3_CanoR_1	50	55	PF00244	0.620
LIG_14-3-3_CanoR_1	546	550	PF00244	0.621
LIG_14-3-3_CterR_2	590	594	PF00244	0.554
LIG_BRCT_BRCA1_1	569	573	PF00533	0.617
LIG_Clathr_ClatBox_1	68	72	PF01394	0.529
LIG_CSL_BTD_1	55	58	PF09270	0.523
LIG_FHA_1	134	140	PF00498	0.612
LIG_FHA_1	272	278	PF00498	0.529
LIG_FHA_1	85	91	PF00498	0.526
LIG_FHA_2	68	74	PF00498	0.643
LIG_Integrin_isoDGR_2	588	590	PF01839	0.717
LIG_LIR_Gen_1	570	578	PF02991	0.612
LIG_LIR_Gen_1	98	108	PF02991	0.580
LIG_LIR_LC3C_4	147	152	PF02991	0.662
LIG_LIR_Nem_3	412	417	PF02991	0.775
LIG_LIR_Nem_3	570	576	PF02991	0.614
LIG_LIR_Nem_3	98	103	PF02991	0.578
LIG_Pex14_1	288	292	PF04695	0.670
LIG_PTAP_UEV_1	333	338	PF05743	0.516
LIG_SH2_PTP2	308	311	PF00017	0.633
LIG_SH2_STAP1	28	32	PF00017	0.592
LIG_SH2_STAT5	308	311	PF00017	0.633
LIG_SH2_STAT5	375	378	PF00017	0.642
LIG_SH3_3	13	19	PF00018	0.561
LIG_SH3_3	228	234	PF00018	0.647
LIG_SH3_3	241	247	PF00018	0.654
LIG_SH3_3	306	312	PF00018	0.635
LIG_SH3_3	331	337	PF00018	0.519
LIG_SH3_3	422	428	PF00018	0.606
LIG_SH3_3	49	55	PF00018	0.616
LIG_SH3_3	495	501	PF00018	0.643
LIG_SUMO_SIM_anti_2	267	274	PF11976	0.538
LIG_SUMO_SIM_par_1	67	73	PF11976	0.528
LIG_TRAF2_1	70	73	PF00917	0.681
MOD_CDK_SPK_2	316	321	PF00069	0.632
MOD_CK1_1	133	139	PF00069	0.616
MOD_CK1_1	153	159	PF00069	0.625
MOD_CK1_1	191	197	PF00069	0.555
MOD_CK1_1	223	229	PF00069	0.573
MOD_CK1_1	230	236	PF00069	0.733
MOD_CK1_1	250	256	PF00069	0.634
MOD_CK1_1	271	277	PF00069	0.608
MOD_CK1_1	301	307	PF00069	0.795
MOD_CK1_1	319	325	PF00069	0.514
MOD_CK1_1	329	335	PF00069	0.609
MOD_CK1_1	358	364	PF00069	0.720
MOD_CK1_1	409	415	PF00069	0.513
MOD_CK1_1	436	442	PF00069	0.699
MOD_CK1_1	529	535	PF00069	0.631
MOD_CK1_1	544	550	PF00069	0.616
MOD_CK1_1	567	573	PF00069	0.616
MOD_CK1_1	67	73	PF00069	0.528
MOD_CK2_1	15	21	PF00069	0.558
MOD_CK2_1	535	541	PF00069	0.635
MOD_CK2_1	67	73	PF00069	0.528
MOD_GlcNHglycan	11	14	PF01048	0.618
MOD_GlcNHglycan	132	135	PF01048	0.623
MOD_GlcNHglycan	147	150	PF01048	0.587
MOD_GlcNHglycan	158	161	PF01048	0.568
MOD_GlcNHglycan	190	193	PF01048	0.679
MOD_GlcNHglycan	208	211	PF01048	0.674
MOD_GlcNHglycan	220	223	PF01048	0.577
MOD_GlcNHglycan	252	255	PF01048	0.648
MOD_GlcNHglycan	258	261	PF01048	0.576
MOD_GlcNHglycan	321	324	PF01048	0.626
MOD_GlcNHglycan	334	337	PF01048	0.592
MOD_GlcNHglycan	408	411	PF01048	0.564
MOD_GlcNHglycan	435	438	PF01048	0.628
MOD_GlcNHglycan	439	442	PF01048	0.595
MOD_GlcNHglycan	44	47	PF01048	0.607
MOD_GlcNHglycan	462	465	PF01048	0.681
MOD_GlcNHglycan	478	481	PF01048	0.745
MOD_GlcNHglycan	486	489	PF01048	0.643
MOD_GlcNHglycan	494	497	PF01048	0.654
MOD_GlcNHglycan	509	512	PF01048	0.726
MOD_GlcNHglycan	531	534	PF01048	0.620
MOD_GlcNHglycan	536	540	PF01048	0.614
MOD_GlcNHglycan	558	561	PF01048	0.624
MOD_GlcNHglycan	585	588	PF01048	0.550
