Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H929_LEIBR

TriTrypDb:

LbrM.17.0850 , LBRM2903_170015000

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H929

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H929

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	449	453	PF00656	0.622
CLV_C14_Caspase3-7	822	826	PF00656	0.571
CLV_C14_Caspase3-7	95	99	PF00656	0.655
CLV_NRD_NRD_1	353	355	PF00675	0.601
CLV_NRD_NRD_1	460	462	PF00675	0.543
CLV_NRD_NRD_1	483	485	PF00675	0.707
CLV_NRD_NRD_1	487	489	PF00675	0.674
CLV_NRD_NRD_1	720	722	PF00675	0.663
CLV_NRD_NRD_1	771	773	PF00675	0.645
CLV_NRD_NRD_1	774	776	PF00675	0.603
CLV_NRD_NRD_1	778	780	PF00675	0.566
CLV_PCSK_FUR_1	484	488	PF00082	0.710
CLV_PCSK_FUR_1	705	709	PF00082	0.614
CLV_PCSK_FUR_1	772	776	PF00082	0.639
CLV_PCSK_KEX2_1	485	487	PF00082	0.709
CLV_PCSK_KEX2_1	549	551	PF00082	0.544
CLV_PCSK_KEX2_1	578	580	PF00082	0.667
CLV_PCSK_KEX2_1	591	593	PF00082	0.575
CLV_PCSK_KEX2_1	707	709	PF00082	0.709
CLV_PCSK_KEX2_1	771	773	PF00082	0.645
CLV_PCSK_KEX2_1	774	776	PF00082	0.603
CLV_PCSK_KEX2_1	777	779	PF00082	0.576
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.709
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.544
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.667
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.565
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.709
CLV_PCSK_PC7_1	774	780	PF00082	0.578
CLV_PCSK_SKI1_1	549	553	PF00082	0.545
CLV_PCSK_SKI1_1	727	731	PF00082	0.704
CLV_PCSK_SKI1_1	745	749	PF00082	0.618
CLV_PCSK_SKI1_1	779	783	PF00082	0.468
DEG_COP1_1	240	249	PF00400	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.502
DEG_ODPH_VHL_1	235	246	PF01847	0.597
DEG_SCF_FBW7_1	517	522	PF00400	0.581
DEG_SCF_FBW7_1	734	739	PF00400	0.542
DEG_SPOP_SBC_1	198	202	PF00917	0.587
DEG_SPOP_SBC_1	599	603	PF00917	0.559
DEG_SPOP_SBC_1	69	73	PF00917	0.560
DOC_CKS1_1	471	476	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.548
DOC_MAPK_gen_1	354	361	PF00069	0.543
DOC_MAPK_gen_1	484	491	PF00069	0.621
DOC_MAPK_gen_1	578	584	PF00069	0.581
DOC_MAPK_gen_1	591	599	PF00069	0.528
DOC_MAPK_HePTP_8	834	846	PF00069	0.534
DOC_MAPK_MEF2A_6	354	361	PF00069	0.543
DOC_MAPK_MEF2A_6	391	399	PF00069	0.562
DOC_MAPK_MEF2A_6	837	846	PF00069	0.540
DOC_PP2B_LxvP_1	116	119	PF13499	0.564
DOC_PP2B_LxvP_1	235	238	PF13499	0.523
DOC_PP2B_LxvP_1	244	247	PF13499	0.519
DOC_PP2B_LxvP_1	740	743	PF13499	0.538
DOC_PP4_MxPP_1	662	665	PF00568	0.542
DOC_USP7_MATH_1	11	15	PF00917	0.500
