PlsC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H937_LEIBR

TriTrypDb:

LbrM.17.0930 , LBRM2903_170015800

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0012505	endomembrane system	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H937

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H937

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0036149	phosphatidylinositol acyl-chain remodeling	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.532
CLV_NRD_NRD_1	150	152	PF00675	0.309
CLV_NRD_NRD_1	387	389	PF00675	0.377
CLV_NRD_NRD_1	462	464	PF00675	0.418
CLV_NRD_NRD_1	467	469	PF00675	0.431
CLV_PCSK_FUR_1	148	152	PF00082	0.151
CLV_PCSK_KEX2_1	150	152	PF00082	0.272
CLV_PCSK_KEX2_1	387	389	PF00082	0.339
CLV_PCSK_KEX2_1	462	464	PF00082	0.411
CLV_PCSK_KEX2_1	467	469	PF00082	0.421
CLV_PCSK_PC7_1	383	389	PF00082	0.318
CLV_PCSK_PC7_1	463	469	PF00082	0.390
CLV_PCSK_SKI1_1	178	182	PF00082	0.209
CLV_PCSK_SKI1_1	338	342	PF00082	0.254
CLV_PCSK_SKI1_1	344	348	PF00082	0.304
CLV_PCSK_SKI1_1	359	363	PF00082	0.266
CLV_PCSK_SKI1_1	37	41	PF00082	0.534
CLV_PCSK_SKI1_1	462	466	PF00082	0.395
DEG_APCC_DBOX_1	416	424	PF00400	0.311
DEG_APCC_DBOX_1	60	68	PF00400	0.263
DEG_MDM2_SWIB_1	415	423	PF02201	0.313
DEG_Nend_UBRbox_1	1	4	PF02207	0.633
DOC_CDC14_PxL_1	164	172	PF14671	0.463
DOC_CDC14_PxL_1	404	412	PF14671	0.192
DOC_CKS1_1	399	404	PF01111	0.164
DOC_CYCLIN_RxL_1	106	114	PF00134	0.575
DOC_CYCLIN_RxL_1	332	343	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.428
DOC_MAPK_gen_1	293	299	PF00069	0.549
DOC_MAPK_gen_1	387	395	PF00069	0.496
DOC_MAPK_MEF2A_6	261	270	PF00069	0.446
DOC_MAPK_MEF2A_6	417	425	PF00069	0.151
DOC_PP1_RVXF_1	134	140	PF00149	0.420
DOC_PP1_RVXF_1	193	200	PF00149	0.511
DOC_PP2B_LxvP_1	117	120	PF13499	0.549
DOC_PP2B_LxvP_1	406	409	PF13499	0.164
DOC_PP2B_PxIxI_1	206	212	PF00149	0.446
DOC_USP7_UBL2_3	161	165	PF12436	0.475
DOC_WW_Pin1_4	203	208	PF00397	0.511
DOC_WW_Pin1_4	216	221	PF00397	0.511
DOC_WW_Pin1_4	398	403	PF00397	0.288
LIG_14-3-3_CanoR_1	150	160	PF00244	0.552
LIG_14-3-3_CanoR_1	78	84	PF00244	0.495
LIG_APCC_ABBA_1	209	214	PF00400	0.425
LIG_CaM_IQ_9	455	471	PF13499	0.578
LIG_deltaCOP1_diTrp_1	138	146	PF00928	0.409
LIG_eIF4E_1	25	31	PF01652	0.164
LIG_eIF4E_1	390	396	PF01652	0.379
LIG_FHA_1	10	16	PF00498	0.307
LIG_FHA_1	147	153	PF00498	0.435