MOD_GSK3_1	122	129	PF00069	0.644
MOD_GSK3_1	152	159	PF00069	0.691
MOD_GSK3_1	220	227	PF00069	0.609
MOD_GSK3_1	30	37	PF00069	0.611
MOD_GSK3_1	315	322	PF00069	0.561
MOD_GSK3_1	337	344	PF00069	0.610
MOD_GSK3_1	353	360	PF00069	0.567
MOD_GSK3_1	38	45	PF00069	0.711
MOD_GSK3_1	387	394	PF00069	0.577
MOD_GSK3_1	433	440	PF00069	0.584
MOD_GSK3_1	46	53	PF00069	0.536
MOD_GSK3_1	476	483	PF00069	0.656
MOD_GSK3_1	486	493	PF00069	0.782
MOD_GSK3_1	507	514	PF00069	0.645
MOD_GSK3_1	535	542	PF00069	0.609
MOD_GSK3_1	556	563	PF00069	0.623
MOD_GSK3_1	564	571	PF00069	0.615
MOD_GSK3_1	58	65	PF00069	0.478
MOD_N-GLC_1	120	125	PF02516	0.699
MOD_N-GLC_1	298	303	PF02516	0.538
MOD_N-GLC_1	38	43	PF02516	0.572
MOD_N-GLC_1	46	51	PF02516	0.549
MOD_N-GLC_1	529	534	PF02516	0.622
MOD_N-GLC_1	560	565	PF02516	0.618
MOD_N-GLC_2	165	167	PF02516	0.513
MOD_NEK2_1	150	155	PF00069	0.695
MOD_NEK2_1	341	346	PF00069	0.620
MOD_NEK2_1	38	43	PF00069	0.551
MOD_NEK2_1	406	411	PF00069	0.508
MOD_NEK2_1	460	465	PF00069	0.587
MOD_NEK2_1	556	561	PF00069	0.626
MOD_NEK2_1	568	573	PF00069	0.618
MOD_NEK2_1	8	13	PF00069	0.608
MOD_NEK2_2	511	516	PF00069	0.551
MOD_PIKK_1	191	197	PF00454	0.555
MOD_PIKK_1	444	450	PF00454	0.642
MOD_PK_1	180	186	PF00069	0.632
MOD_PKA_1	484	490	PF00069	0.714
MOD_PKA_2	238	244	PF00069	0.651
MOD_PKA_2	388	394	PF00069	0.613
MOD_PKA_2	401	407	PF00069	0.595
MOD_PKA_2	484	490	PF00069	0.688
MOD_PKA_2	491	497	PF00069	0.628
MOD_PKA_2	545	551	PF00069	0.618
MOD_PKA_2	9	15	PF00069	0.605
MOD_PKB_1	120	128	PF00069	0.719
MOD_Plk_1	268	274	PF00069	0.536
MOD_Plk_1	46	52	PF00069	0.590
MOD_Plk_1	529	535	PF00069	0.649
MOD_Plk_1	564	570	PF00069	0.615
MOD_Plk_4	168	174	PF00069	0.579
MOD_Plk_4	23	29	PF00069	0.587
MOD_Plk_4	268	274	PF00069	0.536
MOD_Plk_4	341	347	PF00069	0.682
MOD_Plk_4	568	574	PF00069	0.618
MOD_Plk_4	64	70	PF00069	0.526
MOD_ProDKin_1	120	126	PF00069	0.685
MOD_ProDKin_1	128	134	PF00069	0.599
MOD_ProDKin_1	15	21	PF00069	0.558
MOD_ProDKin_1	166	172	PF00069	0.585
MOD_ProDKin_1	230	236	PF00069	0.648
MOD_ProDKin_1	240	246	PF00069	0.656
MOD_ProDKin_1	307	313	PF00069	0.633
MOD_ProDKin_1	316	322	PF00069	0.631
MOD_ProDKin_1	358	364	PF00069	0.615
MOD_ProDKin_1	51	57	PF00069	0.695
MOD_ProDKin_1	62	68	PF00069	0.581
MOD_ProDKin_1	84	90	PF00069	0.532
MOD_SUMO_for_1	504	507	PF00179	0.712
TRG_DiLeu_BaEn_1	268	273	PF01217	0.537
TRG_DiLeu_BaEn_4	268	274	PF01217	0.536
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.526
TRG_ER_diArg_1	119	122	PF00400	0.722
TRG_ER_diArg_1	179	181	PF00400	0.650
TRG_ER_diArg_1	484	486	PF00400	0.720
TRG_ER_diArg_1	518	521	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I516	Leptomonas seymouri	53%	100%
A0A3Q8IJG5	Leishmania donovani	85%	100%
A4HXG0	Leishmania infantum	85%	100%
E9AR55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QEA8	Leishmania major	85%	100%