Leucine_Rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Leucine_Rich_repeat

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H936_LEIBR

TriTrypDb:

LbrM.17.0920 , LBRM2903_170015700

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H936

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H936

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.510
CLV_C14_Caspase3-7	343	347	PF00656	0.543
CLV_C14_Caspase3-7	506	510	PF00656	0.721
CLV_NRD_NRD_1	578	580	PF00675	0.777
CLV_NRD_NRD_1	657	659	PF00675	0.677
CLV_NRD_NRD_1	662	664	PF00675	0.602
CLV_PCSK_FUR_1	7	11	PF00082	0.691
CLV_PCSK_KEX2_1	147	149	PF00082	0.388
CLV_PCSK_KEX2_1	657	659	PF00082	0.692
CLV_PCSK_KEX2_1	662	664	PF00082	0.596
CLV_PCSK_KEX2_1	9	11	PF00082	0.666
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.388
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.666
CLV_PCSK_PC7_1	658	664	PF00082	0.546
CLV_PCSK_SKI1_1	147	151	PF00082	0.435
CLV_PCSK_SKI1_1	657	661	PF00082	0.691
DEG_APCC_DBOX_1	123	131	PF00400	0.553
DEG_APCC_DBOX_1	147	155	PF00400	0.483
DEG_APCC_DBOX_1	309	317	PF00400	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.766
DEG_SCF_FBW7_1	536	543	PF00400	0.700
DEG_SCF_FBW7_2	625	630	PF00400	0.636
DEG_SPOP_SBC_1	329	333	PF00917	0.525
DOC_CYCLIN_RxL_1	332	343	PF00134	0.493
DOC_CYCLIN_RxL_1	447	458	PF00134	0.563
DOC_MAPK_gen_1	387	397	PF00069	0.397
DOC_MAPK_MEF2A_6	10	19	PF00069	0.559
DOC_MIT_MIM_1	617	625	PF04212	0.627
DOC_PP1_RVXF_1	266	272	PF00149	0.544
DOC_PP1_RVXF_1	333	340	PF00149	0.533
DOC_PP2B_LxvP_1	309	312	PF13499	0.393
DOC_USP7_MATH_1	161	165	PF00917	0.638
DOC_USP7_MATH_1	211	215	PF00917	0.691
DOC_USP7_MATH_1	305	309	PF00917	0.490
DOC_USP7_MATH_1	463	467	PF00917	0.640
DOC_USP7_MATH_1	487	491	PF00917	0.677
DOC_USP7_MATH_1	534	538	PF00917	0.778
DOC_USP7_MATH_1	540	544	PF00917	0.755
DOC_USP7_MATH_1	555	559	PF00917	0.794
DOC_USP7_MATH_1	611	615	PF00917	0.538
DOC_WW_Pin1_4	472	477	PF00397	0.654
DOC_WW_Pin1_4	536	541	PF00397	0.695
DOC_WW_Pin1_4	623	628	PF00397	0.586
LIG_14-3-3_CanoR_1	105	109	PF00244	0.440
LIG_14-3-3_CanoR_1	124	128	PF00244	0.336
LIG_14-3-3_CanoR_1	268	272	PF00244	0.499
LIG_14-3-3_CanoR_1	279	288	PF00244	0.619
LIG_14-3-3_CanoR_1	301	309	PF00244	0.402
LIG_14-3-3_CanoR_1	387	393	PF00244	0.420
LIG_14-3-3_CanoR_1	410	416	PF00244	0.487
LIG_14-3-3_CanoR_1	550	559	PF00244	0.814
LIG_14-3-3_CanoR_1	579	588	PF00244	0.569
LIG_BIR_III_4	404	408	PF00653	0.503
LIG_BRCT_BRCA1_1	457	461	PF00533	0.438
LIG_BRCT_BRCA1_1	648	652	PF00533	0.439
LIG_Clathr_ClatBox_1	615	619	PF01394	0.536
LIG_deltaCOP1_diTrp_1	143	150	PF00928	0.521
LIG_eIF4E_1	144	150	PF01652	0.555
LIG_FHA_1	183	189	PF00498	0.544
LIG_FHA_1	194	200	PF00498	0.693