LIG_FHA_1	204	210	PF00498	0.438
LIG_FHA_1	245	251	PF00498	0.418
LIG_FHA_1	320	326	PF00498	0.484
LIG_FHA_2	80	86	PF00498	0.532
LIG_IRF3_LxIS_1	420	426	PF10401	0.164
LIG_LIR_Gen_1	108	117	PF02991	0.495
LIG_LIR_Gen_1	138	147	PF02991	0.409
LIG_LIR_Gen_1	26	36	PF02991	0.398
LIG_LIR_Gen_1	444	455	PF02991	0.552
LIG_LIR_LC3C_4	12	17	PF02991	0.164
LIG_LIR_Nem_3	108	113	PF02991	0.517
LIG_LIR_Nem_3	138	144	PF02991	0.441
LIG_LIR_Nem_3	175	180	PF02991	0.429
LIG_LIR_Nem_3	26	31	PF02991	0.289
LIG_LIR_Nem_3	444	450	PF02991	0.524
LIG_MAD2	115	123	PF02301	0.514
LIG_Pex14_1	139	143	PF04695	0.433
LIG_Pex14_1	385	389	PF04695	0.517
LIG_Pex14_2	177	181	PF04695	0.402
LIG_Pex14_2	414	418	PF04695	0.356
LIG_Pex14_2	432	436	PF04695	0.335
LIG_REV1ctd_RIR_1	412	421	PF16727	0.415
LIG_SH2_CRK	141	145	PF00017	0.430
LIG_SH2_CRK	390	394	PF00017	0.563
LIG_SH2_CRK	56	60	PF00017	0.196
LIG_SH2_NCK_1	81	85	PF00017	0.472
LIG_SH2_STAP1	141	145	PF00017	0.463
LIG_SH2_STAP1	229	233	PF00017	0.511
LIG_SH2_STAP1	25	29	PF00017	0.164
LIG_SH2_STAP1	272	276	PF00017	0.483
LIG_SH2_STAT3	389	392	PF00017	0.504
LIG_SH2_STAT5	110	113	PF00017	0.493
LIG_SH2_STAT5	141	144	PF00017	0.532
LIG_SH2_STAT5	145	148	PF00017	0.520
LIG_SH2_STAT5	158	161	PF00017	0.369
LIG_SH2_STAT5	179	182	PF00017	0.420
LIG_SH2_STAT5	272	275	PF00017	0.483
LIG_SH2_STAT5	34	37	PF00017	0.370
LIG_SH2_STAT5	38	41	PF00017	0.387
LIG_SH2_STAT5	411	414	PF00017	0.291
LIG_SH2_STAT5	447	450	PF00017	0.559
LIG_SH2_STAT5	63	66	PF00017	0.371
LIG_SH2_STAT5	81	84	PF00017	0.471
LIG_SH2_STAT5	96	99	PF00017	0.447
LIG_SH3_2	120	125	PF14604	0.506
LIG_SH3_3	113	119	PF00018	0.469
LIG_SH3_3	207	213	PF00018	0.351
LIG_SH3_3	238	244	PF00018	0.389
LIG_SH3_3	378	384	PF00018	0.574
LIG_SH3_3	396	402	PF00018	0.345
LIG_SH3_3	447	453	PF00018	0.611
LIG_SUMO_SIM_anti_2	205	212	PF11976	0.446
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.368
LIG_SUMO_SIM_anti_2	26	33	PF11976	0.237
LIG_SUMO_SIM_par_1	263	269	PF11976	0.387
LIG_TRAF2_1	321	324	PF00917	0.596
LIG_TRFH_1	404	408	PF08558	0.275
LIG_TYR_ITIM	54	59	PF00017	0.191
LIG_TYR_ITIM	79	84	PF00017	0.452
LIG_UBA3_1	152	161	PF00899	0.541
LIG_UBA3_1	252	261	PF00899	0.364
LIG_UBA3_1	29	37	PF00899	0.233
LIG_UBA3_1	48	53	PF00899	0.174
LIG_WRC_WIRS_1	140	145	PF05994	0.463
LIG_WW_1	408	411	PF00397	0.164
MOD_CK2_1	20	26	PF00069	0.322
