G-patch domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G-patch domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H945_LEIBR

TriTrypDb:

LbrM.17.1010 , LBRM2903_170016700

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H945

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H945

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0090069	regulation of ribosome biogenesis	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.713
CLV_NRD_NRD_1	138	140	PF00675	0.729
CLV_NRD_NRD_1	35	37	PF00675	0.344
CLV_NRD_NRD_1	75	77	PF00675	0.651
CLV_PCSK_FUR_1	136	140	PF00082	0.637
CLV_PCSK_KEX2_1	135	137	PF00082	0.688
CLV_PCSK_KEX2_1	138	140	PF00082	0.693
CLV_PCSK_KEX2_1	164	166	PF00082	0.734
CLV_PCSK_KEX2_1	205	207	PF00082	0.524
CLV_PCSK_KEX2_1	35	37	PF00082	0.328
CLV_PCSK_KEX2_1	77	79	PF00082	0.629
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.688
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.734
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.645
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.629
CLV_PCSK_PC7_1	131	137	PF00082	0.754
CLV_PCSK_SKI1_1	138	142	PF00082	0.527
CLV_PCSK_SKI1_1	164	168	PF00082	0.731
CLV_PCSK_SKI1_1	180	184	PF00082	0.560
DEG_SPOP_SBC_1	140	144	PF00917	0.696
DEG_SPOP_SBC_1	159	163	PF00917	0.510
DOC_MAPK_RevD_3	62	78	PF00069	0.418
DOC_USP7_MATH_1	113	117	PF00917	0.744
DOC_USP7_MATH_1	82	86	PF00917	0.631
DOC_USP7_MATH_1	90	94	PF00917	0.560
DOC_USP7_UBL2_3	28	32	PF12436	0.437
DOC_USP7_UBL2_3	7	11	PF12436	0.449
DOC_USP7_UBL2_3	73	77	PF12436	0.587
LIG_14-3-3_CanoR_1	165	174	PF00244	0.657
LIG_14-3-3_CanoR_1	176	183	PF00244	0.544
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_FHA_2	32	38	PF00498	0.442
LIG_LIR_Gen_1	27	38	PF02991	0.328
LIG_LIR_Nem_3	27	33	PF02991	0.328
LIG_LIR_Nem_3	65	71	PF02991	0.537
LIG_REV1ctd_RIR_1	197	207	PF16727	0.418
LIG_SH2_CRK	68	72	PF00017	0.591
LIG_SH2_PTP2	30	33	PF00017	0.344
LIG_SH2_STAT5	30	33	PF00017	0.335
MOD_CK1_1	104	110	PF00069	0.757
MOD_CK1_1	111	117	PF00069	0.736
MOD_CK1_1	143	149	PF00069	0.642
MOD_CK1_1	55	61	PF00069	0.587
MOD_CK2_1	145	151	PF00069	0.627
MOD_CK2_1	175	181	PF00069	0.564
MOD_CK2_1	96	102	PF00069	0.703
MOD_GlcNHglycan	1	4	PF01048	0.545
MOD_GlcNHglycan	126	129	PF01048	0.635
MOD_GSK3_1	101	108	PF00069	0.668
MOD_GSK3_1	139	146	PF00069	0.623
MOD_GSK3_1	22	29	PF00069	0.410
MOD_GSK3_1	52	59	PF00069	0.669
MOD_N-GLC_1	153	158	PF02516	0.579
MOD_N-GLC_1	82	87	PF02516	0.553
MOD_NEK2_1	141	146	PF00069	0.510
MOD_NEK2_1	56	61	PF00069	0.614
MOD_PKA_2	175	181	PF00069	0.592
MOD_Plk_1	172	178	PF00069	0.542
MOD_Plk_1	82	88	PF00069	0.531
MOD_Plk_2-3	153	159	PF00069	0.586
MOD_Plk_4	26	32	PF00069	0.344
MOD_SUMO_for_1	166	169	PF00179	0.503
TRG_ENDOCYTIC_2	30	33	PF00928	0.344
TRG_ENDOCYTIC_2	68	71	PF00928	0.516
TRG_ER_diArg_1	136	139	PF00400	0.640
TRG_ER_diArg_1	196	199	PF00400	0.564
TRG_NLS_MonoExtC_3	134	139	PF00514	0.668
TRG_NLS_MonoExtC_3	163	169	PF00514	0.730
TRG_NLS_MonoExtN_4	133	139	PF00514	0.629
TRG_NLS_MonoExtN_4	73	80	PF00514	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6K7	Leptomonas seymouri	56%	100%
A0A0S4J7Y3	Bodo saltans	33%	100%
A0A1X0NUI8	Trypanosomatidae	39%	100%
A0A3R7R7G3	Trypanosoma rangeli	43%	100%
A0A3S5H710	Leishmania donovani	74%	100%
A4HXF9	Leishmania infantum	74%	100%
C9ZP33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AR54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QEA9	Leishmania major	75%	98%
V5AQX6	Trypanosoma cruzi	40%	79%