Protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

protein kinase

Species:

Leishmania braziliensis

UniProt:

A4H934_LEIBR

TriTrypDb:

LbrM.17.0900 , LBRM2903_170015600

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0016592	mediator complex	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H934

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H934

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	328	330	PF00675	0.420
CLV_NRD_NRD_1	63	65	PF00675	0.445
CLV_NRD_NRD_1	89	91	PF00675	0.568
CLV_PCSK_KEX2_1	148	150	PF00082	0.340
CLV_PCSK_KEX2_1	260	262	PF00082	0.557
CLV_PCSK_KEX2_1	328	330	PF00082	0.420
CLV_PCSK_KEX2_1	63	65	PF00082	0.445
CLV_PCSK_KEX2_1	89	91	PF00082	0.568
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.367
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.559
CLV_PCSK_PC7_1	256	262	PF00082	0.481
CLV_PCSK_PC7_1	324	330	PF00082	0.420
CLV_PCSK_SKI1_1	114	118	PF00082	0.621
CLV_PCSK_SKI1_1	148	152	PF00082	0.393
CLV_PCSK_SKI1_1	168	172	PF00082	0.227
CLV_PCSK_SKI1_1	324	328	PF00082	0.310
CLV_PCSK_SKI1_1	346	350	PF00082	0.260
CLV_PCSK_SKI1_1	448	452	PF00082	0.335
CLV_PCSK_SKI1_1	536	540	PF00082	0.395
CLV_PCSK_SKI1_1	568	572	PF00082	0.563
DEG_APCC_DBOX_1	323	331	PF00400	0.300
DOC_CKS1_1	404	409	PF01111	0.388
DOC_CYCLIN_RxL_1	445	455	PF00134	0.335
DOC_CYCLIN_RxL_1	60	70	PF00134	0.447
DOC_CYCLIN_yClb1_LxF_4	62	67	PF00134	0.510
DOC_MAPK_gen_1	137	147	PF00069	0.546
DOC_MAPK_gen_1	328	336	PF00069	0.400
DOC_MAPK_gen_1	346	355	PF00069	0.237
DOC_PP1_RVXF_1	330	337	PF00149	0.360
DOC_PP2B_LxvP_1	313	316	PF13499	0.434
DOC_PP2B_LxvP_1	467	470	PF13499	0.412
DOC_PP2B_LxvP_1	479	482	PF13499	0.388
DOC_PP4_FxxP_1	371	374	PF00568	0.420
DOC_USP7_MATH_1	185	189	PF00917	0.536
DOC_USP7_MATH_1	308	312	PF00917	0.534
DOC_USP7_MATH_1	374	378	PF00917	0.409
DOC_USP7_MATH_1	395	399	PF00917	0.410
DOC_USP7_MATH_1	480	484	PF00917	0.388
DOC_USP7_MATH_1	495	499	PF00917	0.370
DOC_USP7_MATH_1	500	504	PF00917	0.384
DOC_WW_Pin1_4	103	108	PF00397	0.474
DOC_WW_Pin1_4	27	32	PF00397	0.666
DOC_WW_Pin1_4	291	296	PF00397	0.689
DOC_WW_Pin1_4	383	388	PF00397	0.434
DOC_WW_Pin1_4	403	408	PF00397	0.291
DOC_WW_Pin1_4	58	63	PF00397	0.539
DOC_WW_Pin1_4	610	615	PF00397	0.523
LIG_14-3-3_CanoR_1	411	415	PF00244	0.305
LIG_14-3-3_CanoR_1	532	539	PF00244	0.291
LIG_14-3-3_CanoR_1	568	573	PF00244	0.504
