Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H941_LEIBR

TriTrypDb:

LbrM.17.0970 , LBRM2903_170016300

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H941

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H941

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.356
CLV_NRD_NRD_1	165	167	PF00675	0.630
CLV_NRD_NRD_1	362	364	PF00675	0.583
CLV_NRD_NRD_1	432	434	PF00675	0.769
CLV_NRD_NRD_1	493	495	PF00675	0.734
CLV_NRD_NRD_1	557	559	PF00675	0.460
CLV_PCSK_KEX2_1	155	157	PF00082	0.708
CLV_PCSK_KEX2_1	165	167	PF00082	0.626
CLV_PCSK_KEX2_1	361	363	PF00082	0.610
CLV_PCSK_KEX2_1	432	434	PF00082	0.770
CLV_PCSK_KEX2_1	493	495	PF00082	0.754
CLV_PCSK_KEX2_1	557	559	PF00082	0.460
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.557
CLV_PCSK_SKI1_1	32	36	PF00082	0.615
CLV_PCSK_SKI1_1	323	327	PF00082	0.622
CLV_PCSK_SKI1_1	330	334	PF00082	0.638
CLV_PCSK_SKI1_1	422	426	PF00082	0.637
CLV_PCSK_SKI1_1	432	436	PF00082	0.573
CLV_PCSK_SKI1_1	493	497	PF00082	0.678
CLV_PCSK_SKI1_1	501	505	PF00082	0.696
CLV_PCSK_SKI1_1	523	527	PF00082	0.593
CLV_Separin_Metazoa	43	47	PF03568	0.374
DEG_SCF_FBW7_1	423	429	PF00400	0.370
DEG_SPOP_SBC_1	227	231	PF00917	0.431
DOC_CKS1_1	1	6	PF01111	0.414
DOC_CKS1_1	423	428	PF01111	0.367
DOC_MAPK_gen_1	312	322	PF00069	0.487
DOC_MAPK_gen_1	432	439	PF00069	0.368
DOC_MAPK_MEF2A_6	422	430	PF00069	0.370
DOC_PP1_RVXF_1	430	437	PF00149	0.371
DOC_PP4_FxxP_1	310	313	PF00568	0.485
DOC_USP7_MATH_1	227	231	PF00917	0.586
DOC_USP7_MATH_1	26	30	PF00917	0.308
DOC_USP7_MATH_1	460	464	PF00917	0.591
DOC_USP7_MATH_1	481	485	PF00917	0.446
DOC_USP7_MATH_1	487	491	PF00917	0.459
DOC_WW_Pin1_4	134	139	PF00397	0.465
DOC_WW_Pin1_4	141	146	PF00397	0.401
DOC_WW_Pin1_4	165	170	PF00397	0.415
DOC_WW_Pin1_4	422	427	PF00397	0.423
LIG_14-3-3_CanoR_1	156	164	PF00244	0.421
LIG_14-3-3_CanoR_1	315	321	PF00244	0.359
LIG_14-3-3_CanoR_1	366	375	PF00244	0.405
LIG_14-3-3_CanoR_1	432	437	PF00244	0.371
LIG_14-3-3_CanoR_1	464	473	PF00244	0.504
LIG_14-3-3_CanoR_1	476	482	PF00244	0.389
LIG_14-3-3_CanoR_1	67	71	PF00244	0.497
LIG_APCC_ABBAyCdc20_2	50	56	PF00400	0.368
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BIR_III_1	1	5	PF00653	0.508
LIG_BIR_III_3	1	5	PF00653	0.508
LIG_BIR_III_4	458	462	PF00653	0.422
LIG_BRCT_BRCA1_1	471	475	PF00533	0.578
LIG_Clathr_ClatBox_1	240	244	PF01394	0.363
LIG_deltaCOP1_diTrp_1	159	164	PF00928	0.456
LIG_deltaCOP1_diTrp_1	303	310	PF00928	0.454
