Intraflagellar transport protein 46 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Intraflagellar transport complex B protein 46 C terminal, putative

Species:

Leishmania braziliensis

UniProt:

A4H935_LEIBR

TriTrypDb:

LbrM.17.0910 , LBRM2903_300023800

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0005856	cytoskeleton	5	6
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0031514	motile cilium	5	2
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4H935

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H935

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7
GO:0010970	transport along microtubule	4	7
GO:0030705	cytoskeleton-dependent intracellular transport	4	7
GO:0031503	protein-containing complex localization	2	7
GO:0042073	intraciliary transport	3	7
GO:0046907	intracellular transport	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0099111	microtubule-based transport	4	7
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	512	516	PF00656	0.468
CLV_NRD_NRD_1	114	116	PF00675	0.543
CLV_NRD_NRD_1	48	50	PF00675	0.446
CLV_PCSK_KEX2_1	114	116	PF00082	0.543
CLV_PCSK_SKI1_1	211	215	PF00082	0.531
CLV_PCSK_SKI1_1	449	453	PF00082	0.284
DEG_APCC_DBOX_1	7	15	PF00400	0.330
DOC_ANK_TNKS_1	113	120	PF00023	0.543
DOC_CKS1_1	207	212	PF01111	0.598
DOC_CKS1_1	252	257	PF01111	0.629
DOC_MAPK_gen_1	114	122	PF00069	0.548
DOC_MAPK_MEF2A_6	115	124	PF00069	0.642
DOC_MAPK_MEF2A_6	50	59	PF00069	0.439
DOC_PP2B_LxvP_1	120	123	PF13499	0.557
DOC_PP2B_LxvP_1	376	379	PF13499	0.407
DOC_PP2B_LxvP_1	505	508	PF13499	0.468
DOC_PP4_MxPP_1	263	266	PF00568	0.544
DOC_USP7_MATH_1	105	109	PF00917	0.640
DOC_USP7_MATH_1	146	150	PF00917	0.584
DOC_USP7_MATH_1	156	160	PF00917	0.686
DOC_USP7_MATH_1	179	183	PF00917	0.531
DOC_USP7_MATH_1	247	251	PF00917	0.684
DOC_USP7_UBL2_3	342	346	PF12436	0.407
DOC_USP7_UBL2_3	445	449	PF12436	0.468
DOC_WW_Pin1_4	124	129	PF00397	0.537
DOC_WW_Pin1_4	144	149	PF00397	0.615
DOC_WW_Pin1_4	152	157	PF00397	0.610
DOC_WW_Pin1_4	177	182	PF00397	0.545
DOC_WW_Pin1_4	206	211	PF00397	0.594
DOC_WW_Pin1_4	243	248	PF00397	0.658
DOC_WW_Pin1_4	251	256	PF00397	0.591
DOC_WW_Pin1_4	51	56	PF00397	0.434
LIG_14-3-3_CanoR_1	160	167	PF00244	0.539
LIG_14-3-3_CanoR_1	328	337	PF00244	0.512
LIG_14-3-3_CanoR_1	438	446	PF00244	0.468
LIG_14-3-3_CanoR_1	49	54	PF00244	0.446
LIG_AP2alpha_2	373	375	PF02296	0.468
LIG_APCC_ABBA_1	36	41	PF00400	0.403
LIG_APCC_ABBA_1	521	526	PF00400	0.468
LIG_BIR_II_1	1	5	PF00653	0.466
LIG_CtBP_PxDLS_1	302	306	PF00389	0.510
LIG_FHA_1	27	33	PF00498	0.396
LIG_FHA_1	349	355	PF00498	0.449
LIG_FHA_1	52	58	PF00498	0.511
LIG_FHA_2	282	288	PF00498	0.711
LIG_FHA_2	520	526	PF00498	0.468
LIG_FHA_2	82	88	PF00498	0.508
LIG_FHA_2	98	104	PF00498	0.694
LIG_GBD_Chelix_1	418	426	PF00786	0.312
LIG_LIR_Apic_2	454	460	PF02991	0.468
LIG_LIR_Gen_1	34	43	PF02991	0.422
LIG_LIR_Gen_1	373	381	PF02991	0.468
LIG_LIR_Gen_1	509	517	PF02991	0.468
LIG_LIR_LC3C_4	54	59	PF02991	0.419
LIG_LIR_Nem_3	152	157	PF02991	0.538
LIG_LIR_Nem_3	339	344	PF02991	0.468
LIG_LIR_Nem_3	34	39	PF02991	0.421
LIG_LIR_Nem_3	373	378	PF02991	0.468
LIG_LIR_Nem_3	509	513	PF02991	0.468
LIG_LIR_Nem_3	522	527	PF02991	0.456
LIG_PCNA_yPIPBox_3	328	341	PF02747	0.407
LIG_PCNA_yPIPBox_3	491	499	PF02747	0.512
LIG_Pex14_1	471	475	PF04695	0.468
LIG_SH2_CRK	154	158	PF00017	0.542
LIG_SH2_CRK	326	330	PF00017	0.468
LIG_SH2_CRK	457	461	PF00017	0.468
LIG_SH2_CRK	510	514	PF00017	0.468
LIG_SH2_NCK_1	154	158	PF00017	0.542
LIG_SH2_NCK_1	326	330	PF00017	0.468