LIG_14-3-3_CanoR_1	616	620	PF00244	0.510
LIG_Actin_WH2_1	319	334	PF00022	0.447
LIG_Actin_WH2_2	347	364	PF00022	0.388
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BRCT_BRCA1_1	367	371	PF00533	0.374
LIG_BRCT_BRCA1_1	385	389	PF00533	0.416
LIG_CtBP_PxDLS_1	407	411	PF00389	0.249
LIG_deltaCOP1_diTrp_1	433	441	PF00928	0.291
LIG_deltaCOP1_diTrp_1	588	593	PF00928	0.447
LIG_eIF4E_1	325	331	PF01652	0.420
LIG_FHA_1	338	344	PF00498	0.379
LIG_FHA_2	104	110	PF00498	0.567
LIG_FHA_2	242	248	PF00498	0.476
LIG_FHA_2	301	307	PF00498	0.600
LIG_FHA_2	428	434	PF00498	0.420
LIG_FHA_2	552	558	PF00498	0.350
LIG_GBD_Chelix_1	322	330	PF00786	0.206
LIG_Integrin_RGD_1	26	28	PF01839	0.489
LIG_LIR_Apic_2	368	374	PF02991	0.420
LIG_LIR_Apic_2	413	419	PF02991	0.302
LIG_LIR_Nem_3	30	36	PF02991	0.529
LIG_LIR_Nem_3	37	43	PF02991	0.562
LIG_LIR_Nem_3	588	593	PF02991	0.447
LIG_NRBOX	326	332	PF00104	0.206
LIG_PCNA_APIM_2	322	328	PF02747	0.305
LIG_PCNA_yPIPBox_3	562	573	PF02747	0.322
LIG_Pex14_2	504	508	PF04695	0.206
LIG_SH2_STAP1	36	40	PF00017	0.469
LIG_SH2_STAT5	223	226	PF00017	0.551
LIG_SH2_STAT5	325	328	PF00017	0.291
LIG_SH3_3	225	231	PF00018	0.390
LIG_SH3_3	401	407	PF00018	0.260
LIG_SH3_3	479	485	PF00018	0.450
LIG_SH3_3	494	500	PF00018	0.400
LIG_Sin3_3	442	449	PF02671	0.206
LIG_SUMO_SIM_anti_2	453	461	PF11976	0.345
LIG_SUMO_SIM_anti_2	516	522	PF11976	0.312
LIG_TRAF2_1	600	603	PF00917	0.519
LIG_UBA3_1	440	448	PF00899	0.420
LIG_UBA3_1	459	465	PF00899	0.335
MOD_CDK_SPK_2	58	63	PF00069	0.483
MOD_CDK_SPxK_1	58	64	PF00069	0.534
MOD_CDK_SPxK_1	610	616	PF00069	0.523
MOD_CDK_SPxxK_3	291	298	PF00069	0.510
MOD_CK1_1	115	121	PF00069	0.456
MOD_CK1_1	190	196	PF00069	0.603
MOD_CK1_1	279	285	PF00069	0.723
MOD_CK1_1	289	295	PF00069	0.735
MOD_CK1_1	311	317	PF00069	0.609
MOD_CK1_1	409	415	PF00069	0.360
MOD_CK1_1	531	537	PF00069	0.206
MOD_CK2_1	103	109	PF00069	0.450
MOD_CK2_1	241	247	PF00069	0.476
MOD_CK2_1	300	306	PF00069	0.552
MOD_CK2_1	385	391	PF00069	0.406
MOD_CK2_1	395	401	PF00069	0.192
MOD_CK2_1	450	456	PF00069	0.337
MOD_CK2_1	531	537	PF00069	0.333
MOD_GlcNHglycan	161	165	PF01048	0.549
MOD_GlcNHglycan	187	190	PF01048	0.616
MOD_GlcNHglycan	194	197	PF01048	0.701
MOD_GlcNHglycan	216	220	PF01048	0.458
MOD_GlcNHglycan	278	281	PF01048	0.660
MOD_GlcNHglycan	284	287	PF01048	0.593
MOD_GlcNHglycan	367	370	PF01048	0.329