DOC_USP7_MATH_1	149	153	PF00917	0.639
DOC_USP7_MATH_1	16	20	PF00917	0.492
DOC_USP7_MATH_1	198	202	PF00917	0.645
DOC_USP7_MATH_1	238	242	PF00917	0.544
DOC_USP7_MATH_1	265	269	PF00917	0.576
DOC_USP7_MATH_1	291	295	PF00917	0.536
DOC_USP7_MATH_1	333	337	PF00917	0.757
DOC_USP7_MATH_1	39	43	PF00917	0.501
DOC_USP7_MATH_1	446	450	PF00917	0.791
DOC_USP7_MATH_1	45	49	PF00917	0.521
DOC_USP7_MATH_1	517	521	PF00917	0.677
DOC_USP7_MATH_1	560	564	PF00917	0.698
DOC_USP7_MATH_1	57	61	PF00917	0.565
DOC_USP7_MATH_1	69	73	PF00917	0.608
DOC_USP7_MATH_1	736	740	PF00917	0.549
DOC_USP7_MATH_1	809	813	PF00917	0.655
DOC_USP7_MATH_1	83	87	PF00917	0.549
DOC_USP7_UBL2_3	613	617	PF12436	0.557
DOC_USP7_UBL2_3	727	731	PF12436	0.548
DOC_USP7_UBL2_3	858	862	PF12436	0.668
DOC_WW_Pin1_4	206	211	PF00397	0.600
DOC_WW_Pin1_4	284	289	PF00397	0.616
DOC_WW_Pin1_4	315	320	PF00397	0.625
DOC_WW_Pin1_4	336	341	PF00397	0.619
DOC_WW_Pin1_4	348	353	PF00397	0.643
DOC_WW_Pin1_4	408	413	PF00397	0.564
DOC_WW_Pin1_4	41	46	PF00397	0.522
DOC_WW_Pin1_4	424	429	PF00397	0.681
DOC_WW_Pin1_4	467	472	PF00397	0.551
DOC_WW_Pin1_4	490	495	PF00397	0.562
DOC_WW_Pin1_4	515	520	PF00397	0.573
DOC_WW_Pin1_4	55	60	PF00397	0.560
DOC_WW_Pin1_4	582	587	PF00397	0.566
DOC_WW_Pin1_4	660	665	PF00397	0.692
DOC_WW_Pin1_4	732	737	PF00397	0.615
DOC_WW_Pin1_4	823	828	PF00397	0.552
DOC_WW_Pin1_4	851	856	PF00397	0.575
LIG_14-3-3_CanoR_1	159	168	PF00244	0.583
LIG_14-3-3_CanoR_1	283	288	PF00244	0.691
LIG_14-3-3_CanoR_1	486	492	PF00244	0.566
LIG_14-3-3_CanoR_1	550	554	PF00244	0.542
LIG_14-3-3_CanoR_1	679	687	PF00244	0.668
LIG_Actin_WH2_2	832	847	PF00022	0.393
LIG_BRCT_BRCA1_1	208	212	PF00533	0.527
LIG_BRCT_BRCA1_1	241	245	PF00533	0.540
LIG_FHA_1	132	138	PF00498	0.569
LIG_FHA_1	151	157	PF00498	0.571
LIG_FHA_1	160	166	PF00498	0.583
LIG_FHA_1	172	178	PF00498	0.504
LIG_FHA_1	230	236	PF00498	0.674
LIG_FHA_1	284	290	PF00498	0.676
LIG_FHA_1	296	302	PF00498	0.553
LIG_FHA_1	394	400	PF00498	0.566
LIG_FHA_1	425	431	PF00498	0.675
LIG_FHA_1	516	522	PF00498	0.577
LIG_FHA_1	559	565	PF00498	0.554
LIG_FHA_1	646	652	PF00498	0.574
LIG_FHA_1	696	702	PF00498	0.695
LIG_FHA_1	82	88	PF00498	0.571
LIG_FHA_1	852	858	PF00498	0.714
LIG_FHA_2	249	255	PF00498	0.534
LIG_FHA_2	297	303	PF00498	0.651
LIG_FHA_2	48	54	PF00498	0.558
LIG_FHA_2	531	537	PF00498	0.539
LIG_FHA_2	74	80	PF00498	0.667
LIG_LIR_Apic_2	135	141	PF02991	0.655
LIG_LIR_Nem_3	209	215	PF02991	0.521
LIG_MYND_1	145	149	PF01753	0.693
LIG_PTAP_UEV_1	442	447	PF05743	0.559
LIG_SH2_CRK	831	835	PF00017	0.458