LIG_FHA_1	111	117	PF00498	0.495
LIG_FHA_1	189	195	PF00498	0.496
LIG_FHA_1	201	207	PF00498	0.424
LIG_FHA_1	26	32	PF00498	0.375
LIG_FHA_1	260	266	PF00498	0.494
LIG_FHA_1	317	323	PF00498	0.387
LIG_FHA_1	399	405	PF00498	0.508
LIG_FHA_1	423	429	PF00498	0.426
LIG_FHA_1	533	539	PF00498	0.325
LIG_FHA_2	266	272	PF00498	0.500
LIG_FHA_2	291	297	PF00498	0.420
LIG_FHA_2	433	439	PF00498	0.424
LIG_IRF3_LxIS_1	522	529	PF10401	0.391
LIG_LIR_Apic_2	307	313	PF02991	0.479
LIG_LIR_Gen_1	172	183	PF02991	0.456
LIG_LIR_Gen_1	193	204	PF02991	0.487
LIG_LIR_Gen_1	255	266	PF02991	0.441
LIG_LIR_Gen_1	303	313	PF02991	0.473
LIG_LIR_Gen_1	374	382	PF02991	0.404
LIG_LIR_Gen_1	435	442	PF02991	0.484
LIG_LIR_Gen_1	62	70	PF02991	0.361
LIG_LIR_Nem_3	193	199	PF02991	0.491
LIG_LIR_Nem_3	255	261	PF02991	0.440
LIG_LIR_Nem_3	303	308	PF02991	0.457
LIG_LIR_Nem_3	374	379	PF02991	0.444
LIG_LIR_Nem_3	435	439	PF02991	0.445
LIG_LIR_Nem_3	62	66	PF02991	0.404
LIG_LIR_Nem_3	80	86	PF02991	0.422
LIG_Pex14_1	555	559	PF04695	0.561
LIG_PTB_Apo_2	242	249	PF02174	0.333
LIG_PTB_Phospho_1	242	248	PF10480	0.334
LIG_REV1ctd_RIR_1	323	332	PF16727	0.472
LIG_SH2_CRK	488	492	PF00017	0.422
LIG_SH2_NCK_1	171	175	PF00017	0.354
LIG_SH2_NCK_1	183	187	PF00017	0.375
LIG_SH2_NCK_1	488	492	PF00017	0.471
LIG_SH2_STAP1	171	175	PF00017	0.448
LIG_SH2_STAT5	196	199	PF00017	0.450
LIG_SH2_STAT5	248	251	PF00017	0.375
LIG_SH2_STAT5	257	260	PF00017	0.400
LIG_SH2_STAT5	86	89	PF00017	0.401
LIG_SH3_3	232	238	PF00018	0.417
LIG_SH3_3	401	407	PF00018	0.541
LIG_SH3_3	420	426	PF00018	0.390
LIG_SH3_3	515	521	PF00018	0.506
LIG_SUMO_SIM_anti_2	340	345	PF11976	0.427
LIG_SUMO_SIM_par_1	239	244	PF11976	0.426
LIG_SUMO_SIM_par_1	524	530	PF11976	0.388
LIG_TRAF2_1	208	211	PF00917	0.345
LIG_TRAF2_1	40	43	PF00917	0.310
LIG_TRAF2_1	467	470	PF00917	0.500
LIG_WRC_WIRS_1	49	54	PF05994	0.462
MOD_CDK_SPxxK_3	134	141	PF00069	0.446
MOD_CK1_1	100	106	PF00069	0.527
MOD_CK1_1	14	20	PF00069	0.383
MOD_CK1_1	188	194	PF00069	0.566
MOD_CK1_1	239	245	PF00069	0.558
MOD_CK1_1	447	453	PF00069	0.479
MOD_CK1_1	529	535	PF00069	0.506
MOD_CK1_1	73	79	PF00069	0.350
MOD_CK2_1	226	232	PF00069	0.430
MOD_CK2_1	464	470	PF00069	0.507
MOD_CMANNOS	161	164	PF00535	0.676
MOD_Cter_Amidation	359	362	PF01082	0.533
MOD_DYRK1A_RPxSP_1	422	426	PF00069	0.360
MOD_GlcNHglycan	14	17	PF01048	0.740
MOD_GlcNHglycan	262	265	PF01048	0.625
MOD_GlcNHglycan	286	289	PF01048	0.585