MOD_Cter_Amidation	465	468	PF01082	0.277
MOD_GlcNHglycan	276	279	PF01048	0.259
MOD_GlcNHglycan	42	45	PF01048	0.485
MOD_GlcNHglycan	425	428	PF01048	0.345
MOD_GSK3_1	1	8	PF00069	0.599
MOD_GSK3_1	20	27	PF00069	0.332
MOD_GSK3_1	266	273	PF00069	0.412
MOD_GSK3_1	79	86	PF00069	0.480
MOD_N-GLC_1	200	205	PF02516	0.168
MOD_NEK2_1	1	6	PF00069	0.556
MOD_NEK2_1	146	151	PF00069	0.524
MOD_NEK2_1	20	25	PF00069	0.265
MOD_NEK2_1	298	303	PF00069	0.556
MOD_NEK2_1	340	345	PF00069	0.483
MOD_NEK2_1	40	45	PF00069	0.280
MOD_NEK2_1	423	428	PF00069	0.212
MOD_NEK2_1	430	435	PF00069	0.177
MOD_NEK2_1	74	79	PF00069	0.329
MOD_NEK2_2	96	101	PF00069	0.616
MOD_PIKK_1	118	124	PF00454	0.579
MOD_PIKK_1	223	229	PF00454	0.496
MOD_PKA_1	314	320	PF00069	0.437
MOD_PKA_2	244	250	PF00069	0.433
MOD_Plk_1	266	272	PF00069	0.403
MOD_Plk_1	282	288	PF00069	0.600
MOD_Plk_1	453	459	PF00069	0.636
MOD_Plk_4	1	7	PF00069	0.488
MOD_Plk_4	139	145	PF00069	0.502
MOD_Plk_4	24	30	PF00069	0.278
MOD_Plk_4	282	288	PF00069	0.473
MOD_Plk_4	442	448	PF00069	0.517
MOD_Plk_4	453	459	PF00069	0.561
MOD_Plk_4	79	85	PF00069	0.460
MOD_ProDKin_1	203	209	PF00069	0.511
MOD_ProDKin_1	216	222	PF00069	0.511
MOD_ProDKin_1	398	404	PF00069	0.288
TRG_AP2beta_CARGO_1	175	184	PF09066	0.446
TRG_DiLeu_BaEn_1	26	31	PF01217	0.164
TRG_DiLeu_BaEn_1	337	342	PF01217	0.528
TRG_DiLeu_BaEn_4	263	269	PF01217	0.515
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.351
TRG_ENDOCYTIC_2	110	113	PF00928	0.510
TRG_ENDOCYTIC_2	141	144	PF00928	0.511
TRG_ENDOCYTIC_2	179	182	PF00928	0.420
TRG_ENDOCYTIC_2	390	393	PF00928	0.562
TRG_ENDOCYTIC_2	411	414	PF00928	0.262
TRG_ENDOCYTIC_2	447	450	PF00928	0.571
TRG_ENDOCYTIC_2	56	59	PF00928	0.197
TRG_ENDOCYTIC_2	81	84	PF00928	0.459
TRG_ER_diArg_1	148	151	PF00400	0.409
TRG_ER_diArg_1	386	388	PF00400	0.519
TRG_ER_diArg_1	461	463	PF00400	0.637
TRG_ER_diLys_1	474	477	PF00400	0.676
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC7	Leptomonas seymouri	57%	100%
A0A0S4J7G6	Bodo saltans	35%	100%
A0A1X0NU94	Trypanosomatidae	40%	100%
A0A3Q8IE09	Leishmania donovani	77%	100%
A0A422NH08	Trypanosoma rangeli	43%	100%
A4HXG9	Leishmania infantum	77%	100%
C9ZP55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AR64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QE99	Leishmania major	75%	100%
Q5F3X0	Gallus gallus	28%	100%
V5BF39	Trypanosoma cruzi	41%	100%