LIG_SH2_SRC	138	141	PF00017	0.596
LIG_SH2_SRC	838	841	PF00017	0.526
LIG_SH2_STAP1	619	623	PF00017	0.547
LIG_SH2_STAP1	831	835	PF00017	0.512
LIG_SH2_STAT3	627	630	PF00017	0.692
LIG_SH2_STAT5	21	24	PF00017	0.504
LIG_SH2_STAT5	769	772	PF00017	0.648
LIG_SH2_STAT5	838	841	PF00017	0.434
LIG_SH3_1	803	809	PF00018	0.596
LIG_SH3_3	204	210	PF00018	0.634
LIG_SH3_3	250	256	PF00018	0.577
LIG_SH3_3	313	319	PF00018	0.654
LIG_SH3_3	335	341	PF00018	0.612
LIG_SH3_3	356	362	PF00018	0.677
LIG_SH3_3	437	443	PF00018	0.570
LIG_SH3_3	468	474	PF00018	0.653
LIG_SH3_3	7	13	PF00018	0.518
LIG_SH3_3	740	746	PF00018	0.684
LIG_SH3_3	803	809	PF00018	0.596
LIG_SUMO_SIM_par_1	25	32	PF11976	0.479
LIG_SUMO_SIM_par_1	394	401	PF11976	0.546
LIG_SUMO_SIM_par_1	431	438	PF11976	0.569
LIG_SUMO_SIM_par_1	86	93	PF11976	0.535
LIG_TRAF2_1	372	375	PF00917	0.555
LIG_TRAF2_1	655	658	PF00917	0.559
LIG_TYR_ITIM	829	834	PF00017	0.496
LIG_WW_1	766	769	PF00397	0.654
MOD_CDC14_SPxK_1	493	496	PF00782	0.563
MOD_CDK_SPK_2	470	475	PF00069	0.554
MOD_CDK_SPxK_1	348	354	PF00069	0.592
MOD_CDK_SPxK_1	490	496	PF00069	0.564
MOD_CDK_SPxxK_3	348	355	PF00069	0.537
MOD_CDK_SPxxK_3	851	858	PF00069	0.584
MOD_CK1_1	112	118	PF00069	0.536
MOD_CK1_1	124	130	PF00069	0.663
MOD_CK1_1	201	207	PF00069	0.611
MOD_CK1_1	217	223	PF00069	0.635
MOD_CK1_1	229	235	PF00069	0.583
MOD_CK1_1	25	31	PF00069	0.502
MOD_CK1_1	268	274	PF00069	0.672
MOD_CK1_1	275	281	PF00069	0.663
MOD_CK1_1	315	321	PF00069	0.630
MOD_CK1_1	336	342	PF00069	0.593
MOD_CK1_1	348	354	PF00069	0.516
MOD_CK1_1	380	386	PF00069	0.686
MOD_CK1_1	398	404	PF00069	0.665
MOD_CK1_1	467	473	PF00069	0.551
MOD_CK1_1	49	55	PF00069	0.625
MOD_CK1_1	490	496	PF00069	0.592
MOD_CK1_1	58	64	PF00069	0.517
MOD_CK1_1	660	666	PF00069	0.680
MOD_CK1_1	668	674	PF00069	0.635
MOD_CK1_1	68	74	PF00069	0.491
MOD_CK1_1	688	694	PF00069	0.571
MOD_CK1_1	703	709	PF00069	0.550
MOD_CK1_1	741	747	PF00069	0.656
MOD_CK1_1	90	96	PF00069	0.551
MOD_CK2_1	11	17	PF00069	0.498
MOD_CK2_1	169	175	PF00069	0.536
MOD_CK2_1	191	197	PF00069	0.550
MOD_CK2_1	296	302	PF00069	0.708
MOD_CK2_1	369	375	PF00069	0.571
MOD_CK2_1	47	53	PF00069	0.557
MOD_CK2_1	502	508	PF00069	0.578
MOD_CK2_1	530	536	PF00069	0.542
MOD_CK2_1	582	588	PF00069	0.579
MOD_CK2_1	652	658	PF00069	0.598
MOD_CK2_1	73	79	PF00069	0.666
MOD_CK2_1	816	822	PF00069	0.605
MOD_GlcNHglycan	123	126	PF01048	0.506
MOD_GlcNHglycan	13	16	PF01048	0.489
MOD_GlcNHglycan	171	174	PF01048	0.684
MOD_GlcNHglycan	212	215	PF01048	0.707
MOD_GlcNHglycan	22	25	PF01048	0.484