MOD_GlcNHglycan	353	356	PF01048	0.589
MOD_GlcNHglycan	414	417	PF01048	0.567
MOD_GlcNHglycan	446	449	PF01048	0.589
MOD_GlcNHglycan	529	532	PF01048	0.669
MOD_GlcNHglycan	99	102	PF01048	0.678
MOD_GSK3_1	106	113	PF00069	0.457
MOD_GSK3_1	181	188	PF00069	0.427
MOD_GSK3_1	256	263	PF00069	0.516
MOD_GSK3_1	422	429	PF00069	0.493
MOD_GSK3_1	44	51	PF00069	0.335
MOD_GSK3_1	460	467	PF00069	0.532
MOD_GSK3_1	66	73	PF00069	0.564
MOD_GSK3_1	97	104	PF00069	0.445
MOD_N-GLC_1	200	205	PF02516	0.578
MOD_N-GLC_1	70	75	PF02516	0.669
MOD_NEK2_1	316	321	PF00069	0.349
MOD_NEK2_1	368	373	PF00069	0.436
MOD_NEK2_1	475	480	PF00069	0.496
MOD_NEK2_1	526	531	PF00069	0.386
MOD_NEK2_1	66	71	PF00069	0.528
MOD_NEK2_2	190	195	PF00069	0.367
MOD_PIKK_1	221	227	PF00454	0.443
MOD_PIKK_1	366	372	PF00454	0.497
MOD_PKA_1	155	161	PF00069	0.476
MOD_PKA_1	432	438	PF00069	0.369
MOD_PKA_2	155	161	PF00069	0.489
MOD_PKA_2	221	227	PF00069	0.478
MOD_PKA_2	298	304	PF00069	0.415
MOD_PKA_2	432	438	PF00069	0.536
MOD_PKA_2	450	456	PF00069	0.468
MOD_PKA_2	475	481	PF00069	0.415
MOD_PKA_2	66	72	PF00069	0.506
MOD_Plk_1	469	475	PF00069	0.492
MOD_Plk_1	73	79	PF00069	0.350
MOD_Plk_2-3	74	80	PF00069	0.457
MOD_Plk_4	236	242	PF00069	0.536
MOD_Plk_4	306	312	PF00069	0.379
MOD_Plk_4	316	322	PF00069	0.474
MOD_Plk_4	371	377	PF00069	0.448
MOD_Plk_4	432	438	PF00069	0.517
MOD_Plk_4	469	475	PF00069	0.579
MOD_ProDKin_1	134	140	PF00069	0.463
MOD_ProDKin_1	141	147	PF00069	0.402
MOD_ProDKin_1	165	171	PF00069	0.414
MOD_ProDKin_1	422	428	PF00069	0.426
TRG_DiLeu_BaEn_3	210	216	PF01217	0.346
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.482
TRG_ENDOCYTIC_2	196	199	PF00928	0.521
TRG_ENDOCYTIC_2	376	379	PF00928	0.452
TRG_ENDOCYTIC_2	488	491	PF00928	0.444
TRG_ER_diArg_1	164	166	PF00400	0.435
TRG_ER_diArg_1	361	363	PF00400	0.395
TRG_ER_diArg_1	432	434	PF00400	0.547
TRG_ER_diArg_1	493	495	PF00400	0.544
TRG_ER_diArg_1	556	558	PF00400	0.659
TRG_NES_CRM1_1	211	225	PF08389	0.360
TRG_NES_CRM1_1	335	350	PF08389	0.341
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	501	506	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P605	Leptomonas seymouri	36%	100%
A0A1X0NTG4	Trypanosomatidae	24%	100%
A0A3S7WUI7	Leishmania donovani	72%	100%
A4HXG6	Leishmania infantum	72%	100%
C9ZP51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AR61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QEA2	Leishmania major	71%	100%