LIG_SH2_SRC	365	368	PF00017	0.405
LIG_SH2_SRC	63	66	PF00017	0.397
LIG_SH2_SRC	94	97	PF00017	0.586
LIG_SH2_STAP1	47	51	PF00017	0.446
LIG_SH2_STAP1	510	514	PF00017	0.468
LIG_SH2_STAT3	297	300	PF00017	0.599
LIG_SH2_STAT5	154	157	PF00017	0.541
LIG_SH2_STAT5	365	368	PF00017	0.468
LIG_SH2_STAT5	497	500	PF00017	0.468
LIG_SH2_STAT5	63	66	PF00017	0.397
LIG_SH3_1	357	363	PF00018	0.468
LIG_SH3_3	122	128	PF00018	0.551
LIG_SH3_3	204	210	PF00018	0.507
LIG_SH3_3	241	247	PF00018	0.653
LIG_SH3_3	249	255	PF00018	0.587
LIG_SH3_3	357	363	PF00018	0.468
LIG_SH3_3	375	381	PF00018	0.469
LIG_SH3_3	390	396	PF00018	0.468
LIG_SH3_3	480	486	PF00018	0.468
LIG_SUMO_SIM_par_1	28	35	PF11976	0.390
LIG_SUMO_SIM_par_1	301	307	PF11976	0.531
LIG_SUMO_SIM_par_1	404	409	PF11976	0.468
LIG_SUMO_SIM_par_1	503	509	PF11976	0.468
LIG_TRAF2_1	100	103	PF00917	0.566
LIG_UBA3_1	340	346	PF00899	0.407
LIG_WW_3	5	9	PF00397	0.376
MOD_CDK_SPK_2	206	211	PF00069	0.594
MOD_CK1_1	110	116	PF00069	0.656
MOD_CK1_1	144	150	PF00069	0.630
MOD_CK1_1	152	158	PF00069	0.611
MOD_CK1_1	159	165	PF00069	0.633
MOD_CK1_1	89	95	PF00069	0.642
MOD_CK2_1	214	220	PF00069	0.538
MOD_CK2_1	519	525	PF00069	0.498
MOD_CK2_1	81	87	PF00069	0.512
MOD_CK2_1	97	103	PF00069	0.576
MOD_GlcNHglycan	107	110	PF01048	0.670
MOD_GlcNHglycan	115	118	PF01048	0.678
MOD_GlcNHglycan	143	146	PF01048	0.552
MOD_GlcNHglycan	151	154	PF01048	0.574
MOD_GlcNHglycan	177	180	PF01048	0.653
MOD_GlcNHglycan	181	184	PF01048	0.665
MOD_GlcNHglycan	226	229	PF01048	0.535
MOD_GlcNHglycan	247	250	PF01048	0.683
MOD_GSK3_1	103	110	PF00069	0.717
MOD_GSK3_1	124	131	PF00069	0.670
MOD_GSK3_1	152	159	PF00069	0.823
MOD_GSK3_1	175	182	PF00069	0.544
MOD_GSK3_1	220	227	PF00069	0.660
MOD_GSK3_1	243	250	PF00069	0.618
MOD_GSK3_1	45	52	PF00069	0.445
MOD_GSK3_1	509	516	PF00069	0.468
MOD_GSK3_1	82	89	PF00069	0.587
MOD_N-GLC_1	149	154	PF02516	0.673
MOD_N-GLC_1	329	334	PF02516	0.300
MOD_N-GLC_1	410	415	PF02516	0.291
MOD_N-GLC_1	76	81	PF02516	0.464
MOD_N-GLC_1	89	94	PF02516	0.526
MOD_NEK2_1	31	36	PF00069	0.431
MOD_NEK2_1	410	415	PF00069	0.484
MOD_NEK2_1	513	518	PF00069	0.468
MOD_PIKK_1	107	113	PF00454	0.650
MOD_PIKK_1	165	171	PF00454	0.564
MOD_PIKK_1	247	253	PF00454	0.622
MOD_PK_1	49	55	PF00069	0.441
MOD_PKA_1	49	55	PF00069	0.441
MOD_PKA_2	113	119	PF00069	0.576
MOD_PKA_2	159	165	PF00069	0.575
MOD_PKA_2	214	220	PF00069	0.627
MOD_PKA_2	81	87	PF00069	0.495
MOD_Plk_1	149	155	PF00069	0.535
MOD_Plk_2-3	281	287	PF00069	0.702
MOD_Plk_4	26	32	PF00069	0.440
MOD_Plk_4	463	469	PF00069	0.468
MOD_Plk_4	509	515	PF00069	0.494
MOD_Plk_4	53	59	PF00069	0.488
MOD_ProDKin_1	124	130	PF00069	0.536
MOD_ProDKin_1	144	150	PF00069	0.619
MOD_ProDKin_1	152	158	PF00069	0.611
MOD_ProDKin_1	177	183	PF00069	0.544
MOD_ProDKin_1	206	212	PF00069	0.596
MOD_ProDKin_1	243	249	PF00069	0.659
MOD_ProDKin_1	251	257	PF00069	0.592
MOD_ProDKin_1	51	57	PF00069	0.433
MOD_SUMO_for_1	345	348	PF00179	0.407
MOD_SUMO_rev_2	437	446	PF00179	0.498
TRG_DiLeu_BaEn_4	281	287	PF01217	0.555
TRG_ENDOCYTIC_2	154	157	PF00928	0.541
TRG_ENDOCYTIC_2	326	329	PF00928	0.468
TRG_ENDOCYTIC_2	347	350	PF00928	0.468
TRG_ENDOCYTIC_2	510	513	PF00928	0.468
TRG_ENDOCYTIC_2	524	527	PF00928	0.457
TRG_ENDOCYTIC_2	63	66	PF00928	0.397
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW27	Leptomonas seymouri	66%	100%
A0A3S7X3G9	Leishmania donovani	87%	100%
A4I5K4	Leishmania infantum	87%	100%
E9B0U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7B7	Leishmania major	86%	100%