MOD_GlcNHglycan	293	296	PF01048	0.535
MOD_GlcNHglycan	31	34	PF01048	0.449
MOD_GlcNHglycan	331	334	PF01048	0.728
MOD_GlcNHglycan	347	350	PF01048	0.564
MOD_GlcNHglycan	371	374	PF01048	0.748
MOD_GlcNHglycan	379	382	PF01048	0.636
MOD_GlcNHglycan	415	418	PF01048	0.655
MOD_GlcNHglycan	448	451	PF01048	0.627
MOD_GlcNHglycan	457	461	PF01048	0.628
MOD_GlcNHglycan	466	469	PF01048	0.564
MOD_GlcNHglycan	521	524	PF01048	0.733
MOD_GlcNHglycan	55	58	PF01048	0.630
MOD_GlcNHglycan	568	571	PF01048	0.676
MOD_GlcNHglycan	67	70	PF01048	0.539
MOD_GlcNHglycan	673	676	PF01048	0.611
MOD_GlcNHglycan	693	696	PF01048	0.504
MOD_GlcNHglycan	698	701	PF01048	0.542
MOD_GlcNHglycan	702	705	PF01048	0.540
MOD_GlcNHglycan	708	711	PF01048	0.555
MOD_GlcNHglycan	72	75	PF01048	0.551
MOD_GlcNHglycan	740	743	PF01048	0.549
MOD_GlcNHglycan	779	782	PF01048	0.472
MOD_GlcNHglycan	799	803	PF01048	0.405
MOD_GSK3_1	11	18	PF00069	0.499
MOD_GSK3_1	120	127	PF00069	0.552
MOD_GSK3_1	181	188	PF00069	0.566
MOD_GSK3_1	197	204	PF00069	0.662
MOD_GSK3_1	206	213	PF00069	0.647
MOD_GSK3_1	214	221	PF00069	0.597
MOD_GSK3_1	225	232	PF00069	0.575
MOD_GSK3_1	25	32	PF00069	0.487
MOD_GSK3_1	265	272	PF00069	0.663
MOD_GSK3_1	273	280	PF00069	0.677
MOD_GSK3_1	291	298	PF00069	0.608
MOD_GSK3_1	321	328	PF00069	0.671
MOD_GSK3_1	329	336	PF00069	0.703
MOD_GSK3_1	393	400	PF00069	0.550
MOD_GSK3_1	41	48	PF00069	0.629
MOD_GSK3_1	420	427	PF00069	0.551
MOD_GSK3_1	434	441	PF00069	0.636
MOD_GSK3_1	49	56	PF00069	0.604
MOD_GSK3_1	515	522	PF00069	0.627
MOD_GSK3_1	549	556	PF00069	0.723
MOD_GSK3_1	65	72	PF00069	0.532
MOD_GSK3_1	674	681	PF00069	0.590
MOD_GSK3_1	685	692	PF00069	0.627
MOD_GSK3_1	696	703	PF00069	0.606
MOD_GSK3_1	723	730	PF00069	0.623
MOD_GSK3_1	732	739	PF00069	0.530
MOD_GSK3_1	773	780	PF00069	0.633
MOD_GSK3_1	81	88	PF00069	0.702
MOD_N-GLC_1	121	126	PF02516	0.508
MOD_N-GLC_1	688	693	PF02516	0.620
MOD_NEK2_1	109	114	PF00069	0.481
MOD_NEK2_1	120	125	PF00069	0.525
MOD_NEK2_1	158	163	PF00069	0.545
MOD_NEK2_1	199	204	PF00069	0.546
MOD_NEK2_1	27	32	PF00069	0.520
MOD_NEK2_1	306	311	PF00069	0.633
MOD_NEK2_1	345	350	PF00069	0.630
MOD_NEK2_1	387	392	PF00069	0.740
MOD_NEK2_1	397	402	PF00069	0.667
MOD_NEK2_1	420	425	PF00069	0.556
MOD_NEK2_1	46	51	PF00069	0.605
MOD_NEK2_1	530	535	PF00069	0.616
MOD_NEK2_1	644	649	PF00069	0.561
MOD_NEK2_1	67	72	PF00069	0.579
MOD_NEK2_1	685	690	PF00069	0.636
MOD_NEK2_1	696	701	PF00069	0.643
MOD_NEK2_1	92	97	PF00069	0.546
MOD_NEK2_2	16	21	PF00069	0.503
MOD_NEK2_2	544	549	PF00069	0.522
MOD_OFUCOSY	542	548	PF10250	0.519