LIG_FHA_1	239	245	PF00498	0.458
LIG_FHA_1	268	274	PF00498	0.449
LIG_FHA_1	281	287	PF00498	0.536
LIG_FHA_1	331	337	PF00498	0.445
LIG_FHA_1	389	395	PF00498	0.406
LIG_FHA_1	489	495	PF00498	0.759
LIG_FHA_1	611	617	PF00498	0.382
LIG_FHA_2	165	171	PF00498	0.529
LIG_FHA_2	205	211	PF00498	0.712
LIG_FHA_2	302	308	PF00498	0.462
LIG_FHA_2	418	424	PF00498	0.430
LIG_FHA_2	543	549	PF00498	0.623
LIG_FHA_2	624	630	PF00498	0.586
LIG_LIR_Apic_2	52	56	PF02991	0.452
LIG_LIR_Gen_1	22	30	PF02991	0.557
LIG_LIR_Gen_1	255	265	PF02991	0.516
LIG_LIR_Nem_3	143	149	PF02991	0.527
LIG_LIR_Nem_3	22	28	PF02991	0.441
LIG_LIR_Nem_3	619	625	PF02991	0.579
LIG_MYND_1	594	598	PF01753	0.516
LIG_PCNA_yPIPBox_3	80	90	PF02747	0.553
LIG_Pex14_1	146	150	PF04695	0.408
LIG_Pex14_2	267	271	PF04695	0.538
LIG_SH2_CRK	87	91	PF00017	0.473
LIG_SH2_STAP1	254	258	PF00017	0.478
LIG_SH2_STAP1	87	91	PF00017	0.521
LIG_SH2_STAT5	238	241	PF00017	0.451
LIG_SH2_STAT5	303	306	PF00017	0.406
LIG_SH2_STAT5	368	371	PF00017	0.422
LIG_SH2_STAT5	53	56	PF00017	0.531
LIG_SH3_2	575	580	PF14604	0.559
LIG_SH3_3	239	245	PF00018	0.566
LIG_SH3_3	357	363	PF00018	0.449
LIG_SH3_3	572	578	PF00018	0.576
LIG_SH3_3	588	594	PF00018	0.674
LIG_SH3_3	92	98	PF00018	0.514
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.494
LIG_SUMO_SIM_par_1	613	619	PF11976	0.542
LIG_TRAF2_1	363	366	PF00917	0.425
LIG_TRAF2_1	525	528	PF00917	0.789
LIG_TRAF2_1	545	548	PF00917	0.561
LIG_TRAF2_1	57	60	PF00917	0.542
LIG_TRAF2_1	627	630	PF00917	0.587
LIG_WRC_WIRS_1	264	269	PF05994	0.532
LIG_WRPW_2	251	254	PF00400	0.589
MOD_CK1_1	131	137	PF00069	0.576
MOD_CK1_1	164	170	PF00069	0.533
MOD_CK1_1	197	203	PF00069	0.754
MOD_CK1_1	340	346	PF00069	0.421
MOD_CK1_1	425	431	PF00069	0.447
MOD_CK1_1	455	461	PF00069	0.570
MOD_CK1_1	468	474	PF00069	0.560
MOD_CK1_1	490	496	PF00069	0.748
MOD_CK1_1	503	509	PF00069	0.723
MOD_CK1_1	514	520	PF00069	0.523
MOD_CK1_1	549	555	PF00069	0.675
MOD_CK1_1	557	563	PF00069	0.751
MOD_CK2_1	301	307	PF00069	0.472
MOD_CK2_1	345	351	PF00069	0.287
MOD_CK2_1	40	46	PF00069	0.667
MOD_CK2_1	54	60	PF00069	0.509
MOD_CK2_1	542	548	PF00069	0.640
MOD_CK2_1	611	617	PF00069	0.542
MOD_CK2_1	623	629	PF00069	0.581
MOD_GlcNHglycan	177	180	PF01048	0.693
MOD_GlcNHglycan	200	203	PF01048	0.726
MOD_GlcNHglycan	41	45	PF01048	0.582
MOD_GlcNHglycan	454	457	PF01048	0.545
MOD_GlcNHglycan	471	474	PF01048	0.595
MOD_GlcNHglycan	498	501	PF01048	0.662
MOD_GlcNHglycan	502	505	PF01048	0.689
MOD_GlcNHglycan	516	520	PF01048	0.641
MOD_GlcNHglycan	540	543	PF01048	0.559
MOD_GlcNHglycan	582	585	PF01048	0.568
MOD_GlcNHglycan	72	75	PF01048	0.401
MOD_GSK3_1	1	8	PF00069	0.697
MOD_GSK3_1	171	178	PF00069	0.670
MOD_GSK3_1	189	196	PF00069	0.559