MOD_GlcNHglycan	497	500	PF01048	0.467
MOD_GlcNHglycan	533	536	PF01048	0.322
MOD_GlcNHglycan	549	552	PF01048	0.578
MOD_GlcNHglycan	97	100	PF01048	0.504
MOD_GSK3_1	185	192	PF00069	0.561
MOD_GSK3_1	27	34	PF00069	0.647
MOD_GSK3_1	271	278	PF00069	0.728
MOD_GSK3_1	282	289	PF00069	0.716
MOD_GSK3_1	294	301	PF00069	0.785
MOD_GSK3_1	311	318	PF00069	0.656
MOD_GSK3_1	383	390	PF00069	0.290
MOD_GSK3_1	406	413	PF00069	0.340
MOD_GSK3_1	53	60	PF00069	0.580
MOD_GSK3_1	547	554	PF00069	0.671
MOD_GSK3_1	73	80	PF00069	0.450
MOD_NEK2_1	241	246	PF00069	0.357
MOD_NEK2_1	275	280	PF00069	0.745
MOD_NEK2_1	288	293	PF00069	0.715
MOD_NEK2_1	337	342	PF00069	0.379
MOD_NEK2_1	348	353	PF00069	0.248
MOD_NEK2_1	389	394	PF00069	0.206
MOD_NEK2_1	410	415	PF00069	0.223
MOD_NEK2_1	615	620	PF00069	0.589
MOD_NEK2_1	77	82	PF00069	0.504
MOD_NEK2_2	271	276	PF00069	0.657
MOD_NEK2_2	31	36	PF00069	0.538
MOD_NEK2_2	73	78	PF00069	0.511
MOD_OFUCOSY	335	341	PF10250	0.388
MOD_PIKK_1	380	386	PF00454	0.206
MOD_PIKK_1	395	401	PF00454	0.239
MOD_PIKK_1	41	47	PF00454	0.694
MOD_PIKK_1	77	83	PF00454	0.384
MOD_PKA_2	410	416	PF00069	0.291
MOD_PKA_2	531	537	PF00069	0.291
MOD_PKA_2	615	621	PF00069	0.502
MOD_Plk_1	168	174	PF00069	0.370
MOD_Plk_2-3	124	130	PF00069	0.508
MOD_Plk_4	112	118	PF00069	0.433
MOD_Plk_4	162	168	PF00069	0.425
MOD_Plk_4	271	277	PF00069	0.663
MOD_Plk_4	474	480	PF00069	0.426
MOD_Plk_4	568	574	PF00069	0.512
MOD_ProDKin_1	103	109	PF00069	0.478
MOD_ProDKin_1	27	33	PF00069	0.658
MOD_ProDKin_1	291	297	PF00069	0.691
MOD_ProDKin_1	383	389	PF00069	0.434
MOD_ProDKin_1	403	409	PF00069	0.291
MOD_ProDKin_1	58	64	PF00069	0.534
MOD_ProDKin_1	610	616	PF00069	0.523
MOD_SUMO_for_1	82	85	PF00179	0.534
MOD_SUMO_rev_2	377	381	PF00179	0.312
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.480
TRG_ENDOCYTIC_2	225	228	PF00928	0.473
TRG_ENDOCYTIC_2	97	100	PF00928	0.492
TRG_ER_diArg_1	327	329	PF00400	0.420
TRG_ER_diArg_1	62	64	PF00400	0.463
TRG_ER_diArg_1	88	90	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJY2	Leptomonas seymouri	49%	96%
A0A1X0P246	Trypanosomatidae	30%	100%
A0A3S5H7N0	Leishmania donovani	76%	100%
A0A422P3I6	Trypanosoma rangeli	29%	100%
A4I5K5	Leishmania infantum	75%	100%
C9ZQY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B0V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q7B6	Leishmania major	76%	100%
V5DQL7	Trypanosoma cruzi	32%	100%