MOD_PIKK_1	275	281	PF00454	0.699
MOD_PIKK_1	333	339	PF00454	0.562
MOD_PIKK_1	39	45	PF00454	0.493
MOD_PIKK_1	428	434	PF00454	0.545
MOD_PKA_1	487	493	PF00069	0.566
MOD_PKA_1	549	555	PF00069	0.540
MOD_PKA_1	721	727	PF00069	0.698
MOD_PKA_1	777	783	PF00069	0.562
MOD_PKA_2	109	115	PF00069	0.588
MOD_PKA_2	158	164	PF00069	0.581
MOD_PKA_2	487	493	PF00069	0.566
MOD_PKA_2	495	501	PF00069	0.554
MOD_PKA_2	549	555	PF00069	0.551
MOD_PKA_2	566	572	PF00069	0.615
MOD_PKA_2	678	684	PF00069	0.668
MOD_PKA_2	773	779	PF00069	0.632
MOD_PKB_1	775	783	PF00069	0.620
MOD_Plk_1	121	127	PF00069	0.507
MOD_Plk_1	16	22	PF00069	0.503
MOD_Plk_1	217	223	PF00069	0.520
MOD_Plk_1	239	245	PF00069	0.534
MOD_Plk_1	272	278	PF00069	0.667
MOD_Plk_1	343	349	PF00069	0.648
MOD_Plk_1	657	663	PF00069	0.606
MOD_Plk_2-3	509	515	PF00069	0.581
MOD_Plk_4	109	115	PF00069	0.659
MOD_Plk_4	125	131	PF00069	0.579
MOD_Plk_4	16	22	PF00069	0.503
MOD_Plk_4	239	245	PF00069	0.534
MOD_Plk_4	487	493	PF00069	0.566
MOD_Plk_4	816	822	PF00069	0.483
MOD_Plk_4	87	93	PF00069	0.523
MOD_ProDKin_1	206	212	PF00069	0.604
MOD_ProDKin_1	284	290	PF00069	0.618
MOD_ProDKin_1	315	321	PF00069	0.629
MOD_ProDKin_1	336	342	PF00069	0.621
MOD_ProDKin_1	348	354	PF00069	0.642
MOD_ProDKin_1	408	414	PF00069	0.564
MOD_ProDKin_1	41	47	PF00069	0.524
MOD_ProDKin_1	424	430	PF00069	0.681
MOD_ProDKin_1	467	473	PF00069	0.551
MOD_ProDKin_1	490	496	PF00069	0.564
MOD_ProDKin_1	515	521	PF00069	0.575
MOD_ProDKin_1	55	61	PF00069	0.560
MOD_ProDKin_1	582	588	PF00069	0.565
MOD_ProDKin_1	660	666	PF00069	0.694
MOD_ProDKin_1	732	738	PF00069	0.614
MOD_ProDKin_1	823	829	PF00069	0.551
MOD_ProDKin_1	851	857	PF00069	0.579
MOD_SUMO_for_1	857	860	PF00179	0.664
MOD_SUMO_for_1	861	864	PF00179	0.636
MOD_SUMO_for_1	869	872	PF00179	0.610
MOD_SUMO_rev_2	348	357	PF00179	0.598
MOD_SUMO_rev_2	503	512	PF00179	0.674
TRG_DiLeu_BaLyEn_6	425	430	PF01217	0.658
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.560
TRG_ENDOCYTIC_2	831	834	PF00928	0.518
TRG_ER_diArg_1	484	487	PF00400	0.709
TRG_ER_diArg_1	622	625	PF00400	0.679
TRG_ER_diArg_1	771	774	PF00400	0.644
TRG_ER_diArg_1	775	778	PF00400	0.594
TRG_NLS_MonoCore_2	483	488	PF00514	0.709
TRG_NLS_MonoExtC_3	483	488	PF00514	0.709
TRG_NLS_MonoExtN_4	481	488	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	793	797	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3D6	Leishmania donovani	54%	100%
A4I5L0	Leishmania infantum	54%	100%
E9B0V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4Q7B1	Leishmania major	53%	98%