MOD_GSK3_1	197	204	PF00069	0.670
MOD_GSK3_1	20	27	PF00069	0.375
MOD_GSK3_1	263	270	PF00069	0.415
MOD_GSK3_1	301	308	PF00069	0.530
MOD_GSK3_1	465	472	PF00069	0.620
MOD_GSK3_1	481	488	PF00069	0.796
MOD_GSK3_1	489	496	PF00069	0.667
MOD_GSK3_1	511	518	PF00069	0.738
MOD_GSK3_1	534	541	PF00069	0.760
MOD_GSK3_1	542	549	PF00069	0.736
MOD_GSK3_1	551	558	PF00069	0.720
MOD_GSK3_1	582	589	PF00069	0.565
MOD_N-GLC_1	2	7	PF02516	0.589
MOD_N-GLC_1	301	306	PF02516	0.511
MOD_N-GLC_1	329	334	PF02516	0.323
MOD_N-GLC_1	388	393	PF02516	0.391
MOD_N-GLC_1	611	616	PF02516	0.536
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	104	109	PF00069	0.427
MOD_NEK2_1	189	194	PF00069	0.707
MOD_NEK2_1	267	272	PF00069	0.462
MOD_NEK2_1	328	333	PF00069	0.456
MOD_NEK2_1	337	342	PF00069	0.364
MOD_NEK2_1	411	416	PF00069	0.499
MOD_NEK2_1	452	457	PF00069	0.476
MOD_NEK2_1	587	592	PF00069	0.668
MOD_NEK2_1	646	651	PF00069	0.632
MOD_NEK2_2	263	268	PF00069	0.527
MOD_NEK2_2	305	310	PF00069	0.537
MOD_NEK2_2	388	393	PF00069	0.240
MOD_PIKK_1	189	195	PF00454	0.711
MOD_PIKK_1	33	39	PF00454	0.532
MOD_PIKK_1	337	343	PF00454	0.490
MOD_PIKK_1	444	450	PF00454	0.582
MOD_PIKK_1	455	461	PF00454	0.538
MOD_PIKK_1	463	469	PF00454	0.648
MOD_PIKK_1	582	588	PF00454	0.820
MOD_PKA_2	104	110	PF00069	0.508
MOD_PKA_2	123	129	PF00069	0.375
MOD_PKA_2	131	137	PF00069	0.528
MOD_PKA_2	267	273	PF00069	0.459
MOD_PKA_2	549	555	PF00069	0.816
MOD_PKA_2	669	675	PF00069	0.660
MOD_Plk_1	2	8	PF00069	0.586
MOD_Plk_1	211	217	PF00069	0.685
MOD_Plk_1	301	307	PF00069	0.512
MOD_Plk_1	329	335	PF00069	0.325
MOD_Plk_1	345	351	PF00069	0.280
MOD_Plk_1	388	394	PF00069	0.433
MOD_Plk_1	422	428	PF00069	0.419
MOD_Plk_1	534	540	PF00069	0.823
MOD_Plk_1	611	617	PF00069	0.542
MOD_Plk_1	646	652	PF00069	0.699
MOD_Plk_2-3	511	517	PF00069	0.560
MOD_Plk_4	171	177	PF00069	0.691
MOD_Plk_4	345	351	PF00069	0.532
MOD_Plk_4	49	55	PF00069	0.566
MOD_Plk_4	611	617	PF00069	0.542
MOD_Plk_4	97	103	PF00069	0.605
MOD_ProDKin_1	472	478	PF00069	0.657
MOD_ProDKin_1	536	542	PF00069	0.693
MOD_ProDKin_1	623	629	PF00069	0.581
TRG_DiLeu_BaEn_1	291	296	PF01217	0.517
TRG_DiLeu_BaEn_1	351	356	PF01217	0.537
TRG_DiLeu_BaEn_1	365	370	PF01217	0.232
TRG_DiLeu_BaEn_4	81	87	PF01217	0.512
TRG_ENDOCYTIC_2	254	257	PF00928	0.432
TRG_ENDOCYTIC_2	303	306	PF00928	0.448
TRG_ENDOCYTIC_2	87	90	PF00928	0.442
TRG_NLS_MonoExtN_4	578	583	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWS3	Leptomonas seymouri	55%	100%
A0A0S4J741	Bodo saltans	33%	100%
A0A3S7WUQ4	Leishmania donovani	78%	100%
A4HXG8	Leishmania infantum	78%	100%
E9AR63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QEA0	Leishmania major	78%	99%
V5B626	Trypanosoma cruzi	39%	100%