LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
RNA-binding protein, putative
Species:
Leishmania braziliensis
UniProt:
A4H944_LEIBR
TriTrypDb:
LbrM.17.1000 , LBRM2903_170016600 *
Length:
380

Annotations

LeishMANIAdb annotations

A Kinetoplastid-specific protein. Unlikely to be a membrane protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H944
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H944

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 3
GO:0005488 binding 1 3
GO:0097159 organic cyclic compound binding 2 3
GO:1901363 heterocyclic compound binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 17 21 PF00656 0.473
CLV_C14_Caspase3-7 188 192 PF00656 0.426
CLV_NRD_NRD_1 10 12 PF00675 0.486
CLV_NRD_NRD_1 182 184 PF00675 0.447
CLV_NRD_NRD_1 276 278 PF00675 0.558
CLV_NRD_NRD_1 52 54 PF00675 0.589
CLV_PCSK_KEX2_1 10 12 PF00082 0.440
CLV_PCSK_KEX2_1 182 184 PF00082 0.569
CLV_PCSK_KEX2_1 52 54 PF00082 0.589
CLV_PCSK_SKI1_1 183 187 PF00082 0.487
DEG_Nend_UBRbox_3 1 3 PF02207 0.502
DOC_CKS1_1 110 115 PF01111 0.476
DOC_CYCLIN_yClb5_NLxxxL_5 171 180 PF00134 0.336
DOC_MAPK_MEF2A_6 204 212 PF00069 0.481
DOC_USP7_MATH_1 160 164 PF00917 0.512
DOC_USP7_MATH_1 268 272 PF00917 0.549
DOC_USP7_MATH_1 352 356 PF00917 0.401
DOC_USP7_MATH_1 64 68 PF00917 0.637
DOC_USP7_MATH_1 73 77 PF00917 0.551
DOC_USP7_MATH_1 88 92 PF00917 0.644
DOC_USP7_UBL2_3 278 282 PF12436 0.591
DOC_WW_Pin1_4 106 111 PF00397 0.649
DOC_WW_Pin1_4 262 267 PF00397 0.698
DOC_WW_Pin1_4 341 346 PF00397 0.489
DOC_WW_Pin1_4 84 89 PF00397 0.606
LIG_14-3-3_CanoR_1 197 205 PF00244 0.361
LIG_14-3-3_CanoR_1 241 247 PF00244 0.511
LIG_14-3-3_CanoR_1 41 47 PF00244 0.440
LIG_Actin_WH2_2 322 340 PF00022 0.489
LIG_BIR_III_4 191 195 PF00653 0.471
LIG_CaM_IQ_9 269 284 PF13499 0.492
LIG_CtBP_PxDLS_1 209 213 PF00389 0.497
LIG_FHA_1 103 109 PF00498 0.653
LIG_FHA_1 159 165 PF00498 0.479
LIG_FHA_1 267 273 PF00498 0.736
LIG_FHA_1 310 316 PF00498 0.466
LIG_FHA_1 41 47 PF00498 0.480
LIG_FHA_1 7 13 PF00498 0.463
LIG_FHA_2 186 192 PF00498 0.415
LIG_FHA_2 256 262 PF00498 0.525
LIG_FHA_2 338 344 PF00498 0.540
LIG_Integrin_RGD_1 301 303 PF01839 0.649
LIG_PCNA_yPIPBox_3 227 239 PF02747 0.351
LIG_SH2_SRC 92 95 PF00017 0.484
LIG_SH2_STAT5 274 277 PF00017 0.598
LIG_SH3_3 107 113 PF00018 0.602
LIG_SH3_3 346 352 PF00018 0.399
LIG_SUMO_SIM_anti_2 314 321 PF11976 0.362
LIG_SUMO_SIM_anti_2 357 363 PF11976 0.427
LIG_SUMO_SIM_anti_2 4 9 PF11976 0.462
LIG_SUMO_SIM_par_1 346 351 PF11976 0.383
LIG_SUMO_SIM_par_1 4 9 PF11976 0.488
LIG_TRAF2_1 258 261 PF00917 0.601
LIG_WRC_WIRS_1 186 191 PF05994 0.408
MOD_CK1_1 102 108 PF00069 0.609
MOD_CK1_1 281 287 PF00069 0.574
MOD_CK1_1 58 64 PF00069 0.517
MOD_CK2_1 255 261 PF00069 0.523
MOD_CK2_1 337 343 PF00069 0.451
MOD_GlcNHglycan 152 155 PF01048 0.595
MOD_GlcNHglycan 284 287 PF01048 0.575
MOD_GlcNHglycan 289 292 PF01048 0.612
MOD_GlcNHglycan 320 323 PF01048 0.474
MOD_GlcNHglycan 354 357 PF01048 0.452
MOD_GlcNHglycan 57 60 PF01048 0.563
MOD_GlcNHglycan 66 69 PF01048 0.594
MOD_GlcNHglycan 75 78 PF01048 0.555
MOD_GlcNHglycan 88 91 PF01048 0.599
MOD_GSK3_1 150 157 PF00069 0.569
MOD_GSK3_1 193 200 PF00069 0.376
MOD_GSK3_1 262 269 PF00069 0.658
MOD_GSK3_1 278 285 PF00069 0.609
MOD_GSK3_1 337 344 PF00069 0.609
MOD_GSK3_1 58 65 PF00069 0.563
MOD_GSK3_1 84 91 PF00069 0.578
MOD_GSK3_1 99 106 PF00069 0.584
MOD_LATS_1 280 286 PF00433 0.489
MOD_NEK2_1 150 155 PF00069 0.637
MOD_NEK2_1 6 11 PF00069 0.475
MOD_NEK2_1 81 86 PF00069 0.597
MOD_NEK2_2 160 165 PF00069 0.439
MOD_PIKK_1 197 203 PF00454 0.344
MOD_PIKK_1 58 64 PF00454 0.562
MOD_PKA_2 196 202 PF00069 0.403
MOD_PKA_2 240 246 PF00069 0.585
MOD_PKA_2 337 343 PF00069 0.561
MOD_PKA_2 40 46 PF00069 0.532
MOD_PKA_2 68 74 PF00069 0.689
MOD_Plk_4 160 166 PF00069 0.620
MOD_Plk_4 185 191 PF00069 0.440
MOD_ProDKin_1 106 112 PF00069 0.645
MOD_ProDKin_1 262 268 PF00069 0.696
MOD_ProDKin_1 341 347 PF00069 0.479
MOD_ProDKin_1 84 90 PF00069 0.606
TRG_ER_diArg_1 10 12 PF00400 0.441
TRG_ER_diArg_1 182 184 PF00400 0.447
TRG_Pf-PMV_PEXEL_1 218 223 PF00026 0.411

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKU0 Leptomonas seymouri 43% 74%
A0A1X0NT51 Trypanosomatidae 27% 76%
A0A3Q8ICU3 Leishmania donovani 79% 100%
A0A3R7JY32 Trypanosoma rangeli 26% 83%
C9ZP32 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 82%
E9AR53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
Q4QEB0 Leishmania major 76% 100%
V5B6D3 Trypanosoma cruzi 25% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS